Burden Of Cardiovascular Risk Factors Research Articles

Cardiovascular outcomes of cancer patients in rural Australia.

Cancer and heart disease are the two most common health conditions in the world, associated with high morbidity and mortality, with even worse outcomes in regional areas. Cardiovascular disease is the leading cause of death in cancer survivors. We aimed to evaluate the cardiovascular outcomes of patients receiving cancer treatment (CT) in a regional hospital. This was an observational retrospective cohort study in a single rural hospital over a ten-year period (17th February 2010 to 19th March 2019). Outcomes of all patients receiving CT during this period were compared to those who were admitted to the hospital without a cancer diagnosis. 268 patients received CT during the study period. High rates of cardiovascular risk factors: hypertension (52.2%), smoking (54.9%), and dyslipidaemia (38.4%) were observed in the CT group. Patients who had CT were more likely to be readmitted with ACS (5.9% vs. 2.8% p = 0.005) and AF (8.2% vs. 4.5% p = 0.006) when compared to the general admission cohort. There was a statistically significant difference observed for all cause cardiac readmission, with a higher rate observed in the CT group (17.1% vs. 13.2% p = 0.042). Patients undergoing CT had a higher rate of mortality (49.5% vs. 10.2%, p ≤ 0.001) and shorter time (days) from first admission to death (401.06 vs. 994.91, p ≤ 0.001) when compared to the general admission cohort, acknowledging this reduction in survival may be driven at least in part by the cancer itself. There is an increased incidence of adverse cardiovascular outcomes, including higher readmission rate, higher mortality rate and shorter survival in people undergoing cancer treatment in rural environments. Rural cancer patients demonstrated a high burden of cardiovascular risk factors.

Exercise and the Heart: Benefits, Risks and Adverse Effects of Exercise Training.

Exercise has multiple health benefits and reduces cardiovascular morbidity and mortality. Regular exercise decreases the burden of cardiovascular risk factors and improves prognosis in several cardiac conditions. Despite these premises, sudden cardiac death (SCD) during sports may occur in apparently healthy athletes who perform at the highest levels. Accurate identification and prompt treatment of individuals at risk may reduce the burden of SCD. A possible cardiotoxic effect of intense exercise has been recently postulated, however this is still matter of controversy as causal relationships are often difficult to establish taking into account multiple confounders. Exercise is safe for the majority, even with cardiovascular disease. In this review, we focus on exercise and sports, discussing their benefits and risks and exercise recommendations for healthy individuals and those with cardiovascular disease.

Assault on salt Intake

Assault on salt Intake

Abstract P189: Sexual Minority Status Disparities in Life’s Simple 7 and Life’s Essential 8 Cardiovascular Health Scores, a French Nationwide Population-Based Study

A higher burden of cardiovascular disease risk factors has been reported in sexual minority populations (SM), such as lesbian, gay, bisexual, and non-heterosexual, compared to heterosexual populations. Therefore, primordial prevention, i.e., preventing risk factor onset in the first place, may be a relevant preventative strategy in this population. This study aimed to quantify the associations of SM status in each sex with Life’s Simple 7 (LS7) and Life’s Essential 8 (LE8) cardiovascular health (CVH) scores. The CONSTANCES study is a multicentric study that recruited randomly selected adults in 24 health examination centers in 21 cities in the French European territory. Sexual minority status was based on self-reported lifetime sexual behavior and categorized as lesbian, gay, bisexual, or heterosexual. The study included 169,434 CVD-free participants (53.64% women, mean age: 46.00 years). Among 90879 women, 555 were lesbian, 3149 bisexual, and 84363 heterosexual. Among 78555 men, 2421 were gay, 2748 bisexual, and 70994 heterosexual. Overall, 2812 women and 2392 men declined to answer. In women, the prevalence of high LS7 scores (12-14) ranged from 9.00% (declined to answer) to 12.38% (bisexual), whereas in men, it ranged from 4.06% (declined to answer) to 9.17% (gay). In multivariate analyses (Table 1), lesbian and bisexual women had lower LS7 score compared to heterosexual women. However, this was observed only among those who had never been pregnant (p for interaction <0.05). Conversely, gay and bisexual men living in urban areas had higher LS7 score compared to heterosexual men, while those living in rural areas had lower LS7 score than their heterosexual counterparts (p for interaction <0.05). Findings were consistent when using the LE8 score but with stronger effect sizes (Table 1). This study supports the presence of CVH disparities in sexual minority adults and may help identify vulnerable populations for prioritizing primordial CVD prevention.

