Related Cardiovascular Diseases Research Articles

Whole grain germinated brown rice intake modulates the gut microbiota and alleviates hypertriglyceridemia and hypercholesterolemia in high fat diet-fed mice.

Hyperlipidemia is a common clinical disorder of lipid metabolism in modern society and is considered to be one of the major risk factors leading to cardiovascular-related diseases. Germinated brown rice (GBR) is a typical whole grain food. The lipid-lowering effect of GBR has received increasing attention, but its mechanism of action is not fully understood. The gut microbiota has been proposed as a novel target for the treatment of hyperlipidemia. The aim of this study was to investigate the effects of GBR on the gut microbiota and lipid metabolism in high-fat diet (HFD)-fed C57BL/6J mice. The effect of GBR on hyperlipidemia was evaluated by measuring blood lipid levels and by pathological examination. The gut microbiota was detected by 16S rRNA sequencing, and the protein and mRNA expression levels involved in cholesterol metabolism were detected by western blotting and RT-qPCR to find potential correlations. The results showed that GBR supplementation could effectively reduce the levels of TC, TG, LDL-C and HDL-C in the serum and alleviate the excessive accumulation of fat droplets caused by HFD. Moreover, GBR intervention improved HFD-fed gut microbiota disorder via increasing the diversity of the gut microbiota, reducing the Firmicutes/Bacteroidetes ratio, and improving gut barrier damage. In addition, GBR could inhibit endogenous cholesterol synthesis and promote cholesterol transport and excretion. These findings suggest that GBR may be a competitive candidate for the development of functional foods to prevent abnormal lipid metabolism.

Cholesterol-lowering Effect of Protein Hydrolysates from Lemongrass (Cymbopogon citratus Stapf.)

Lemongrass (Cymbopogon citratus Stapf.) has been used in the Philippines for cooking and as an herb to treat a variety of ailments including hypertension and related cardiovascular diseases (CVDs). This study determined the potential of peptides obtained from the hydrolysis of lemongrass proteins to lower cholesterol in vitro and in an animal model. Proteins were extracted and digested in vitro simulating gastrointestinal conditions. Protein hydrolysates were collected and fractionated using RP-SPE column, and assayed for HMG-CoA reductase inhibitory activity against pravastatin as a control drug. Tannin-free protein extract (TFPE) and total protein hydrolysates (TPC) were administered to Sprague-Dawley rats maintained on a high-fat high-cholesterol diet for two weeks. TFPE yield was 0.03%. Simulated gastrointestinal digestion of the TFPE resulted in 74% yield of protein hydrolysates. Three fractions were obtained from RP-SPE elution of the protein hydrolysates, each with potent HMG-CoA inhibitory activity. The F3 fraction had the highest inhibition of HMG-CoA reductase (IC50 = 0.76 ppm, comparable to pravastatin (IC50 = 0.25 ppm). The inhibitory activity of the fractions was further confirmed through significant serum cholesterol reduction (p < 0.05) in Sprague-Dawley rats. Thus, protein hydrolysates from lemongrass have potential cholesterol-lowering effects in vitro through HMG-CoA reductase inhibition and in vivo through significant reduction of cholesterol levels in an animal model. Protein hydrolysates from lemongrass dietary proteins may serve as promising functional foods for the prevention of CVD risk.

The Modulatory Bioeffects of Pomegranate (Punica granatum L.) Polyphenols on Metabolic Disorders: Understanding Their Preventive Role against Metabolic Syndrome

