Carcinogenic Risk Values Research Articles

Ecological distribution, heavy metals profiling and human health risk assessment of medicinal plants used for tonsillitis and wounds treatment: A chemometric approach

Medicinal plants in Ethiopia are easily accessible, relatively low cost and trusted by the community, which drives people to use them to treat a variety of ailments for many years. For instance, Kalanchoe petition, Rhamnus prinoide & Acmella caulirhiza are the most popular medicinal plants that have been used for treating tonsillitis, while Brucea antidysenteric, Justicia shimperian, Jatropha curcas & Prunus Africana have been used for treating wounds. However, the presence of toxic chemicals like heavy metals above threshold concentrations poses a global threat to human health. This study was conducted to determine the levels of heavy metals and to evaluate non-carcinogenic and carcinogenic health impacts posed by using medicinal plants so as to create awareness among users about the chemical compositions of these plants. Five hundred grams of leaves, barks and flowers of the medicinal plants were collected randomly from ten plants from Ayehu Guwagusa and Asagirt districts, Amhara Regional State, Ethiopia in July 2022, and 0.5 g of homogenized samples were digested with HNO3 and HClO4 and the levels of metals were determined using Flame Atomic Absorption Spectroscopy (FAAS). The levels were (mg/kg) Fe: 173.6 ± 9.1-332.2 ± 9.2, Zn: 8.7 ± 0.2-40.2 ± 0.3, Cu: 29 ± 4- 84.1 ± 4.7, Mn: 17.03 ± 1.6- 77.4 ± 1.7, Ni: BDL- 41.4 ± 4.3, and Pb: 21.3 ± 15.1- 49.9 ± 9.6. Cd was found to below the detection limit. The hazard index is less than unity, ranged from 6.64 × 10−4 (J. schimperiana) to 6.43 × 10−3 (J. curcas) for all samples, indicating no significant non-carcinogenic effect on users due to heavy metals. Similarly, the carcinogenic risk values of Ni were raged from 6.64 × 10−9 in B. antidysenterica to 1.16 × 10−8 in J. curcas and for Pb it was found to be 6.04 × 10−8 in R. prinoides and 1.41 × 10−7 in J. curcas.Therefore, the results of this study indicated that the exposed populations are unlikely to experience any adverse cancer risk.

Health risk assessment of municipal solid waste incineration emissions based on regression analysis

This study examined the potential health risks posed by the operation of 96 waste-to-energy (WtE) plants in 30 cities in the Bohai Rim of China. Utilizing a sophisticated simulation approach, the Weather Research and Forecasting (WRF) model coupled with the California Puff (CALPUFF) model, we obtained the spatial distribution of pollutants emitted by WtE plants in the atmosphere. Hazard indices (HI) and cancer risks (CR) were calculated for each plant using the United States Environmental Protection Agency's recommended methodologies. The results indicated that both HIs and CRs were generally low, with values below the accepted threshold of 1.0 and 1.0 × 10−6, respectively. Specifically, the average HI and CR values for the entire study area were 2.95 × 10−3 and 3.43 × 10−7, respectively. However, some variability in these values was observed depending on the location and type of WtE plant. A thorough analysis of various parameters, such as waste composition, moisture content, and operating conditions, was conducted to identify the factors that influence the health risks associated with incineration. The findings suggest that proper waste sorting and categorization, increased cost of construction, and elevated height of chimneys are effective strategies for reducing the health risks associated with incineration. Overall, this study provides valuable insights into the potential health risks associated with WtE plants in the Bohai Rim region of China. The findings can serve as useful guidelines for law enforcement wings and industry professionals seeking to minimize the risks associated with municipal solid waste (MSW) management and promote sustainable development.

Release characteristics of volatile organic compounds at residential garbage collection points: a case study of Hangzhou, China.

With the implementation of garbage classification, perishable waste has become increasingly concentrated. This has led to a significant change in the VOC release characteristics at residential garbage collection points, posing a potential risk with unknown characteristics. This study investigated the release characteristics, odor pollution, and health risks of VOCs at garbage collection points under different classification effectiveness, seasons, garbage drop-off periods, and garbage collection point types. The results showed that the average concentration of VOCs released from the garbage sorting collection points (SPs) was 341.43 ± 261.16 μg/m3, and oxygenated compounds (e.g., ethyl acetate and acetone) were the main VOC components. The VOC concentration increased as the community classification effectiveness improved, and it was higher in summer (followed by spring, autumn, and winter). Moreover, the VOC concentrations were higher in the evenings than in the mornings and at centralized garbage collection points (CPs) than at SPs. Further, odor activity value (OAV) assessments indicated that acrolein, styrene, and ethyl acetate were the critical odorous components, with an average OAV of 0.87 ± 0.85, implying marginal odor pollution in some communities. Health risk assessments further revealed that trichloroethylene, benzene, and chlorotoluene were the critical health risk substances, with an average carcinogenic risk (CR) value of 10-6-10-4, and a non-carcinogenic risk (HI) value < 1. These results indicated that HIs were acceptable, but potential CRs existed in the communities. Therefore, VOC pollution prevention and control measures should be urgently strengthened at the garbage collection points in high pollution risk scenarios.

