Carboxylic Acid Functional Groups Research Articles

Synthetic Strategies for the Development of Ibuprofen Derivatives: A Classified Study.

Ibuprofen, a widely used NSAID from the aryl propionic acid class, effectively relieves pain, fever, and inflammation. On prolonged use, it leads to gastrointestinal, hepatic, and renal toxicities, particularly gastrointestinal ulcers. These side effects are largely attributed to the carboxylic acid functional group common to NSAIDs. The present review highlights the different modifications done to the carboxylic group in Ibuprofen, by various researchers such as estersgramma, amides, hydroxamic acids, and N-substituted hydrazides, along with the integration of heterocyclic moieties like triazoles, tetrazoles, and oxadiazoles. Additionally, Ibuprofen has been hybridized with other drugs and complexed with metals to enhance therapeutic effects. The different synthetic strategies that were employed were esterification, amidation, condensation, Schiff's base formation, etc. These modifications have resulted in derivatives with antimicrobial, antifungal, anticancer, and other biological activities, aiming to reduce side effects while retaining or enhancing antiinflammatory, analgesic, and antipyretic properties.

Preparation of Novel H3PO4 Mixed Sludge‐Sunflower Seeds Husk Biochar and its Application in TC Removal

AbstractThis study primarily focuses on creating a new biochar substance using a combination of sewage sludge and sunflower seed husk. The biochar shows significant efficacy in eliminating tetracycline (TC). The characteristics of biochar, such as SEM, XPS, FT‐IR, and BET, were investigated respectively. After H3PO4 was added to change the surface, the novel biochar exhibited a porous and stiff surface, a larger specific surface area, and more carboxylic acid functional groups. Consequently, the activated biochar exhibited a higher adsorption capacity for TC than the pristine biochar, with values of 39.57 mg/g and 15.74 mg/g, respectively. The pseudo‐second‐order kinetics could describe the sorption of TC on PBCSS and BCSS well (R2 for PBCSS and BCSS is 0.876 and 0.824, respectively). The adsorption process was described using the Langmuir, Freundlich, and Dubinin–Radushkevich adsorption isotherms. Chemical adsorption helps TC and biochar stick to each other. Donor‐acceptor interactions, hydrogen bonds, and electrostatic interactions all make this possible. The study showed that the new biochar has the potential to be an economical adsorbent for the removal of TC from wastewater.

Screening and isolation of polyethylene microplastic degrading bacteria from mangrove sediments in southern China.

Mangrove sediments in southern China are a large reservoir for microplastics (MPs). In particular, polyethylene microplastics (PE-MPs) are environmentally toxic and have accumulated in large quantities in these sediments, posing a potential threat to the overall mangrove and the organisms that inhabit it. We screened sediments from 5mangrove sites and identified a potential source of PE-MP degrading bacteria. We purified the bacterial strains Acinetobacter venetianus E1-1, Serratia marcescens E1-2, Chryseobacterium cucumeris E1-3 and Bacillus albus E1-4 from P1 that were able to reduce the mass of the 75μm PE-MPs substrate by 3.67 to 6.59%, respectively and use it as a sole carbon source. The degradation was accompanied by surface deformation of the MPs and introduction of polar oxygen-containing carbonyl and carboxylic acid functional groups thereby decreasing the hydrophobicity of the substrate. Whole-genome sequencing of S. marcescens E1-2, the most effective degrader, revealed it possesses a variety of enzymes and metabolic pathways related to PE degradation. Our results indicated that the PE-MP degrading bacteria isolated from screened mangrove sediments represent an effective strategy for in situ MP pollution remediation and uncovering mechanisms associated with PE degradation.

