Background: Cardiac disorders are the leading causes of morbidity and mortality globally. Aim: The current study aimed to compare the effectiveness of echocardiographic and scintigraphy investigation in cardiovascular disorders detection and evaluation, including ischemic heart disease (IHD) diagnosis at King Abdulaziz University in Saudi Arabia. Methods: 157 patients (male/ female: 68%/32%; mean age 64 ± 0.83 years) were included in the report in the current study. All subjects underwent gated myocardial perfusion scintigraphy and standard Echocardiography. Results: About 84% of cases were diagnosed with any types of cardiac disorders by Echocardiography, whereas through scintigraphy, 61% of patients were detected cardiac disorders. The age stratification did not impact the prevalence of cardiac disorders detected by them. Scintigraphy showed a higher detection rate (59%), while only 29% of cases were detected with IHD by eco-cardiograph. Conclusions: In conclusion, both techniques, namely standard Echocardiography, and myocardial scintigraphy, are useful in the evaluation and detection of cardiac disorders in patients having any type of cardiac problems. Both investigations showed a differential pattern in cardiac disorders diagnosis with a particular focus on IHD. Gender differences and age stratification also contributed to this differential pattern of diagnosis. Trial Registration: The research doesn’t include experiments in humans or animals. It is a retrospective study for data record review as an observational study, so no trial registration is required.