Carboxymethyl Guar Research Articles

Overcoming Chemical and Mechanical Instabilities in Lithium Metal Anodes with Sustainable and Eco-Friendly Artificial SEI Layer.

Construction of a robust artificial solid-electrolyte interphase (SEI) layer has proposed an effective strategy to overcome the instability of the lithium (Li). However, existing artificial SEI layers inadequately controlled ion distribution, leading to dendritic growth and penetration. Furthermore, the environmental impact of the manufacturing process and materials of the artificial layer is often overlooked. In this work, a chemically and physically reinforced membrane (C-Li@P) composed of the biocompatible Li+ coordinated carboxymethyl guar gum (CMGG) and polyacrylamide (PAM) polymers serves as an artificial SEI membrane for dendrite-free Li. This membrane with hollow channels not only directs ion flux along the interspace of fibers, fostering uniform Li plating but also induces a desirable interface chemistry. Consequently, artificial SEI membrane-covered Li exhibits stable electrochemical plating/stripping reactions, surpassing the cycle life of ≈750% of bare Li. It demonstrates exceptional capacity retention of ≈93.9%, ≈88.1%, and ≈79.18% in full cells paired with LiNi0.8Mn0.1Co0.1O2 (NMC811), LiNi0.6Mn0.2Co0.2O2 (NMC622) and S cathodes, respectively over 200 cycles at 1 C rate. Additionally, the water-based green manufacturing and biodegradability of the membrane demonstrated the sustainable development and disposal of electrodes. This work provides a comprehensive framework for the design of an artificial layer chemically and physically regulating dendritic growth.

Fabrication of anti-freezing and self-healing hydrogel sensors based on carboxymethyl guar gum and poly(ionic liquid)

As classical soft materials, conductive hydrogels have attracted wide attention in the field of strain sensors due to their unique flexibility and conductivity. However, there are still challenges in developing conductive hydrogels with comprehensive mechanical strength, self-healing ability and sensitive sensing properties. In this paper, a novel PAV/CMGG hydrogel was prepared by a simple one-pot method through the introduction of 1-vinyl-3-butylimidazolium bromide (VBIMBr), acrylic acid (AA), carboxymethyl guar gum (CMGG) and AlCl3. The coordination bond between Al3+ and –COO− groups on PAA and CMGG, the hydrogen bond between PAA and CMGG, and the electrostatic interaction between [VBIM]+ and –COO− endow the hydrogel with good mechanical properties, self-recovery ability, fatigue resistance and great self-healing properties. PAV/CMGG hydrogel had good conductivity of 2.31 S/m which could successfully light up the bulb. The hydrogel as the strain sensor had not only a wide strain sensing capability (strain ranging from 0 to 800 %), but also a high strain sensitivity (gauge factor (GF) = 28.50 for the strain ranging from 600 to 800 %). This study can provide inspiration for the construction of new high-performance flexible sensors.

Poly(allylamine)-adorned heptylcarboxymethyl galactomannan nanocarriers of canagliflozin for controlling type-2 diabetes: Optimization by Box-Behnken design and in vivo performance

In the past three decades, the prevalence of type-2 diabetes has arisen dramatically in countries of all income levels. A novel, most effective nanotechnology-based strategy may reduce the prevalence of diabetes. Recently, the shell-crosslinked polysaccharide-based micellar nanocarriers (MNCs) have shown great promise in terms of stability, controlled drug release, and improved in vivo performance. In this study, heptyl carboxymethyl guar gum was synthesized and characterized by ATR-FTIR, 1HNMR spectroscopy, surface charge, critical micelle concentration (23.9 μg/mL), and cytotoxicity analysis. Box-Behnken design was used to optimize the diameter, zeta potential, drug entrapment efficiency (DEE), and drug release characteristics of poly (allylamine)-crosslinked MNCs containing canagliflozin. The optimized MNCs revealed spherical morphology under TEM and had 149.3 nm diameter (PDI 21.2 %), +53.8 mV zeta potential, and 84 % DEE. The MNCs released about 63 % of the drug in 12 h under varying pH of the simulated gastrointestinal fluid. DSC and x-ray analyses suggested amorphous dispersion of drugs in the MNCs. CAM assay demonstrated the biocompatibility of the MNCs. The MNCs showed hemolysis of <1 %, 85 % mucin adsorption, and stability over three months. The MNCs demonstrated excellent anti-diabetic efficacy in streptozotocin-nicotinamide-induced diabetic rats, continuously lowering blood glucose levels up to 12 h.