Abstract P675: GlycA, but Not C-reactive Protein is Associated With Baseline Carotid Artery Plaque in the Brazilian Longitudinal Study of Adult Health (ELSA-Brasil)

Introduction: Elevated GlycA and C-reactive protein (CRP) are associated with carotid artery plaque (CAP). However, it is not yet established if the presence of both inflammatory biomarkers provides incremental association with CAP. Objective: We cross-sectionally analyzed the association of high CRP and GlycA with CAP at baseline in the ELSA-Brasil cohort. Methods: Participants with information on CRP, GlycA, and CAP with no previous cardiovascular disease nor CRP greater than 10mg/L were included. GlycA was measured by nuclear magnetic resonance and values in the upper quintile were defined as high. CRP was measured by immunoassay and defined as high if greater than 3mg/L. Participants were classified into 4 groups: i. non-elevated CRP/GlycA (reference); ii. elevated CRP alone; iii. elevated GlycA alone; and iv. both elevated. The association with CAP was analyzed by logistic regression models and presented in odds ratio (OR) and 95% confidence interval (CI) both crude and adjusted for sex, age, ethnicity, education attainment, private health insurance, body mass index, smoking, alcohol consumption, physical activity, and medical diagnosis of diabetes, hypertension, and dyslipidemia. Results: The analysis included 4,126 participants (50.0 [45.0 - 57.0] median years-old, 54.2% women). The prevalence of CAP, elevated CRP, and elevated GlycA was 36.1%, 25.5%, and 20.1%, respectively. Males showed higher prevalence of CAP than females (42.8% vs. 30.3%, p<0.001), but had lower prevalence of elevated CRP (20.7% vs. 29.6%, p<0.001) and of elevated GlycA (17.1% vs. 22.7%, p<0.001). Comparing groups, participants with high CRP were mostly women and had the highest frequency of obesity, while participants with high GlycA presented with less socioeconomic support and higher prevalence of cardiovascular risk factor (CVRF) burden. Participants with CAP were older, mostly men, non-Whites, with low education attainment, current smokers, with high levels of CVRF and GlycA than participants without CAP (p<0.001 for all). Participants with high GlycA were more likely to have CAP than the reference group (OR: 1.39; 95% CI: 1.11 - 1.73; p=0.004), even after multivariable adjustment (OR: 1.37; 95% CI: 1.02 - 1.84; p=0.038). In contrast, no association was observed between high CRP and CAP (OR: 0.86; 95% CI: 0.71 - 1.04; p=0.110). Participants with both elevated CRP and GlycA were more likely to have CAP in crude (OR: 1.35; 95% CI: 1.10 - 1.65; p=0.003) but not in adjusted model (OR: 1.32; 95% CI: 0.99 - 1.77; p=0.059). Conclusions: The findings suggest that elevations in different serum markers of inflammation correlate with different disease states, where high GlycA is associated with CAP while high CRP is more associated with obesity.

Impact of Nut Consumption on Cognition across the Lifespan.

Cognitive health is a life-long concern affected by modifiable risk factors, including lifestyle choices, such as dietary intake, with serious implications for quality of life, morbidity, and mortality worldwide. In addition, nuts are a nutrient-dense food that contain a number of potentially neuroprotective components, including monounsaturated and polyunsaturated fatty acids, fiber, B-vitamins, non-sodium minerals, and highly bioactive polyphenols. However, increased nut consumption relates to a lower cardiovascular risk and a lower burden of cardiovascular risk factors that are shared with neurodegenerative disorders, which is why nuts have been hypothesized to be beneficial for brain health. The present narrative review discusses up-to-date epidemiological, clinical trial, and mechanistic evidence of the effect of exposure to nuts on cognitive performance. While limited and inconclusive, available evidence suggests a possible role for nuts in the maintenance of cognitive health and prevention of cognitive decline in individuals across the lifespan, particularly in older adults and those at higher risk. Walnuts, as a rich source of the plant-based polyunsaturated omega-3 fatty acid alpha-linolenic acid, are the nut type most promising for cognitive health. Given the limited definitive evidence available to date, especially regarding cognitive health biomarkers and hard outcomes, future studies are needed to better elucidate the impact of nuts on the maintenance of cognitive health, as well as the prevention and management of cognitive decline and dementia, including Alzheimer disease.

