Cardinal Axes Research Articles

Modeling positioning uncertainties of prostate cancer external beam radiation therapy using pre-treatment data

PurposeTo investigate the influence of treatment plan data and image guidance (IG) on positioning uncertainty during prostate cancer (PCa) radiotherapy (RT). MethodsBody mass index (BMI), planning target volume (PTV), bladder volume (BV), and rectal cross section area (RCS) were collected for 267 consecutive PCa patients undergoing daily IGRT. Radiographic isocenter corrections to intra-prostatic fiducials for 12,490 treatment fractions were used to derive random (RE) and systematic (SE) inter-fraction uncertainties for the cardinal axes. These data were used to simulate RE and SE for weekly IG and Action Level (AL)-IG treatment protocols. ResultsSE and RE were 2–5 and 3–4mm in the cardinal axes, respectively, during simulation of no IG. Without IG, positive correlations (p<0.01) were noted for (1) anterior-posterior RE vs. RCS and BV and (2) cranio–caudal RE vs. RCS, BV and BMI. The RE increase was 3mm for the highest quartile of RCS, BV and BMI. Daily IGRT eliminated this relationship. 3D IG corrections of 1cm or more occured in 27% of treatment fractions and in 97% of patients. ConclusionPCa patients with elevated pre-treatment BV, RCS and BMI have increased inter-fractionation positioning uncertainty and appear the primary candidates for daily IGRT.

S-cone discrimination in the presence of two adapting fields: data and model

This study investigated S-cone discrimination using a test annulus surrounded by an inner and outer adapting field with systematic manipulation of the adapting l=L/(L+M) or s=S/(L+M) chromaticities. The results showed that different adapting l chromaticities altered S-cone discrimination for a high adapting s chromaticity due to parvocellular input to the koniocellular pathway. In addition, S-cone discrimination was determined by the combined spectral signals arising from both adapting fields. The "white" adapting field or an adapting field with a different l chromaticity from the other fields was more likely to have a stronger influence on discrimination thresholds. These results indicated that the two cardinal axes are not independent in S-cone discrimination, and the two adapting fields jointly contribute to S-cone discrimination through a cortical summation mechanism.

Counting colors

Recent studies have demonstrated that observers can readily extract the average value of a stimulus set, for dimensions ranging from motion to orientation to facial expressions. We have examined the ability to judge the average value of pairs of colors. Stimuli were composed of two alternating colors displayed in an 11 by 11 array of x deg spots. Observers adjusted one or both colors to a specified average (e.g. gray or a balanced blue-green) or so that the two colors appeared complementary. Performance on these tasks suggest that observers are very good at judging the relative amounts of different colors; while poor at inferring the actual average value of different color combinations, especially for pairs that include different color categories. In current work, we explore the internal “color space” in which observers quantify the colors, by comparing the balance for different color pairs predicted by a cone-opponent vs. perceptually-opponent representation of the components. The latter was derived from hue-scaling of the component colors (e.g. to estimate the perceived proportion of blue or green within each component). These individual proportions fail to predict the average proportions selected for the full set of color pairs, which also deviate from the pattern predicted by averaging the linear or log cone-opponent contrasts. Thus judgments of hue combinations are nonlinear in a way that does not directly reflect simple putative models of early (cardinal axes) or late (Hering axes) color coding. Supported by EY-10834

Quantifying Preferences for the Natural World Using Monetary and Nonmonetary Assessments of Value

Given that funds for biodiversity conservation are limited, there is a need to understand people’s preferences for its different components. To date, such preferences have largely been measured in monetary terms. However, how people value biodiversity may differ from economic theory, and there is little consensus over whether monetary metrics are always appropriate or the degree to which other methods offer alternative and complementary perspectives on value. We used a choice experiment to compare monetary amounts recreational visitors to urban green spaces were willing to pay for biodiversity enhancement (increases in species richness for birds, plants, and aquatic macroinvertebrates) with self-reported psychological gains in well-being derived from visiting the same sites. Willingness-to-pay (WTP) estimates were significant and positive, and respondents reported high gains in well-being across 3 axes derived from environmental psychology theories (reflection, attachment, continuity with past). The 2 metrics were broadly congruent. Participants with above-median self-reported well-being scores were willing to pay significantly higher amounts for enhancing species richness than those with below-median scores, regardless of taxon. The socio-economic and demographic background of participants played little role in determining either their well-being or the probability of choosing a paying option within the choice experiment. Site-level environmental characteristics were only somewhat related to WTP, but showed strong associations with self-reported well-being. Both approaches are likely to reflect a combination of the environmental properties of a site and unobserved individual preference heterogeneity for the natural world. Our results suggest that either metric will deliver mutually consistent results in an assessment of environmental preferences, although which approach is preferable depends on why one wishes to measure values for the natural world.