LNMR analysis of the retention of different guar gum structure in sandstone: Based on a new characterization method

The adsorption and retention damage of guar gum to reservoirs are important factors affecting the effectiveness of hydraulic fracturing. Accurately understanding and evaluating the adsorption and retention of guar gum can better support the research of low-damage fracturing fluid. However, previous indoor evaluation methods have some limitations in studying the adsorption and retention characteristics of guar gum. The analysis object of low-field nuclear magnetic resonance (LNMR) is water rather than guar gum, which cannot achieve visualization of guar gum retention. In addition, Ordinary guar gum (GG), hydroxypropyl guar gum (HPG), and carboxymethyl guar gum (CMG) are commonly used in the hydraulic fracturing of sandstone gas reservoirs, but there are very few studies that focus on the differences in the adsorption and retention damage of the three guar gums from a microscopic perspective. In this study, a new characterization method for evaluating the retention of polymer in fracturing fluid based on the principles and properties of LNMR was proposed. This method can quantitatively evaluate the amount of guar gum adsorption retention and achieve a visual evaluation of the adsorption and retention of guar gum in cores. The aggregation characteristics of guar gum in porous media can be reflected. The dynamic retention process of GG, HPG, and CMG in sandstone cores was directly characterized through this method. The aggregation and entanglement characteristics of the three types of guar gum in sandstone were analyzed from the structure of guar gum. The experimental results show that the difference in molecular weight and modified groups of guar gum has an impact on its adsorption and retention. The molecular chain after the gel-breaking of GG was longer due to the large molecular weight. Long chains and intramolecular hydrogen bonds caused a larger curling degree of GG molecules. The entanglement degree of guar gum increased due to the introduction of non-ionic long-chain hydroxypropyl. The introduction of anionic carboxymethyl made CMG molecules more stretched due to electrostatic repulsion. The median particle size of the gel breaking liquid of GG was 10.65 μm, HPG was 8.8 μm, and CMG was 5.88 μm. A larger molecular particle size after guar gum gel breaking would aggravate the retention in sandstone porous media. After 150 min of displacement, the adsorption and retention amount of GG in the core was 4.59 mg/g, HPG was 4.17 mg/g, and CMG was 3.86 mg/g. The compactness of aggregates formed by guar gum in the core was HPG > GG > CMG. The gas flooding can relieve the adsorption and retention of guar gum. The higher the degree of entanglement of guar gum molecules, the more difficult to remove them from the core. The flowback degree of gas flooding of GG was 10.2%, HPG was 6.8%, and CMG was 21.9%. This research provides an experimental strategy for the microscopic evaluation of polymer adsorption and retention in rock porous media. The research results provide a deep understanding of the microscopic characteristics of guar gum adsorption and retention from the perspective of guar gum structure, which has some significance for guiding the optimization of fracturing fluid and the study of low-damage fracturing fluid.

Fabrication and assessment of carboxymethyl guar gum-based sustainable films for packaging application

Fabrication and assessment of carboxymethyl guar gum-based sustainable films for packaging application

Carboxymethyl Guar Gum-Based Bioactive and Biodegradable Film for Food Packaging

Carboxymethyl Guar Gum-Based Bioactive and Biodegradable Film for Food Packaging

Development of an eco-friendly dust suppressant based on modified guar gum: Performance and mechanism analysis

In order to solve the soil fugitive dust pollution at the infrastructure construction site, a new environment friendly dust suppressant was prepared with carboxymethyl guar gum (CMGG) as the core raw material. The optimal formulation of the dust suppressant was determined using single factor experiments and RSM (Response surface method). The performance test results showed that the water erosion rate of the soil dust was <5%, and wind erosion rate reached 97.51%. The water retention rate of dust suppressant reached 31.33%. The dust suppressant contained substantial oxygen-containing functional groups (-OH, -COOH). The -COOH and -OH contained in the soil were interactively attracted with -OH and -COOH in dust suppressant to form hydrogen bonds, resulting in interfacial between dust suppressant and soil dust surface. The dust suppressant-soil dust adhesion system is formed, thereby inhibiting the spread of soil dust.

