This paper employs fractional calculus (FC) for modeling three-dimensional prey-predator populations model. This study uses an eco-epidemiological system in which the prey disease is constructed as a susceptible-infected (SI) disease. The Caputo and Caputo-Fabrizio (CF) operators are consolidated into this model and the existence of a solution is explored. The model is evaluated for uniqueness under what conditions it provides a unique solution. Based on the singular kernel of the Caputo operator, we investigate the properties of the proposed model and show it can be stable locally. We developed maximum bifurcation diagrams to analyze the dynamics of the epidemiological model as varying transmission rates β and attack rates b1. To simulate the dynamics of proposed fractional systems, we employed the Toufik-Atangana (TA) numerical technique with the Caputo operator. Moreover, we present another numerical approach based on Adams-Bashforth (AB) technique with CF operators. Results of the numerical analysis show that diverse non-integer operator alternatives to the eco-epidemiological predator-prey model result in a range of dynamical behaviors.
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