Cardiovascular Risk Factors In Children Research Articles

Cardiovascular risk factors in children with type 1 diabetes mellitus.

Objective Cardiovascular disease is a major complication among children with type 1 diabetes mellitus (T1DM). This prospective study aimed at examining the presence of cardiovascular risk factors in children with T1DM. Methods We evaluated several cardiovascular risk factors, including atherosclerosis, artery intima-media thickness (IMT) and metabolic responses, in 175 children with T1DM, with 150 non-diabetic children as normal controls. Results The diabetic children had significantly higher carotid IMT (cIMT) and aortic IMT (aIMT), higher values for diastolic wall stress (DWS), incremental elastic modulus (IEM), and flow-mediated dilatation (FMD) than the controls. The levels of tumor necrosis factor-α (TNF-α), interleukin-4 (IL4), high-sensitivity C-reactive protein (hs-CRP) and leptin were significantly higher in T1DM patients. In T1DM children, the cIMT and aIMT were correlated with several risk factors, including age, weight, body mass index (BMI), duration of diabetes, waist/hip ratio, as well as levels of total cholesterol, triglycerides and apolipoprotein B (apoB). In addition to common risk factors, cIMT was also associated with systolic blood pressure (BP). Other risk factors, such as height, diastolic BP, low-density lipoprotein (LDL)/high-density lipoprotein (HDL)-cholesterol ratio, apolipoprotein A1 (apoA1) and S-creatinine levels, were not all independent risk factors of cardiovascular disease in T1DM children. Conclusions T1DM is associated with early impairment of the common carotid and aortic artery structure and function, and the diabetic state may be the main risk factor for arterial wall stiffening and thickening.

The Relationship Between Serum Asymmetric Dimethylarginine Levels and Cardiovascular Risk Factors in Children with Nephrotic Syndrome

The Relationship Between Serum Asymmetric Dimethylarginine Levels and Cardiovascular Risk Factors in Children with Nephrotic Syndrome

Associations between Sleep Pattern and Quality and Cardiovascular Risk Factors among Macao School Students

Background: Despite accumulating evidence showing that sleep duration and cardiometabolic health are correlated, the association of sleep regularity and quality with cardiovascular risk factors in children and adolescents remains inconclusive. Therefore, we examined the relationship between sleep regularity/quality and cardiovascular risk factors in children and adolescents in Macao, China. Methods: We conducted a cross-sectional study among primary and secondary school students (age range: 9-18 years) in Macao, China. Body weight, height, waist circumference (WC), and serum lipid levels were measured. Sleep regularity and sleep quality were assessed by using the Pittsburgh Sleep Quality Index. Multivariable logistic regression was conducted to examine the relationship of sleep variables with the increased likelihood of body mass index (BMI)-classified overweight/obesity, WC-classified obesity, and dyslipidemia. Results: A total of 1078 school students were included in the analysis. Differences of >2 hours between weekday and weekend bedtimes were associated with the increased risk of BMI-classified overweight/obesity (odds ratio = 2.58, 95% confidence interval = 1.55-4.31, p < 0.01) after being adjusted for sleep variables and lifestyle factors. No statistically significant association was found between poor sleep quality and any other outcome. Conclusions: Irregular bedtime was associated with elevated body weight regardless of sleep amount and quality. Thus, regular bedtimes are recommended as a simple but practical strategy for preventing obesity.

Relation between Dietary Habits, Physical Activity, and Anthropometric and Vascular Parameters in Children Attending the Primary School in the Verona South District.

