A common problem of concrete bridges is corrosion damages of the steel reinforcement. The related loss of capacity as well as visual effects often require expensive and elaborate refurbishment or even reconstruction. To overcome these drawbacks, the application of non-corrosive fiber reinforced polymer (FRP) reinforcement in concrete structures has been established and investigated throughout the last three decades. The successful application of prestressed carbon fiber reinforced polymer (CFRP) reinforcement in bridge constructions was demonstrated by several projects realized in the United States and Canada. Nevertheless, despite the successful realization of these projects, a widespread application has not yet been possible due to the lack of consistent and approved design regulations. In Germany and Europe, the use of FRP reinforcement in bridge construction is even limited to individual cases and non-prestressed reinforcement. Thus, further investigations are necessary to develop a comprehensive guideline for the design of members with pre-tensioned CFRP tendons in compliance with current codes of practice.In order to achieve this objective, a flexural design model for the design of bridge girders prestressed with CFRP reinforcement was developed. In this paper, the reliability analysis of the flexural design model applied to a modular footbridge system pre-tensioned with CFRP tendons is presented. Stochastic simulations are conducted to evaluate the safety of the developed footbridge concepts and to determine an appropriate partial safety factor for the CFRP tendons. For this purpose, the reliability requirements according to the specifications of Eurocode 0 (EC0) are analyzed and evaluation benchmarks are defined to allow for a sufficient reliability of the bridges. The statistical characteristics of the variable parameters needed for the analysis were defined based on a literature review and own investigations.