Correlation Of Carcinoma Research Articles

The added value of 68Ga-PSMA PET/CT in anatomical staging of prostatic carcinoma in correlation with the histopathological zonal staging

BackgroundProstate cancer is well known as the commonest cancer in men and the second leading cause of cancer-related death. CT, MRI and bone scintigraphy are considered the commonly widely used imaging diagnostic tools for detection, staging and follow-up of prostate cancer. Prostate-specific membrane antigen (PSMA) is a membrane glycoprotein, that can be concentrated in prostate cancer cells up to 100 times higher than in normal cells. PSMA-targeted imaging modalities have now proven their efficacy in diagnosis, staging and follow-up of prostate cancer. The use of 68Ga PSMA PET-CT has efficiently improved the detection of loco-regional and metastatic disease. 68Ga PSMA PET-CT also has an effective role in the primary diagnosis, staging, and detecting biochemical recurrence after curative treatment and in metastasis-targeted therapy. This work aims to review the role of 68Ga PSMA PET-CT in anatomical staging of prostate cancer in correlation with histopathological staging.ResultsZonal correlation between 68Ga PSMA findings and biopsy results showed sensitivity ranging between 76.9 and 90.6% and specificity ranging from 85.7 to 100%. There was high significant correlation between the SUVmax uptake and the biopsy results, between the SUVmax uptake and the local staging as well as between the Gleason score and 68Ga PSMA PET/CT findings.Conclusions68Ga PSMA PET/CT is a highly promising imaging modality with an effective role in detection of prostate cancer showing high sensitivity and specificity in prediction of zonal histopathological results and loco-regional Gleason score staging with significant positive correlation between the SUV uptake results, Gleason score and the PSA levels.

Preoperative Ultrasound local Staging of Endometrial Carcinoma in Correlation to Intraoperative and Histopathology Findings

Preoperative Ultrasound local Staging of Endometrial Carcinoma in Correlation to Intraoperative and Histopathology Findings

Stromal CD10 Expression in Invasive Breast Carcinoma in Correlation with ER, PR and Her2 Status and Tumor Grade.

Background: Increasing prevalence of breast cancer in our population is a leading cause of morbidity and mortality. Association of the tumor markers with the behavior of tumor cells may pave a way to better outcomes. Objectives: To investigate the frequency of Stromal CD10 expression in invasive breast carcinoma in correlation with ER, PR and Her2 status and tumor grade.Material and Methods: A total of 102 diagnosed cases of breast carcinoma who underwent mastectomies were examined. Immunohistochemistry was performed for Cluster of differentiation 10 (CD10), Estrogen receptor(ER) Progesterone receptor (PR) and Human epidermal receptor factor 2(HER2)for all the samples. Demographic characteristics and immunopathological variables were recorded. Results: Mean age of the participants was 54.05 ± 8.58 years. Immunohistochemical analysis revealed 83 (81.3%) cases as CD10 positive out of which 15 (14.7%) specimens were weak positive and 68 (66.6%) were strong positive. The expression of CD10 was significantly greater for patients with higher tumor grades (p-value 0.014). Significant association of stromal CD10 expression and ER negativity was observed (p-value < 0.01). Out of 83 (81.3%) specimens that revealed positive CD10 expression, 64 (62.7%) were found HER2 positive and 19(18.6%) were HER2 negative signifying a positive correlation with p-value of <0.01. Conclusion: Frequency of stromal CD10 expression is significantly associated with increasing tumor grade, HER2 positivity and ER negativity. It employs a prognostic role in predicting the aggressiveness of tumor as indicated by higher tumor grade and preemptive therapy with anti CD10 antibody may be beneficial in such candidates.Keywords: Breast carcinoma, CD10, ER, PR, HER2.

Immunohistochemical expression of CK20, CK7, and CDX2 in colorectal carcinoma in correlation with pathomorphological characteristics.

Colorectal carcinoma is the third most common cancer worldwide. The usual immunophenotype of colorectal adenocarcinoma is CDX2 positive, CK20 positive, and CK7 negative. Aberrant expression is reported in a variety of colorectal carcinomas but its relation to morphological variables and survival data is still unclear.

Distinct Gene Mutations Are Associated With Clinicopathologic Features in Urachal Carcinoma.