The aim of this school-based study was to identify the possible association between diet and physical activity, as well as the anthropometric, vascular, and gluco-lipid parameters. We administered two validated questionnaires for diet and physical activity (Food Frequency questionnaire (FFQ), Children-Physical Activity Questionnaire (PAQ-C)) to children at four primary schools in Verona South (Verona, Italy). Specific food intake, dietary pattern, and physical activity level expressed in Metabolic Equivalent of Task (MET) and PAQ-C score were inserted in multivariate linear regression models to assess the association with anthropometric, hemodynamic, and gluco-lipid measures. Out of 309 children included in the study, 300 (age: 8.6 ± 0.7 years, male: 50%; Obese (OB): 13.6%; High blood pressure (HBP): 21.6%) compiled to the FFQ. From this, two dietary patterns were identified: “healthy” and “unhealthy”. Direct associations were found between (i) “fast food” intake, Pulse Wave Velocity (PWV), and (ii) animal-derived fat and capillary cholesterol, while inverse associations were found between vegetable, fruit, and nut intake and capillary glucose. The high prevalence of OB and HBP and the significant correlations between some categories of food and metabolic and vascular parameters suggest the importance of life-style modification politics at an early age to prevent the onset of overt cardiovascular risk factors in childhood.

The study of lipid profile and other cardiovascular risk factors in children born to parents having premature ischemic heart disease

Background: Most of the studies on cardiovascular risk factors are concentrated on adults. But atherosclerotic process begins in childhood and is influenced by genetics, diet and life style. Hence, present study was undertaken. The objectives of the study were to study lipid profile and other cardiovascular risk factors like hypertensive status, BMI(Body mass index) in children aged between 5years and 18 years born to parents having premature IHD(Ischemic heart disease), to study diet and life style factors in study group having family history of IHD, to study the sociodemographic profile of dyslipidemia.Methods: A 200 Cases of premature IHD were selected. Their children(n=200) in the age group of 5 to 18 years were selected and analysed for cardiovascular risk factors. They were compared with 200 normal children without any family history of IHD.Results: On comparison of mean lipid profile between cases and controls HDL cholesterol was very low amongst cases (p=0.001). The mean values of triglycerides and VLDL were very high amongst cases (p=0.001). The mean atherogenic index (AI) was high amongst cases (p=0.001). Prehypertension or hypertension was seen amongst 8.5% cases (p=0.004). Amongst the cases 19.5% had excess junk food intake (p=0.001). 51.5% of cases had sedentary life style (p=0.001).Conclusions: Children in our area born to parents with premature IHD have significant incidence of dyslipidaemia. There is an increased incidence of other cardiovascular risk factors like hypertension, excess junk food intake, sedentary life style in these children.

Cord Blood Vitamin D Levels and Early Childhood Blood Pressure: The Healthy Start Study.

BackgroundVitamin D deficiency is associated with cardiovascular events among adults, but it is unclear whether early‐life vitamin D deficiency influences cardiovascular risk factors in children.Methods and ResultsWe measured total and bioavailable 25‐dihydroxyvitamin D (25OHD) in cord blood and in blood from 4‐ to 6‐year‐old children, and we assessed cardiovascular risk factors (blood pressure, arterial stiffness, body size, and adiposity) at 4 to 6 years. We tested for racial/ethnic differences in total and bioavailable 25OHD (n=715) and modeled the adjusted association between cord blood 25OHD and childhood cardiovascular risk factors (n=171). We observed racial/ethnic differences in total and bioavailable 25OHD levels in both cord and child blood samples (all P<0.05). Each 25‐nmol/L increase in cord blood total 25OHD was associated with a 2.5–mm Hg (SE 0.8) decrease in systolic blood pressure (P=0.002) and a 1.7–mm Hg (SE 0.6) decrease in diastolic blood pressure (P=0.01), independent of childhood 25OHD levels, race/ethnicity, and other covariates. There was no association between cord blood total 25OHD and any other cardiovascular risk factors. Cord blood levels of bioavailable and free 25OHD were not associated with any cardiovascular risk factor in childhood.ConclusionsIn this diverse prebirth cohort, we observed lower systolic and diastolic blood pressure among children with higher total 25OHD levels at birth. Our findings suggest that intrauterine exposure to vitamin D may contribute to early‐life programming of offspring blood pressure. Intervention studies are needed to determine whether increasing fetal vitamin D exposure can reduce the risk of elevated blood pressure in childhood.