Motion trajectories and object properties influence perceived direction of motion

Judging the motion of objects is a fundamental task that the visual system executes in everyday life in order for us to navigate and interact safely with our surroundings. A number of strategies have been suggested to explain how the visual system uses motion information from different points of an object to compute veridical directions of motion. These include combining ambiguous signals from object contours via a vector summation (VS) or intersection of constraints (IOC) calculation, pooling information using a maximum likelihood or tracking object features. We measured the perceived direction of motion for a range of cross-shaped stimuli (composed of two superimposed lines) to test how accurately humans perceive their motion and compared data to predictions from these strategies. Crosses of different shapes (defined by the angle between the component lines) translated along 16 directions of motion with constant speed. The crosses either moved along one of their symmetry axes (balanced conditions with line components equidistant to the direction of motion) or had their symmetry axis tilted relative to the motion (unbalanced conditions) Data show reproducible differences between observers, including occasional bimodal behaviour, and exhibit the following common patterns. There is a general dependence on direction of motion: For all conditions, when motion is along cardinal axes (horizontal and vertical), perception is largely veridical. For non-cardinal directions, biases are typically small (<10 deg) when crosses are balanced but large biases occur (≥30 deg) when crosses are tilted relative to their direction of motion. Factors influencing the pattern of biases are the shape and tilt of the cross as well as the proximity of its direction of motion to cardinal axes. The dependence of the biases on the direction of motion is inconsistent with any isotropic mechanisms including VS, IOC, maximum likelihood or feature tracking. Instead, perception is biased by a number of intrinsic properties of the cross and external references. The strength of these cues depends on the type, with elongation producing the strongest weight, and their proximity to the direction of motion. This suggests that the visual system may rely on a number of static cues to improve the known low precision for non-cardinal directions of motion, a process which can, however, result in large perceptual biases in certain circumstances.

Introducing a Quadristable Auditory Spatial Illusion: Imagining objects moving through space

Object perception is a multimodal task, involving both sight as well as sound to localize objects. Several visual illusions have made use of multi-stable percepts of object direction and location (Necker, 1832; Kayahara, 2003). Here, we created an auditory correlate of such visual illusions that causes differential interpretations of object direction and location, yet with a constant visual input. This quadristable auditory illusion makes use of back-front confusions to give varying perceptions of an object approaching and retracting from the listener. Observers can perceive the sound as traveling: 1) front to back, 2) back to front, 3) coming from and returning to the front, and 4) coming from and returning to the back. To test this illusion, participants sat in a symmetrical, customized chamber with four speakers positioned on the cardinal axes around them and performed several psychophysics experiments where participants were asked to discriminate between 1) sounds really moving between the speakers and 2) the illusion (which is played equally in the front and back speakers and does not move). When asked to discriminate between real and illusory sounds, observers performed at chance. They localized the illusory sound as all different directional possibilities. When asked to rate their confidence in perceiving a sound cued by directional instructions, they gave equal confidence for the real and illusory sounds (despite the illusion having no direction). When rotated 90 degrees, so that the sounds now traveled between the left and right speakers, observers performed at ceiling. These results show the illusion along the front-back axis is not differentiable from truly moving sounds, and is successful in producing directional percepts. Such quadristable auditory illusions open new opportunities in multimodal science, for studying the perceptual, cognitive and neural representation of objects and space, as well as exploring multi-dimensional perceptual awareness. Meeting abstract presented at VSS 2013

Contrast magnitude and polarity effects on color filling-in along cardinal color axes