Determination of Major and Trace Metals in Date Palm Fruit (Phoenix dactylifera) Samples Using Flame Atomic Absorption Spectrometry and Assessment of the Associated Public Health Risks.

This study aimed to assess the concentrations of major and trace metals (Na, Ca, Fe, Zn, Ni, Mn, Cu, Cd, and Pb) in date palm fruit samples collected from diverse regions, including Afar (Ethiopia), Iraq, and Saudi Arabia, utilizing flame atomic absorption spectrometry (FAAS). The wet acid digestion method was employed for sample treatment, with optimization of the key parameters such as reagent volume ratio, oven temperature, and digestion time for analytical applications. Under the optimized parameters, average metal concentrations in date palm fruit samples ranged from 205-299, 134-320, 38.8-115, 25.1-42.2, 9.27-27.9, 7.11-16.3, and 0.002-1.15 mg/kg for Ca, Na, Fe, Ni, Zn, Mn, and Cu, respectively. Cd and Pb levels were below detection limits within the linear range. Generally, date palm samples exhibited higher Ca and Na contents and lower concentrations of Cu and Mn than other metals. Pearson correlation analysis revealed very strong positive correlations between Fe and Na, Na and Zn, Na and Mn, Ca and Zn, Fe and Ni, Fe and Mn, and Mn and Ni. Strong negative correlations were observed for Ni and Na, Fe and Cu, and Cu and Ni. Weak correlations were noted among Na and Cu, Ca and Fe, Ca and Ni, Ca and Mn, Ca and Cu, Fe and Zn, Ni and Zn, Zn and Mn, and Zn and Cu. A recovery study using the spiking method demonstrated acceptable percentage recoveries ranging from 91.6% to 97.8%. Health risk assessment, including chronic daily intake (CDI), hazard quotient (HQ), total exposure hazard index (HI), and carcinogenic risk (CR), indicated CDI, HQ, and HI values below 1.0, except for the HI value for Ni. This suggests that the metals pose no probable public health risk, with the absence of Cd and Pb in date palm samples affirming no carcinogenic threats associated with their consumption.

Determination of metals in different tissues of Trachurus trachurus from the Marmara Sea and evaluation of their health risks

The present study aimed to determine the differences in metal levels of Aluminum (Al), Cadmium (Cd), Chromium (Cr), Copper (Cu), İron (Fe), Manganese (Mn), Nickel (Ni), Lead (Pb) and Zinc (Zn) between muscle and liver tissues of Trachurus trachurus, the correlation of metal accumulation in tissues with fish length and weight was examined. Health risks and nutritional adequacy were evaluated based on metal levels accumulated in fish muscle. The results demonstrated that fish liver accumulated higher metal levels than muscle. The investigation revealed that the majority of metals present in the tissues of the fish did not exhibit a significant correlation with their size (p&gt;0.05). It can be concluded that fish are not an adequate source of these nutrients because their nutrient levels are below reference values. The fish were found to be nutrient deficient, as the levels of nutrients were below reference values. The estimated daily intakes of all metals accumulated in muscle were below reference doses. The target hazard coefficient and target hazard index values were less than 1. Lifetime carcinogenic risk values were below 10-4, and total carcinogenic risk values were within the acceptable range. Pb and Cd concentrations in muscle exceeded the tolerable limit. The daily amount of fish that could be consumed without non-carcinogenic health risk was 181 grams for Cd and 295 grams for Pb. The daily amount of fish that could be consumed without carcinogenic health risk was 1.21 grams for Cd and 231 grams for Pb.