Valorization of textile waste for removal of Cadmium from contaminated water

AbstractThe rapid development in agriculture and industrial sectors has raised some serious global issues like heavy metals pollution of water resources. Cadmium (Cd) is amongst the major water pollutants worldwide. In this study, two novel sorbents were prepared by using post-consumer textile waste (PCTW). The waste denim fabric was recycled with environmentally friendly H2O2 and Ozone through oxidation under alkaline conditions to produce several functional groups at the surface (named as ODF@H202 and ODF@03 respectively) that could trap the heavy metal cations from contaminated water. The functionalized fabric sorbents were characterized by Fourier transform infrared spectroscopy (FT-IR), X-Ray diffraction (XRD), scanning electron microscopy (SEM), and energy dispersive X-Ray (EDX) that revealed the presence of carboxylic acid, hydroxyl, and amine functional groups on their surfaces. The sorption isotherm, sorption kinetics and sorption thermodynamics were carried out to unravel the sorption process mechanism. The ODF@H202 sorbent was proved more effective by giving maximum adsorption capacity of (238.09 mg g−1) compared to Ozone treatment (175.44 mg g−1) for Cd2+ and achieved within just 20 min for both sorbents. Pseudo 2nd order and Langmuir models confirmed the chemosorption as dominant mechanism for the monolayer sorption of Cd2+ ions onto ODF@H202 and ODF@03. The sorption thermodynamic revealed the sorption process as endothermic and spontaneous in nature. The results showed that both ODF@H202 and ODF@03 sorbents have an efficient potential for sorbing Cd from contaminated water. Furthermore, both ODF@H202 and ODF@03 sorbents were also tested in a regeneration study to investigate the reuse of these sorbents, and we achieved marvelous results. Both sorbents gave up to 90% of the sorption capacity even after 10 recycles. Conclusively, both sorbents can have their implications for the preparation of filters that can be used for the treatment of wastewater. This study has practical significance by tackling the two environmental problems i.e. heavy metal pollution and denim waste.

Acoustic Wave Sensor Detection of an Ovarian Cancer Biomarker with Antifouling Surface Chemistry.

Ovarian cancer (OC) must be detected in its early stages when the mortality rate is the lowest to provide patients with the best chance of survival. Lysophosphatidic acid (LPA) is a critical OC biomarker since its levels are elevated across all stages and increase with disease progression. This paper presents an LPA assay based on a thickness shear mode acoustic sensor with dissipation monitoring that involves a new thiol molecule 3-(2-mercaptoethanoxy)propanoic acid (HS-MEG-COOH). HS-MEG-COOH is an antifouling linker that provides (a) antifouling properties for gold substrates and (b) linking ability via its terminal carboxylic acid functional group. The antifouling ability of HS-MEG-COOH was tested in whole human serum. The new molecule was applied to the LPA assay in conjunction with a spacer molecule, 2-(2-mercaptoethoxy)ethan-1-ol (HS-MEG-OH), in a 1:1 v/v ratio. HS-MEG-COOH was covalently linked to gelsolin-actin, a protein complex probe that dissociates due to LPA-binding. LPA was detected in phosphate-buffered saline and undiluted human serum and achieved a low limit of detection (1.0 and 0.7 μM, respectively) which was below the concentration of LPA in healthy individuals. The antifouling properties of HS-MEG-COOH and the detection of LPA demonstrate the ability of the sensor to successfully identify the early-stage OC biomarker in undiluted human serum.

Carboxylic Acid Functionalized Ionic Liquid Electrolyte Additives for Stable Zinc Metal Anodes

