Europäische Wissenschaftliche Gesellschaft Home About the Journal Peer Review Editorial Board For Authors Reviewer Recognition Archiv Kontakt Impressum EWG e.V. indexing in the Clarivate Analytics indexing in the Emerging Sources Citation Index Crossref Member Badge Erfolgreich durch internationale Zusammenarbeit DENTISTRY Cite as: Archiv EuroMedica. 2022. 12; 3: e1. DOI 10.35630/2199-885X/2022/12/3.27 Received 26 April 2022; Received in revised form 13 May 2022; Accepted 16 May 2022 DIAGNOSTIC FEATURES OF VIRUS-ASSOCIATED DISORDERS OF THE ORAL MUCOSA Svetlana Gazhva , Yulia Ibragimova , Alina Tsirdava, Adeliya Cherkasova, Alexandra Navolokina , Lev Sergeev Privolzhsky Research Medical University, Nizhny Novgorod, Russia download article (pdf) yuliatalipova@mail.ru ABSTRACT About 9500 neoplasms of the oral mucosa compromised by Covid infection are registered annually in Russia. They have high mortality rates - more than 50%. One of the risk factors for occurrence of malignant neoplasms of the oral mucosa are human papillomaviruses and Epstein-Barr virus, the mechanism of carcinogenesis of which is not fully understood and is still a subject of research. At the same time, the virus-associated pathology tends to grow, increasingly impacting younger people. With good visual accessibility of the oral mucosa, advanced cases of oncopathology (3-4 stages) are observed quite often (67%), preceded by undiagnosed virus-associated processes. The aim of this study is to optimize the early diagnosis of the mucosal virus-associated processes and to prevent malignization. We examined 375 patients of both sexes aged 18 to 65 years with various diseases of the oral mucosa. 18% of them were carriers of human papillomavirus (HPV) and Epstein-Barr. The examination algorithm included a clinical stage (instrumental examination, index assessment, autofluorescent stomatoscopy) and a laboratory stage (liquid cytology, PCR diagnostics of human papillomavirus and Epstein-Barr, and, if EBV was detected, an immunochemical blood test for capsid and nuclear antigens). The results of the study show that pathological changes in the oral mucosa and the red border of the lips associated with viral damage, which manifests itself in the form of hyperkeratosis (40 people - 59%), cheilitis (12 people - 17.6%), long-term non-healing erosive and ulcerative phenomena (9 people - 13.1%), oncopathologies (7 people - 10.3%). Thus, our diagnostic algorithm for examining patients with oral mucosal disorders reduces enables to reduce the risk of oncopathology and its neglected forms.