As CFRP (carbon fiber-reinforced polymer) offers high retrofit efficiency for structural members in bending and shear due to its superior mechanical properties compared to steel, sheets made from this material have become ubiquitous in strengthening existing reinforced concrete (RC) structures. However, there needs to be more research on RC beams with no stirrups that have been shear-strengthened with side-bonded CFRP sheets. As such, this study aims to investigate this specific topic and assess design-related parameters that impact the load-bearing capacity of these shear-strengthened beams. To achieve this, nonlinear finite element models of four RC beams, including one control beam and three beams strengthened with side-bonded CFRP sheets, were built and verified regarding shear capacity, crack patterns, and failure mechanisms. The simulated beams demonstrated a high level of accuracy in all mentioned aspects. Numerical models were then developed to evaluate the design-oriented parameters that affect the response of shear-strengthened beams, including the concrete compressive strength, the amount of steel reinforcement, the number of CFRP layers, the CFRP bonding configuration, and the shear span-to-effective depth ratio. The results showed that not only the compressive strength of the concrete but also the amount of steel longitudinal reinforcement had a significant relationship with the load-bearing capacity of shear-strengthened beams. Meanwhile, the bonding configuration and the layer number of side-bonded CFRP sheets considerably influenced the ductility, the crack pattern, and the failure mode of shear-strengthened beams.