Aspirin Therapy, Cognitive Impairment, and Dementia—A Review

Background: Dementia is associated with a greater burden of cardiovascular risk factors. There is a significant vascular contribution to dementia, and aspirin may play a role in targeting this vascular dysregulation via its anti-inflammatory and antiplatelet effects. We provide an overview of the effects of aspirin therapy on the prevention of dementia and cognitive decline in patients with or without dementia and/or cognitive impairment. Methods: We performed a search for studies enrolling adults with or without dementia or MCI and comparing aspirin with placebo, usual care, or active control with respect to cognitive outcomes. Results: We describe aspirin’s effects on the primary prevention of cognitive impairment and various subtypes of dementia, as well as its role in cognitive decline in certain subsets of patients, including those with cerebral small vessel disease (CVSD), coronary heart disease (CHD), and gender differences. Overall, the benefits of aspirin in preventing dementia and cognitive decline remain inconclusive. The majority of cohort studies investigating aspirin’s role in preventing cognitive decline or dementia looked promising, but this was not supported in most randomised controlled trials. However, aspirin may still be beneficial in certain subgroups of patients (such as CHD, VD, and CSVD) and warrants further investigation.

Abstract WP187: Takotsubo Cardiomyopathy And Subsequent Risk Of Major Adverse Cardiovascular Events: A Cluster Analysis

Introduction: Takotsubo Cardiomyopathy (TCM) is a form of transient regional left ventricular dysfunction. The risk of MACE after TCM is poorly understood but appears to be higher. Predictors of cardiovascular (CV) events remain unclear. Methods: Retrospective study of patients admitted to London Health Sciences Centre hospitals with TCM between 2014 and 2021. Clinical data were collected. MACE during follow-up (FU) included stroke, acute coronary syndrome, admission for heart failure or CV death. Outcomes were assessed until the end of FU. A two-step cluster analysis was used to stratify patients' phenotypes. Variables for clustering included: TCM aetiology, age, sex, hypertension, dyslipidemia, smoking, previous stroke, diabetes, chronic kidney disease, ejection fraction, atrial fibrillation (AF), and antithrombotics. A Cox proportional-hazards model was used to determine the association between clusters and MACE. Results: We included 152 patients (88.8% females). Median age was 72.5 [65.5-80.0] years and aetiologies were emotional stress (31.6%), neurogenic (6.6%), acute medical conditions (23.7%), and unknown (38.2%). Overall, 80% received antithrombotic drugs post-TCM. At a median FU of 22.0 [8.2-44.5] months, 11.8% of the patients experienced a MACE. Cluster 1 (n=41) included more male patients (31.7%), and the highest rate of hypertension (100%), dyslipidemia (92.7%), smoking (31.7%), previous stroke (14.6%), and antiplatelet use (82.9%). Cluster 2 (n=21) included older patients (78 [73.5-84.5] years) with the highest prevalence of diabetes (23.8%), AF (95.2%) and anticoagulation (71.4%). Cluster 3 (n=90) included younger patients (69 [62.7-84.0] years) with the lowest burden of CV risk factors (CHA 2 DS 2 VASc 2.0 [1.0-2.2]) and antithrombotic therapy (68.9%). Cluster 1 was associated with increased risk of MACE (OR 2.9; 95%CI 1.1-7.3; p=0.02) and stroke (OR 4.9; 95%CI 1.1-20.6; p=0.02). Conclusion: CV events are relatively frequent after a diagnosis of TCM, affecting over one-tenth of patients. We identified a high-risk phenotype, predominantly characterized by male sex, a higher burden of CV comorbidities, and low anticoagulation rates, which was associated with an increased risk of MACE and stroke after TCM.

The Burden of Uncontrolled Cardiovascular Risk Factors in MenWithProstate Cancer: A RADICAL-PC Analysis.