Novel flexible hydrogels based on carboxymethyl guar gum and polyacrylic acid for ultra-highly sensitive and reliable strain and pressure sensors

To realize on stable and real-time monitoring of human activities, novel hydrogels using polyacrylic acid (PAA) and carboxymethyl guar gum (CMGG) were fabricated as wearable and flexible strain or pressure sensors in the presence of lignosulfonate (LS) and Al3+. Based on the co-existence of metal coordination bonds, hydrogen bonds and ionic interaction in this system, the obtained hydrogels exhibited desirable mechanical properties with good self-recovery ability. The hydrogels displayed good self-adhesion behavior and an ultra-high tensile sensitivity (gauge factor (GF) = 24.30), therefore, they could precisely detect human joints movements such as elbow, wrist, and finger bending as well as tiny movements and external stimuli such as swallowing, smile, frown, pulse, speaking, writing, and even the falling of different liquid drops. Additionally, the hydrogels showed excellent self-healing ability with the healing efficiency as high as 100 % after 30 h. Most importantly, the healed hydrogel could perform the same sensing performance as before. Based on these distinguished characteristics, this hydrogel represents great potentials in wearable and flexible sensors for long-term and stable health monitoring application.

An all-biopolymer self-assembling hydrogel film consisting of chitosan and carboxymethyl guar gum: A novel bio-based composite adsorbent for Cu2+ adsorption from aqueous solution

A novel bio-based composite adsorbent, all biopolymer self-assembled hydrogel film has been prepared by eco-friendly amalgamating chitosan (CS) and carboxymethyl guar gum (CMGG) biopolymers in water without needing small molecules for cross-linking. Various analysis demonstrated the electrostatic interactions and hydrogen bondings within the network structure are responsible for gelling, crosslinking, and forming a 3D structure. Various experimental parameters were optimized to evaluate the CS/CMGG's potential for removing Cu2+ ions from aqueous solution, including pH, dosage, Cu(II) initial concentration, contact time, and temperature. The pseudo-second-order kinetic and Langmuir isotherm models are highly correlated with the kinetic and equilibrium isotherm data, respectively. Using the Langmuir isotherm model for an initial metal concentration of 50 mg/L at pH 6.0 and 25 °C, the maximum adsorption of Cu(II) was calculated to be 155.51 mg/g. A combination of adsorption-complexation and ion exchange must be involved in Cu(II) adsorption on the CS/CMGG. Five cycles of the loaded CS/CMGG hydrogel regeneration and reuse were successfully achieved without an appreciable difference in Cu(II) removal percentage. Thermodynamic analysis indicated that copper adsorption occurred spontaneously (ΔG°: −2.85 J/mol, 298 K) and exothermically (ΔH°: −27.58 J/mol). A reusable bio-adsorbent for removing heavy metal ions was developed that is eco-friendly, sustainable, and efficient.

Stretchable Semi-Interpenetrating Carboxymethyl Guar Gum-Based Composite Hydrogel for Moisture-Proof Wearable Strain Sensor.

Wearable strain sensors of conductive hydrogels have very broad application prospects in electronic skins and human-machine interfaces. However, conductive hydrogels suffer from unstable signal transmission due to environmental humidity and inherent shortcomings of their materials. Herein, we introduce a novel moisture-proof conductive hydrogel with high toughness (2.89 MJ m-3), mechanical strength (1.00 MPa), and high moisture-proof sensing performance by using dopamine-functionalized gold nanoparticles as conductive fillers into carboxymethyl guar gum and acrylamide. Moreover, the hydrogel can realize real-time monitoring of major and subtle human movements with good sensitivity and repeatability. In addition, the hydrogel-assembled strain sensor exhibits stable sensing signals after being left for 1 h, and the relative resistance change rate under different strains (25-300%) shows no obvious noise signal up to 99% relative humidity. Notably, the wearable strain sensing is suitable for wearable sensor devices with high relative humidity.