Pollution status and health risk assessment of a specific organophosphate pesticide-contaminated site

Organophosphate pesticide pollution is a severe global environmental issue, posing significant threats to human health. This study focuses on an organophosphate pesticide production site in North China. Controlled soil and groundwater were sampled using grid sampling and direct-push technology. Analytical methods such as headspace gas chromatography-mass spectrometry (GC-MS), gas chromatography (GC), and purge and trap GC-MS were employed to detect contaminants, including volatile organic compounds (VOCs), semi-volatile organic compounds (SVOCs), pesticides, and heavy metals. The results indicate that the maximum exceedances in the contaminated soil for benzene, xylene, tri-chloromethane, Parathion, phosphorodithioic acid, Phorate, and Terbufos were 490.63, 411.22, 3459.09, 507.89, 277.29, 1946.15, and 281.5 times the standard limits, respectively. In groundwater, benzene, dichloromethane, trichloromethane, and Phorate exceeded the standard limits by 220.83, 1374, 1853.33, and 806.67 times, respectively, severely contaminating the local soil and groundwater and damaging the eco-system. Additionally, the carcinogenic risk values in the contaminated soil for benzene, toluene, phenylethane, xylene, 1,3,5-trimethylbenzene, 1,2,4-trimethylbenzene, Parathion, 1,2,4-trichlorobenzene, tri-chloromethane, naphthalene, and aniline were 2.75E–3, 1.36E–2, 1.034E–2, 9.72E–1, 1.5E–3, 8.9E–3, 1.85E–3, 4E–3, 3.48E–2, 2.7E–2, 1.03E–3, respectively. In groundwater, toluene, xylene, dichloro-methane, and trichloromethane showed carcinogenic risk values of 8E–3, 1.86E–2, 1.23E–2, 3.07E–2, respectively, significantly exceeding the acceptable limits and posing severe threats to the health of nearby residents. Furthermore, the hazard quotient for non-carcinogenic effects of Cypermethrin in soil was 1.15, and 2,6-dichlorophenol in groundwater was 1.22, both slightly above the standard, indicating a mild impact on the health of nearby residents. Overall, this study provides a theoretical basis for subsequent remediation work at the contaminated site through pollutant analysis.

Health risk analysis of heavy metal exposure bonded in PM2.5 at industrial area in Bandung Regency

Heavy metal contents in PM2.5 particulate dust poses potential risk to the health of human beings. This study aims to measure PM2.5 dust concentrations and characterize heavy metals bound in PM2.5 to estimate health risks in both children and adult groups. PM2.5 dust was measured in Bandung Regency in industrial land uses, located in the Dayeuhkolot sub-district. Measurement of PM2.5 concentrations using a Low Volume Air Sampler (LVAS) with PTFE filters. Sample was collected for 7 days x 24 hours. Heavy metals in PM2.5 dust were characterized using ED-XRF. Calculation of non-carcinogenic and carcinogenic health risks was only performed on metals classified as Hazardous Air Pollutants (HAPs). The average concentration of PM2.5 during the measurement period was 59,10±9,10 μg/m3, exceeding the daily ambient air quality standard based on PP No.22 of 2021 which is&gt; 55μg/m3. The risk of non-carcinogenicity is expressed in Health Index (HI) values. The heavy metals considered in determining non-carcinogenic risk are As, Cd, Cr, Pb, Mn, Ni, Se, Fe, Zn, Si, and Sb as well as the crustal elements Si and Fe. Non-carcinogenic risk associated with exposure to heavy metals in PM2.5 showed HI&lt;1 for both children and adults. This indicates that the exposure to heavy metals in PM2.5 around the Dayeuhkolot industrial area is at an acceptable risk level. HI value for heavy metal exposure for children was 0.34±0.17 and 0.42±0.28 for adults. In estimating the carcinogenic risk value, elements taken into account include As, Cd, Cr, Ni and Pb. Carcinogenic risk in both children and adults showed ECR&gt;10-6 of 4.5×10-5 and 2.1×10-4, respectively. This indicates that there is an unsafe health risk that can potentially cause carcinogenic effects in the population around the Dayeuhkolot industrial area The results of this study can be used as a reference database for establishing policies related to air quality in Bandung Regency.

Evaluation of single particle morphological characteristics and human health risks in different functional areas