Cardiovascular disease (CVD) incidence is higher in men with prostate cancer (PC) than without. We describe the rate and correlates of poor cardiovascular risk factor control among men with PC. We prospectively characterized 2,811 consecutive men (mean age 68 ± 8 years) with PC from 24 sites in Canada, Israel, Brazil, and Australia. We defined poor overall risk factor control as≥3 of the following: suboptimal low-density lipoprotein cholesterol (>2mmol/L if Framingham Risk Score [FRS]≥15 and≥3.5mmol/L if FRS<15), current smoker, physical inactivity (<600 MET min/wk), suboptimal blood pressure (BP) (≥140/90mmHg if no other risk factors, systolic BP ≥120mmHg if known CVD or FRS≥15, and≥130/80mmHg if diabetic), and waist:hip ratio>0.9. Among participants (9% with metastatic PC and 23% with pre-existing CVD), 99% had≥1 uncontrolled cardiovascular risk factor, and 51% had poor overall risk factor control. Not taking a statin (odds ratio [OR]: 2.55; 95% CI: 2.00-3.26), physical frailty (OR: 2.37; 95% CI: 1.51-3.71), need for BP drugs (OR: 2.36; 95% CI: 1.84-3.03), and age (ORper 10-year increase: 1.34; 95% CI: 1.14-1.59) were associated with poor overall risk factor control after adjustment for education, PC characteristics, androgen deprivation therapy, depression, and Eastern Cooperative Oncology Group functional status. Poor control of modifiable cardiovascular risk factors is common in men with PC, highlighting thelargegap in care and the need for improved interventions to optimize cardiovascular risk management inthispopulation.

Prevalence of cardiovascular disease in Sickle cell disease (SCD)- An echocardiographic and pharmacological analysis

Abstract Funding Acknowledgements Type of funding sources: None. Introduction Sickle cell disease (SCD) is an inherited disorder of globin chains that cause haemolysis and chronic organ damage. It is an autosomal recessive condition. SCD is a condition more prevalent in sub-saharan Africa. It is estimated that there are between 12,500 and 15,000 people with SCD in the United Kingdom (UK) in 2014. The prevalence of the disease is increasing due to immigration into the UK and new births. As a result, there is a need to understand cardiovascular complications within this population, as despite a significant increase in longevity for SCD patients over the last few decades, there are significant cardiac complications. Method We present retrospective data from a single center tertiary centre for SCD. A total of 318 patients were followed up from diagnosis to current day with a mean age of 43.4 and median of 42. 136 (43%) were male and 182 (57%) Female. Results A total of 157 (49%) patients underwent a transthoracic echocardiogram (TTE). 56 (17.5%) had a dilated Left Atrium, 36 (11.3%) had Valvular heart disease, 18 (5.7%) Pulmonary Hypertension (PHT) or Right Heart Dysfunction and 17 (5.34%) had a dilated Left Ventricular cavity. 14 patients had Tricuspid regurgitation (13 mild and 1 severe), 15 had Mitral regurgitation (14 mild and 1 moderate), 7 had mild Aortic regurgitation, 6 had Mild Pulmonary regurgitation, 3 had mild Pulmonary Stenosis and 3 were noted to have sclerotic aortic valve. From a Left ventricular systolic function perspective, 151 patients had a normal ejection fraction, 4 had mild Left ventricular systolic dysfunction (LVSD), 1 moderate LVSD and 1 severe LVSD. A normal ejection fraction was defined as &amp;gt;55%, mild 45-55%, moderate 35-45% and severe &amp;lt;35%. 40 (12.60%) Patients were taking Calcium channel blockers (Dihydropyridine), 25 (7.86%) were taking Angiotensin converting enzyme inhibitor/ Angiotensin receptor blocker, 20 (6.29%) taking an anticoagulant (DOAC), 16 (5.03%) were taking a statin, 15(4.72%) taking B blockers, 11(3.46%) taking an antiplatelet, 5(1.57%) patients were taking a loop diuretic, 4 (1.26%) thiazide diuretic, 4 (1.26%) on an alpha blocker and 1(0.3%) patient on digoxin. The prevalence of Atrial Fibrillation was 1.57% (5 patients). Conclusions The Echocardiographic data suggests the commonest findings are of a dilated left atrium, dilated ventricle, valvular heart disease and PHT. The dilated left atrium is secondary to the hyperdynamic states found in sickle cell disease. Despite this being very common the rates of arrhythmia are low. The prevalence of LVSD remains low. The findings of PHT are of particular interest as it guides SCD management with exchange transfusion. The pharmacological data suggests high burden of cardiovascular risk factors i.e. hypertension and hypercholesterolemia despite the young demographic. It is vital to follow up these patients with aggressive primary prevention medications to reduce risk of future cardiovascular events.