Modern research achievements support the health-promoting effects of natural products and diets rich in polyphenols. Pomegranate (PG) (Punica granatum L.) contains a considerable number of bioactive compounds that exert a broad spectrum of beneficial biological activities, including antimicrobial, antidiabetic, antiobesity, and atheroprotective properties. In this context, the reviewed literature shows that PG intake might reduce insulin resistance, cytokine levels, redox gene expression, blood pressure elevation, vascular injuries, and lipoprotein oxidative modifications. The lipid parameter corrective capabilities of PG-ellagitannins have also been extensively reported to be significantly effective in reducing hyperlipidemia (TC, LDL-C, VLDL-C, and TAGs), while increasing plasma HDL-C concentrations and improving the TC/HDL-C and LDL-C/HDL-C ratios. The health benefits of pomegranate consumption seem to be acheived through the amelioration of adipose tissue endocrine function, fatty acid utilization, GLUT receptor expression, paraoxonase activity enhancement, and the modulation of PPAR and NF-κB. While the results from animal experiments are promising, human findings published in this field are inconsistent and are still limited in several aspects. The present review aims to discuss and provide a critical analysis of PG’s bioeffects on the components of metabolic syndrome, type-2 diabetes, obesity, and dyslipidemia, as well as on certain cardiovascular-related diseases. Additionally, a brief overview of the pharmacokinetic properties, safety, and bioavailability of PG-ellagitannins is included.

Predictors of in-hospital mortality of patients with COVID-19 infection in a major treatment facility in Ghana.

Background: An estimated 17 –18% of hospitalisedCOVID-19 patients die. This has been attributed to varying symptomatic, prophylactic, patient management and health care factors. However, these factors have been shown to vary with population and setting dynamics. There is limited literature on the impact of these factors on COVID-19 mortality in the Ghanaian setting. This study, therefore, assessed the factors associated with mortality among COVID-19 hospitalised patients. Objective: The study aimed to assess the clinical and health-related factors associated with the mortality of COVID-19 patients admitted to a major treatment facility in Ghana. Methods: We conducted a retrospective study at Ghana Infectious Disease Center, involving a review of data collected on patients admitted to the facility from January 2021 to December 2021. Using a data abstraction tool on Kobo Collect, data on patient sociodemographic characteristics, clinical presentation, underlying conditions and vaccination status were extracted from patient folders and other inpatient registers. We analysed the data and estimated Odds ratios and their respective 95%CI intervals. Results: Out of the 271 patients admitted to the hospital within the study period, 8.86% (95%CI: 5.76–12.89) died. Being diabetic (aOR = 2.62, 95%CI: 1.08-6.35), having a cardiovascular-related disease (aOR = 4.06, 95%CI: 1.03–15.91), having a kidney disease (aOR = 4.56, 95%CI: 1.40-14.92), a chronic lung disease (aOR = 4.42, 95%CI: 1.45-13.53), and longer duration of admission (aOR = 1.06, 95%CI: 1.01-1.11) were associated with increased odds of death among the patients. Being vaccinated (aOR = 0.40, 95%CI: 0.11-0.49) was associated with a reduction in the odds of death among the patients. Conclusion: This study revealed a less than 10% mortality rate among the patients. Being unvaccinated, having an underlying condition (diabetes, cardiovascular-related diseases, chronic lung diseases and kidney disease) and having a longer duration of admission in the hospital were associated with increased risk of death among the patients.

Acute exposure to PM2.5 promotes arterial stiffening by down-regulating serine and trans-4-hydroxyproline dependent pathways - results from an Asutralian cohort metabolomic study

