The successful implementation of supercritical carbon dioxide technology in the production of new drugs with enhanced bioavailability necessitates an assessment of the solubility of the drug in supercritical carbon dioxide. In this investigation, the solubility of Levetiracetam in green solvent with ethanol (co-solvent) was conducted. The investigation was considered at pressures of 120, 150, 180, 210, 240, 270, and 300 bar and temperatures of 308, 318, 328 and 338 K. The solubility of Levetiracetam in supercritical carbon dioxide + ethanol is measured at two mole fractions of the ethanol (1 and 3 mol %). The results show that the solubility is enhanced to a range of 0.940 × 10−4 to 6.087 × 10−4 (1 mol %) and 1.971 × 10−4 to 15.485 × 10−4 (3 mol %). In the 3 mol % of ethanol at 300 bar and 338 K the highest solubility of Levetiracetam is obtained (15.485 × 10−4). Furthermore, some semi-empiricals are employed to correlate the solubility of Levetiracetam in scCO2 + co-solvent. The results confirmed that all models have a good description of the data and the Soltani-Mazloumi model is the best to correlate the data (AARD of 5.28 %). Furthermore, the solubility values of the drug in the ternary system indicated the potential utility of the RESS method for the production of micro- and nano-medicine.