Sudden Cardiac Arrest During Sports Activity in Older Adults

BackgroundSports activity among older adults is rising, but there is a lack of community-based data on sports-related sudden cardiac arrest (SrSCA) in the elderly. ObjectivesIn this study, the authors investigated the prevalence and characteristics of SrSCA among subjects ≥65 years of age in a large U.S. population. MethodsAll out-of-hospital sudden cardiac arrests (SCAs) were prospectively ascertained in the Portland, Oregon, USA, metro area (2002-2017), and Ventura County, California, USA (2015-2021) (catchment population ∼1.85 million). Detailed information was obtained for SCA warning symptoms, circumstances, and lifetime clinical history. Subjects with SCA during or within 1 hour of cessation of sports activity were categorized as SrSCA. ResultsOf 4,078 SCAs among subjects ≥65 years of age, 77 were SrSCA (1.9%; 91% men). The crude annual SrSCA incidence among age ≥65 years was 3.29/100,000 in Portland and 2.10/100,000 in Ventura. The most common associated activities were cycling, gym activity, and running. SrSCA cases had lower burden of cardiovascular risk factors (P = 0.03) as well as comorbidities (P < 0.005) compared with non-SrSCA. Based on conservative estimates of community residents ≥65 years of age who participate in sports activity, the SrSCA incidence was 28.9/100,000 sport participation years and 18.4/100,000 sport participation years in Portland and Ventura, respectively. Crude survival to hospital discharge rate was higher in SrSCA, but the difference was nonsignificant after adjustment for confounding factors. ConclusionsAmong free-living community residents age ≥65 years, SrSCA is uncommon, predominantly occurs in men, and is associated with lower disease burden than non-SrSCA. These results suggest that the risk of SrSCA is low, and probably outweighed by the high benefit of exercise.

Family income and cardiovascular disease risk in American adults

Socioeconomic status is an overlooked risk factor for cardiovascular disease (CVD). Low family income is a measure of socioeconomic status and may portend greater CVD risk. Therefore, we assessed the association of family income with cardiovascular risk factor and disease burden in American adults. This retrospective analysis included data from participants aged ≥ 20 years from the National Health and Nutrition Examination Survey (NHANES) cycles between 2005 and 2018. Family income to poverty ratio (PIR) was calculated by dividing family (or individual) income by poverty guidelines specific to the survey year and used as a measure of socioeconomic status. The association of PIR with the presence of cardiovascular risk factors and CVD as well as cardiac mortality and all-cause mortality was examined. We included 35,932 unweighted participants corresponding to 207,073,472 weighted, nationally representative participants. Participants with lower PIR were often female and more likely to belong to race/ethnic minorities (non-Hispanic Black, Mexican American, other Hispanic). In addition, they were less likely to be married/living with a partner, to attain college graduation or higher, or to have health insurance. In adjusted analyses, the prevalence odds of diabetes mellitus, hypertension, coronary artery disease (CAD), congestive heart failure (CHF), and stroke largely decreased in a step-wise manner from highest (≥ 5) to lowest PIR (< 1). In adjusted analysis, we also noted a mostly dose-dependent association of PIR with the risk of all-cause and cardiac mortality during a mean 5.7 and 5.8 years of follow up, respectively. Our study demonstrates a largely dose-dependent association of PIR with hypertension, diabetes mellitus, CHF, CAD and stroke prevalence as well as incident all-cause mortality and cardiac mortality in a nationally representative sample of American adults. Public policy efforts should be directed to alleviate these disparities to help improve cardiovascular outcomes in vulnerable groups with low family income.

Association of cardiovascular risk factors and blood biomarkers with cognition: The HABS-HD study.