To investigate the gene mutational profile of urachal carcinoma in correlation with its clinicopathologic features. We analyzed genetic mutations in 30 cases of urachal carcinoma by next-generation sequencing (NGS) test. Histologic slides and clinical data were reviewed. The patients included 21 men and 9 women, with a mean age of 53 years (range, 24-75 years). The urachal carcinomas included mucinous (11), enteric (10), signet ring cell (8), and high-grade neuroendocrine (1) subtypes. Targeted NGS analysis demonstrated genetic mutations in all the urachal tumors (mean, 2; range, 1-4). TP53 was the most mutated gene (25), followed by KRAS (9) and GNAS (8) genes. TP53 mutations were more common in the signet ring cell subtype (7/8), and GNAS mutations were present only in the mucinous (5/11) and signet ring cell subtypes (3/8) but not in the enteric subtype (0/10). KRAS mutations were significantly associated with cancer stage IV (P = .02) and younger patient age (P = .046). Furthermore, the presence of KRAS mutations in urachal carcinoma portended a poorer overall survival (P = .006). Urachal carcinoma demonstrates frequent gene mutations that are associated with distinct clinicopathologic features. Gene mutation may underlie the development and progression of this aggressive disease.

MULTI-DETECTOR COMPUTED TOMOGRAPHY ROLE IN LOCAL STAGING OF COLONIC CARCINOMA

Background: Pre-operative staging is critical for the treatment and surgical planning of colonic carcinomas. Objectives: To evaluate the role of the contrast enhanced multi-detector computed tomography (CEMDCT) in locoregional staging of the colonic carcinoma in correlation with pathological data as standard. Patients and Methods: The study included 30 consecutive patients diagnosed with colonic carcinoma by biopsy and colonoscopy and referred from the clinic at the National Cancer Institute. MDCT was performed for all patients after being submitted to intravenous non ionic contrast and oral and rectal positive or negative colon opacification. All patients underwent surgery. Tumors were classified with the TNM staging system. The MDCT findings for each patient were recorded and correlated with operative and pathological findings as reference standard. The sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy were calculated. Results: In the detection of extramural invasion, the sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), and diagnostic accuracy of CEMDCT were 90%, 70%, 85.7%, 77.8% and 83.3% respectively. Regarding the accuracy of the T staging, the study accurately staged 20 patients (66.6%). In the detection of lymph node status, the sensitivity, specificity, positive predictive value, negative predictive value and diagnostic accuracy were 84.6%, 70.6%, 68.8%, 85.7% and 76.7% respectively. Conclusions: Contrast enhanced multi-detector computed tomography (CEMDCT) is a sensitive tool in the evaluation of extra-mural invasion, and promising technique in the evaluation of preoperative staging and prognostic factors of colon cancer.

Immunohistochemical expression of AMACR and Cyclin D1 in bladder urothelial carcinoma in correlation to the histopathological characteristics

Background Bladder cancer is the tenth most common cancer in the world, and its incidence is increasing worldwide, particularly in the developed countries. Various markers have an important role in assessing the risk of bladder cancer, and their identification may have an impact on the prognosis or treatment of the tumour. Alpha-methylacyl-CoA racemase (AMACR) is well known as a marker for prostatic carcinoma. Cyclin D1 is a cell cycle regulator that control G1–S phase progression. Materials and methods Our study was retrospective, including 60 cases of urothelial carcinoma. Immunohistochemical expression was done and evaluated using AMACR and Cyclin D1. Correlations with clinicopathologic parameters were statistically assessed. Results AMACR expression was positive in 31 (51.7%) cases. Cyclin D1 expression was positive in 36 (60%) cases. Positive AMACR expression was significantly correlated with tumour size, high grade, advanced tumour stage, and muscle invasion. Positive Cyclin D1 expression was significantly correlated with papillary histologic type and perivesical soft tissue invasion. A significant correlation was reported between the concordance of positive immunohistochemical expression of both AMACR and Cyclin D1 and tumour grade. Conclusions AMACR expression results suggest the potential for AMACR to be used as a poor prognostic indicator as well as a therapeutic target in urothelial carcinomas. Cyclin D1 expression results implies a function in tumour invasiveness and progression. A significant correlation between concordance of expression of both markers and high tumour grade was reported. Therefore, an interaction between AMACR and Cyclin D1 could be present that has a specific impact on tumour grade.

Single-centre evaluation and staging of rectal carcinoma on a 3-Tesla magnetic resonance imaging and correlation with histological profile.

