Carcinosarcoma Of Lung Research Articles

A case of renal abscess mimicking metastatic lesion in a patient with lung carcinosarcoma

A case of renal abscess mimicking metastatic lesion in a patient with lung carcinosarcoma

Molecular Biology of Lung Carcinosarcoma: A Review of the Literature

Lung Carcinosarcoma (LCS) is a rare, malignant aggressive biphasic tumor with an unfavorable prognosis, high mortality rate, and is composed of a mixture of epithelial and mesenchymal elements. The epithelial or carcinomatous element is most commonly squamous followed by adenocarcinoma, whereas the mesenchymal or sarcomatous element commonly contains the main component of the tumor and shows poorly differentiated spindle cell characteristics. Moreover, other foci of differentiated sarcomatous elements such as chondrosarcoma and osteosarcoma may be observed. LCS accounts for less than 0.1% of all lung cancers, has a poor prognosis due to late diagnosis and early metastases. It has been estimated that the median survival time is 9 (3-25) months, a prognosis poorer than other non-small cell lung carcinomas (NSCLC). According to the most recent 2015 World Health Organization (WHO) classification, pleomorphic carcinoma, giant cell carcinoma, lung blastoma, spindle cell carcinoma, and carcinosarcoma consist a heterogeneous category of primary lung cancer accounting from 0.3% to 3% of all primary lung malignancies, known as lung sarcomatoid carcinoma, depending on the observed morphology. Although genetic mutations of some common lung cancer subtypes have been extensively investigated, the molecular characteristics of LCS and the existence of abnormal target genes still remain unknown.

Lung Carcinosarcoma Report of One Case Treated With Immunotherapy with Review

Pulmonary Carcinosarcoma is an uncommon malignant biphasic tumor that accounts for less than 1% of all lung cancers. It is defined by coexisting histologic elements of carcinomatous and sarcomatous components. We report a case of advanced stage pulmonary carcinosarcoma in a 83-year-old patient, treated with immunotherapy with good response lasted for more than one year.

A case of lung carcinosarcoma

A case of lung carcinosarcoma

Huge carcinosarcoma of lung presenting as an intra-abdominal mass

We report a case of huge carcinosarcoma of lung initially presenting as an intra-abdominal mass: treatment with enucleation of the firm sarcomatous component followed by pulmonary resection. A 65-year-old man with mild mental retardation who smoked one pack of cigarettes per day until 1-month before he was admitted to our hospital complaining of a progressively poorer appetite, vomiting and an abdominal mass at the left upper quadrant region. Physical examination revealed a palpable mass over the left upper abdomen with percussion dullness of the lower hemithorax. Chest radiograph revealed a homogeneous mass lesion in the left lower lung field with obliteration of the costophrenic angle. Computed tomography scans of the chest disclosed a huge mass over the left lower thorax and upper abdomen with compression of the heart and shift of the esophagus and descending aorta to the midline. Sono-guided aspiration biopsy cytology revealed squamous cell carcinoma. Surgical intervention with enucleation of the very firm sarcomatous component with fragmentation followed by radical lobectomy. Chemotherapy was planned as adjuvant therapy in the postoperative period, but the patient's family declined it. The patient is currently survived without tumor recurrence 14 months after surgery. Our case revealed a huge tumor not only mediastinal compression but also initial presenting abdominal symptoms. Initially, from the symptoms and nonbiopsy study, we were unable to determine exactly if it was an intrathoracic tumor or an intra-abdominal tumor. This case highlights the importance of remaining clinically vigilant to differentiate an unusual tumor mass, and preoperative tissue proof is warranted.

Treatment of Lung Carcinosarcoma and Other Rare Histologic Subtypes of Non-small Cell Lung Cancer

Lung carcinosarcoma (PCS) and other histological subtypes of non-small cell lung cancer, such as primary pulmonary lymphoma (PPL), pulmonary carcinoid (PC), and primary pulmonary lymphoepithelioma-like carcinoma (LELC), are rare. For their low incidence, the diagnosis and treatment are still controversial. Some patients only need surgery, while others may need chemotherapy, radiotherapy, or targeted therapy. In this paper, we retrospectively reviewed the literature of some rare histological subtype of NSCLC for the recent 20years, and try to get some conclusions.