Aqueous zinc batteries are promising devices among next-generation low-cost rechargeable batteries due to low cost, high specific capacity (820 mAh g-1 and 5,855 mAh cm-2), and safe compatibility of zinc. However, zinc metal anode suffers from irregular zinc deposition and consequent formation of dendrite that deteriorates the cycle life of zinc batteries. Herein, we proposed designing strategies of electrolyte additives for stable metal anode during repeated plating/stripping by using carboxylic acid functionalized imidazolium-based ionic liquid. Imidazolium ionic liquids that has a carboxylic acid functional group (IL-COOH) formed a shielding layer on the zinc surface by electrostatic adhesion, which leads to facilitated Zn2+ ion flux by proper interaction between hydrophilic COOH and Zn2+. It leads to uniform zinc nucleation and deposition. Ex-situ scanning electron microscopy that tracks the Zn deposition verified the suppressed growth of the zinc dendrite by the IL-COOH. High Coulombic efficiency over 99% and a stable life span over 1,400 hr (1 mA cm-2 and 1 mAh cm-2) are achieved in a symmetric zinc cell. Even under harsh plating/stripping conditions (10 mA cm-2 and 5 mAh cm-2), stable cycle performance was retained. These results give obvious evidence of stable Zn deposition and suppressed dendrite growth by a zincophilic and hydrophilic functional group, which provides innovative strategies for a long lifespan of zinc batteries.

Chemical composition and properties of Ski wax: A comprehensive analysis of fluorinated, non-fluorinated, and bio-based waxes

This study analyzes the chemical composition and thermal properties of various ski wax materials, including fluorinated, non-fluorinated petroleum-based, and bio-based waxes. Advanced characterization techniques (FTIR, EDS, and DSC) were used to investigate the chemical functionality, elemental composition, and thermal behavior of these waxes. Fluorinated powder waxes were found to be composed almost entirely of fluorocarbons, while solid fluorinated waxes are primarily hydrocarbons with minimal fluorine content. Bio-based waxes exhibit unique ester and carboxylic acid functional groups. Different brands, models, and suggested temperature uses of waxes within the same physical and chemical type show similar chemical compositions. While petroleum-based compared to bio-based waxes show a significant difference in chemical structure. EDS analysis identified silicon, magnesium, and aluminum in certain waxes, possibly indicating the use of additives. DSC results showed similar thermal behavior at sub-freezing temperatures. This research lays the groundwork for understanding ski wax material science and opens up new avenues for future investigation and innovation in the ski and ski wax industry.

Adsorptive removal of cadmium (II) from wastewater using activated carbon synthesized from stem of Khat (Catha edulis)

IntroductionCadmium is among the most hazardous heavy metals, posing the greatest risk to human beings and the environment. Adsorption with activated carbon prepared from agricultural waste is the most effective way to remove cadmium (II) from wastewater. In this study, activated carbon prepared from the stem of Khat (Catha edulis) plant was used for the removal of cadmium (II) from wastewater. ObjectiveTo evaluate the efficiency and mechanism of the removal of cadmium (II) from wastewater using Khat (Catha edulis) stem activated carbon at different operating parameters. MethodProximate and Fourier transform infrared analyses were conducted to characterise the prepared Khat stem-activated carbon. The effects of initial cadmium concentration, adsorbent dose, pH, contact time, and agitation speed on the cadmium removal efficiency of Khat stem-activated carbon were evaluated. Furthermore, isotherm and kinetic models of adsorption were used to evaluate the mechanism of cadmium removal. ResultThe proximate analysis indicated that the activated carbon derived from Khat stems possesses a bulk density of 0.58 g/cm3 and surface area of 615 m2/g. Additionally, the prepared Khat stem activated carbon has 4 %, 14 %, and 22 % of moisture content, ash content, and volatile matter, respectively. Furthermore, the proximate analysis indicated that the Khat stem activated carbon has a porosity of 55 %. The Fourier transformed infrared spectroscopy result indicated the presence of phenolic, alcoholic, and carboxylic acid functional groups on the surface of Khat stem activated carbon. The experimental data showed a better fit with the Langmuir isotherm model (R-squared and chi-square value of 0.9727 and 1.3936, respectively) and the pseudo-second-order kinetic model (R-squared and chi-square values of 0.9032 and 0.2179, respectively). The highest adsorption efficiency of cadmium (97 %) was attained at an adsorbent dose of 0.125 g, a contact time of 30 min, an initial cadmium concentration of 20 mg/L, a pH of 5, and an agitation speed of 100 rpm at room temperature (25 °C). ConclusionThe results obtained in this research demonstrated that activated carbon from Khat stems can be employed as an economical, ecologically friendly, easily accessible and efficient activated carbon to remove Cd (II) from wastewater.