Evaluation of cardiovascular risk by growth-differentiation factor-15 and tissue Doppler imaging in children with subclinical hypothyroidism.

Subclinical hypothyroidism, defined as increased TSH serum levels and normal serum free T4 concentrations, has been associated with an increased risk of heart disease in adults. But, data in children and adolescents are scanty and treatment of subclinical hypothyroidism is controversial. Growth differentiation factor-15 (GDF-15) is a promising biomarker of cardiac remodeling. This study aimed to evaluate the cardiovascular risk factors in children with subclinical hypothyroidism, measured with tissue Doppler echocardiography (TDE), and conventional echocardiography and GDF-15 level. The study comprised a total of 41 pediatric patients with subclinical hypothyroidism (SH) (mean age 9.6 ± 4.7 years) and 31 healthy children (mean age 11.2 ± 3.4 years) as the control group. Subclinical hypothyroidism was defined as a thyroid-stimulating hormone level higher than 4 mIU/l and a normal free-thyroxine level (0.6-1.8 ng/dl). Tissue Doppler echocardiography was performed to all individuals in the control group and patient group at the beginning of the study. Global systolic function as assessed by left ventricular ejection fraction was compared between groups. The serum GDF-15 level was measured. There were no significant differences in demographic parameters between the SH and control groups. The left ventricular internal diameter end systole, interventricular septal end diastole, left ventricular posterior wall end diastole, and tricuspid annular plane systolic excursion values were significantly different between the SH and control groups (p = 0.038, 0.028, 0.005, and 0.000, respectively). The mean mitral isovolumic relaxation time value of the SH group was 57.2 ± 9.3 ms, compared to 44.5 ± 5.6 ms for the control group (p = 0.000). The mean tricuspid isovolumic contraction time value of the SH group was 58.7 ± 9.4 ms, and that of the control group was 45.1 ± 5.3 ms (p = 0.000). The mean tricuspid isovolumic relaxation time value of the SH group was 58.03 ± 9.5 ms, and that of the control group was 45.1 ± 5.3 ms (p = 0.000). There were no significant differences in the other m-mode or pulse Doppler echocardiography values between two groups. The GDF-15 value of the SH group was 382.6 ± 268.2 pg/mL, and that of the control group was 473.6 ± 337.9 pg/mL; this difference was not significant. Patients with subclinical hypothyroidism versus healthy individuals had some changes in echocardiographic parameters that indicate involvement of diastolic function of the left ventricle. They were significantly different when compared SH group and the control group. This study demonstrated ventricle diastolic dysfunction in pediatric patients with hypothyroidism. The results of our study suggest that cardiac follow-up may be useful in patients with subclinical hypothyroidism and clinical trials are needed to explore therapeutic effects of T4 and T3 administration in this patients.

Abstract P053: The Frequency of High Glycemic Load Meals is Predictive of Cardiovascular Risk Factors in Children at Risk for Obesity After 2 Years