Purpose This study aims to better understand the morphological characteristics of single particle and the health risk characteristics of heavy metals in PM2.5 in different functional areas of Handan City. Design/methodology/approach High resolution transmission electron microscopy was used to observe the aerosol samples collected from different functional areas of Handan City. The morphology and size distribution of the particles collected on hazy and clear days were compared. The health risk evaluation model was applied to evaluate the hazardous effects of particles on human health in different functional areas on hazy days. Findings The results show that the particulate matter in different functional areas is dominated by spherical particles in different weather conditions. In particular, the proportion of spherical particles exceeds 70% on the haze day, and the percentage of soot aggregates increases significantly on the clear day. The percentage of each type of particle in the teaching and living areas varied less under different weather conditions. Except for the industrial area, the size distribution of each type of particle in haze samples is larger than that on the clear day. Spherical particles contribute more to the small particle size segment. Soot aggregate and other shaped particles contribute more to the large size segment. The mass concentrations of hazardous elements (HEs) in PM2.5 in different functional areas on consecutive haze pollution days were illustrated as industrial area &gt; traffic area &gt; living area &gt; teaching area. Compared with the other functional areas, the teaching area had the lowest noncarcinogenic risk of HEs. The lifetime carcinogenic risk values of Cr and As elements in each functional area have exceeded residents’ threshold levels and are at high risk of carcinogenicity. Among the four functional areas, the industrial area has the highest carcinogenic and noncarcinogenic risks. But the effects of HEs on human health in the other functional areas should also be taken seriously and continuously controlled. Originality/value The significance of the study is to further understand the morphological characteristics of single particles and the health risks of heavy metals in different functional areas of Handan City. the authors hope to provide a reference for other coal-burning industrial cities to develop plans to improve air quality and human respiratory health.

Potential Health Hazards of Consuming Lutjanus Goreensis from Coastal Waters in the Niger Delta Contaminated with Toxic Metals

This study investigates the health risks associated with trace elements in Gorean snapper (Lutjanus goreensis) from Buguma Creek, Southern Nigeria. Fish samples were collected monthly from May to August 2023, and muscle tissues were analyzed for potential health risks posed by elevated levels of hazardous metals. The concentrations of various heavy metals (Fe, Zn, Pb, Cd, Cu, and As) in Gorean Snapper collected from different locations (Station 1, Station 2, and Station 3) were measured in milligrams per kilogram (mg/Kg) of fish tissue. Results revealed varying metal concentrations across stations, with notable differences in Fe, Zn, Pb, Cd, Cu, and As levels. The Estimated Daily Intake (EDI) values for Cadmium (Cd) were relatively low for both adults and children across all three stations. However, Lead (Pb) and Arsenic (As) exhibited low EDI values, while Zinc (Zn) showed significantly higher values, especially at Station 3. The Hazard Quotient (HQ) and Hazard Index (HI) results indicated potential health risks associated with Zinc exposure, particularly at Station 3, for both adults and children. Carcinogenic Risk (CR) analysis revealed potential health risks associated with long-term exposure to Cadmium for adults. The CR values for Lead and Arsenic fell within acceptable ranges. This study raises concerns about potential health risks associated with the consumption of L. goreensis from Buguma and recommends the continuous monitoring of heavy metal concentrations, public awareness programs, further research, collaboration among stakeholders, and the implementation of best practices in aquaculture and fisheries management to reduce heavy metal concentrations in fish.

Size-classified aerosol-bound heavy metals and their effects on human health risks in industrial and remote areas in Japan

Airborne aerosols were collected in six size classes (PM<0.1, PM0.1–0.5, PM0.5–1, PM1–2.5, PM2.5–10 and PM>10) to investigate aerosol health risks in remote and industrial areas in Japan. We focused on heavy metals and their water-dispersed fractions. The average concentration of heavy metals was 18 ± 25–86 ± 48 ngm−3 for PM<0.1, 46 ± 19–154 ± 80 for PM0.5–1 ngm−3, 98 ± 49–422 ± 186 ngm−3 for PM1–2.5, 321 ± 305–1288 ± 727 ngm−3 for PM2.5–10 and 65 ± 52–914 ± 339 ngm−3 or PM>10, and these concentrations were higher in industrial areas. Heavy metals emitted from domestic anthropogenic sources were added to the long-range transport component of the aerosols. The water-dispersed fraction of heavy metals contained 3.3–40.1% of the total heavy metals in each size class. The relative contribution of Zn and other species (As, Cd, Cr, Ni, Pb, Mn, V and Cu) increased in the water-dispersed fraction. Smaller particles contained greater proportions of the water-dispersed heavy metal fraction. Carcinogenic risk (CR) and the hazard index (HI) were estimated for each size class. The CR of carcinogens was at acceptable levels (<1 ×10−6) for five particle size fractions. The HI values for carcinogens and noncarcinogens were also below acceptable levels (<1) for the same five size fractions. The estimated CR and HI values were dominated by contributions from the inhalation process.

Spice-Induced Metal Contamination and Microbiological Risk Assessment of Instant Noodles Prepared for Human Consumption.

