Development and Evaluation of Mucoadhesive Tablets of Cinnarizine Using Carboxymethylated Guar Gum by Compression Coating Technique

Abstract

The e study was designed to perform carboxymethylation of guar gum and to develop mucoadhesive tablets of cinnarizine by compression coating technology. Carboxymethyl guar gum was synthesized and characterized by FTIR, SEM, XRD and DSC techniques. Inner core tablets of cinnarizine were compression coated with guar gum and carboxymethylated guar gum. The formulated mucoadhesive tablets were evaluated for various tablet parametric tests viz. hardness, friability, content uniformity, thickness. Ex vivo mucoadhesion strength and in vitro drug release studies were also conducted. Appearance of new FTIR peaks, surface morphology analysis by SEM, reduction in crystallinity by XRD and appearance of the endothermic peak in DSC thermogram point out towards successful carboxymethylation of guar gum. Mucoadhesive strength of F1CGG to F4CGG batches of mucoadhesive tablets prepared with carboxymethyl guar gum found higher than F1GG to F4GG batches of tablets prepared with guar gum. Carboxymethyl guar gum exhibited sustained release effect on in vitro release cinnarizine from compression coated mucoadhesive tablets. The study confirms that carboxymethylation of guar gum improves the mucoadhesive properties of pure guar gum. Also, the compression coating of carboxymethylated guar gum enhances the gastric retention time and sustained release of cinnarizine. Carboxymethyl guar gum can be used as mucoadhesive polymer for developing different mucoadhesive drug delivery systems.