This research work focuses on the efficacy of minimum quantity lubrication (MQL) and cryogenic carbon dioxide (CO2) cooling in high-speed machining of nickel-based alloy. CO2 and MQL supplied in the rake face were compared to CO2 and MQL in turning of Monel 400. Tool wear, temperature, surface roughness, and microstructural assessments were done to compute the cooling influence of distinct approaches. Energy dispersive spectrometry (EDS) mapping is employed to investigate the abrasion and adhesion mechanisms. The wear levels were reduced under the use of the hybrid approach; the decrease in flank wear value relative to the hybrid condition is 78%, 36%, and 27%, and in terms of crater wear, the reduction was 78%, 54%, and 48% over dry, MQL, and cryo CO2 conditions, respectively. Findings have portrayed that the lessening of temperature at the cutting area with the hybrid condition reduces the roughness by 58%, 44%, and 20% over dry, MQL, and cryo CO2 cutting strategies, respectively. Moreover, verdicts of the investigation confirm smaller grain size and high hardness under cryo cooling condition.