Objective: In general surgery, venous port catheters (VPC) are useful for maintaining long-term parenteral nutrition and protecting the venous system from trauma due to repeated access, such as in cancer patients. However, the most common users of this technique are cardiovascular surgeons and radiologists. The most popular route for long-term central venous catheterization is the subclavian vein, although it carries a 12% rate of peri-procedural complications. The aim of this retrospective study was to investigate the early and late complications associated with percutaneous insertion of VPCs by general surgeons and to compare the complication rates with those reported in the literature. Material and Methods: We investigated clinical and demographical data of 238 cancer patients who underwent totally implantable, indwelling, subclavian port catheterization in our General Surgery Clinic between March 2006 and December 2009. The port catheters implanted to the patients by the two experienced surgeons, using the same technique. Results: One patient developed pneumothorax (0.42%) and in 4 (1.68%) patients inadvertent subclavian artery puncture was occurred. Catheter migration developed in 3 (1.26%) cases, two caused by spontaneous catheter rupture (Pinchoff Syndrome) and the other one caused by catheter disconnection. Conclusion: In experienced hands, percutaneous implantation of an indwelling port catheter through the subclavian vein is safe with low complications and a high success rate. Good patient monitoring and a multidisciplinary approach are important for management of any likely complications.