Color filling-in is the phenomenon in which the color of a visual area is perceived as the color that is only presented in an adjacent area. In a stimulus with multiple edges, color filling-in can occur along any edge and in both centripetal and centrifugal directions when maintaining steady fixation. The current study aimed to investigate the role of chromatic contrast magnitude and polarity along the two chromaticity cardinal axes and the interaction of the axes in the color filling-in process. In Experiment 1, the color filling-in process was examined using stimuli with three different regions and two edges. The three regions had chromaticities that varied only in one of the chromaticity axes. In Experiment 2, the regions along both edges differed in chromaticity along both axes. The results showed that the contrast magnitudes and polarity relationship of the two edges worked together to determine the filled-in direction and time course of the filled-in percepts. Further, the results pointed to a common mechanism mediating the color filling-in process along the two cardinal axes, and the two axes did not act independently in this process.

Latency of chromatic information in area V4

In the primate visual system, information about color is known to be carried in separate divisions of the retino-geniculo-cortical pathway. From the retina, responses of photoreceptors to short (S), medium (M), and long (L) wavelengths of light are processed in two different opponent pathways. Signals in the S-opponent pathway, or blue/yellow channel, have been found to lag behind signals in the L/M-opponent pathway, or red/green channel in primary visual area V1, and psychophysical studies have suggested similar perceptual delays. However, more recent psychophysical studies have found that perceptual differences are negligible with the proper controls, suggesting that information between the two channels is integrated at some stage of processing beyond V1. To study the timing of color signals further downstream in visual cortex, we examined the responses of neurons in area V4 to colored stimuli varying along the two cardinal axes of the equiluminant opponent color space. We used information theory to measure the mutual information between the stimuli presented and the neural responses in short time windows in order to estimate the latency of color information in area V4. We found that on average, despite the latency difference in V1, information about S-opponent signals arrives in V4 at the same time as information about L/M-opponent signals. This work indicates a convergence of signal timing among chromatic channels within extrastriate cortex.

SU‐E‐T‐693: Comparison of Discrete Spot Scanning and Passive Scattering Craniospinal Proton Irradiation

Purpose: To compare plan robustness, dose variations at field junctions, and overall dose conformity to target between passive scattering and discrete spot scanning (DSS) proton craniospinal irradiation. Methods: A DSS treatment plan was generated for three craniospinal CT image sets. A forward planning approach was used to generate treatment plans for the cranium and lower spine, which exhibited dose tapering of about 10 Gy/cm towards the thoracic spine to facilitate the low‐gradient field junctions. In‐house software accomplished optimization of discrete spot weights for the thoracic‐level field, which was then imported into the Varian Eclipse clinical treatment planning system for dose calculation. Planning was guided using clinical targets defined for craniospinal irradiation with passively scattered proton beams. Robustness analysis was performed by varying the position of each beam isocenter +/−3 mm along each cardinal axis, simulating setup errors, as well as adjusting the CT number to relative stopping power curve to mimic +/−3.5% range variation, and then analyzing the resulting dose distribution. Dose profiles along the craniospinal axis were used to evaluate intrafraction dose variation at field junctions. Dose volume histograms (DVH) were generated for each robustness element, and then combined to create composite DVH illustrating a range of possible delivered dose. Results: Results of robustness analysis indicate that field isocenter shifts along the craniospinal axis can Result in dose intrafraction variations at the junction in excess of 25% for passive scattering proton plans. This value is markedly reduced for the same shifts applied to DSS plans using a tapered‐dose field matching technique. Conclusion: This work demonstrates the potential for improved robustness of proton craniospinal irradiations using a DSS delivery method, as well as significant decreases in clinic expenses. The use of apertures to define the sagittal plane field edge for DSS delivery improves the dose to target.

