Carboxyamide Group Research Articles

The Crystal Structure of m-Hydroxybenzamide

Abstract Crystals of m-hydroxybenzamide are monoclinic with four molecules in a unit cell of dimensions a=11.59, b=5.03, c=15.53 Å, β=136.1°, space group P21⁄c. An approximate angular orientation of the molecule in the cell was quickly obtained by an application of the vector-set seeking method. The location of the molecule was then determined with the help of the orientation. The positional and anisotropic thermal parameters of the carbon, nitrogen and oxygen atoms were refined by means of the least-squares method with three-dimensional intensity data. The final R factor was 0.138. The carboxyamide group and benzene ring twist to each other about the C-C bond by an angle of 24.4°. The interatomic distances and bond angles are close to those expected. The molecules are linked by three types of hydrogen bonds to form the infinite double-layered sheets perpendicular to the c axis, and the crystal structure shows somewhat different features from those of the related compounds.

Potentiation of the toxicity to insects and mice of phosphorothionates containing carboxyester and carboxyamide groups

The toxicity to mice of seven phosphorothionates containing carboxyester and carboxyamide groups was potentiated by EPN, tri- o-cresyl phosphate, and tri- o-cresyl phosphorothionate, in confirmation of the hypothesis that the principal mode of potentiation by such compounds is their inhibition of carboxyesterase or carboxyamidase degradation. However, the toxicity of an eighth compound, cis-thionophosdrin, was not potentiated by EPN. The toxicity of one compound, Dowco 109, which does not contain a carboxyester or carboxyamide group, was also potentiated, but the toxicities of two other such compounds were not. Potentiation was also shown in the case of the American cockroach and the housefly, but to a lesser extent than in the mouse.