560P A next-generation sequencing analysis indicates genomic alterations in pathological morphologies: A genomic case report of pulmonary carcinosarcoma harbouring EGFR mutation

Background Lung carcinosarcoma is a rare malignancy of lung cancers and little analyses is performed for identification of the genomic alterations including oncogenic drivers. Methods Postoperative material from 129 patients with RCC has been studied. The average age of the patients was 57.8 6 9.7 years. DLI in PZ was evaluated at a 1000x magnification in 5 fields of view using tissue specimens stained with hematoxylin and eosin. Statistical analysis was carried out using the program Statistica 6.1. Results We found a correlation between DLI and: 1) TNM stage (r = 0.312; p<0.05), 2) nuclear grade (r=0.489; p<0.05), 3) size of tumor node (r=0.184; p<0,.5), 4) the presence of necrosis in the tumor (r=0.364; p<0.05), 5) the presence of metastasis (r=0.426; p<0.05). DLI in PZ increased with the rise of nuclear grade from 31.7±3.2 lymphocytes in G1 to 91.2±4.9 cells in G4 (p=0.000001). DLI in PZ was 43.0±2.9 in the absence of necrosis in the tumor node. The growth of lymphoid cells amount to 73.7±6.3 (p=0.00012) was observed in the presence of necrosis. The DLI of patients with metastasis was two times higher than that of the ones without it (84.1±6.4 versus 43.2±2.8; p=0.000008). The five-year survival rate of patients was assessed using the Kaplan-Meier method. Cumulative proportion surviving in the group with the number of lymphoid cells less than 80 was 87.7% versus 54.1% in the group with more than 80 cells in the field of view (log-rank test; p=0.00068). Conclusions Based on our findings, we believe that high DLI in PZ found in RCC patients can be attributed as a negative prognostic marker. Legal entity responsible for the study The Ethics Committee of Kanazawa University Hospital (#327) Funding Kanazawa University Respiratory Medicine Disclosure All authors have declared no conflicts of interest.

The first case of lung carcinosarcoma harboring in-frame deletions at exon19 in the EGFR gene

Mutations of the epidermal growth factor receptor (EGFR) gene play a critical role in carcinogenesis of lung cancer, particularly adenocarcinoma. However, to the best of our knowledge, no mutations of the EGFR in patients with lung carcinosarcoma have been identified. We herein report the case of a 61-year-old female referred for a detailed examination of a left pulmonary mass shadow. Although bronchoscopy was performed, it failed to lead to a diagnosis, and video-assisted thoracoscopic surgery was therefore carried out to diagnose the tumor. The pathology revealed biphasic features consisting of both adenocarcinoma and chondrosarcoma. Intriguingly, both the adenocarcinoma and chondrosarcoma components were proven to harbor an exon19 deletion in the EGFR gene. Although carcinosarcoma is a rare malignancy of the lungs, genetic analyses of oncogenic drivers, such as the EGFR gene, should be conducted.

Coexistence of a lung carcinosarcoma and hydatid cyst

Coexistence of a lung carcinosarcoma and hydatid cyst

Carcinosarcoma of the lung associated with neurofibromatosis type 1: a case report

Neurofibromatosis or von Recklinghausen's disease is the most common inherited syndrome predisposing to neoplasia. Carcinosarcoma is a rare malignant mixed tumor of the lung. Association of carcinosarcoma of lung with Neurofibromatosis-1 is not common. A 57-year-old man presented with history of fever, cough, hemoptysis, breathlessness, weight loss, chest pain. Multiple cutaneous neurofibromas and café au lait spots were revealed by physical examination. A homogeneous opacity was found in the right middle and right upper zone on posterior-anterior chest radiography. A 8x8x7 cm mass that had irregular borders in right upper posterior and apical segment was seen on contrast enhanced chest computed tomography. On bronchoscopy, the lumen of right upper apical segment was obstructed with vegetating tumoral lesion. The biopsy taken from this region was diagnosed as carcinosarcoma by histopathological and immunohistochemical examination.A rare case with carcinosarcoma of the lung and Neurofibromatosis-1 was reported.

Squamotous-type sarcomatoid carcinoma of the lung with rhabdomyosarcomatous components

Lung carcinosarcoma is an infrequently biphasic tumor composed of carcinomatous and sarcomatous components. It is divided into endobronchial (squamous-type) and peripheral (glandular type) categories. The carcinomatous component is usually a squamous carcinoma, and the sarcomatous component usually resembles a fibrosarcoma or a malignant fibrous histiocytoma. The presence of rhabdomyoblastic differentiation in such neoplasms is exceedingly rare. There are strong associations with smoking and asbestosis. In this study, we describe a unique case of a 43-year-old man with a 75 packet/year smoking history in whom a rare mixed malignant tumor of the lung was diagnosed and treated by left pneumonectomy. Histological examination of the resected specimen showed squamous cell carcinoma and rhabdomyosarcoma components. Although rare, the association of a sarcomatoid carcinoma of the lung with squamous cell carcinoma and rhabdomyosarcomatous component is possible and should be kept in mind when dealing with these unusual tumors.