Abstract Background Exposure to air pollution is known to have both acute and chronic adverse effects on the cardiovascular system, but the pathophysiology of cardiac complications associated with air pollutants remains poorly understood; however, utilizing high-throughput omic studies can provide a better understanding of involved biomarkers, which may ultimately help identify, prevent, and discover drugs for high-risk populations. Purpose Utilising the targeted metabolomics in the BioHEART Discovery cohort we set to identify metabolites implicated in cardiovascular diseases in relation to acute exposure to air pollution. Method We included 1002 clinically stable study participants who were referred for a clinically indicated CT coronary angiogram (CTCA) between November 2015 and March 2020. Coronary artery disease (CAD) burden was assessed using coronary artery calcium scores (CACS) and the Gensini scores. We performed targeted metabolomic analysis of hydrophilic metabolites in positive and negative ionisation using Liquid chromatography–mass spectrometry (LC-MS). Acute air pollution exposure was defined as the daily average and maximum climatic (temperature and humidity) and particulate matter levels on the day of and up to 3 days prior to enrollment, based on the patient's postcode. Using K-means clustering, we grouped the population based on their overall maximum PM2.5 exposure. We also used PCA and sPLS-DA to cluster and perform variable importance selection. Results PCA demonstrated good separation between the high vs normal PM2.5 exposure groups in PC1-PC2 dimensions, with scores of 29.5% and 8.5% respectively [Figure 1]. All of the top five metabolites detected by sPLS-DA, including Trans-4-Hydroxyproline and Serine, demonstrated down-regulation in the high exposure cohort.Trans-4-Hydroxyproline is involved in the urea cycle and arginine and proline metabolism, while Serine is a marker of glycine, serine, and threonine metabolism. Previous studies [1] have shown that these metabolites have an inverse correlation with carotid-femoral pulse-wave velocity (PWV), an indirect measure of arterial stiffness and an indication of increased risk of all-cause mortality and cardiac morbidity [2]. Conclusion Here we have demonstrated that acute exposure to PM2.5 can potentially result in a shift in metabolimic signature that is associated with vascular dysfunction.PCA clusters demonstrating a good separaComparing Trans-4-HYP and Serine

Abnormal expression of sphingolipid-metabolizing enzymes in the heart of spontaneously hypertensive rat models

Sphingolipids exert important roles within the cardiovascular system and related diseases. Perturbed sphingolipid metabolism was previously reported in cerebral and renal tissues of spontaneously hypertensive rats (SHR). Specific defects related to the synthesis of sphingolipids and to the metabolism of Sphingosine-1-Phospahte (S1P) were exclusively identified in the stroke-prone (SHRSP) with the respect to the stroke-resistant (SHRSR) strain.In this study, we explored any existing perturbation in either protein or gene expression of enzymes involved in the sphingolipid pathways in cardiac tissue from both SHRSP and SHRSR strains, compared to the normotensive Wistar Kyoto (WKY) strain.The two hypertensive rat models showed an overall perturbation of the expression of different enzymes involved in the sphingolipid metabolism in the heart. In particular, whereas the expression of the S1P-metabolizing-enzyme, SPHK2, was significantly reduced in both SHR strains, SGPL1 protein levels were decreased only in SHRSP. The protein levels of S1P receptors 1–3 were reduced only in the cardiac tissue of SHRSP, whereas S1PR2 levels were reduced in both SHR strains. The de novo synthesis of sphingolipids was aberrant in the two hypertensive strains. A significant reduction of mRNA expression of the Sgms1 and Smpd3 enzymes, implicated in the metabolism of sphingomyelin, was found in both hypertensive strains. Interestingly, Smpd2, devoted to sphingomyelin degradation, was reduced only in the heart of SHRSP.In conclusion, alterations in the expression of sphingolipid-metabolizing enzymes may be involved in the susceptibility to cardiac damage of hypertensive rat strains. Specific differences detected in the SHRSP, however, deserve further elucidation.

Age-related alterations in the cardiovascular responses to acute exercise in males and females: role of the exercise pressor reflex.

Autonomic adjustments of the cardiovascular system are critical for initiating and sustaining exercise by facilitating the redistribution of blood flow and oxygen delivery to meet the metabolic demands of the active skeletal muscle. Afferent feedback from active skeletal muscles evokes reflex increases in sympathetic nerve activity and blood pressure (BP) (i.e., exercise pressor reflex) and contributes importantly to these primary neurovascular adjustments to exercise. When altered, this reflex contributes significantly to the exaggerated sympathetic and BP response to exercise observed in many cardiovascular-related diseases, highlighting the importance of examining the reflex and its underlying mechanism(s). A leading risk factor for the pathogenesis of cardiovascular disease in both males and females is aging. Although regular exercise is an effective strategy for mitigating the health burden of aging, older adults face a greater risk of experiencing an exaggerated cardiovascular response to exercise. However, the role of aging in mediating the exercise pressor reflex remains highly controversial, as conflicting findings have been reported. This review aims to provide a brief overview of the current understanding of the influence of aging on cardiovascular responses to exercise, focusing on the role of the exercise pressor reflex and proposing future directions for research. We reason that this review will serve as a resource for health professionals and researchers to stimulate a renewed interest in this critical area.