To determine if cardiovascular risk factor (CVRF) burden is associated with Alzheimer's disease (AD) biomarkers and whether they synergistically associate with cognition. We cross-sectionally studied 1521 non-demented Mexican American (52%) and non-Hispanic White individuals aged ≥50 years. A composite score was calculated by averaging the z-scores of five cognitive tests. Plasma β-amyloid (Aβ) 42/40, total tau (t-tau), and neurofilament light (NfL) were assayed using Simoa. CVRF burden was assessed using the Framingham Risk Score (FRS). Compared to low FRS (< 10% risk), high FRS (≥ 20% risk) was independently associated with increased t-tau and NfL. High FRS was significantly associated with higher NfL only among Mexican American individuals. Intermediate or high FRS (vs. low FRS) were independently associated with lower cognition, and the association remained significant after adjusting for plasma biomarkers. Hypertension synergistically interacted with t-tau and NfL (p < 0.05). CVRFs play critical roles, both through independent and neurodegenerative pathways, on cognition.

1127 APPLICABILITY OF THE EXCEL TRIAL CRITERIA IN AN ALL-COMERS REAL-WORLD POPULATION OF UNPROTECTED LEFT MAIN PCI

Abstract Background The Evaluation of XIENCE versus Coronary Artery Bypass Surgery for Effectiveness of Left Main Revascularization (EXCEL) trial is the largest randomized trial comparing percutaneous coronary intervention (PCI) with 2nd generation drug eluting stents (DES) and bypass surgery in unprotected left main disease (ULMD). Our aim was to assess which proportion of patients from a contemporary all-comers population of ULMD-PCI would be eligible for the EXCEL trial and whether these patients showed different short- and long-term outcomes than the rest of the population. Methods and results A total of 246 consecutive patients that underwent ULMD-PCI between January 2018 and December 2021, were retrospectively analyzed. After application of the EXCEL trial inclusion ed exclusion criteria, 98 patients (38.9%) were allocated in the "Excel-like" cohort and 148 in the "Non-Excel-like". Baseline characteristics of the two groups were substantially comparable. Mean baseline Syntax Score (SS) was significantly lower in the "Excel-like" patients (Excel 20.1 ± 7.1 VS Non-Excel 23.0 ± 11.2; p-value = 0.025) than the "Non-Excel-like" group with the latter showing also a higher degree of incomplete revascularization (rSS &amp;gt;8: Excel 11.2%.VS Non-Excel 25.7%; p-value 0.005). At 1 year the cumulative major adverse cardiovascular and cerebral events (MACCEs) rates were 7.2% and 17.2% for the "Excel-like" and "Non-Excel-like" patients respectively (Log-rank p-value = 0.03). At last follow-up available the significant difference in MACCEs rate persisted (Excel 19.3%, VS Non-Excel 37%, Log-rank p-value 0.02) and a significant difference in any unplanned revascularization was also shown (Excel 1.5% VS Non-Excel 12.6%; p-value 0.04). Conclusions in a contemporary real-world cohort of ULMD-PCI only a minority of the patients could be enrolled in the EXCEL trial. This cohort of patients showed a more extensive revascularization and less clinical events at long-term follow-up despite comparable burden of cardiovascular risk factors and atherosclerotic coronary disease. These findings "challenge" the external applicability of the results of the Excel trial in the routine clinical activity.

Cardiovascular Risk Factor Burden and Association With CKD in Ghana and Nigeria

Cardiovascular disease is the leading cause of morbidity and mortality in patients with chronic kidney disease (CKD); however, the burden of cardiovascular risk factors in patients with CKD in Africa is not well characterized. We determined the prevalence of selected cardiovascular risk factors, and association with CKD in the Human Heredity for Health in Africa Kidney Disease Research Network study. We recruited patients with and without CKD in Ghana and Nigeria. CKD was defined as estimated glomerular filtration rate of<60 ml/min per 1.73 m2 and/or albuminuria as albumin-to-creatinine ratio<3.0 mg/mmol (<30 mg/g) for≥3 months. We assessed self-reported (physician-diagnosis and/or use of medication) hypertension, diabetes, and elevated cholesterol; and self-reported smoking as cardiovascular risk factors. Association between the risk factors and CKD was determined by multivariate logistic regression. We enrolled 8396 participants (cases with CKD, 3956), with 56% females. The mean age (45.5 ± 15.1 years) did not differ between patients and control group. The prevalence of hypertension (59%), diabetes (20%), and elevated cholesterol (9.9%), was higher in CKD patients than in the control participants (P< 0.001). Prevalence of risk factors was higher in Ghana than in Nigeria. Hypertension (adjusted odds ratio [aOR]= 1.69 [1.43-2.01, P< 0.001]), elevated cholesterol (aOR= 2.0 [1.39-2.86, P< 0.001]), age >50 years, and body mass index (BMI)<18.5 kg/m2 were independently associated with CKD. The association of diabetes and smoking with CKD was modified by other risk factors. Cardiovascular risk factors are prevalent in middle-aged adult patients with CKD in Ghana and Nigeria, with higher proportions in Ghana than in Nigeria. Hypertension, elevated cholesterol, and underweight were independently associated with CKD.