Supplement 2, Proceedings of the 14th World Conference on Lung Cancer, Book 2

Supplement 2, Proceedings of the 14th World Conference on Lung Cancer, Book 2

Lung carcinosarcoma

Lung carcinosarcoma is a neoplasm of high grade composed of epithelial and mesenchymal cells. It is exceptional; and usually affects men who are smokers, between the fifth and eighth decades of life. Medical treatment, chemotherapy and radiotherapy are not active in this kind of tumour, so surgery is the treatment of choice. Prognosis is poor with survival rates at 6 months around 27%. We describe the diagnostic process and the clinical outcome of a patient with lung carcinosarcoma with several paraneoplastic syndromes.

Lung carcinosarcoma as a rare biphasic sarcomatoid carcinoma: a case report

Lung carcinosarcoma as a rare biphasic sarcomatoid carcinoma: a case report

Lung carcinosarcoma as a rare biphasic sarcomatoid carcinoma: a case report

IntroductionA fit, 57-year-old man admitted with chest pain and haemoptysis turned out to have a primary tumour in the left lung.Case presentationIn this 57-year-old Caucasian man, the diagnosis followed a computed tomography scan and histopathological evidence gained post-resection. The biopsy showed a uniform, spindle shape with focal pleomorphism which was suggestive of lung carcinosarcoma.ConclusionsThe authors report this case in literature and discuss how a rare malignant tumour can be found in those presenting with trivial chest symptoms.

Lung carcinosarcoma with liposarcoma element: Autopsy case

Pulmonary carcinosarcoma, consisting of both carcinoma and sarcoma with a heterologous element, is a rare subtype, comprising approximately 0.3% of primary lung neoplasia. A 57-year-old man was admitted because of severe dyspnea. A tumor wholly occupying the right thorax was biopsied and diagnosed as pleomorphic sarcoma. The tumor did not respond to chemotherapy, and the patient died of respiratory failure and sepsis. At autopsy, pleomorphic sarcoma was histologically dominant and contained a liposarcoma element confirmed by histocytological and electron microscopic analysis. Adenocarcinoma component with papillary and tubular patterns was confined to the medial lesion of the right lower lobe (3x8 cm), which was found in the chest X-ray 3 years before admission, and had continuously merged with the sarcomatous lesion through the histological transition of both components. Aggressive and rapid growth of the sarcoma derived from the earlier adenocarcinoma became prevalent and contributed to the severe clinical outcome. This is the first documented case of primary lung carcinosarcoma with a liposarcoma element.

Potentiated cyclophosphane: experimental study of the effect on tumor development and efficiency of cytostatic therapy.

Experiments on animals with transplanted tumors (Lewis lung carcinoma and carcinosarcoma Walker-256) showed that combination treatment with cyclophosphane and its homeopathically potentiated forms increases antiblastic activity of the preparation.

Carcinosarcoma pulmonar con metástasis cutánea

We describe a case of lung carcinosarcoma in a 70-years-old patient with chronic obstructive pulmonary disease. Pulmonary carcinosarcoma is an unfrequent lung tumor, and usually histologic diagnosis is carried out by microscopic examination of the resected tumor. We observed these situation in our patient that was diagnosed of squamous cell carcinoma before the surgical resection by transthoracic needle aspiration. One month after surgery he developed a lesion in the infranasal area that was identified as a skin metastasis of lung carcinosarcoma. There is no previously reported case of skin metastasis of this rare tumor of the lung, that contain an admixture of malignant epithelial and mesenchymal elements. Clinical symptoms of pulmonary carcinosarcomas are not different from other lung tumors. The treatment when it is possible is the surgical resection of the tumor. We review histologic, diagnostic and therapeutic features of lung carcinosarcomas.

Lung Carcinosarcoma in a Dog: Gross and Microscopic Examination

Lung Carcinosarcoma in a Dog: Gross and Microscopic Examination

A Case of Lung Carcinosarcoma with Rapid Endobronchial Growth

A Case of Lung Carcinosarcoma with Rapid Endobronchial Growth