Environmental urea-free pretreatment process to form new surface on hemp for enhancing the inkjet printing performance

Because of the non-cellulose substance in hemp fabric, such as pectin and waxiness, the inkjet printing products have light color yield and poor color fastness. Moreover, the inkjet printing pretreatment solution generally included urea, which might pollute the environment. Thus, an environmentally friendly pretreatment process was used in this study for improving hemp inkjet printing, which only included carboxymethyl guar gum (CMG) and NaHCO3. The results shown that the hemp fabrics pretreated with CMG had a longer wetting time and bigger contact angle. The pores of the freeze-dried CMG were far more than the sodium alginate. CMG pretreated fabric could absorb more dyes, which reacted with fibers. The results demonstrated that the K/S values of inkjet-printed hemp fabric reached the maximum when the pretreatment solution was 1.5 % CMG and 2 % NaHCO3. Compared with sodium alginate, the K/S values of the cyan, magenta, yellow and black color blocks of CMG pretreated hemp fabric increased by 36 %, 10 %, 26 % and 63 % respectively. Thus, the free-urea pretreatment process cannot only improve the inkjet printing performance and reduce the discharge of industrial wastewater, but also save raw materials and promote the development of the textile industry.

Synthesis, Characterization, and Swelling Properties of a New Highly Absorbent Hydrogel Based on Carboxymethyl Guar Gum Reinforced with Bentonite and Silica Particles for Disposable Hygiene Products.

Superabsorbent polymers derived from petroleum have been widely used as the primary component of high-water-absorption disposable sanitary products. However, environmental concerns as well as unstable market prices influence the quality of disposable hygiene products. The development of superabsorbent polymers from natural, non-petroleum-derived materials has become more predominant. In the present study, two borax-cross-linked carboxymethyl guar-based superabsorbents with bentonite (CMG-Bt) and fumed silica particle reinforcement (CMG-Bt-Si) were synthesized. The materials have been fully characterized by various techniques. The swelling behavior was studied through free swelling capacity (FSC) and centrifuge retention capacity (CRC). The swelling kinetics and urea absorption capacity were further analyzed. The effects of the cross-linking ratio, mineral clay, silica particles, and pH of the liquids on the swelling properties of the superabsorbents have been studied. The incorporation of silica particles demonstrated a positive effect on water uptake reaching 78.63 and 41.09 g/g of FSC and CRC, respectively, at an optimum pH of 6.8. The optimum swelling kinetics were attributed to CMG-Bt-Si of 5 wt % silica particle content, indicating a velocity parameter (ζ) of 41 s in saline solution. Finally, the highest swelling values were obtained at 10, 10, and 5 wt % for the cross-linking ratio, bentonite content, and silica particle content, respectively; in addition, the absorption of urea by the CMG-Bt-Si material was also confirmed.

Synthesis and characterization of water injection fracturing fluid for wetting and softening coal seam

This study aims to achieve dust control from the source, reduce the dust concentration of coal mining faces, and provide a safe and pollution-free working environment for underground operators. In this study, dodecyl polyglucoside was used as the matrix material , tris-benzoic acid was used as the crosslinking agent, and eramidopropyl was used as the graft. A new carboxylic anionic surfactant (CAS) was prepared by esterification and amidation crosslinking reactions, nano sodium carboxymethyl cellulose was a micellar accelerator, and a new type of anionic fracturing fluid was prepared. The reaction process and structure of the product were analyzed by infrared spectroscopy , X-ray diffraction and scanning electron microscopy, and the thermal stability of the product was analyzed by thermogravimetry experiments. Related performance testing experiments showed that CAS had a relatively low surface tension , and the product had a relatively high shear viscosity and low filtration. Compared with water and carboxymethyl guar gum fracturing fluid, the product has a better wetting and softening effect on coal. In addition, through molecular dynamics simulation, it is determined that CAS in the product can form a good connection with coal molecules and act firmly on the surface of coal, which greatly promotes the wetting of coal.

POLYANILINE/CARBOXYMETHYL GUAR GUM NANOCOMPOSITES: AS BIODEGRADABLE, CONDUCTIVE FILM

Biomaterial-based nanocomposites have been increased in demand in industries for a purpose of packaging and sensing because of their low cost and environmentally friendly nature. But less work has been done on conductive, biodegradable film preparations. This article is devoted to the preparation of Polyaniline/ Carboxymethyl guar gum nanocomposites film and their applications. Controlled synthesis of polyaniline in the presence of carboxymethyl guar gum solution has been carried out for the synthesis of these nanocomposites. Then nanocomposite films have been obtained by solution casting method in one step. The object of this research work was to prepare a conductive, biodegradable, flexible film. Such made nanocomposites film has been further tested for FTIR, SEM, UTM, Conductivity, Swelling behavior and biodegradability. The results have been concluded that by this method a fine flexible, conductive, biodegradable film may be prepared that can be applied in different fields for further study.