Prevalence and risk factors for atrial fibrillation in a semi-rural sub-Saharan African population: The hEart oF ethiopia: Focus on Atrial Fibrillation (TEFF-AF) Study.

There is a scarcity of reported data on the prevalence of atrial fibrillation (AF) in sub-Saharan Africa. To undertake AF screening in semi-rural Ethiopia. The TEFF-AF (The hEart oF Ethiopia: Focus on Atrial Fibrillation) study conducted AF screening using a single-lead electrocardiogram device (KardiaMobile) on willing community participants at the Soddo Christian Hospital, Ethiopia. Participants' clinical parameters and medical history were obtained to characterize their risk factor profile, including calculation of CHARGE-AF (Cohorts for Heart and Aging Research in Genomic Epidemiology Atrial Fibrillation) score. A total of 3000 Ethiopians (median 31 [interquartile range 25-41] years of age; 65% men) were screened. The participants were generally well educated, from the local region and with a low burden of cardiovascular risk factors. A total of 50 participants had a CHARGE-AF score (5-year AF risk) of ≥2%. AF was detected in 13 (0.43%) individuals (median 50 [interquartile range 36-60] years of age; n = 7 men). The prevalence among participants over 40 years of age was 1% (n = 9 of 930). AF prevalence was higher for older age groups, with ≥70 years of age reaching 6.67% (n = 3 of 45). Population prevalence was estimated to be 234 (95% confidence interval 7-460) per 10,000 persons for ≥60 years of age. Four (31%) of the 13 participants with AF had a CHA2DS2-VASc (congestive heart failure, hypertension, age ≥75 years, diabetes mellitus, prior stroke or transient ischemic attack or thromboembolism, vascular disease, age 65-74 years, sex category) score of ≥2, and others likely had rheumatic valvular AF, but only 2 of the 13 participants with AF were on oral anticoagulation therapy. In this semi-rural Ethiopian community of relatively younger participants, AF prevalence was found to be low but increased with increasing age. Mobile single-lead electrocardiogram technology can be used effectively for AF screening in low-resource settings.

Smoking across adolescence and adulthood with cardiovascular risk among American Indian peoples.

American Indian peoples (AIs) have high smoking rates and cardiovascular risk factor burden. The present study aimed to (a) investigate latent smoking classes across adolescence and adulthood, (b) investigate adolescent predictors of smoking classes, and (c) assess how smoking class is related to adult cardiovascular risk in a sample of AIs. A sample of AIs (N = 338) from the National Adolescent to Adult Health Study self-reported on smoking across four assessment waves (W1: 7th-12th grade; W2: 8th-12th grade; W3: ages 18-26; W4: ages 24-32). The socioecological framework for addressing tobacco-related disparities was used to identify potential adolescent (W1) risk and resource factors. C-reactive protein, blood pressure, and lipids were collected at W4. Growth mixture modeling and regressions were used. Six smoking classes were identified: light smoking (36%), nonsmoking (23%), escalating, adult daily smoking (13%), chronic heavy smoking (12%), escalating, young adult daily smoking (9%), and reducing smoking (7%). Risk factors for being in the chronic heavy smoking class included peer smoking and older age at W1. Compared with the chronic heavy smoking class, AIs in the reducing smoking class lived in in more impoverished neighborhoods during adolescence. Relative to several classes with less smoking, being in the chronic heavy smoking class was associated with higher C-reactive protein and less favorable lipid levels. W1 social support was a resource factor for adult diastolic blood pressure and some lipids. Socioecologically informed tobacco interventions have the potential to reduce smoking and cardiovascular risk among AIs, and bolstering social support may be important. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

National levels, changes and correlates of ideal cardiovascular health among Beninese adults: evidence from the 2008 to 2015 STEPS surveys

IntroductionA higher number of ideal cardiovascular health (CVH) metrics is associated with a lower risk of cardiovascular-related and all-cause mortality. However, the change in CVH metrics has rarely been studied...

