Health utility of caregivers of children with autism was assessed using the EuroQol five-dimensional questionnaire (EQ-5D). Utility scores of autism caregivers were compared to norms for the general adult United States (US) population. Predictors of health utility were identified. A cross-sectional online survey design was conducted. Caregivers registered with the Interactive Autism Network (IAN) were approached for participation in the online survey. Three hundred and sixteen usable responses were received. Health utility among caregivers was calculated and compared with the US population norms using Student’s t-test. Problems in EQ-5D domains and utility scores were analyzed by study characteristics using Kruskal-Wallis ANOVA. Ordinary least square regression using a fully adjusted multivariable model was used to determine the factors predicting health utility of autism caregivers. The Bruesh-Pagan test revealed presence of heteroskedasticity. To adjust for heteroskedasticity, White’s robust standard error estimates were reported. Roughly 94% of caregivers who participated in the study were females. As compared to their counterparts in the general US population, caregivers who were aged 18-44 years and were females had lower utility scores (P < 0.001). Significant differences in utility scores were observed among caregivers. When compared to males, females had lower health utility. Caregivers of lower socioeconomic status had lower utility scores and reported more problems in EQ-5D domains than those from higher socioeconomic status. Caregiver burden was inversely correlated with health utility. Caregiver physical and mental health status, objective strain, education, and relationship with the care recipient were found to significantly predict health utility (adjusted R-squared ~57%). Autism caregivers had lower health utility than the general adult US population. Utility scores were found to vary by both caregiver and care recipient characteristics. There is an immediate need to address health concerns among this growing population.