Perceptions, experiences, facilitators, and inhibitors of disease among patients may be shaped by their lifestyle and cultural background. Despite the significance of understanding their perspectives and experiences about disease for the prevention and management of osteoarthritis (OA) through physiotherapy, this subject has not been explored among patients with knee OA (PKOA) from lower and middle-income countries (LMICs). This study aims to explore the perception, and experiences of knee OA and physiotherapy treatment and identify the facilitators and inhibitors of physiotherapy treatment in PKOA from a lower- and middle-income country, India. 40 PKOA (n=10 in each Kellgren and Lawrence grade) will be recruited using a purposive sampling technique. Data will be collected through semi-structured interviews which are composed of pre-determined open-ended questions. Based on patients' flexibility and feasibility, the interview will be conducted face-to-face or by telephone or videoconference. The interview will be recorded using a digital audio recorder. Recorded data will be transcribed verbatim. Data will be analysed using thematic analysis based on the Braun and Clark approach. The verbatim transcript will be evaluated to identify sub-themes and themes through thematic analysis. Generated data will be investigated through inductive qualitative analysis to examine the viewpoints of PKOA. This study will explore the patients' perspectives, experiences, and the factors which will facilitate and inhibit the physiotherapy treatment for knee osteoarthritis. The result might reveal a new way to promote insightful decision-making towards physiotherapy care for PKOA and help to improve their access to physiotherapy care.