Introduction: Consuming a daily diet of high glycemic load (GL) carbohydrates has potential long-term effects on obesity and cardiovascular health. However, it is possible that the GL of certain meals (breakfast, lunch and supper) have different effects. Few studies have examined the effect of meal-specific GL and frequency of high GL meals on adiposity and cardiovascular health in children. We hypothesized that the number of high GL meals per day, and secondarily, the meal-specific GL, would predict cardiovascular risk factors in children after two years of follow-up. Methods: We used data from the QUALITY cohort which recruited 630 children, ages 8-10 years at baseline with at least one obese parent. Three separate 24-hour dietary recalls were administered by a dietitian at baseline and individual meal-specific GL scores were calculated using the International table of GI. CV risk factors measured at 2 years of follow-up included continuous values of BMI z-score, percent fat mass, triglycerides, LDL and HDL cholesterol, and systolic (SBP) and diastolic (DBP) blood pressure obtained through direct measurement (blood pressure, blood lipids, anthropometrics) or questionnaires (socio-economic characteristics). Linear regressions between meal-specific GL categorized as high ( 2 33) vs. low (&lt;33) and CV risk factors were estimated, adjusting for important confounders, including underreporting, as well as anthropometric, socio-economic and dietary factors. Secondary analysis consisted of linear regression with number of high GL meals as an ordinal exposure variable. Results: Mean age at baseline was 9.6 years, with 33% of children overweight or obese. Breakfast, lunch and supper glycemic load were positively associated with each other. A higher number of high GL meals was positively associated with BMI z-score (β=0.18, 95%CI: 0.06, 0.30), percent fat mass (β=1.74, 95%CI: 0.52, 2.96) and triglycerides (β=0.08, 95%CI: 0.03, 0.14) and negatively associated with HDL (β=-0.04, 95%CI: -0.07, -0.01). Our secondary analysis revealed that High breakfast GL was positively associated with increased triglycerides (β=0.14, 95%CI: 0.05, 0.23) after 2 years but not adiposity, HDL, LDL and blood pressure. High GL lunch (β=0.27, 95%CI: 0.08, 0.46) and supper (β=0.22, 95%CI: 0.02, 0.41) were associated with higher BMI z-score after 2 years. Conclusion: In conclusion, consuming more than one high GL meal per day is associated with greater BMI and unhealthy lipid profile after 2 years.

Cardiovascular Risk Assessment in Pediatric Liver Transplant Patients.

Cardiovascular (CV) diseases play a leading role in the mortality of adult liver transplant (LT) recipients. However, data regarding CV risk factors in children after LT remain sparse. The present study assessed the presence of CV risk factors and signs of CV impairment in LT children. A total of 42 LT recipients (21 men, age 9.93 ± 3.57 years) were studied. Body composition [body mass index standard deviation score, percentage of body fat (by bioimpedance analysis)], lipid profiles, glycemic control, blood pressure, and arterial stiffness [assessed by aortic pulse wave velocity (PWV)] were evaluated. The effect of different treatment modalities [tacrolimus (TAC) (n = 30) or cyclosporine (CyA) (n = 11)] was also analyzed. Almost 18% of children were overweight or obese. Patients on TAC had a significantly higher body fat mass and percentage of body fat compared with the CyA group (P < 0.02). Borderline to high lipid values were present in 40% of patients. Children on CyA had higher serum cholesterol levels compared to TAC (P < 0.004). Nineteen percent of patients had hypertension. Half of the patients had glomerular filtration rate values <90 mL/min/1.73 m, whereas PWV values were above the 95th percentile in 12%. Increased body fat, chronic kidney disease, high lipid content, hypertension, and increased arterial stiffness are already present and are in part related to the type of immunosuppression regimen in LT children >5 years following transplantation. Long-term follow-up is needed to evaluate their impact on CV health and survival.

Increased ApoB/ApoA1 ratio is associated with excess weight, body adiposity, and altered lipid profile in children

ObjectiveTo investigate ApoB/ApoA1 ratio and its association with cardiovascular risk factors in children. MethodsCross‐sectional study with 258 children aged 8 and 9 years old, enrolled in all urban schools in the city of Viçosa‐MG. Anthropometric and body composition assessment, as well as biochemical profile of the children was performed. Socioeconomic variables and sedentary lifestyle were evaluated through a semi‐structured questionnaire. ResultsMany children had excess weight (35.2%), abdominal adiposity (10.5%), and body fat (15.6%), as well as increased ApoB/ApoA1 ratio (14.7%), total cholesterol (51.8%), and triglycerides (19.8%). Children with excess weight and total and central fat had a higher prevalence of having a higher ApoB/ApoA1 ratio, as well as those with atherogenic lipid profile (increased LDL‐c and triglycerides and low HDL‐c). A direct association was found between the number of cardiovascular risk factors and the ApoB/ApoA1 ratio (p=0.001), regardless of age and income. ConclusionThe increased ApoB/ApoA1 ratio was associated with excess weight, body adiposity (total and central), and altered lipid profile in children. Children with a higher number of cardiovascular risk factors had higher ApoB/ApoA1 ratio, in both genders.

