Capping Strategy Research Articles

Reconsidering the International Business Capstone: Capping, Bridging, or Both?

The capstone experience has become ubiquitous in undergraduate education. Originally, it served as a terminal display of academic excellence and bridging experience between study and work; more recently, however, it has been seen in terms of academic completion and consolidation. In times of increased turbulence for new business graduates, and in an international business (IB) landscape where appreciation of sociocultural and communication skills are critical, capstone experiences can provide a valuable means of demonstrating relevant and transferable professional competencies. This article considers the origins and context of the capstone, its evolutionary history, and current potential. It uses an analysis of undergraduate dissertations of non-American students studying at an American college in the Czech Republic to explore capping, bridging, and balanced strategies.

Dendritic Arenethiol-Based Capping Strategy for Engineering Size and Surface Reactivity of Gold Nanoparticles

The report describes a strategy for the synthesis of gold nanoparticles for which size and surface reactivity of the particles are controlled by the molecular sizes of dendritic arenethiols (DAT) as capping agents. This strategy exploits two important attributes of the DAT molecules: one involving the utilization of the umbrella-like structure with a single thiol as the anchorage handle and the other involving the rib with an expandable dendritic structure as a spacing-tunable cap. The synthesis of gold nanoparticles with controllable sizes below 10 nm has been demonstrated using different sizes of DAT in both one-phase and two-phase solutions. The unique structural properties of the dendritic arenethiol capping molecules not only enable the ability to control size growth of gold nanoparticles but also ready surface exchange reaction for surface derivatization and interparticle assembly. The viability of this strategy for the control of size and surface reactivity has been demonstrated by results from the structural and morphological characterizations of the nanoparticles and assemblies.

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Abstract Cover Story More budget cuts could undo programs, compromise athletes' safety Minimize risk by finding ways to stem cuts, reductions The bottom line: Coping with budget cuts The Two‐Minute Drill College wins top diversity award from NCAA Men's basketball tournament expanding to 68 teams University to make switch from Division I to Division III NCAA sanctions IUPUI for eligibility errors Leaders & Innovators ERIC ZILLMER, ATHLETICS DIRECTOR, DREXEL UNIVERSITY AD takes gender equity to new levels Talk about gender equity to get desired results Title IX Time to review your method for measuring Title IX compliance What is the 3‐prong test? Model survey courts controversy from start NCAA Update Mitigate factors that can cause lengthy investigations Understand the investigation process Managing Your Office Use CAP strategy to achieve buy‐in for change Strategy works to manage up Use strategy to change staffers' nonproductive behavior You Make The Call Can university claim sovereign immunity against injured athlete's claims? Lawsuits & Rulings DISABILITY DISCRIMINATION School district must ensure accessibility at stadium NEGLIGENCE Districts face Title IX claims over preferred game dates DISCRIMINATION Athlete loses most claims in discrimination lawsuit A Conversation With … SCOTT MCQUILKIN, ACTING VP FOR INSTITUTIONAL ADVANCEMENT, WHITWORTH UNIVERSITY Former AD offers pointers on athletics fundraising Resources/Ideas Book features longtime college AD Customized bus = savings, recognition Names in the News

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Abstract Cover Story 4‐pronged approach to attracting transfers boosts enrollment at DePaul Comprehensive approach boosts transfer enrollment Keep these principles in mind for success recruiting transfers News & Notes Private colleges predict enrollment will increase slightly in the fall Funding cuts in student services lower graduation rates Charges dropped against hacker who sought better security Court indicts leader, 64 others in massive financial aid fraud scheme Compliance Respond to census‐worker requests with caution Tools of the Trade Let needs drive purchase of document‐imaging system Plan carefully for document‐imaging implementation Ongoing projects boost value of document‐imaging system Ethics When should you communicate about staffing cuts? Professional Development Use the CAP strategy to achieve buy‐in for change Use strategy to change staffers' nonproductive behavior Strategy works to manage up Lawsuits & Rulings FINANCIAL AID School must issue degree, transcripts or pay $10,000 fine FERPA FPCO initiates own investigation of FERPA violations FPCO recommends implementing privacy safeguards to protect education records ACADEMIC AFFAIRS Ruling dashes Ph.D. candidate's last hope for degree Leaders & Innovators ROLAND A. COTÉ, REGISTRAR AND ASSC. VICE PROVOST FOR ENROLLMENT MANAGEMENT, INDIANA UNIVERSITY AT BLOOMINGTON Hire staff members with passion, ability to work with faculty Guide staff members through change

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Abstract Cover Story It's time to start ‘tweeting’ to reach prospective students Is it time for your unit to use Twitter as part of its marketing mix? The bottom line on using Twitter Check out these resources to learn more Briefing Create more off‐campus admissions shops 2‐year colleges offer more adult programming Be wary of disgruntled former staffers Transitions Start a Facebook page to stay connected to students What Would You Do? How would you keep classes on track after natural disaster? Retention Create committee, annual plan to address retention goals Try coaching to increase retention Help students create degree completion maps Managing Your Office Use the CAP strategy to achieve buy‐in for change Use this strategy to manage up Change staffers' nonproductive behavior with this strategy Program Profile Entice students into enrolling by offering credit for prior learning At a glance... Tips on getting faculty buy‐in Lawsuits & Rulings ADMINISTRATION Company that provided online course support can't enforce illegal contract ENROLLMENT MANAGEMENT Court dismisses former University of Phoenix employee's claims Student wins battle, loses money in breach of contract claim Leaders & Innovators JOAN DOLAMORE, DEAN OF LIFELONG LEARNING, WENTWORTH INSTITUTE OF TECHNOLOGY Collaborate with local industries to create degree programs Avoid these 5 mistakes