PurposeTo assess magnetic resonance imaging (MRI) features of rectal carcinoma in correlation with pathology, and to evaluate the diagnostic accuracy of 3-Tesla MRI.Material and methodsA total of 86 patients were included. 3T MR imaging was conducted pre-operatively, with imaging data correlated to pathology results. High-resolution, 2-dimensional, T2-weighted fast-spin echo sequences in the sagittal, axial, and coronal planes used to tumour staging. Diffusion-weighted images were used to increase the accuracy of tumour evaluation.ResultsRectal carcinoma was staged as T3 in 45.3% of all patients (n = 39), without involvement of the mesorectal fascia in 31.4% (n = 27), and with a possible or obvious invasion in 14% of patients (n = 12). The diagnostic accuracy of 3T MRI was 97.6% for the T1 stage, 92.1% for T2, 89% for T3, and 90% for T4 tumours. MR-derived extramural vascular invasion (EMVI) was found in 16.2% (n = 14), with an estimated diagnostic accuracy of 95%. Diffusion-weighted images and apparent diffusion coefficient were estimated for the different histology types of rectal carcinoma. The average apparent diffusion coefficient for adenocarcinoma was 0.846 ± 0.17, for mucinous adenocarcinoma it was 1.17 ± 0.08, and for signet cell and squamous carcinomas it was 0.91 ± 0.11 and 0.796 ± 0.21 mm2/s, respectively.Conclusions3T MRI enables high levels of diagnostic accuracy in local rectal carcinoma staging, including assessment of mesorectal fascia infiltration and EMVI-status with high accuracy.

The accuracy of computed tomography in the diagnosis of upper urinary tract urothelial carcinoma in correlation with the final histopathology: A retrospective study in 275 patients at a Tertiary Urology Institute.

Introduction:Because the reports in the literature of radiologic investigations for upper tract urothelial cancer (UTUC) are limited by the number of patients, and included patients with different pathologies, we aimed to study the overall accuracy of computed tomography (CT) in the diagnosis of UTUC and their accuracy on predicting tumor location.Methods:A retrospective review from 1990 to 2017 included patients who were treated for UTUC. Unenhanced CT scan was obtained first using Multi-Detector Computed Tomography (MDCT, Philips Medical Systems), then nonionic contrast medium, containing 350 mg iodine/ml was injected at 4 mL/s. Analysis was performed using SPSS®.Results:Of 275 patients, complete data on CT was available on 270 (98%) patients. CT reported only two false positive and six false negative results and the overall accuracy was 96-97%. In comparison to the final pathological reports, CT/CTU detected 85% of the tumor location of in the renal pelvic and 50% of the calyceal tumors. In ureteric tumors, they detected distal (66/71= 93%) more than proximal ureteric tumors (60%).Conclusion:In our cohort, CT/ CTU has a high overall accuracy (97%) in diagnosing UTUC, capability to well visualize tumors of distal ureter and renal pelvis, but could miss calyceal tumors. The matter to rely only on CT without ureteroscopic biopsy in the diagnosis of UTUC especially if radical surgery is planned needs further prospective studies.

Twist and Snail/Slug Expression in Oropharyngeal Squamous Cell Carcinoma in Correlation With Lymph Node Metastasis.

Oropharyngeal squamous cell carcinoma (OPSCC) could be clinically undetectable despite the relatively large size of lymph node metastases. Here, we aimed to elucidate the correlation of p16 expression with epithelial-to-mesenchymal transition (EMT) markers. Radically resected 121 OPSCC and 270 non-OPSCC tissue samples were included in the analysis, and p16, Twist, and Snail/Slug immunohistochemistry was performed. Compared to non-OPSCCs, OPSCCs were significantly associated with lymphovascular invasion, lymph node metastasis, larger maximal diameter of metastatic foci in the lymph nodes, and p16 expression. In addition, p16 expression correlated with high Twist and Snail/Slug expression. Expression of EMT markers, such as Twist and Snail/Slug, is related to p16 expression in OPSCC. This might indicate that HPV infection in OPSCCs alters the expression of EMT markers and results in metastases.