Asian Cohort Studies on Cardiovascular Risk Factors in Childhood

Asian Cohort Studies on Cardiovascular Risk Factors in Childhood

The role of body fat in the relationship of cardiorespiratory fitness with cardiovascular risk factors in Brazilian children

Abstract Aims: To analyze the association between the percentage of body fat and cardiorespiratory fitness (CRF) with cardiovascular risk factors in children, and; to examine whether percentage of body fat acts as a mediator on the association between CRF and cardiovascular risk factor. Methods: This cross-sectional study included 128 children aged 7-11 years (Mean 8.54, SD: 1.42). The following variables were evaluated: the percentage of body fat, CRF, diastolic and systolic blood pressure, glucose, triglycerides (TG) and total cholesterol. For statistical analysis were performed Partial correlation and mediation analysis. All analysis was adjusted for sex, age and height. Results: CRF, the percentage of body fat, mean arterial pressure (MAP) and TG showed a correlation between each other. Percentage of body fat mediated the association between CRF and MAP (Indirect Effect= -0.008; IC: -0.0159 -0.0030), explaining 29% of this association. However, it was found that the percentage of body fat was not a mediator of the association between CRF and TG. Conclusion: The percentage of body fat mediates the association between CRF and MAP. Our findings show that the importance of a healthy body composition for the prevention of high blood pressure levels in childhood as well as the relevance of physical activity on these parameters.

Hipertensión y obesidad en niños de un centro de educación preescolar de la ciudad de Popayán –Colombia: Un estudio descriptivo

Objetivo: el objetivo de la presente investigación es describir la prevalencia de hipertensión y obesidad, como factores de riesgo cardiovascular en niños pertenecientes a un centro de educación preescolar la Ciudad de Popayán- Colombia. Materiales y métodos: Estudio descriptivo, de corte transversal. Se estimaron medidas antropométricas y de presión arterial en 45 preescolares. Resultados: la obesidad, de acuerdo a IMC, se presentó en un 11.1% de los preescolares, mientras que 6.6% de los individuos evaluados tuvieron mediciones de tensión arterial sistólica o diastólica, en rango de hipertensión arterial. Conclusiones: los hallazgos de la presente investigación sugieren que la aparición de factores de riesgo para la enfermedad cardiovascular, tiene lugar en edades muy tempranas. La generación de hábitos saludables podría prevenir la aparición y persistencia de dichos factores.

Cardiovascular risk factors in children on dialysis: an update.

Cardiovascular disease (CVD) is a life-limiting comorbidity in patients with chronic kidney disease (CKD). In childhood, imaging studies have demonstrated early phenotypic characteristics including increases in left ventricular mass, carotid artery intima-media thickness, and pulse wave velocity, which occur even in young children with early stages of CKD. Vascular calcifications are the signature of an advanced phenotype and are mainly found in adolescents and young adults treated with dialysis. Association studies have provided valuable information regarding the significance of a multitude of risk factors in promoting CVD in children with CKD by using intermediate endpoints of measurements of surrogate parameters of CVD. Dialysis aggravates pre-existing risk factors and accelerates the progression of CVD with additional dialysis-related risk factors. Coronary artery calcifications in children and young adults with CKD accumulate in a time-dependent manner on dialysis. Identification of risk factors has led to improved understanding of principal mechanisms of CKD-induced damage to the cardiovascular system. Treatment strategies include assessment and monitoring of individual risk factor load, optimization of treatment of modifiable risk factors, and intensified hemodialysis if early transplantation is not possible.