Conversion of Carboxylic Acids to Sulfonamide Bioisosteres via Energy Transfer Photocatalysis.

More than 450 drugs containing a carboxylic acid functional group have been marketed worldwide. Herein, we report a concise and environmentally friendly organic photoinduced protocol for the interconversion of carboxylic acids into their bioisosteres. With this strategy, a variety of substrates, including alkyl, (hetero)aryl, and alkenyl acids, as well as various biologically relevant acids are successfully converted into primary sulfonamides.

Crystal structure of perfluorononanoic acid, C9HF17O2

The crystal structure of perfluorononanoic acid (PFNA) was solved via parallel tempering using synchrotron powder diffraction data obtained from the Brockhouse X-ray Diffraction and Scattering (BXDS) Wiggler Lower Energy (WLE) beamline at the Canadian Light Source. PFNA crystallizes in monoclinic space group P21/c (#14) with lattice parameters a = 26.172(1) Å, b = 5.6345(2) Å, c = 10.9501(4) Å, and β = 98.752(2)°. The crystal structure is composed of dimers, with pairs of PFNA molecules connected by hydrogen bonds via the carboxylic acid functional groups. The Rietveld-refined structure was compared to a density functional theory-optimized structure, and the root-mean-square Cartesian difference was larger than normally observed for correct powder structures. The powder data likely exhibited evidence of disorder which was not successfully modeled.

Activatable Heavy-Atom-Free Photosensitizer with Large Stokes Shift and a NIR-II Emission Harnessing Rhodamine Ring-Opening Strategy.

Activatable photosensitizers (PSs) generating 1O2 only under specific conditions can minimize concomitant injury to normal tissues. Heavy-atom-free PSs hold the merits of low dark toxicity, long triplet-state lifetimes, good photostability, and relatively low cost. PSs with emission in the second near-infrared (NIR-II) window are highly valuable for deep-tissue, high-contrast imaging. Herein, we have designed and synthesized a series of heavy-atom-free PSs by a one-step reaction between an easily accessible rhodamine derivative and commercially available thiophene aldehydes. One of the as-prepared PSs, 2b-3T, exhibits emission maxima at 810 nm and tails to the NIR-II region at 1140 nm, together with large Stokes shift (178 nm). Importantly, the newly developed PSs, featuring functional carboxylic acid groups, present promising opportunities as versatile platforms for creating activatable PSs. To validate our concept, we developed Cu2+/pH-activatable PSs using the spirocyclization mechanism of rhodamine. Ultimately, we showcased the effectiveness of these innovative PSs in photodynamic therapy through in vitro experiments.

Efficient removal and reusage of acid soluble oil in waste H2SO4 of isobutane alkylation by low-temperature carbonization process

Waste H2SO4 from industrial isobutane alkylation, a hazardous thick liquid with a high concentration of acid soluble oil (ASO) impurities, poses challenges in the regeneration process. Herein, an innovative low-temperature carbonization process was proposed to convert waste H2SO4 into the regenerated concentrated H2SO4 and sulfonated activated carbon materials (SACMs) under mild reaction conditions. The optimal reaction temperature is identified at 423.15 K with the highest TOC removal of 90.57%. The high-purity regenerated H2SO4 with a concentration of 95% as a catalyst for isobutane alkylation exhibits excellent catalytic performance with 94.54 research octane number (RON) of the alkylate. SACMs, characterized as a novel porous carbon material with plentiful hydroxyl, carboxylic acid, and sulfonic acid functional groups, demonstrate an efficient catalytic activity in the dimerization of lactic acid to produce lactide with a yield of 46.95%. Hopefully, the novel recovery process provides a promising application to optimize the regeneration process of waste H2SO4 from industrial isobutane alkylation.