Prognostic and Clinicopathological Correlations of Cell Cycle Marker Expressions before and after the Primary Systemic Therapy of Breast Cancer

We aimed to analyze the expression of cell-cycle regulation markers – minichromosome maintenance protein 2 (MCM2), Ki-67, Cyclin-A and phosphohistone-H3 (PHH3) − in pre-treatment core-biopsy samples of breast carcinomas in correlation with known predictive and prognostic factors. Totally 52 core biopsy samples obtained prior to neoadjuvant therapy were analyzed. Immunohistochemistry was performed to analyze the expression of MCM2, Ki-67, Cyclin A and PHH3, which were correlated with the following clinicopathological parameters: clinical TNM, tumor grade, biological subtype, the presence of tumor infiltrating lymphocytes (TIL), pathological tumor response rate to the neoadjuvant therapy and patient survival. All investigated markers showed higher expression in high grade and in triple negative tumors (p < 0.01 and p < 0.05, respectively). Hormone receptor negative tumors showed significantly higher expression of Ki-67 (p < 0.01), MCM2 (p < 0.01) and Cyclin A (p < 0.01) than hormone receptor positive ones. Tumors with increased TIL showed significantly higher Ki-67 expression (p = 0.04). Pattern analysis suggested that novel cell-cycle marker-based subgrouping reveals predictive and prognostic potential. Tumors with high MCM2, Cyclin A or PHH3 expression showed significantly higher rate of pathological complete remission. Tumors with early relapse (progression-free survival ≤2 years) and shortened overall survival also show a higher rate of proliferation. Our cell cycle marker (Ki-67, MCM2, Cyclin A, PHH3) based testing could identify tumors with worse prognosis, but with a favorable response to primary systemic therapy. The pattern of cell-cycle activity could also be useful for predicting early relapse, but our findings need to be further substantiated in larger patient cohorts.

Fibronectin protein expression in renal cell carcinoma in correlation with clinical stage of tumour

BackgroundCarcinogenesis is a multistep process which involves interplay between the tumour cells and the matrix proteins. This occurs by adherence between the tumour cells and proteins in the extracellular matrix. VHL mutation affects through the hypoxia inducible factor (HIF) and causes changes in various tissue proteins like VEGF, PDGF, TGF, Fibronectin and others. As not much literature is available, we aim to quantify the changes of fibronectin protein in renal cell carcinoma (RCC) tissue.MethodsThis Prospective unbalanced case control study was conducted over a period of 18 months from April 2016 to September 2017. The patients undergoing nephrectomy for the diagnosis of RCC were included in the study after obtaining written informed consent. Patients were excluded from study, if normal renal tissue could not be identified in the resected kidney and if the artery clamp time to retrieval of tissue was more than 30 min. Fibronectin protein is estimated in the tumour tissue by gel electrophoresis and western blotting which is compared with that of normal kidney tissue of the same kidney. Results have been expressed as absolute values with standard deviation and relative expression (RE).ResultsOf the 21 patients analysed 15 showed an increase in fibronectin expression in the renal tumour tissue while 6 did not. The mean expression of Fibronectin protein has increased 1.5 times in the tumour tissue when compared with the normal tissue. The increase was 1.54 times in early tumours compared to 1.37 times in advanced tumours of RCC.ConclusionsFibronectin showed a 1.5 times increase in the tumour compared to normal. This increase is more in Stage 1&2 tumours when compared to the Stage 3&4 tumours.

Vascular endothelial growth factor (VEGF) expression in dogs suffering from squamous cell carcinoma

The aim of the present study was to monitor VEGF expression in the blood serum of dogs suffering from squamous cell carcinoma in correlation with the speed of metastasis. The research material consisted of tumour tissue and blood samples collected from 26 dogs of various breeds, aged between 5 and 15 years, and 10 control group animals. Blood samples were centrifuged, and the serum obtained was examined by immunoenzymatic assays to determine vascular endothelial growth factor (VEGF) levels. The study group animals were observed for a period of 6 months, during which their blood was drawn twice for immunoenzymatic tests. In all study group animals, elevated blood serum VEGF levels were observed on the day of surgery compared with the control group. In 14 cases, disease relapse was observed with metastases to the bones or lungs. In all relapsing animals, significantly higher blood serum VEGF levels were observed. VEGF levels are closely related to the neoplastic process, but the exact mechanism of the factor's involvement in neoplastic progression remains unclear, as does the complexity of the angiogenic processes. Studies of the mechanisms affecting tumour proliferation and the monitoring of VEGF levels can facilitate better diagnostics and prognostics, as well as improve the effectiveness of cancer treatment and the planning of new therapeutic strategies for both human and animal patients.