Exploring Cutting-Edge Approaches to Potentiate Mesenchymal Stem Cell and Exosome Therapy for Myocardial Infarction.

Cardiovascular diseases (CVDs) continue to be a significant global health concern. Many studies have reported promising outcomes from using MSCs and their secreted exosomes in managing various cardiovascular-related diseases like myocardial infarction (MI). MSCs and exosomes have demonstrated considerable potential in promoting regeneration and neovascularization, as well as exerting beneficial effects against apoptosis, remodeling, and inflammation in cases of myocardial infarction. Nonetheless, ensuring the durability and effectiveness of MSCs and exosomes following in vivo transplantation remains a significant concern. Recently, novel methods have emerged to improve their effectiveness and robustness, such as employing preconditioning statuses, modifying MSC and their exosomes, targeted drug delivery with exosomes, biomaterials, and combination therapy. Herein, we summarize the novel approaches that intensify the therapeutic application of MSC and their derived exosomes in treating MI.

Inhaled nitric oxide: can it serve as a savior for COVID-19 and related respiratory and cardiovascular diseases?

Nitric oxide (NO), as an important gaseous medium, plays a pivotal role in the human body, such as maintaining vascular homeostasis, regulating immune-inflammatory responses, inhibiting platelet aggregation, and inhibiting leukocyte adhesion. In recent years, the rapid prevalence of coronavirus disease 2019 (COVID-19) has greatly affected the daily lives and physical and mental health of people all over the world, and the therapeutic efficacy and resuscitation strategies for critically ill patients need to be further improved and perfected. Inhaled nitric oxide (iNO) is a selective pulmonary vasodilator, and some studies have demonstrated its potential therapeutic use for COVID-19, severe respiratory distress syndrome, pulmonary infections, and pulmonary hypertension. In this article, we describe the biochemistry and basic characteristics of NO and discuss whether iNO can act as a "savior" for COVID-19 and related respiratory and cardiovascular disorders to exert a potent clinical protective effect.

Chemically modified electrochemical sensors for the detection of β-blockers: an overview of electrode modifiers

β-blockers are a significant class of medications generally used to treat cardiovascular related diseases, but toxicity from overdoses can lead to serious side effects. In addition to this, they may also be used as doping agents by athletes due to their sedative effects. Therefore, it is crucial for their detection. Traditional detection methods include chromatography, spectroscopy, etc., but these techniques are tedious and labor-intensive, and the instruments are cumbersome. Electrochemical methods have become an important alternative to traditional methods because of their high selectivity, high sensitivity, minimal expense, and portability. For the purpose of enhancing the performance of electrochemical methods, this article focuses on three types of electrode modification materials: molecularly imprinted polymers (MIPs), carbon nanomaterials, and metal nanoparticles. MIPs are an important class of selective adsorption materials, which can adsorb a certain type of β-blockers through hydrophobic interaction, π-π interaction, hydrogen bonding, etc., thereby improving the selectivity and sensitivity of electrochemical sensors. Carbon nanomaterials and metal nanoparticles have strong electroconductivity and enormous specific surface area, which can promote the electron transfer rate on the working electrode surface and improve the sensitivity of the sensor. In addition, they also have some unique properties respectively. Furthermore, the trend of electrochemical detection of β-blockers and the prospect of future development are suggested.