Carotid intima-media thickness and cardiovascular risk factors in childhood and adolescent obesity

Background: Childhood obesity is a significant health problem that has reached epidemic proportions around the world and it is a risk factor for atherosclerosis. The study aimed to investigate carotid intima-media thickness (CIMT) in obese children and evaluate the relationship of CIMT to various cardiovascular risk factors.Methods: This was achieved through including 40 obese children aged 5-16 years who were referred to Alexandria University Children's Hospital (AUCH) and 20 non-obese age and sex-matched children as the control group. All obese children in this study were subjected to thorough history taking, thorough clinical examination stressing on anthropometric measurement, blood pressure measurement and laboratory investigations including lipid profile, liver function tests, fasting glucose and fasting insulin and ultrasonographic study for the liver and carotid intima-media thickness measurement.Results: compared to the control, the obese children demonstrated a significantly thicker carotid intima-media (p&lt;0.001). Univariate correlation analysis revealed that CIMT was significantly correlated with the body mass index (BMI), waist circumference measurement, diastolic blood pressure (DBP), high-density lipoprotein cholesterol (HDLC), fasting insulin, homeostasis model assessment- insulin resistance (HOMA-IR), quantitative insulin-sensitivity check index (QUICKI) and fatty liver. In multiple linear regression analysis, CIMT correlated significantly with DBP in the obese group.Conclusions: Atherosclerosis begins in obese children and adolescents and CIMT measurement is a noninvasive, feasible, reliable and inexpensive method to detect subclinical atherosclerosis.

The Effect of Modified Biscuit on Cardiovascular Risk Factors in Children and Adolescents: Randomized Controlled Clinical Trial

The Effect of Modified Biscuit on Cardiovascular Risk Factors in Children and Adolescents: Randomized Controlled Clinical Trial

Associations of maternal and fetal vitamin D status with childhood body composition and cardiovascular risk factors.

Maternal vitamin D deficiency during pregnancy may have persistent adverse effects on childhood growth and development. We examined whether 25-hydroxyvitamin D (25(OH)D) concentrations during pregnancy and at cord blood were associated with childhood body composition and cardiovascular outcomes. This study was embedded in a population-based prospective cohort in Rotterdam, The Netherlands, among 4,903 mothers and their offspring. We measured 25(OH)D concentrations at a median gestational age of 20.4weeks (95% range 18.5-23.4weeks) and at birth (40.1weeks [95% range 35.8-42.3weeks]). 25(OH)D concentrations were categorized into severely deficient (<25.0nmol/L); deficient (25.0 to 49.9nmol/L); sufficient (50.0 to 74.9nmol/L) and optimal (≥75.0nmol/L). At 6years, we measured childhood body mass index; fat and lean mass by Dual-energy X-ray Absorptiometry; blood pressure; and serum cholesterol, triglycerides, and insulin concentrations. Compared with children from mothers with optimal 25(OH)D concentrations (≥75.0nmol/L), those of severely deficient vitamin D (<25.0nmol/L) mothers had a 0.12 standard deviation score (SDS); (95% Confidence Interval (CI) [0.03, 0.21]) higher fat mass percentage and a 0.13 SDS (95% CI [-0.22, -0.04]) lower lean mass percentage. These associations remained after adjustment for current child vitamin D status. Maternal and cord blood 25(OH)D concentrations were not associated with cardiovascular risk factors in childhood. In conclusion, severe maternal 25(OH)D deficiency (<25.0nmol/L) during pregnancy is associated with an adverse childhood body composition profile, but we did not observe evidence for an association with childhood cardiovascular risk factors. Further studies are needed to replicate our findings, to examine the underlying mechanisms, the causality of the associations, and the potential for public health interventions.

