Previously it was found that methyl o-hydroxybenzoylpyruvate was easily converted into 1,2-diaryl[1], 1-aryl-2-heteryl[2], or 2-alkyl-1-aryl-1,2-dihydrochromeno[2,3-c]pyrrole-3,9-diones [3]. Isatin and its N-alkyl derivatives are known to behave in many transformations like aromatic aldehydes. We found that the short-time heating of equimolar amounts of methyl ohydroxybenzoylpyruvate I, N-methylisatin II, and aliphatic amines IIIa, IIIb in methanol afford spiro derivatives of 3-hydroxy-3-pyrrolin-2-one IVa, IVb in high yield. This three-component cyclocondensation has been well studied [4], but isatin and its derivatives have not been used as carbonyl components. Pyrrole derivatives IV possess acidic properties and form adducts with aliphatic amines. Compound IVb exists as an internal salt. Similar adducts with monoethanolamine were described [5].