Simulated self-motion in a visual gravity field: Sensitivity to vertical and horizontal heading in the human brain

Multiple visual signals are relevant to perception of heading direction. While the role of optic flow and depth cues has been studied extensively, little is known about the visual effects of gravity on heading perception. We used fMRI to investigate the contribution of gravity-related visual cues on the processing of vertical versus horizontal apparent self-motion. Participants experienced virtual roller-coaster rides in different scenarios, at constant speed or 1g-acceleration/deceleration. Imaging results showed that vertical self-motion coherent with gravity engaged the posterior insula and other brain regions that have been previously associated with vertical object motion under gravity. This selective pattern of activation was also found in a second experiment that included rectilinear motion in tunnels, whose direction was cued by the preceding open-air curves only. We argue that the posterior insula might perform high-order computations on visual motion patterns, combining different sensory cues and prior information about the effects of gravity. Medial-temporal regions including para-hippocampus and hippocampus were more activated by horizontal motion, preferably at constant speed, consistent with a role in inertial navigation. Overall, the results suggest partially distinct neural representations of the cardinal axes of self-motion (horizontal and vertical).

A Titanium Plasma-Sprayed Cup with and without Hydroxyapatite-Coating: A Randomised Radiostereometric Study of Stability and Osseointegration

We present a prospective, two-centre radiostereometric analysis (RSA) regarding the stability of a flattened pole titanium press-fit cup (EP-FIT PLUS), and whether additional hydroxyapatite coating leads to faster bone ingrowth into the porous coating. Forty-two postmenopausal female patients (44 hips) undergoing total hip arthroplasty for primary osteoarthritis, selected to avoid hormonal factors influencing bone metabolism, were randomised to receive this cup with a titanium-plasma-sprayed surface with or without an additional hydroxyapatite coating. RSA was used to measure cup translation and rotation along three cardinal axes with respect to the host bone at the following time points: immediately postoperatively, at 6 weeks, and at 3, 6, 12, and 24 months. The most pronounced translation was proximal (0.11 mm) and posterior tilt (-0.27°). No difference in translation and rotation could be detected between the two groups. With the exception of one cup with an isolated radiolucent line <2 mm in zone 1, all cups showed complete osseointegration on conventional radiographs. The flattened pole cup provided excellent early stability and no advantage could be detected with additional hydroxyapatite coating.

Functional relationship between cognitive representations of movement directions and visuomotor adaptation performance

The aim of our study was to explore whether or not different types of learners in a sensorimotor task possess characteristically different cognitive representations. Participants' sensorimotor adaptation performance was measured with a pointing paradigm which used a distortion of the visual feedback in terms of a left-right reversal. The structure of cognitive representations was assessed using a newly established experimental method, the Cognitive Measurement of Represented Directions. A post hoc analysis revealed inter-individual differences in participants' adaptation performance, and three different skill levels (skilled, average, and poor adapters) have been defined. These differences in performance were correlated with the structure of participants' cognitive representations of movement directions. Analysis of these cognitive representations revealed performance advantages for participants possessing a global cognitive representation of movement directions (aligned to cardinal movement axes), rather than a local representation (aligned to each neighboring direction). Our findings are evidence that cognitive representation structures play a functional role in adaptation performance.

Detection thresholds of macaque otolith afferents.

The vestibular system is our sixth sense and is important for spatial perception functions, yet the sensory detection and discrimination properties of vestibular neurons remain relatively unexplored. Here we have used signal detection theory to measure detection thresholds of otolith afferents using 1 Hz linear accelerations delivered along three cardinal axes. Direction detection thresholds were measured by comparing mean firing rates centered on response peak and trough (full-cycle thresholds) or by comparing peak/trough firing rates with spontaneous activity (half-cycle thresholds). Thresholds were similar for utricular and saccular afferents, as well as for lateral, fore/aft, and vertical motion directions. When computed along the preferred direction, full-cycle direction detection thresholds were 7.54 and 3.01 cm/s(2) for regular and irregular firing otolith afferents, respectively. Half-cycle thresholds were approximately double, with excitatory thresholds being half as large as inhibitory thresholds. The variability in threshold among afferents was directly related to neuronal gain and did not depend on spike count variance. The exact threshold values depended on both the time window used for spike count analysis and the filtering method used to calculate mean firing rate, although differences between regular and irregular afferent thresholds were independent of analysis parameters. The fact that minimum thresholds measured in macaque otolith afferents are of the same order of magnitude as human behavioral thresholds suggests that the vestibular periphery might determine the limit on our ability to detect or discriminate small differences in head movement, with little noise added during downstream processing.

