Aims & Objectives: To determine the frequency of thrombocytopenia associated multi organ failure without infection criteria and its impact on the evolution and survival of patients undergoing cardiac surgery with extracorporeal circulation Methods: Longitudinal, prospective, observational study to determine the frequency in the presentation of thrombocytopenia associated multiple organ failure ant its impact in patients undergoing cardiac surgery under extracorporeal circulation of the Hospital Infantil de Mexico Federico Gómez that have not infection criteria, admitted to the intensive care unit Results: A total of 47 patients under extracorporeal circulation were analyzed. Proportion for low cardiac output syndrome 23% (n = 11) being this complication most frequent presented by our patients, with a direct relationship to the appearance of TAMOF with a p <0.05, there is a direct relationship between the appearance of TAMOF in patients with> 140 minutes of extracorporeal circulation time, the presence of deep hypothermia, lactate more than 5mmol / L on admission, a PSOFA score of more than 8 points, and a higher score on the RASCH risk scale with a p <0.05. There was a significant difference with a p <0.05 in the days of stay in therapy intensive, and mortality among patients who developed TAMOF and those who did not. Conclusions: The incidence of TAMOF associated with extracorporeal circulation during cardiac surgery in children and its role in impoverishment within the prognosis makes it important to identify this entity to establish action measures with appropriate therapies for this patiens. It is it is necessary to normalize the ADAMTS 13 activity tests in children undergoing extracorporeal circulation