The Contribution of Serum Sialic Acid Binding Immunoglobulin-Like Lectin 1(sSIGLEC-1) as an IFN I Signature Biomarker in the Progression of Atherosclerosis in Egyptian Systemic Lupus Erythematosus (SLE) Patients.

Clinical symptoms of systemic lupus erythematosus (SLE), such as atherosclerosis and related cardiovascular diseases, are caused by inflammatory cytokines and endothelial cell damage. The serum sialic acid binding immunoglobulin-like lectin 1 (sSIGLEC-1) is thought to be an alternative biomarker of IFN signature and may have a role in the pathogenesis of atherosclerosis. The aim of the study was to measure the levels of sSIGLEC-1 in the serum of SLE patients in comparison to a control group and examine the associations between sSIGLEC-1, SLEDAI, lipid profile, oxidized low density lipoprotein (oxLDL), and carotid intima media thickness (CIMT) to investigate whether sSIGLEC-1 participates in the development of atherosclerosis. sSIGLEC-1 levels were tested in 53 patients and 20 volunteers using ELISA kit. Duplex measurements were performed on all subjects to measure CIMT. SLE patients had significantly higher values of sSIGLEC-1 (P < 0.0001), total cholesterol (P = 0.029), triglycerides (P = 0.001), low density lipoprotein (P = 0.032), oxLDL (P = 0.001), right CIMT (P = 0.0099) and a significantly lower value of high-density lipoprotein (P = 0.04) when compared to controls. sSIGLEC-1 had significant positive correlations with right CIMT (r = 0.5, P < 0.0002) and oxLDL (r = 0.67, P < 0.0001) in all SLE patients. When compared to non-dyslipidemic patients, the dyslipidemic group exhibited significantly higher levels of all previous parameters except HDL and left CIMT. Circulating form of SIGLEC-1 accelerates atherosclerosis and provides a simple way to predict the occurrence of atherosclerosis in SLE patients.

Metformin reduces the risk of developing influenza A virus related cardiovascular disease

This study investigated the drug repositioning potential of metformin for cardiovascular risk due to influenza A virus infection. Statistical analysis was performed to analyze factors related to the risk of death after IAV infection in diabetic patients. Through in vitro and in vivo experiments, the effect of metformin on influenza A virus infection in non-diabetic conditions was analyzed. In logistic regression analysis, influenza vaccination (OR = 0.378, p-value = 0.007, 0.186 < 95% C·I < 0.768) and metformin treatment (OR = 0.380, p-value = 0.016, 0.173 < 95% C·I < 0.835) were associated with a decreased influenza-related mortality in diabetic patients. In vitro and in vivo studies showed that viral replication and influenza A virus-induced cytokine expression were inhibited by metformin. In particular, MCP-1 and IP-10, cytokines related to cell infiltration and cardiovascular disease development, were significantly reduced by metformin under influenza A virus infection condition. As a result, the acute exacerbation of atherosclerosis caused by influenza A virus in mouse aorta was inhibited by metformin. In addition, we found that regulation of AKT/MAPK signaling plays an important role in the mechanism of metformin. In conclusion, we demonstrated the potential and mechanism of metformin as a treatment for acute exacerbation of atherosclerosis caused by influenza A virus infection.

The role of exosomal circular RNA ZNF292 in intermittent hypoxia-induced AC16 cardiomyocytes injury.

