This research is an attempt to suppress the spread of COVID-19 in public buildings through the application of materials that may prevent the spreading of SARS-CoV-2 while at the same time improving audial comfort in such buildings. Study on the capability of materials to break further spreading of the virus applied by measuring the presence of SARS-CoV-2 RNA on the material based on exposure time (0, 3, 6, and 9 minutes). This RNA tracing procedure is repeated on the surface of aluminum, tiles, carbon steel, glass, gypsum, copper, and painted cement on the wall. The results showed that the CT value (cycle threshold) of all materials was approximately 25, which means that they still have the potential to spread the virus. Slightly different results occur on the gypsum surface where the viral envelope (gene E) is not detected with a CT value of 36, meaning no chance of the virus spreading. The same materials will undergo measurement of sound absorptive characteristics to assess their effect on the audial comfort in the building. The results of the study are expected to be a reference before their application as interior materials in public buildings.