Atomic force microscopy investigation of smart superabsorbent hydrogels based on carboxymethyl guar gum: Surface topography and swelling properties

Atomic force Microscopy (AFM) is commonly used to study various mechanical, functional, and electrical properties of materials at the nanoscale, as well as for characterizing the topography and surface properties. Up to our knowledge, this is the first investigation to study the surface properties of some carboxymethyl guar gum-based smart superabsorbent hydrogels before and after swelling. In this regard, three sets of modified carboxymethyl guar gum (CMGG) hydrogels were prepared via reaction with different weight ratios of acrylate monomers. The chemical composition of these hydrogels was assured via the IR spectroscopy and the morphology of the dry and swelled gels was studied via the ESEM. The swelling data were correlated with the chemical composition of the prepared hydrogels together with a detailed AFM study of their maps. The chemical modifications were also confirmed by a recent model of AFM. The data reveal that the highest swelling was achieved by C2 in which the weight ratio of acrylate monomers is twice that of guar gum (Qmax = 676 g g after 150 min) It was also found that the swelling capacity of all the prepared hydrogels decreases slightly from the first to the third swelling cycle. For instance, the swelling performance for C2 is as following: 767, 750 and 734 g g for the first, second and third cycles respectively. The data extracted from the AFM showed that surface roughness increases from 15.62 nm to 22.47 and the height rises from 11.2 nm to 43.9 nm as a result of chemical modification for guar gum into carboxymethyl guar gum.

A carboxymethyl vegetable gum as a robust water soluble binder for silicon anodes in lithium-ion batteries

The dramatic volume change and electrode pulverization hinder the practical utilization of silicon-based anodes for lithium-ion batteries. Studies show that binders can be an effective approach to solve these issues. Herein, the natural vegetable gum-guar gum (GG) is modified through carboxymethylation method. The carboxymethyl guar gum (CMGG) exhibits rapid water solubility, excellent thermal stability, high viscosity and robust adhesion. When it is applied as a binder for silicon anodes, the CMGG possessing affluent hydroxyl and carboxyl groups can effectively accommodate the significant volume variations of silicon particles through the formation of intensive hydrogen bonds. The Si @ CMGG electrode not only retains a high reversible capacity of 1865 mAh g−1 after 200 cycles with a capacity decay rate of 0.12% for each cycle, but also holds a capacity of 1287.1 mAh g−1 after 100 cycles with high mass loading of 1.15 mg cm−2. Furthermore, the CMGG binder can promote the lithium-ion transport like guar gum and reduce the electrode polarization, which is helpful in maintaining the electrochemical stability of Si anodes at high current density.

Fabrication and characterization of carboxymethyl guar gum nanocomposite for application of wound healing

Bio scaffolds used for cutaneous tissue regeneration is a challenging issue in the healthcare system. To help this problem, we aimed to report on fabrication and characterization of citric acid cross-linked carboxymethyl guar gum (CMGG) nanocomposite films loaded with ciprofloxacin for faster wound healing application. Differential scanning calorimeter (DSC) and attenuated total reflectance Fourier transform infrared (ATR-FTIR) spectroscopy studies, dynamic light scattering (DLS), scanning electron microscopy (SEM) and X-ray diffraction (XRD) were used as analytical techniques for characterization of the nanocomposite film. The morphological characters of nanocomposite film were determined by SEM. The prepared scaffolds were evaluated for the carboxyl content and swelling ratio. Ciprofloxacin was loaded into scaffold and drug release was studied at pH 7.4. The hemolysis assay was used to study the biocompatibility of scaffold films. The formation of ester cross-links between citric acid and CMGG was confirmed by DSC and ATR- FTIR. The total carboxyl content of scaffold was found to be decreased when the amount of CMGG was increased. The swelling of scaffold film was found to be decreased with increase in curing temperature and time. CMGG scaffold films showed high drug loading with non-Fickian release mechanism suggesting controlled release of drug. In vivo wound healing studies were carried out for 5 days. In this study we observed a faster wound healing effect within 5 days by incorporation of ciprofloxacin in the CMGG film and found biocompatible. Hence, these Nanocomposite films show greater potential in treating wounds.