With the rising worries of potential metal contamination in cooked noodles, this study aimed at unravelling, for the first time, the possible source of metal contamination in cooked noodles. Noodles cooked with full spices (CWFS), cooked with half spices (CWHS), cooked with quarter spices (CWQS), and cooked with no spices (CWNS: control) and their spices were analysed for metals using inductively coupled plasma-atomic emission spectrometry. The microbiological quality of the noodles was also evaluated. Metal concentrations in cooked noodles varied with spice quantity. Noodles CWFS had the highest significant (p < 0.05) concentration of Pb (0.36 ± 0.12mg/kg), Ni (1.05 ± 0.01mg/kg), Cd (0.07 ± 0.04mg/kg), Co (0.02 ± 0.002mg/kg), and Na (9.45 ± 0.04mg/kg), compared to the control (CWNS). The mean Pb and Ni of spice and cooked noodles were above the WHO acceptable limits for food and could be harmful to consumers. Pearson's correlation and PCA showed that packed noodle spices introduced metals into the cooked noodles. Although the hazard indices (adults and children) in all noodle's groups were less than 1, children still had the potential to contract cancer from Ni exposure because the carcinogenic risk values of CWQS (2.87 × 10-4), CWHS (3.03 × 10-4), and CWFS (3.21 × 10-4) were greater than 10-4. Microbiological analysis revealed the presence of potential pathogens that showed multidrug resistance and the ability to elaborate protease and amylase enzymes. Given the impending chronic health risks inherent in processed noodles, consistent consumption should be avoided.

A Dynamic Multiple Reaction Monitoring Analytical Method for the Determination of Fungicide Residues in Drinking Water

The extensive use of fungicides causes their continuous release into the environment through spraying, soil seepage, leaching, and runoff. It has been observed that their residues can be found in foods and a variety of environmental compartments, such as wastewater, lakes, rivers, sediments, drinking water sources (groundwater and surface water), treated water, and drinking water. A sensitive GC-MS/MS, using dynamic multiple reaction monitoring, an analytical method was developed to determine 10 fungicides (azoxystrobin, boscalid, captan, cyproconazole, cyprodinil, hexaconazole, metalaxyl, myclobutanil, paclobutrazol, and prochloraz) in drinking water. A solid-phase extraction method for sample preparations and validations was performed according to SANTE 2019 guidelines. All fungicides demonstrated mild or medium matrix effects (ME) ranging from 40.1% to 11.2%. Their recoveries ranged between 60% and 110%. The limits of detection were equal to or higher than 0.01 μg/L. The method was employed on 18 drinking water samples collected from public taps in Northern Evros, Greece, distributed in six sampling sites. Azoxystrobin, boscalid, cyproconazole, cypronidil, metalaxyl, and paclobutrazol mean concentrations did not surpass the allowable limit of 0.1 μg/L set by EU in any sampling site. Hexaconazole mean concentrations were higher than 0.1 μg/L in one sampling site, while prochloraz mean concentration showed limit exceedances in all sampling sites. Captan was not detected in any sampling site, and myclobutanil mean concentrations demonstrated exceedances of the permissible limit in four sampling sites. The presence of fungicide residues in the studied area is mainly due to the occasional point-sources pollution and preferential flow. Additionally, through the use of water, the risk of pesticides to human health was assessed for two different age groups. The sum of the hazard quotient values in each of the studied drinking water was less than unity. Consequently, the acute risk assessment procedure regards the examined drinking water as safe. Nevertheless, as prochloraz carcinogenic risk values were higher than the safe limit suggested by USEPA for both age groups, the existence of prochloraz residues raises concerns about chronic toxicity.

Assessment of Heavy Metals in Biscuit Samples Available in Iraqi Markets.

Baby foods contain these toxic heavy metals which occur naturally or from pollution in the environment. The purpose of this research is to investigate the concentration of heavy metals in the biscuit samples that are commonly used in Iraq as food babies. The concentrations of three metals viz zinc (Zn), lead (Pb), and cadmium (Cd) are measured using atomic absorption spectroscopy (Buck Scientific/USA, 210 VGA). Health risk parameters such as Estimated Daily Intake (EDI), Target Hazard Quotients (THQ), Hazard Index (HI), and Carcinogenic Risk (CR), are determined. The average values of the concentrations of Zn, Pb, and Cd in these samples of biscuits are 0.584 ± 0.099 mg/kg, 0.066 ± 0.008 mg/kg, and 0.205 ± 0.011 mg/kg, respectively, while the average values of HI and CR × 10-6 for all samples are 0.768 ± 0.040 and 1.94 ± 0.25, respectively. On the basis of comparing these elements, the study finds that the average value of Zn is dominating with the highest concentration, followed by Cd, and Pb. This is relied on the statistical examination that revealed a weak correlation and no significance (p > 0.05) in the amounts of these heavy metals in all samples. The concentrations of Cd, in seven samples, are relatively higher than their permissible limits according to FAO/WHO (0.2 mg/kg). Conversely, the concentrations of Zn and Pb are lower than their permissible limits which was 9.4 mg/kg and 0.3 mg/kg, respectively. The values of health risk parameters for Zn, Pb, and Cd for all samples do not surpass their permissible intake limits according to FAO/WHO, Therefore, it is concluded that the overall estimated healthy risk, due to the heavy metals, is safe since it is within the permissible limits; thus, there are no concerns for a baby who consume biscuit consistently daily.

