Dynamic magnetic resonance elastography (MRE) is a new imaging technique 1 recently developed for the noninvasive determination of biomechanical properties of biological tissue. 2 Compared to traditional medical palpation techniques, MRE is characterized by a high spatial resolution and a high sensitivity to the varying stiffness between healthy and pathologic tissues even in nonaccessible body regions. 3 Moreover, MRE also provides new information for other research fields. We report the spatially and temporally resolved observation of the sol/gel phase transition in a thermo-reversible gel. Observed wave patterns were reproduced using a model calculation based on temperature-dependent biomechanical properties of the sample. Dynamic MRE is based on the visualization of propagating shear waves in harmonically excited samples. The shear waves are usually generated mechanically with excitation frequencies between 50 and 600 Hz. 1 Minimum amplitudes for particle displacement are in the order of 0.1 Im. This enables the transmission of shear waves with low damping into the sample. The wave patterns, which depend on the local biomechanical properties of the sample, are visualized by using motion-sensitive MRI techniques. 1 Maps of local shear stiffness or shear moduli (elastograms) can be reconstructed from the wave images. 4 The gel phantom was prepared by dissolving 22.5 g of agar (1.5%) in 1.5 L of water heated to 90 °C. The fluid gel was examined in a double-walled container open at the top. The cooling of the sample (total cooling time 5 h), monitored with a thermometer between 60 and 25 °C, showed an exponential time dependence. Shear waves with a frequency of 200 Hz were induced parallel to the B0-field direction (z) by a copper coil fixed to a pivoting carbon fiber rod connected with the surface of the gel. The excitation device was fixed to the standard head coil of a clinical scanner (1.5 T, Siemens, Erlangen, Germany). Data were
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