Development and Evaluation of Mucoadhesive Tablets of Cinnarizine Using Carboxymethylated Guar Gum by Compression Coating Technique

The e study was designed to perform carboxymethylation of guar gum and to develop mucoadhesive tablets of cinnarizine by compression coating technology. Carboxymethyl guar gum was synthesized and characterized by FTIR, SEM, XRD and DSC techniques. Inner core tablets of cinnarizine were compression coated with guar gum and carboxymethylated guar gum. The formulated mucoadhesive tablets were evaluated for various tablet parametric tests viz. hardness, friability, content uniformity, thickness. Ex vivo mucoadhesion strength and in vitro drug release studies were also conducted. Appearance of new FTIR peaks, surface morphology analysis by SEM, reduction in crystallinity by XRD and appearance of the endothermic peak in DSC thermogram point out towards successful carboxymethylation of guar gum. Mucoadhesive strength of F1CGG to F4CGG batches of mucoadhesive tablets prepared with carboxymethyl guar gum found higher than F1GG to F4GG batches of tablets prepared with guar gum. Carboxymethyl guar gum exhibited sustained release effect on in vitro release cinnarizine from compression coated mucoadhesive tablets. The study confirms that carboxymethylation of guar gum improves the mucoadhesive properties of pure guar gum. Also, the compression coating of carboxymethylated guar gum enhances the gastric retention time and sustained release of cinnarizine. Carboxymethyl guar gum can be used as mucoadhesive polymer for developing different mucoadhesive drug delivery systems.

Green synthesis and characterization of carboxymethyl guar gum: Application in textile printing technology

AbstractThis study focusses on the synthesis of carboxymethyl guar gum (CMG) via monochloroacetic acid under alkaline conditions. The reaction conditions were also optimized during the course of experiment. Guar derivative with variable degree of substitution (DS) were prepared and were confirmed by Fourier transform infrared (FTIR) spectroscopy. The DS was determined quantitatively by titration method for each derivative. The synthesized guar gum derivatives, being the natural thickners, have been used in textile printing technology. Substituted guar gum has been proved environmental friendly thickener as compared to synthetic thickeners. Penetration properties, fixation ability, colour fastness, levelness and fabric handling was compared with alginate thickener (commercially available). Guar gum thickeners showed enhanced properties versus alginate thickener and can be used as an alternative to synthetic thickeners in view of its green, non-hazardous and economical derivatives. Guar gum is the outstanding natural thickener, stabilizer, gelling agent and could possibly be used in various industrial units including food, cosmetic, textile, oil fracturing and mining.

Glyceryl monooleate functionalized matrix with an inter polyelectrolyte complex system for the management of drug resistance in tuberculosis

ObjectiveInter polyelectrolyte complexes (IPECs) are an emerging biocompatible polymeric carrier system to transport active substances at target sites. The aim of this study was to evaluate the use of hydrophobic waxy retardant polymer glyceryl monooleate in hydrophilic inter polyelectrolyte matrix system containing three principal anti-tubercular drugs (ATDs). Sustained release polymeric matrix system was prepared by melt granulation technique, which allowed for the manufacture of the multi-layered tablets for segregated delivery of rifampicin, isoniazid and pyrazinamide.The matrix system consisting of hydrophilic IPEC of chitosan and carboxymethyl guar gum in combination with hydrophobic waxy retardant polymer, prepared by melt granulation technique was found to achieve segregated delivery of rifampicin, isoniazid and pyrazinamide. The applicability of piperine, an organic alkaloid as bio enhancer and rifampicin-sodium lauryl sulphate (SLS) complex was tested for improvement in bioavailability of antituberculosis fixed dose combination (FDC), lowering dosage levels and shortening the treatment course.ResultsThere was no incompatability observed between drug and excipeints based upon FTIR, DSC and X-RD studies. The optimized tablet (composition IPEC 46 % w/w (275mg), glyceryl monooleate 2 % w/w (11.5mg), piperine 1 % w/w (5 mg), pyrazinamide (150mg), isoniazid (50mg) and rifampicin-SLS complex (95.2mg) sustained the delivery of drugs for 12 h. IPECs alone lack sufficient mucoadhesion hence, suitable combination of polymeric blends along with IPEC played a key role in controlling the initial burst release pattern, desired bioadhesion (14.25g) and swelling index (1248.8%).This biocompatible, biodegradable and naturally renewable polymeric matrix system could be successfully utilized in a FDC to maximally release ATDs in a sustained manner achieving complete dissolution.