Research Objectives was to examine the feasibility and efficacy of exercises in women with lymphedema post breast cancer. Breast cancer treatment often results in the development of upper extremity lymphedema. Evidence is lacking on the effects exercise has on lymphedema in breast cancer survivors. This analysis looks to see the impact of exercise programs on lymphedema in breast cancer survivors. Design Retrospective data analysis. Setting The data in this study came from an original research project, Project IMPACT (Improving Mental and Physical ACTivity), that took place in San Antonio, Texas. Participants This analysis included data from a sub-group of 9 participants with lymphedema in at least one of their arms. The original study had 94 participants who were breast cancer survivors. Interventions Project Impact looked at the effects six month exercise interventions on breast cancer survivors: yoga-based exercise, a comprehensive individualized designed program (including aerobic, resistance and flexibility exercises), and exercise of the participant's own choice. Main Outcome Measures Affected side volume, passive range of motion (PROM), and self-reported effects of Lymphedema on daily life measured by the Norman Lymphedema Self-Report Survey (NLSS). All outcomes were measured at the beginning and end of the exercise program. Results All participants completed the exercise program with no adverse events. A significant difference (p < 0.05) was found in four subscales pertaining to the affected upper extremity's forearm and hand in the NLSS. No other significant changes were found. Conclusions The results of this pilot study suggest that it is safe for breast cancer survivors with lymphedema to exercise. Performing exercises can positively reduce some symptoms related to lymphedema. Future studies with bigger sample sizes can help confirm these findings. Author(s) Disclosures The authors also gratefully acknowledge the support of Dr. Amy Lang, the ThriveWell Cancer Foundation, and the START Center for Cancer Care. There are no other disclosures from any of the authors. was to examine the feasibility and efficacy of exercises in women with lymphedema post breast cancer. Breast cancer treatment often results in the development of upper extremity lymphedema. Evidence is lacking on the effects exercise has on lymphedema in breast cancer survivors. This analysis looks to see the impact of exercise programs on lymphedema in breast cancer survivors. Retrospective data analysis. The data in this study came from an original research project, Project IMPACT (Improving Mental and Physical ACTivity), that took place in San Antonio, Texas. This analysis included data from a sub-group of 9 participants with lymphedema in at least one of their arms. The original study had 94 participants who were breast cancer survivors. Project Impact looked at the effects six month exercise interventions on breast cancer survivors: yoga-based exercise, a comprehensive individualized designed program (including aerobic, resistance and flexibility exercises), and exercise of the participant's own choice. Affected side volume, passive range of motion (PROM), and self-reported effects of Lymphedema on daily life measured by the Norman Lymphedema Self-Report Survey (NLSS). All outcomes were measured at the beginning and end of the exercise program. All participants completed the exercise program with no adverse events. A significant difference (p < 0.05) was found in four subscales pertaining to the affected upper extremity's forearm and hand in the NLSS. No other significant changes were found. The results of this pilot study suggest that it is safe for breast cancer survivors with lymphedema to exercise. Performing exercises can positively reduce some symptoms related to lymphedema. Future studies with bigger sample sizes can help confirm these findings.