Comparative Analysis of Local CDC and IOTF Criteria for Detecting Cardiovascular Risk Factors in Children from Tehran

Background: To develop body mass index (BMI) cut-offs for overweight and obesity based on international obesity task force (IOTF) definition, in children in Tehran, and to compare these values with those of center for disease control (CDC) for local pediatric subjects in discriminating cardiometabolic risk factors. Methods: Anthropometric and biochemical information of 1555 participants, aged 5 - 18 years, from phase IV of the Tehran lipid and glucose study (TLGS), were used to obtain local IOTF and CDC cut-offs. We used the LMS method to develop BMI curves matching the adult cut-offs at the age of 18 years for defining obesity and overweight based on the IOTF definition. Using the CDC growth curves, overweight was defined as 85th ≤ BMI < 95th percentile, and obesity as a BMI ≥ 95th percentile. Results: The overall prevalence of overweight was 22.2, 23.9 and 10.5%; and that of obesity was 7.8, 9.0 and 4.2% using international IOTF, local IOTF and local CDC criteria, respectively. IOTF curves better discriminated the presence of all cardiometabolic risk factors, compared with local CDC curves. Conclusions: Local IOTF cut-offs for children in Tehran are in agreement with international IOTF values and better discriminate the cardiometabolic risk factors in children compared with local CDC cut-offs.

Macro- and Microvascular Parameters After Toxic Shock Syndrome.

Whether individuals who had toxic shock syndrome in childhood have differences in macro- and retinal microvascular parameters indicative of increased cardiovascular risk is unknown. We found no evidence of adverse macrovascular changes in 22 toxic shock syndrome participants compared with 60 control participants. Microvascular comparisons showed a reduction in retinal total fractal dimension, which has been associated with cardiovascular risk factors in children.

The Impact of Obesity and Lifestyle Status on Cardiovascular Risk Factors in Children and Adolescents with Type 1 Diabetes (T1D)

Cardiovascular disease is more frequent in patients with T1D than the general population. The aim of the study was to examine the impact of obesity, diet and physical activity (PA) on common cardiovascular risk factors in youth with T1D. Cross-sectional analyses were performed using data from 96 T1D subjects [mean age 13.4 ± 2.7 years, (females 57%), median disease duration 5.3 (range 3.5-8.4) years]. Dietary intake was evaluated by a single 24-hour dietary recall and a food frequency questionnaire (FFQ). Diet quality was assessed with the KIDMED test. The ENERGY-child questionnaire was used for the assessment of PA. Systolic (SBP), diastolic (DBP) blood pressure, HbA1c levels and lipid profile were evaluated. The prevalence of overweight/obesity was 31%. Overweight/obese individuals were in higher SBP percentile, compared to those with normal weight (68.59 ± 26.58 vs. 51.77 ± 26.72, P = 0.006). In multiple regression analysis, higher BMI z-score, was associated with higher ηbA1c (standardized β = 0.334, P = 0.002, R2 = 0.268) and higher triglycerides (standardized β = 0.224, P = 0.05, R2 = 0.095). Most participants (80%) abstained from optimal Mediterranean Diet (MD). Lower KIDMED score was associated with higher ηbA1c (standardized β = - 0.432 P &amp;lt; 0.001, R2 = 0.268). Partial correlation analyses after controlling for confounding factors revealed that BMI z-score was negatively correlated with low fat dairy portions/d (r = - 0.315, P &amp;lt; 0.05), HbA1c was positively correlated with high fat dairy portions/d (r = 0.305, P &amp;lt; 0.05) and SBP percentile was negatively correlated with total milk and yogurt portions/d (r = - 0.313, P &amp;lt; 0.05). Moreover, higher participation in sports (hours/week), was associated with lower DBP percentile (standardized β = - 0.283, P = 0.015, R2 = 0.080). The maintenance of a healthy body weight and a physically active lifestyle, was accompanied by lower BP levels in the participants of this study. Greater adherence to MD was associated with lower HbA1c. Disclosure A. Lampousi: None. D.E. Delis: None. M. Xatzipsalti: None. A. Vazeou: None.