Origin, spatial distribution, sediment contamination, ecological and health risk evaluation of trace metals in sediments of ship breaking area of Bangladesh

Eleven trace metals (Cd, Cr, Fe, Mn, Cu, Ni, Co, Zn, As, Pb, and Ag) in sediments of Bangladesh’s ship breaking area were measured by an atomic absorption spectrometer to determine origin, contamination extent, spatial distributions, and associated ecological and human health hazards. This study found considerable quantities of Pb, Cd, Mn, Zn, and Cu when compared with standards and high levels of Pb, Cd, Zn, Cu, As, and Ag contamination according to pollution evaluation indices. Different indices indicate most of the sampling sites were highly polluted. However, spatial distribution maps indicate that trace metals were predominantly deposited in the northern and southern region. The ecological risk index revealed that Cd has the highest while Pb and As had moderate risk. Based on the health index values, Zn for both adults and children were higher than the safe limit while Mn, Pb, Cr, As, Fe, Cu, Ni, and Co for children were close to the threshold. The mean total carcinogenic risk values of Cr, As, and Ni for children and Ni for adults exceeded the permissible threshold. The cancer risk possibilities were further assessed using Monte Carlo simulation. Most trace metals have anthropogenic origins, which were attributed to ship breaking activities.

Potentially toxic metals in irrigation water, soil, and vegetables and their health risks using Monte Carlo models

Food safety has become a serious global concern because of the accumulation of potentially toxic metals (PTMs) in crops cultivated on contaminated agricultural soils. Amongst these toxic elements, arsenic (As), cadmium (Cd), chromium (Cr), and lead (Pb) receive worldwide attention because of their ability to cause deleterious health effects. Thus, an assessment of these toxic metals in the soils, irrigation waters, and the most widely consumed vegetables in Nigeria; Spinach (Amaranthushybridus), and Cabbage (Brassica oleracea) was evaluated using inductively coupled plasma-optical emission spectroscopy (ICP-OES). The mean concentration (measured in mg kg−1) of the PTMs in the soils was in the sequence Cr (81.77) > Pb(19.91) > As(13.23) > Cd(3.25), exceeding the WHO recommended values in all cases. This contamination was corroborated by the pollution evaluation indices. The concentrations (measured in mg l−1) of the PTMs in the irrigation water followed a similar pattern i.e. Cr(1.87) > Pb(1.65) > As(0.85) > Cd(0.20). All the PTMs being studied, were found in the vegetables with Cr (5.37 and 5.88) having the highest concentration, followed by Pb (3.57 and 4.33), and As (1.09 and 1.67), while Cd (0.48 and 1.04) had the lowest concentration (all measured in mg kg−1) for cabbage and spinach, respectively. The concentration of the toxic metals was higher in spinach than in cabbage, which may be due to the redistribution of the greater proportion of the metals above the ground tissue, caused by the bioavailability of metals in the aqueous phase. Expectedly, the hazard index (HI),and carcinogenic risk values of spinach were higher than that of cabbage. This implies that spinach poses potentially higher health risks. Similarly, the Monte Carlo simulation results reveal that the 5th percentile, 95th percentile, and 50th percentile of the cumulative probability of cancer risks due to the consumption of these vegetables exceeds the acceptable range of 1.00E−6 and 1.00E−4. Thus, the probable risk of a cancerous effect is high, and necessary remedial actions are recommended.

Human health risk assessment of PM10-bound heavy metals and PAHs around the Latin America’s Largest opencast coal mine

