Objective To study the effect of transitional care model on the treatment of patients with transitional period of intensive care. Methods A total of 80 cases of patients who were admitted to the hospital from May 2015 to September 2016 were selected as the study subjects and were randomly divided into the control group and the intervention group, 40 cases of each group.The patients in the control group were given routine care, and the intervention group carried out transitional nursing mode.The changes of oxidative stress index, inflammatory factor level, psychological status score, incidence of adverse events and the return of ICU rate and nursing satisfaction of the two groups were compared. Results The serum superoxide dismutase (SOD) and glutathione (GSH) levels in the intervention group were significantly higher than those in the control group at the end of 7 days, and the differences were statistically significant(P<0.05). The level of serum malondialdehyde (MDA) in the intervention group was significantly lower than that in the control group, and the difference was statistically significant(P<0.05). The levels of serum hypersensitivity C-reactive protein (hs-CRP), tumor necrosis factor (TNF-α), interleukin (IL)-10 were significantly lower than those in the control group, and the differences were statistically significant(P<0.05). Self-evaluation of Anxiety Scale (SAS), Hamilton Anxiety Scale (HAMA), Depression Self-rating Scale (SDS) and Hamilton Depression Scale (HAMD) scores of the intervention group were significantly lower than those of the control group, and the differences were statistically significant, and the difference was statistically significant(P<0.05). The occurrence rate of adverse event of intervention group was 5.00%, which was significantly lower than control group that was 12.50%(P<0.05). The rate of intervention group returning to ICU was 7.50%, which was significantly lower than control group that was 20.00%(P<0.05). The nursing satisfaction of patients in intervention was 97.50%, which was significantly higher than control group that was 80.00%, and the difference was statistically significant(P<0.05). Conclusion The transitional period nursing mode implemented in the curing process for intensive care patients during transitional period can reduce oxidative stress level and inflammatory factor level, improving the mental state of patients, reducing the occurrence rate of adverse event and the rate of returning to ICU.In addition, the nursing satisfaction of patients can also be improved, which is worth popularizing and applying. Key words: Transitional care model; Critically ill patients; ICU monitoring; Oxidative stress; Inflammatory factors