Expression of the glucocorticoid receptor in breast cancer-associated fibroblasts

Cancer- associated fibroblasts (CAFs) are actively involved in breast carcinoma. Our previous study demonstrated that the majority of these CAFs were smooth muscle actin (SMA) positive and were therefore termed peritumoral myofibroblast (PMY). Glucocorticoid, linked or not with its receptor (GR), has been postulated to serve a major role in normal breast and breast carcinoma; however, their role in CAFs remains poorly understood. The aim of the present study was to assess the presence of GR in breast CAFs and particularly in PMY in 56 cases of invasive breast carcinoma in correlation with clinicopathological parameters, by immunohistochemistry. GR was observed in CAFs in 51 cases (91%) and were more frequent in luminal A subtype (19/19 cases; 100%). The stromal expression was statistically correlated with the tumor grade (P=0.03), the Ki-67 index (P=0.003) and the presence of GR in the epithelial component (P=0.01). The demonstration of a frequent expression of GR in breast CAFs may serve as an interesting target for future therapeutics for the regulation of the tumoral breast microenvironment.

Evaluation of Cytological Grading in Breast Carcinoma in Correlation with Histopathological Grading

Carcinoma breast is the most common malignancy in females next to carcinoma cervix. Fine needle aspiration cytology of the lumps is the primary method in establishing the diagnosis of carcinoma. The nuclear grade of the tumor is an important prognostic factor that determines the outcome in breast cancer. The material obtained from the aspirate smears can be used to assess the cytological grade using Robinson criteria. This was correlated with well established histological grading of Scarff Bloom Richardson. Total of 70 cases were studied for which the histopathological correlation was available. The accuracy was 76.8%.

Expression of insulin-like growth factor receptor type 1 correlate with lymphatic metastases in human gastric cancer.

Most patients with gastric cancer are diagnosed at advanced clinical stages with a high frequency of lymph node metastasis. It is very important to find novel factors for the early diagnostic and prognostic evaluation of gastric cancer. It has been shown that IGF-1R activates mitotic division and inhibits apoptosis of cancer cells through the activation of signaling MAP/ERK and PI3K/Akt-1 pathways. IGF-1R plays a role in cell transformation and maintenance of the phenotype in modified cells. Moreover, an IGF-1 receptor effect influences the processes of adhesion, migration, invasion and metastasis of tumor cells. The aim of the study was to assess the expression of IGF-1R in gastric carcinoma in correlation with selected anatomo-clinical parameters. The study enrolled a group of 49 patients treated surgically for gastric cancer. 28 patients had no lymph node metastases. The expression of the studied proteins was assessed using the immunohistochemical method. We found that the expression of IGF-1R in gastric cancer is associated with lymph node metastasis (p < 0.001), is correlated with worse prognosis and high histological malignancy grade, and is an independent predictor of survival in patients with gastric cancer (p < 0.001). IGF-1R may play an important role in tumor growth and metastasis via the lymphatic pathway.

Clinicopathology Significance of p53 and p63 Expression in Indonesian Cervical Squamous Cell Carcinomas

Human papilloma virus infection is associated with genesis and malignant potential of cervical cancer. E6 and E7 oncogens are known to bind to p53 and retinoblastoma gene products, abrogating their functions as tumor suppressors, leading to an abnormal cell cycle machinery. Roles of the p53 homolog p63 have also been postulated, E6 expression leading to TAp63b degradation allowing anchorage independent growth. Molecular studies correlated with clinicopathological factors are important to determine prognosis and treatment strategies, but results have been controversial and need to be clarified. To investigate expression of p53 and p63 in cervical squamous cell carcinomas in correlation with age, FIGO staging, morphology, and cancer cell proliferation. Expression of p53 and p63 immunohistochemical staining in a total of 56 paraffin-embedded tissues of cervical squamous cell carcinomas from Dr. Sardjito General Hospital Indonesia, was evaluated for correlation with clinicopathological parameters. The Mann-Whitney test was used to compare the percentage of p53 and p63 expression with patient age, FIGO staging and morphology and to compare mean p53 and p63 expression. The Spearman correlation test was applied to correlate p53 and p63 expression with that of Ki-67. A p-value of <0.05 was considered statistically significant. There were significant associations between p53 expression with age (p=0.019) and FIGO staging (p=0.026), but not with with morphology or Ki-67 expression. There were no links between p63 expression and age, morphology, FIGO staging or Ki-67. This study indicated that p53 has a prognostic value in cervical squamous cell carcinomas given the relation with FIGO staging.