Link between orientation and retinotopic maps in primary visual cortex

Maps representing the preference of neurons for the location and orientation of a stimulus on the visual field are a hallmark of primary visual cortex. It is not yet known how these maps develop and what function they play in visual processing. One hypothesis postulates that orientation maps are initially seeded by the spatial interference of ON- and OFF-center retinal receptive field mosaics. Here we show that such a mechanism predicts a link between the layout of orientation preferences around singularities of different signs and the cardinal axes of the retinotopic map. Moreover, we confirm the predicted relationship holds in tree shrew primary visual cortex. These findings provide additional support for the notion that spatially structured input from the retina may provide a blueprint for the early development of cortical maps and receptive fields. More broadly, it raises the possibility that spatially structured input from the periphery may shape the organization of primary sensory cortex of other modalities as well.

Variation in the Local Motion Statistics of Real-Life Optic Flow Scenes

Optic flow motion patterns can be a rich source of information about our own movement and about the structure of the environment we are moving in. We investigate the information available to the brain under real operating conditions by analyzing video sequences generated by physically moving a camera through various typical human environments. We consider to what extent the motion signal maps generated by a biologically plausible, two-dimensional array of correlation-based motion detectors (2DMD) not only depend on egomotion, but also reflect the spatial setup of such environments. We analyzed the local motion outputs by extracting the relative amounts of detected directions and comparing the spatial distribution of the motion signals to that of idealized optic flow. Using a simple template matching estimation technique, we are able to extract the focus of expansion and find relatively small errors that are distributed in characteristic patterns in different scenes. This shows that all types of scenes provide suitable motion information for extracting ego motion despite the substantial levels of noise affecting the motion signal distributions, attributed to the sparse nature of optic flow and the presence of camera jitter. However, there are large differences in the shape of the direction distributions between different types of scenes; in particular, man-made office scenes are heavily dominated by directions in the cardinal axes, which is much less apparent in outdoor forest scenes. Further examination of motion magnitudes at different scales and the location of motion information in a scene revealed different patterns across different scene categories. This suggests that self-motion patterns are not only relevant for deducing heading direction and speed but also provide a rich information source for scene structure and could be important for the rapid formation of the gist of a scene under normal human locomotion.

Uniform color spaces and natural image statistics.

Many aspects of visual coding have been successfully predicted by starting from the statistics of natural scenes and then asking how the stimulus could be efficiently represented. We started from the representation of color characterized by uniform color spaces, and then asked what type of color environment they implied. These spaces are designed to represent equal perceptual differences in color discrimination or appearance by equal distances in the space. The relative sensitivity to different axes within the space might therefore reflect the gamut of colors in natural scenes. To examine this, we projected perceptually uniform distributions within the Munsell, CIE L(*)u(*)v(*) or CIE L(*)a(*)b(*) spaces into cone-opponent space. All were elongated along a bluish-yellowish axis reflecting covarying signals along the L-M and S-(L+M) cardinal axes, a pattern typical (though not identical) to many natural environments. In turn, color distributions from environments were more uniform when projected into the CIE L(*)a(*)b(*) perceptual space than when represented in a normalized cone-opponent space. These analyses suggest the bluish-yellowish bias in environmental colors might be an important factor shaping chromatic sensitivity, and also suggest that perceptually uniform color metrics could be derived from natural scene statistics and potentially tailored to specific environments.

Cardinal axes are not independent in color discrimination

We measured chromatic discrimination under conditions where the target fields could be distinguished only by the ratio of excitation of the long- (L) and middle-wavelength (M) cones. The excitation level of the short-wavelength (S) cones was varied in the experiments, although for any given measurement the S-cone excitation was common to the two target fields and could not be directly used for discrimination. Adaptation was maintained by a steady neutral background metameric to Illuminant D65. Thresholds varied substantially and systematically with the S-cone level of the target probes, but in a complex way: when the ratio of L:M cone excitation was low, an increase in S-cone excitation reduced the thresholds, but when the L:M ratio was higher, an increase in S-cone excitation raised the thresholds. To account for the pattern of results, we postulate a neural channel that draws synergistic inputs from L and S cones and an opposed input from M cones. The proposed channel has a compressive response function and is most sensitive at the point set by the steady background.