Exosomes are involved in cell-to-cell communication in numerous diseases including cardiovascular diseases, neurological diseases. Little attention has been dedicated to exosomal circularRNAs in obstructive sleep apnea (OSA)-related cardiovascular diseases. The aim of this study was to explore the role of exosomal circular RNA ZNF292 (circZNF292) on AC16 cells exposure to intermittent hypoxia (IH). Exosome release inhibitor GW4869 was usedto examine the effect of exosomes on IH-induced AC16 cells apoptosis. The expression of exosomal circZNF292 was detected by qRT-PCR in AC16 cells exposure to IH, and a luciferase reporter assay was conducted to confirm the connection between circZNF292 and miR-146a-5p. Exosomal circZNF292 was stably transfected with short hairpin RNAs (shRNAs) against circZNF292 and co-cultured with AC16 cells. The expression of miR-146a-5p and apoptosis-related protein was thenmeasured to evaluate the effect of exosomal circZNF292. We found that IH contributed to the AC16 cells apoptosis, and the administration of GW4869 increased the apoptosis of cardiomyocytes when exposed to IH. The expression of exosomal circZNF292 decreased and miR-146a-5p increased significantly in AC16 cells exposed to IH compared to normoxic conditions. Bioinformatics analysis predicted a circZNF292/miR-146a-5p axis in IH-induced cardiomyocytes apoptosis. The dual-luciferase reporter system validated the direct interaction of circZNF292 and miR-146a-5p. Knockdown of circZNF292 increased the expressions of miR-146a-5p and accelerated the AC16 cardiomyocytes apoptosis. The findings of this study suggested a novel mechanism by which exosomes transmit intrinsic regulatory signals to the myocardium through the exosomal circZNF292/miR-146a-5p axis. This finding highlights the potential of targeting this pathway as a therapeutic approach for treating cardiovascular diseases associated with OSA.

Telenursing and Remote Patient Monitoring in Cardiovascular Health.

Background: Since the decline in death rates from cardiovascular diseases has slowed down recently, promoting cardiovascular health in patients and the general public has become more important than ever, particularly for elder and rural patients. This study is a collaborative effort between a regional health network in Virginia and associated organizations to implement and assess telenursing and remote patient monitoring (RPM) to help home care patients better manage their own cardiovascular related diseases and promote sustainable health delivery options. Method: Eighty cardiovascular patients with diabetes, congestive heart failure, or both who had a recent disease-related hospital stay were enrolled in the RPM program to receive services, including care coordination, coaching, referral for behavioral health, and aging-related services for 90+ days. The program used telenursing and RPM through home care monitoring equipment to coach patients on effective measures to stay compliant with posthospitalization regimens, track and evaluate readmissions, and assess physiological status and mental health. Result: There was a decline in hospital admissions of 65%, 85% for observations and related inpatient services for enrolled CVD patients in the RPM program. In addition, the longer the patient was enrolled the less likely they were to readmit. The program saved ∼$615,127 in patient claims costs and had net savings of $390,296, ∼173% of the total program expenses. Discussion: Evidence showed that 90+ day enrollments are sufficient for realization of readmissions and Emergency Department reductions, increased health care access, and lower costs. This resulted from consistent monitoring using the technology to alert nurses and care coordinators who were able to respond and facilitate patients accessing care in the most helpful and generally less costly care environment. Conclusion: The study has confirmed that care coordination and RPM are effective in supporting self-management of chronic conditions and cost reductions through telenursing and RPM.

Association of prior bariatric surgery with financial and clinical outcomes of acute myocardial infarction