Abstract 14396: Periprocedural Myocardial Injury After Elective Percutaneous Coronary Intervention is Associated With Excess Long-Term Mortality

Introduction: Periprocedural myocardial injury (pMI), characterized by elevations in circulating cardiac biomarkers, is common following percutaneous coronary intervention (PCI) for stable ischemic heart disease. We sought to characterize incidence, risk factors, and long-term outcomes of pMI early after PCI. Methods: Patients who underwent elective PCI at a large academic medical center between 2011 and 2020 were included in this retrospective, observational study. We characterized patient and procedural characteristics from local submissions to the NCDR CathPCI registry. All patients underwent routine measurements of CK-MB at 1 and 3 hours post-PCI. Patients with abnormal CK-MB or troponin pre-PCI were excluded. For patients with multiple PCI, only the first PCI was included in the analysis. pMI was defined as any post-PCI CK-MB &gt;99th percentile upper reference limit of the assay. The primary outcome was all-cause mortality derived from the Social Security Administration Death Master File. Cox proportional hazards models were generated to estimate the hazard of mortality associated with pMI. Results: We identified 10,923 patients undergoing elective PCI with routine post-PCI CK-MB measurement, with 47,959 patient-years of follow-up (mean: 4.4 years, range: 0 - 9.7). pMI occurred in 1843 cases (16.9%). Patients with pMI were older, more likely to be men, and had a higher burden of cardiovascular risk factors compared to those without pMI ( Table ). Over long-term follow-up, 483 patients (4.4%) died. Long-term, all-cause mortality was higher among patients with versus without pMI (8.0% vs. 3.7%, p&lt;0.001). After adjustment for age and sex, pMI was associated with an excess hazard for long-term mortality (hazard ratio 1.48, 95% CI 1.22-1.80). Conclusion: Myocardial injury detected early after PCI is common and is associated with increased long-term all-cause mortality. Efforts to reduce pMI incidence are needed.

Abstract 10423: US Counties With Low Broadband Internet Access Have a High Burden of Cardiovascular Risk Factors, Disease, and Mortality

Introduction: Nationwide broadband internet access is a major federal priority. The bipartisan infrastructure law invested $65 billion into equitable broadband expansion, driven by concern that broadband access is a social determinant of health. However, the difference in health outcomes between counties with low vs. higher broadband access has not been studied, and could provide insights on the implications of expansion efforts. Objectives: We evaluated demographic factors, health resources, and cardiovascular disease (CVD) burden in counties with low broadband access compared to those with higher access. Methods: We assessed all 3,142 US counties in 2019 and identified those with low broadband access, defined as &lt;50% of residents having access to internet subscriptions with speeds &gt; 25 Mbps download / &gt; 3 Mbps upload, using the US Broadband Usage Percentages Dataset. We linked these data to the American Community Survey, American Health Resource File, PLACES, and CDC WONDER for demographic, health resource, CVD risk factor and outcomes, and mortality data respectively. Results: There were 461 counties with low broadband access and 2,650 counties with higher access. Compared to those with higher broadband access, counties with low broadband access had lower high school graduation rates (47% vs 54%, p&lt;0.001) and were more likely to be rural (86% vs 59%, p&lt;0.001). Low-access counties had fewer primary care physicians and fewer cardiologists, but similar hospital beds per capita ( Table ). These counties had higher rates of CVD risk factors, coronary artery disease, and stroke, as well as higher age-adjusted rates of CVD mortality and all-cause mortality ( Table ). Conclusions: Counties with low broadband access have lower access to physicians and significantly higher rates of CVD risk factors, CVD, and CVD mortality. Expanding access to broadband internet and telemedicine has the potential to improve access to care and reduce disparities in CVD outcomes.