Air pollution in opencast coal mine areas is a critical issue, resulting in harmful severe effects on human health. Therefore, it is essential to understand the air pollution factors and to assess the risks to humans. This study evaluated the potential risks (carcinogen and non-carcinogen) of inhalation exposure to PM10-bound heavy metals and Polycyclic Aromatic Hydrocarbons (PAHs) in an open pit mine in northern Colombia. During February-May 2022, PM10 samples were collected at eight sites. Heavy metals (i.e., Al, Cr(VI), Mn, Cu, Zn, As, Pb) and PAHs (thirteen priority PAHs, and one non-priority PAH) levels linked to PM10 were analyzed by X-ray fluorescence and gas chromatography–mass spectrometry, respectively. PM10 concentrations were found to range between 4.70 and 59.90 µg m−3. Out of the three different zones of the study area (i.e., North Zone, South Zone, and Populated Zone), the North Zone recorded the highest daily average concentrations of Cr(VI) (104.16 ng m−3), Mn (28.39 ng m−3), Cu (33.75 ng m−3), Zn (57.99 ng m−3), As (44.92 ng m−3), and Pb (27.13 ng m−3). The fraction of the analyzed heavy metals at all monitoring sites was 82%–89% for Al, followed by Cr(VI) with 3%–6%. Cr(VI) was the major contributor to the carcinogenic risk values, while Cu, Cr(VI), and As were the main drivers for the non-carcinogenic risk. The average cancer risk range for heavy metals was 3.30 × 10–04 –5.47 × 10–04. On the other hand, the cancer risk for PAHs exposure was acceptable. The average incremental lifetime cancer risk (ILCR) values varied between 2.87 × 10–07 and 4.21 × 10–07. Benzo[a]pyrene contributed to 54%–56% of the total risk from inhalation of PM10-bound PAHs, while Indeno[1,2,3-cd]pyrene contributed to 16%–19%. Based on the Monte Carlo sensitivity analysis, exposure to Cr(VI) was the main factor affecting cancer risk in the North, South, and Populated Zones. A suitable risk assessment and management plan requires understanding PM10-bound heavy metals and PAHs concentration levels as well as their potential health risks, mainly in open-cast coal mine zones. Our study found that people living near open-pit mines face potential health risks, so it is crucial to establish policies and regulations to control emission sources.

Groundwater contamination & health risk assessment with special reference to As in different tehsils of Bhakkar district

The present study was conducted to evaluate the concentration of arsenic in groundwater in Bhakkar district, Western Punjab Province, Pakistan. To analyze hydrochemical characteristics, 68 groundwater samples from various water schemes in four tehsils were taken. While most of the samples' concentrations of major cations and anions were within the WHO's maximum allowed range, almost 44% had higher arsenic levels than what was considered acceptable for drinking water. Gibbs diagrams were used to show how groundwater chemistry is affected by the dominance of rocks and evaporation crystallization. An investigation of the Indus River's lateral distribution and upstream to downstream locations' arsenic concentrations showed variability. According to the Health Risk Assessment (HRA), samples from Bhakkar tehsil (73.3%), Darya Khan tehsil (60%), and Kalur Kot tehsil (13.3%) all surpassed the hazard quotient level of “1,” whereas all samples from Mankera tehsil were within acceptable bounds. The hazard quotient numbers displayed a range of 0.038–5.127, with an average of 1.149 – suggesting that a considerable portion of people consuming water laden with high levels of arsenic may suffer from non-cancerous health complications. Moreover, the carcinogenic risk values were as high as 2.31 × 10−3, implying a heightened danger of cancer over the long term due to arsenic-contaminated water. It was determined that Bhakkar tehsil had the highest quantity of arsenic among the tehsils in the Bhakkar district, making the groundwater unfit for drinking.

Pollution status and ecological risks of metals in surface water of a coastal estuary and health risk assessment for recreational users

Since the areas close to the Sundarbans mangrove estuary, which is one of the most dynamic and productive ecosystems in the world, are very suitable for urban and industrial activities, the coastal areas of this ecosystem are constantly exposed to metal contamination. In this study, we analyzed the levels, spatial distributions, sources, pollution status, ecological risks, and health risks for recreational users of 16 metals in surface water collected from 18 sampling sites in the Sundarbans estuary. Considering the mean values of metals, Sr (2523 μg/L), Al (1731 μg/L), B (1692 μg/L) and Fe (1321 μg/L) were the most abundant metals in the coastal waters of the estuary, while Cd (0.977 μg/L), Ni (3.11 μg/L), Cu (5.98 μg/L) and Cr (9.77 μg/L) were the less abundant metals. All metals except Zr had the coefficient of variation (CV) values of over 35%, suggesting that other metals showed strong variation between sampling sites due to anthropogenic activities. Al, Fe and Pb levels of all sampling sites were above the limit values set for coastal and marine waters. Similarly, Pb levels of all sites exceeded the USEPA chronic criterion set for saltwater aquatic life. The results of pollution indices indicated that there was a serious metal pollution in almost all sampling sites. Low ecological risk (ER) at four sites, moderate ER at five sites and considerable ER at nine sites were recorded. Dual hierarchical clustering analysis grouped 16 metals into four clusters based on their potential sources and 18 sampling sites into three clusters based on their similar pollution characteristics. Health risk assessment results indicated that total hazard index (THI) values of all sites for recreational children were above the acceptable level of 1, indicating that water of all sites is not safe for health of children. However, THI values of all sites except ST8 (1.1) and ST11 (1.19) for recreational adults were below 1. Among the metals studied, Zr was found to be metal that contributes the most (75.89%) to total health risk in this coastal estuary. This finding reveals the necessity of monitoring of such less-studied metals such as Zr in the surface water of coastal estuaries. Carcinogenic risk values of As were within or below the acceptable range at all sites, indicating that carcinogenic risks would not be expected for recreational users.