H3trica: Versatile Macrocyclic Chelator for [225Ac]Ac3+ and [155/161Tb]Tb3+ Theranostics.

H3trica is a nonadentate chelating ligand intended for coordinating large radiometal ions, such as those used in nuclear medicine. This chelator, featuring a triaza-18-crown-6 macrocycle with three pendant carboxylic acid functional groups, was synthesized and characterized. Complementary nuclear magnetic resonance (NMR) spectroscopy and high-resolution electrospray-ionization mass spectroscopy (HR-ESI-MS) studies were used to explore the coordination of H3trica with metal ions such as La3+, Y3+ (as a model for Tb3+), and Lu3+ at the bulk scale. Thermodynamic solution studies provided valuable insights, highlighting robust metal complexation of H3trica with La3+, Tb3+, and Lu3+, with the most noteworthy log KML value observed for Tb3+ (log KTbL = 17.08), followed by La3+ (log KLaL = 16.64) and Lu3+ (log KLuL = 16.25). Concentration-dependent radiolabeling studies with [225Ac]Ac3+, [155Tb]Tb3+, and [161Tb]Tb3+ demonstrated rapid complexation (5-30 min) under mild conditions (pH 6-7, 25 °C). Importantly, the radiolabeled complexes exhibited stability during incubation in human serum for one-half-life of the corresponding radiometal. Thus, H3trica emerges as a valuable chelator, demonstrating its potential to coordinate the theranostic couple [225Ac]Ac3+/[155Tb]Tb3+ as well as the powerful terbium quartet ([149/152/155/161Tb]Tb3+) with efficiency and stability.

Sugar derived hydrochar catalysts for enhanced biodiesel production via esterification

Sugars and sugar alcohols are renewable raw materials which can be used for char production. Their acid-catalyzed hydro-carbonization results in the formation of carbon materials with acidic functional groups on the surface, which makes them suitable to be used as heterogeneous catalysts in esterification reactions. Hydrochars materials were prepared by low-temperature slow carbonization of glycerol, xylitol, sucrose, and glucose in the presence of different amounts of H2SO4 (mass ratios from 1 to 4). The hydrochars were extensively characterized and tested in the methanolysis reaction of oleic acid. All the carbon materials were amorphous with features of polyaromatic sheets with hydroxyl (–OH), carboxylic acid (–COOH), and sulfonic (−SO3H) functional groups. The effect of the oleic acid water content on catalytic performance was studied, showing a strong inhibition effect due to the hygroscopic character of catalysts induced by sulfonic groups and other surface groups with oxygen. Under the conditions evaluated (5 % wt. of catalyst, methanol/oleic acid = 9 M ratio, methanol reflux temperature) the sucrose-derived catalyst prepared with the highest H2SO4 content showed the best performance, leading to methyl oleate yield > 90 % after 2 h of reaction, which is only achieved by the majority of analogous catalysts reported in the literature after 4 to 8 h of reaction. The data showed that there is a correlation between the methyl ester yield and the graphitization of the catalyst, as this makes the catalyst more hydrophobic, which is an advantage in esterification catalysts.

Gelation and Plugging Performance of Low-Concentration Partially Hydrolyzed Polyacrylamide/Polyethyleneimine System at Moderate Temperature and in Fractured Low-Permeability Reservoir.