Contrast adaptation reveals increased organizational complexity of chromatic processing in the visual evoked potential

Results from psychophysics and single-unit recordings suggest that color vision comprises multiple stages of processing. Postreceptoral channels appear to consist of both a stage of broadly tuned opponent channels that compare cone signals and a subsequent stage, which includes cells tuned to many different directions in color space. The chromatic visual evoked potential (crVEP) has demonstrated chromatic processing selective for cardinal axes of color space. However, crVEP evidence for higher-order color mechanisms is lacking. The present study aimed to assess the contribution of lower- and higher-order color mechanisms to the crVEP by using chromatic contrast adaptation. The results reveal the presence of mechanisms tuned to intermediate directions in color space in addition to those tuned to the fundamental cardinal axes.

The effect of surface material on colour constancy in real world scenes

Event Abstract Back to Event The effect of surface material on colour constancy in real world scenes Annette Werner1* and Lara Zebrowski1, 2 1 Tübingen University, Ophthalmology, Germany 2 Ophthalmology, Germany The visual appearance of real world objects depends on their reflectance properties, illumination and geometrical factors. We asked how human colour constancy performance deals with the depth-mesostructure of surfaces, which may provide additional cues or, alternatively, worsen colour constancy. In our experiments we presented samples (circular patches, 90 mm) of different materials (paper, fur, tile, cloth, leather), each mounted on a black sample holder (front 30 x 15 cm, 60 deg slope) and presented in the middle of a black viewing box (1.0 x 1.0 x 0.8 m). All samples appeared nearly achromatic under daylight. The samples and the box were illuminated by a computer controlled, calibrated LCD-projector (Panasonic PT AE 1000E) which was mounted above the observers' head. The observers (2 male, 2 female) viewed the samples frontally (viewing distance 90 cm). The chromaticity of the standard illuminant was D65, the equiluminant test-illuminants were chosen from one of the cardinal axes. After viewing the samples under the standard illuminant for 15 s, the respective test-illuminant was presented for 5 s. Colour constancy was quantified by a hue-cancellation method, whereby the observer adjusts the appearance of the sample so that it appears achromatic (“gray”) under the respective test illuminant. Colour constancy for the different materials was found not to differ significantly, but there was a trend for compensating illumination changes best for fur and worst for tile surfaces, across all illuminants and observers, with paper ranking in the middle. The possible role of depth-mesostructure as a cue for colour constancy is discussed. Acknowledgements Supported by BMBF grant FKZ 01GQ1002. Keywords: colour constancy, material &amp, surfaces, mesostructure, Perception Conference: Bernstein Conference 2012, Munich, Germany, 12 Sep - 14 Sep, 2012. Presentation Type: Poster Topic: Sensory processing and perception Citation: Werner A and Zebrowski L (2012). The effect of surface material on colour constancy in real world scenes. Front. Comput. Neurosci. Conference Abstract: Bernstein Conference 2012. doi: 10.3389/conf.fncom.2012.55.00051 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 25 May 2012; Published Online: 12 Sep 2012. * Correspondence: Dr. Annette Werner, Tübingen University, Ophthalmology, Tübingen, 72070, Germany, annette.werner@uni-tuebingen.de Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Annette Werner Lara Zebrowski Google Annette Werner Lara Zebrowski Google Scholar Annette Werner Lara Zebrowski PubMed Annette Werner Lara Zebrowski Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page.

Shaping sound in space: the regulation of inner ear patterning

The inner ear is one of the most morphologically elaborate tissues in vertebrates, containing a group of mechanosensitive sensory organs that mediate hearing and balance. These organs are arranged precisely in space and contain intricately patterned sensory epithelia. Here, we review recent studies of inner ear development and patterning which reveal that multiple stages of ear development - ranging from its early induction from the embryonic ectoderm to the establishment of the three cardinal axes and the fine-grained arrangement of sensory cells - are orchestrated by gradients of signaling molecules.