Health risk assessment of heavy metals in exposed workers of municipal waste recycling facility in Iran

Exposure to heavy metals (HMs) present in the particulate matter from municipal solid waste during pretreatment and recycling processes may pose a serious health risk to workers. This was the first study on the exposure of municipal solid waste (MSW) recycling workers to toxic metals. The concentrations of HMs (Cd, Pb, As, Co, Cr, Ni, Cu, Fe, Mn, and Zn) during personal exposure to PM2.5 among municipal waste recycling facility workers in Kashan City, Iran, were investigated from January 15 to March 15, 2023. The research was performed in the three main stages of the waste recycling process: dismantling, sorting, and collecting. PM2.5 samples were collected using a personal environmental monitor (PEM) attached to a sampling pump. The non-carcinogenic and carcinogenic health risk values and related uncertainty for waste recyclers from HMs inhalational exposure were calculated using USEPA methodology and Monte Carlo simulations. The results showed that the dismantlers exhibited the highest exposure concentrations of PM2.5 (mean 2148 ± 1257 μg m−3), followed by sorters (mean 1864 ± 965 μg m−3), and collectors (mean 1782 ± 876 μg m−3). Health risk assessment indicated that 95th percentile contents of Ni, As, Co, and Zn were responsible for the non-carcinogenic risk (HQ) values exceeding the acceptable level of 1. The contents of As, Ni, and Cr in PM2.5 caused a non-acceptable carcinogenic risk for waste recyclers due to inhalational exposure, as the carcinogenic risk (CR) values exceeded the acceptable threshold of 1 × 10−6. Monte Carlo simulation results revealed that the mean and median CR values from inhalational exposure to carcinogenic HMs exceeded the acceptable level of 1 × 10−6 for municipal waste recyclers. As results of this study indicated the high-risk to hazardous metals for waste recyclers due to occupational exposure in the MSW recycling sites, it is suggested to consider workers’ exposure as the public health concern.

Heavy metal concentrations in various tissues of two fish species from Damsa Dam Lake (Turkey) and associated health risk assessment

Purpose of review and methodIn this study, indicate the average or range of 10 heavy metal concentrations in muscle, gills and liver of two fish species (Squalius pursakensis and Cyprinus carpio) living in the Damsa Dam Lake (Turkey) was examined in relation to fish gender and size. Inductively coupled plasma-tandem mass spectrometry was used to evaluate the concentrations of heavy metals. The average contents of the metals in S. pursakensis muscle samples were 0.877, 9.285, 0.614, 0.488, 8.190, 0.155, 0.015, 0.010, 0.218, 0.009 mg/kg for Cu, Fe, Mn, Ni, Zn, As, Cd, Co, Cr and Pb respectively. On the other hand, the average contents of the metals in C. carpio muscle samples were 0.673, 8.001, 0.367, 0.435, 6.107, 0.188, 0.007, 0.007, 0.371, 0.012 mg/kg for Cu, Fe, Mn, Ni, Zn, As, Cd, Co, Cr and Pb respectively. In addition, human health risks were evaluated considering the estimated daily intake of heavy metals in adults. The target hazard quotient, hazard index and carcinogenic risk values were determined based on the frequency of fish consumption for the population living in the region. Result and conclusionThe highest quantities of all heavy metals were determined in the gills and liver of the fish species. The levels of most heavy metals in tissues did not differ significantly between both fish species. Only a few heavy metals in the tissues of both fish species demonstrated significant associations with fish length or weight. In terms of the levels of most of the heavy metals in the tissues, there weren’t any significant differences between the male and the female fish. The estimated daily intakes of all of the heavy metals were lower than the reference doses. The values of the target hazard quotient and the hazard index were found to be below 1 and the values regarding carcinogenic risk were assessed to be within or lower than the permissible levels. Cr, Cu, Zn, Cd, Pb and inorganic As values assessed in the muscle tissues of fish were found below the values acceptable by national and international institutions. These results proved that the examined fish species can be consumed safely.