HPAM/PEI gel is a promising material for conformance control in hydrocarbon reservoirs. However, its use in low-permeability reservoirs is limited by the high polymer concentrations present. In this study, the gelation performance of an HPAM/PEI system with HPAM < 2.0 wt.% was systematically investigated. The gelation time for HPAM concentrations ranging from 0.4 to 2.0 wt.% varied from less than 1 h to 23 days, with the highest gel strength identified as grade H. The hydrodynamic radius manifested the primary effect of HPAM on the gelation performance. Branched PEI provided superior gelation performance over linear PEI, and the gelation performance was only affected when the molecular weight of the PEI varied significantly. The optimal number ratio of the PEI-provided imine groups and the HPAM-provided carboxylic acid functional groups was approximately 1.6:1~5:1. Regarding the reservoir conditions, the temperature had a crucial effect on the hydrodynamic radius of HPAM. Salts delayed the gelation process, and the order of ionic influence was Ca2+ > Na+ > K+. The pH controlled the crosslinking reaction, primarily due to the protonation degree of PEI and the hydrolysis degree of HPAM, and the most suitable pH was approximately 10.5. Plugging experiments based on a through-type fracture showed that multi-slug plugging could significantly improve the plugging performance of the system, being favorable for its application in fractured low-permeability reservoirs.

An Optimized Method for LC-MS-Based Quantification of Endogenous Organic Acids: Metabolic Perturbations in Pancreatic Cancer.

Accurate and reliable quantification of organic acids with carboxylic acid functional groups in complex biological samples remains a major analytical challenge in clinical chemistry. Issues such as spontaneous decarboxylation during ionization, poor chromatographic resolution, and retention on a reverse-phase column hinder sensitivity, specificity, and reproducibility in multiple-reaction monitoring (MRM)-based LC-MS assays. We report a targeted metabolomics method using phenylenediamine derivatization for quantifying carboxylic acid-containing metabolites (CCMs). This method achieves accurate and sensitive quantification in various biological matrices, with recovery rates from 90% to 105% and CVs ≤ 10%. It shows linearity from 0.1 ng/mL to 10 µg/mL with linear regression coefficients of 0.99 and LODs as low as 0.01 ng/mL. The library included a wide variety of structurally variant CCMs such as amino acids/conjugates, short- to medium-chain organic acids, di/tri-carboxylic acids/conjugates, fatty acids, and some ring-containing CCMs. Comparing CCM profiles of pancreatic cancer cells to normal pancreatic cells identified potential biomarkers and their correlation with key metabolic pathways. This method enables sensitive, specific, and high-throughput quantification of CCMs from small samples, supporting a wide range of applications in basic, clinical, and translational research.

Real-Time Identification of Aerosol-Phase Carboxylic Acid Production Using Extractive Electrospray Ionization Mass Spectrometry.

Comprehensive identification of aerosol sources and their constituent organic compounds requires aerosol-phase molecular-level characterization with a high time resolution. While real-time chemical characterization of aerosols is becoming increasingly common, information about functionalization and structure is typically obtained from offline methods. This study presents a method for determining the presence of carboxylic acid functional groups in real time using extractive electrospray ionization mass spectrometry based on measurements of [M - H + 2Na]+ adducts. The method is validated and characterized using standard compounds. A proof-of-concept application to α-pinene secondary organic aerosol (SOA) shows the ability to identify carboxylic acids even in complex mixtures. The real-time capability of the method allows for the observation of the production of carboxylic acids, likely formed in the particle phase on short time scales (<120 min). Our research explains previous findings of carboxylic acids being a significant component of SOA and a quick decrease in peroxide functionalization following SOA formation. We show that the formation of these acids is commensurate with the increase of dimers in the particle phase. Our results imply that SOA is in constant evolution through condensed-phase processes, which lower the volatility of the aerosol components and increase the available condensed mass for SOA growth and, therefore, aerosol mass loading in the atmosphere. Further work could aim to quantify the effect of particle-phase acid formation on the aerosol volatility distributions.