Regulation of BMI1 Polycomb gene expression in histological grades of invasive ductal breast carcinomas and its correlation with hormone receptor status

BMI1 is the first functional mammalian Polycomb group (PcG) proto-oncogene involved in multiple biological processes. Regulation of B cell-specific Moloney murine leukaemia virus integration site 1 (BMI1) expression with increase in histological grades of breast carcinoma in correlation with hormone receptor status was studied in 60 Indian breast cancer patient's formalin-fixed paraffin-embedded tissue blocks. Relative expression of BMI1 was studied using real-time PCR. Immunohistochemistry explained the distribution of hormone receptor markers. Correlation of BMI1 gene expression with oestrogen receptor, progesterone receptor (PR) and human epidermal growth factor receptor 2/neu status was analysed using Hex-protein docking tool. The hormone receptor expression was reduced with increasing grades of breast tumour. BMI1 gene expression was downregulated (real-time polymerase chain reaction analysis). Docking analysis explained the correlation between BMI1 and PR expression. BMI1 gene was co-regulated (down) with PR in the invasive ductal breast carcinoma with relative progression explicating it a diagnostic biomarker for ductal carcinoma of the breast.

Expression of p21 and PTEN in renal cell carcinoma in correlation with the different clinicopathological parameters

Expression of p21 and PTEN in renal cell carcinoma in correlation with the different clinicopathological parameters

Abstract 2054: GP88 (Progranulin) is a therapeutic and prognostic target for Non-Small Cell Lung Carcinoma.

Abstract Annually, about 220,000 patients are diagnosed with lung cancer in the US and 150,000 die of the disease. Advanced and recent therapeutic development in NSCLC addresses targets found in small percentages of patients, thereby emphasizing the need for continued discoveries of additional targets of lung cancer, in order to develop of novel therapies and diagnosis. We have investigated the role of the autocrine growth and survival factor GP88 (Progranulin) on the biology of Non-Small Cell Lung Carcinoma (NSCLC). Previously, GP88 had been shown to play a critical role in the proliferation and survival of breast cancer. Pathological studies with 600 cases of estrogen receptor positive invasive ductal carcinoma in correlation with clinical outcome data have also shown that GP88 tissue expression was associated with a 4-fold increased risk of recurrence and a 2.5-fold increase in mortality whereas inhibition of GP88 action by a neutralizing antibody resulted in inhibition of tumor formation of breast adenocarcinoma in vivo. In the present study, we examined the role of GP88 in NSCLC. Examination of GP88 protein expression by immunohistochemistry was carried out with formalin fixed paraffin embedded sections of lung cancer cases. Results showed that both human adenocarcinoma and squamous carcinoma stained positive for GP88 whereas normal lung tissues were negative. Pathological studies of tissue GP88 expression by IHC in 85 stage 1 and 2 NSCLC tumors in correlation with clinical outcomes demonstrated that high GP88 expression was associated with a 4-fold increase in the risk of recurrence (p=0.0004) indicating that GP88 is a prognostic factor for NSCLC. Based on these observations, expression and action of GP88 in NSCLC were examined using two representative human NSCLC cell lines A549 and H1299. Inhibition of GP88 expression by GP88 SiRNA resulted in an inhibition of cell migration and proliferation of these cells. Similarly, neutralization of GP88 action by treating the cells with AG1, an anti-human GP88 neutralizing monoclonal antibody expressed in recombinant form also inhibited cell proliferation and migration. Based on these results, studies were carried out to examine the effect of AG1 antibody on NSCLC tumor formation in nude mice. Preclinical studies show that AG1 treatment inhibits tumor formation by 30-50% when used as a single agent or in combination therapy with chemotherapeutic drugs used in the standard of care in NSCLC. These data to be presented here point out that GP88 is a novel therapeutic and prognostic target and provide new opportunities for targeted therapy with companion diagnostic for NSCLC. Citation Format: Ginette Serrero, Guanjun Xia, Jianping Dong, Binbin Yue, Amanda Schech, Douglas Hawkins, David Reisman, Pablo Bejarano, Jun Hayashi. GP88 (Progranulin) is a therapeutic and prognostic target for Non-Small Cell Lung Carcinoma. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr 2054. doi:10.1158/1538-7445.AM2013-2054