BackgroundSuperior clinical outcomes after hospitalization for cardiovascular-related disease such as acute heart failure have been linked with prior history of bariatric surgery, but similar analyses in acute myocardial infarction (MI) are currently limited. ObjectiveThis work examines clinical outcomes and resource utilization in patients with acute MI hospitalizations with a prior history of bariatric surgery. SettingAcademic university-affiliated hospital in the United States. MethodsAll adult patients with hospitalizations with a primary diagnosis of acute MI were queried using the 2016–2020 Nationwide Readmissions Database. The study population was comprised of patients with an International Classification of Diseases, Tenth Revision (ICD-10) diagnosis code for obesity (body mass index ≥35 kg/m2) as well as those with a prior history of bariatric surgery regardless of their body mass index status. Comparison was made between those with a prior history of bariatric surgery and those without. Univariate analysis and multivariate regression models were used to examine the association between bariatric surgery and outcomes of interest, which included in-hospital mortality, medical complications, and resource utilization. ResultsOf an estimated 2,736,606 hospitalizations for acute MI, 296,902 patients (10.8%) had a diagnosis of obesity and/or a prior history of bariatric surgery. The bariatric cohort was more frequently female and had a lower prevalence of congestive heart failure, chronic lung disease, diabetes, and electrolyte derangements than the nonbariatric cohort. After risk adjustment, prior history of bariatric surgery was associated with significantly lower odds of in-hospital mortality, cardiogenic shock, and acute kidney injury. Additionally, prior history of bariatric surgery was linked to a decreased duration of hospital stay and lower hospitalization costs as well as lower odds of nonhome discharge. ConclusionAmong acute MI patients with obesity, prior history of bariatric surgery was associated with decreased odds of in-hospital mortality, improved clinical outcomes, and lower resource utilization. Expansion of bariatric surgery programs may provide improved access to a medical intervention that is intertwined with cardiovascular health.

429 Service Evaluation of the Royal Orthopaedic Hospital Bone Infection Service in Patients with Spinal Infections, Both Native and Following Surgery - Five Years of Experience

Abstract Aim The Royal Orthopaedic Hospital Bone Infection Service (ROH BIS) is one of the four formal bone infection services in the United Kingdom, providing multidisciplinary care and community support for patients with bone infection. This service evaluation is to document burden, pattern of infection and subsequent treatment by the ROH BIS in treating those with spinal infection, both native and following spinal surgery. Method This is a retrospective analysis of spinal infections treated from 2017-2022 at the ROH BIS. Clinical, MDT and investigation notes were reviewed for demographics, comorbidities and details of identification and management of the infection. Results 39 patients (median age = 63, IQR = 34, male = 46.2%) were identified. 23 patients had previous metal implanted, 16 did not. The infection rate in ROH spinal surgery is 3%, 15 infections were native, and 24 were iatrogenic. Cardiovascular-related disease (38.5%) is the most common comorbidity. The mean time taken to identify a bone infection and infectious organism was 1.5 days and 4.0 days. Enterobacteriaceae (33.3%) and Staphylococcus Aureus (20.5%) were most commonly identified. Recurrent infection rate was 5.1%, and 5 (21.7%) cases required removal of implant. The mean number of MDT meetings for each patient is 1.7 meetings, and the mean extra hospital stay is 20 days. Conclusions Infections following spinal surgery are well managed by the multidisciplinary ROH BIS model. Rapid referral acceptance, strict diagnostic sampling criteria and specialised nursing care enabled precise management and lessened the burden of reoperation or metal implant removal on patients

A Focused Group Perspective of Risk Factors for Hypertension Among Middle-Aged Adults in Rural Areas of Anambra State, Nigeria

ABSTRACT Purpose Recent records by the World Health Organization show that hypertension is more prevalent in Africa than in other parts of the world, and remains the foremost common risk factor for cardiovascular-related diseases, stroke, renal diseases, and death. However, little is known about the risk factors for hypertension by people from rural areas, especially among middle-aged adults. Therefore, the study examined the knowledge of the risk factors for hypertension among middle-aged adults in rural areas of Anambra state, Nigeria. Materials, and method Focus group discussions were used to collect data from 40 middle-aged adults (20 males and 20 females). Two key themes stood out from the data collection guides. These are “awareness of hypertension and its’ symptoms” and “knowledge of risk factors of hypertension”. Results The findings showed that the participants were aware of hypertension but lacked in-depth knowledge of the risk factors for the disease. Most participants did not believe that intake of certain foods like starchy foods and excess alcohol consumption could lead to one being hypertensive. Discussion and conclusion There is a need for social workers to sensitize and enlighten the middle-aged adults in the study area on the risk factors for the disease.

Impaired cardiac glycolysis and glycogen depletion are linked to poor myocardial outcomes in juvenile male swine with metabolic syndrome and ischemia.