Evidences for the influence from key chemical structures of per- and polyfluoroalkyl substances on their environmental behaviors

This study carried out the atmospheric and precipitation observation in Beijing for nearly one year, and firstly simultaneously observed the pollution characteristics of PFASs and their main isomers, focusing on their gas-particle partitioning mechanism and dry and wet deposition characteristics. After deducting PFASs in the aqueous phase of particulate matter, the gas-particle partitioning coefficients (−7.04 to −5.49) were about 3–4 units smaller than before (−2.77 to −1.51), and all were smaller than 0, which indicated that each PFAS and isomer were more distributed in the gas phase. Dry deposition was dominant in the atmospheric deposition of each PFAS and isomer with relative contribution of 66 ± 17%, but the relative contribution of dry deposition was significantly different. It was found that the gas-particle partitioning coefficient can be influenced by key chemical structures such as carbon chain length, functional group type, and isomer structure. Furthermore, the gas-particle partitioning can influence the dry and wet deposition of PFASs. Specifically, PFASs with longer carbon chains, carboxylic acid functional group (compared to sulfonic acid functional group) or PFOA branched chain structures had larger gas-particle partitioning coefficients and can be more distributed in the hydrophobic phase of particulate matter, and their relative contributions of dry deposition were smaller.

Surface functionalized visible light-responsive yttrium orthovanadate for photocatalytic hydrogen production

Yttrium orthovanadate (YVO4), a wide-bandgap photocatalyst was tuned into a visible responsive material by anchoring an organic framework on the surface of YVO4 nanoparticles using polyethyleneimine (PEI). The surface organic framework was identified as the decomposed PEI derivatives with the carbonyl and carboxylic acid functional groups by the FTIR and XPS analyses. The top of the valence band (VB) was raised and the bottom of the conduction band was moved down; hence, the band gap of YVO4 was reduced to absorb the light in the visible region for all three synthesized samples, which was confirmed by DRS UV–Vis analysis. The functional groups facilitated more water molecules on the YVO4 surface via hydrogen bonding; hence, the YVO4 surface acquired superhydrophilicity. Among the three YI, YII, and YIII samples synthesized with three different calcination temperatures of 80, 260 and 400 °C respectively, YII showed many advantageous photocatalytic properties. The optimum loading of organic compounds obtained on YII surface at 260 °C, which improved the surface area, visible light absorption, hydrophilicity, and exciton's life. Hence, YII showed a better performance of 3.75 mmol h−1g−1cat H2 production than YI and YII. This work interestingly revealed the influence of calcination temperature on surface functionalization and the performance of catalytic materials.

Hyaluronic acid functionalized citric acid dendrimer/UiO-66-COOH as a stable and biocompatible platform for daunorubicin delivery

This work aimed to prepare a new system for daunorubicin (DNR) delivery to improve therapeutic efficiency and decrease unwanted side effects. Typically, at first, a carboxylic acid functional group containing metal-organic framework (UiO-66-COOH) was synthesized in a simple way. Then, a third generation of citric acid dendrimer (CAD G3) was grown on it (UiO-66-COOH-CAD G3). Finally, the system was functionalized with pre-modified hyaluronic acid (UiO-66-COOH-CAD-HA). SEM analysis displayed that the synthesized particles have a spherical shape with an average particle size ranging from 260 to 280 nm. An increase in hydrodynamic diameter from 223 nm for UiO-66-COOH to 481 nm for UiO-66-COOH-CAD-HA is a sign of success in the performed reactions. Also, the average pore size was calculated at about 4.04 nm. The DNR loading efficiency of UiO-66-COOH-CAD-HA was evaluated at ∼74 % (DNR@UiO-66-COOH-CAD-HA). It was observed that the drug release rate at a lower pH is more than higher pH. The maximum hemolysis of <3 % means that the UiO-66-COOH-CAD-HA is hemocompatible. The use of DNR-loaded UiO-66-COOH-CAD-HA led to cell-killing of 77.9 % for MDA-MB 231. These results specified the great potential of UiO-66-COOH-CAD-HA for tumor drug delivery, so it could be proposed as a new carrier for anticancer agents to minimize adverse effects and improve therapeutic efficacy.