Objectives: Acne vulgaris is a chronic disease affecting the face in adolescents and adults. It has considerable psycho-social impact on Health Related Quality of Life (HRQOL).The aim of our study is to assess the impact of acne on Quality of Life. Material and Methods: The study sample consisted of 483 consecutive patients with facial acne vulgaris. Patients who had attended the Dermatology OPD of Dr.Pinnamaneni Siddhartha Institute of Medical Sciences between November 2012 to March 2013 were included in the study. After obtaining the history, the acne was graded into mild, moderate and severe based on the type and number of lesions. Dermatology Life Quality Index(DLQI) and Cardiff Acne Disability Index(CADI) were administered on the patients to measure the Quality of Life. Results: Majority (53.2%) of the study population were betweeen16-20 years and the number of males was more than the number of females. Most of the patients were educated and unmarried.61.4% of patients belonged to the urban areas & (60.04%) had an acne duration of >1 year. Severe acne was seen in 30.64% of patients and 50.35% had a moderate grade of acne. In 333 patients (68.94%) the CADI scores were >8 showing a clear impact on QOL. Based on the DLQI scores 75.1% of the patients had a moderate to extremely large impairment of QOL. Conclusion: Acne has an impact on Quality of Life (QOL) and evaluation of Quality of Life helps in the better management of patients with acne.