Obesity continues to rise in the juveniles and obese children are more likely to develop metabolic syndrome (MetS) and related cardiovascular disease. Unfortunately, effective prevention and long-term treatment options remain limited. We determined the juvenile cardiac response to MetS in a swine model. Juvenile male swine were fed either an obesogenic diet, to induce MetS, or a lean diet, as a control (LD). Myocardial ischemia was induced with surgically placed ameroid constrictor on the left circumflex artery. Physiological data were recorded and at 22 weeks of age the animals underwent a terminal harvest procedure and myocardial tissue was extracted for total metabolic and proteomic LC/MS-MS, RNA-seq analysis, and data underwent nonnegative matrix factorization for metabolic signatures. Significantly altered in MetS versus. LD were the glycolysis-related metabolites and enzymes. In MetS compared with LD Glycogen synthase 1 (GYS1)-glycogen phosphorylases (PYGM/PYGL) expression disbalance resulted in a loss of myocardial glycogen. Our findings are consistent with the concept that transcriptionally driven myocardial changes in glycogen and glucose metabolism-related enzymes lead to a deficiency of their metabolite products in MetS. This abnormal energy metabolism provides insight into the pathogenesis of the juvenile heart in MetS. This study reveals that MetS and ischemia diminishes ATP availability in the myocardium via altering the glucose-G6P-pyruvate axis at the level of metabolites and gene expression of related enzymes. The observed severe glycogen depletion in MetS coincides with disbalance in expression of GYS1 and both PYGM and PYGL. This altered energy substrate metabolism is a potential target of pharmacological agents for improving juvenile myocardial function in MetS and ischemia.

Analysis for calibration pre-post difference in BP estimation of Galaxy Watch.

The use of smartwatches has become increasingly common with the release of major products such as the Galaxy Watch by Samsung and the Apple Watch by Apple. The common aim of smartwatches is to target the healthcare market with a wearable, physically-attached device, with blood pressure at the core. As blood pressure is an important biomarker for cardiovascular-related diseases, it is a necessary index to inspect in hospitals when checking an individual's health state. Smartwatches are expected to provide a cuff-less, non-invasive method of estimating blood pressure. However, not many experiments have been conducted on blood pressure datasets obtained from smartwatches. Smartwatches are unique compared to other devices because they require "calibration" to sustain their accuracy.In this paper, we investigate the difference between before and after calibration to better understand the calibration pattern. Not only do we seek to understand the demographic differences in calibration, but we also analyze the possible variables that influence calibration differences. Our results show that hypertensive patients are more prone to high calibration differences, which implies that the calibration period should be adjusted by considering the average blood pressure of users.Clinical Relevance- This paper investigates the possibility for daily BP measurement to be used as clinical data while suggesting proper method to sustain its validity.

Protective effects and molecular mechanisms of tea polyphenols on cardiovascular diseases.

Aging is the most important factor contributing to cardiovascular diseases (CVDs), and the incidence and severity of cardiovascular events tend to increase with age. Currently, CVD is the leading cause of death in the global population. In-depth analysis of the mechanisms and interventions of cardiovascular aging and related diseases is an important basis for achieving healthy aging. Tea polyphenols (TPs) are the general term for the polyhydroxy compounds contained in tea leaves, whose main components are catechins, flavonoids, flavonols, anthocyanins, phenolic acids, condensed phenolic acids and polymeric phenols. Among them, catechins are the main components of TPs. In this article, we provide a detailed review of the classification and composition of teas, as well as an overview of the causes of aging-related CVDs. Then, we focus on ten aspects of the effects of TPs, including anti-hypertension, lipid-lowering effects, anti-oxidation, anti-inflammation, anti-proliferation, anti-angiogenesis, anti-atherosclerosis, recovery of endothelial function, anti-thrombosis, myocardial protective effect, to improve CVDs and the detailed molecular mechanisms.