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Abstract Cover Story Prepare to meet mental health needs of veterans on campus Make changes to address mental health needs of vets Try 4 ideas for welcoming vets Follow these tips to help student vets with mental health needs Many vets have brain injuries Briefs Brown considers a slavery memorial Biden tours Penn, views energy model Farmers' markets moving to college campuses Georgia Tech staff misuse state cards Assessment Advice Try alternatives to surveys for assessment Student Development Create residential seminars to aid in student success Follow 11 steps to ensure successful residential seminars Student Conduct Use online rehab program to help more students stay in college Patients prefer anonymity of group Managing Your Office Use the CAP strategy to achieve buy‐in for change You Be The Judge Did nondiscrimination policy deny students' constitutional rights? Law & Campus SECURITY University faces jury trial in student's murder DISCRIMINATION OCR orders revision of nondiscrimination notice ACCOMMODATIONS Athletic facility falls short of disability standards JUDICIAL AFFAIRS Court clears student found guilty of plagiarizing final exam COPYRIGHT INFRINGEMENT University must identify file‐sharing students Leaders & Innovators EUGENE L. ZDZIARSKI, II, VICE PRESIDENT FOR STUDENT AFFAIRS AND DEAN OF STUDENTS, ROANOKE COLLEGE Transition from large to small college yields valuable lessons Word of Advice Find the right fit

Trace Element Uptake by Mitchell Grasses Grown on Mine Wastes, Cannington Ag–Pb–Zn Mine, Australia: Implications for Mined Land Reclamation

This study was conducted to determine the metal (Ag, Al, As, Cd, Co, Cu, Fe, Mn, Ni, Pb, Sb, Zn) tolerance and uptake of Mitchell grasses when grown on waste rocks and tailings of a base metal mine, Australia. The objective of conducting such phytoremediation studies was to gain data relating to the implementation and effectiveness of capping and revegetation strategies for mine waste repositories in regions of native grasslands. Pot trials demonstrate that Mitchell grasses are metal tolerant and have the ability to accumulate significant concentrations of metals (Pb, Zn) into their above-ground biomass. Concentrations of metals in Mitchell grasses were evaluated in terms of maximum allowable dietary levels in livestock. The pot trial project revealed that if Mitchell grasses were to be used for mined land reclamation and were grown on tailings, the grasses could potentially accumulate large quantities of Zn in their tissue, potentially causing harmful effects on animals feeding on them. Hence, it is undesirable that Mitchell grasses are grown on and their root system come in contact with tailings with elevated level of Zn. Otherwise, the species may accumulate phyto- and zootoxic concentrations of Zn. The metal tolerance, the tendency to accumulate metals in the above-ground biomass and the significant root penetration depth of Mitchell grasses have implications for the design of tailings storage facilities. Capping of waste repositories, containing elevated metal concentrations and using a cover system without capillary breaks, clay layers or alternative strategies, may not be sustainable in the long term. The application of phosphate amendments to tailings may represent an alternative strategy to limit the uptake of metals by Mitchell grasses. The pot trials prove that the addition of phosphate to mine wastes decreases the bio-availability of metals in these materials and reduces the Pb and Zn concentration in Mitchell grasses growing on them. Thus, the addition of phosphate amendments to the top layers of metalliferous mine wastes may represent an alternative waste management strategy.

Metal ion-dependent, reversible, protein filament formation by designed beta-roll polypeptides

BackgroundA right-handed, calcium-dependent β-roll structure found in secreted proteases and repeat-in-toxin proteins was used as a template for the design of minimal, soluble, monomeric polypeptides that would fold in the presence of Ca2+. Two polypeptides were synthesised to contain two and four metal-binding sites, respectively, and exploit stacked tryptophan pairs to stabilise the fold and report on the conformational state of the polypeptide.ResultsInitial analysis of the two polypeptides in the presence of calcium suggested the polypeptides were disordered. The addition of lanthanum to these peptides caused aggregation. Upon further study by right angle light scattering and electron microscopy, the aggregates were identified as ordered protein filaments that required lanthanum to polymerize. These filaments could be disassembled by the addition of a chelating agent. A simple head-to-tail model is proposed for filament formation that explains the metal ion-dependency. The model is supported by the capping of one of the polypeptides with biotin, which disrupts filament formation and provides the ability to control the average length of the filaments.ConclusionMetal ion-dependent, reversible protein filament formation is demonstrated for two designed polypeptides. The polypeptides form filaments that are approximately 3 nm in diameter and several hundred nm in length. They are not amyloid-like in nature as demonstrated by their behaviour in the presence of congo red and thioflavin T. A capping strategy allows for the control of filament length and for potential applications including the "decoration" of a protein filament with various functional moieties.

Trends - the future belongs to hybrid thermosets

mostly due to their ‘blending’. Via ‘blending, alloying’ the beneficial properties of the related thermoplastic resins can be combined and even tailored upon request in many cases. Blending does not necessary mean melt compounding, but covers numerous other techniques, as well (e.g. ‘reactor blends’ produced by in-situ polymerization). Interestingly, fewer efforts were dedicated to follow this concept for thermosets, except rubbers. Similar to thermoplastic systems, the ‘blending concept’ was introduced for thermosets when starting with their toughening. Nowadays, toughened thermosets, especially epoxy resins, are commercialized. Their toughener content is usually less than 10 wt.%. The vivid academic interest in the past to prepare interpenetrating network (IPN) structured systems can be considered as the beginning of thermoset ‘hybridization’. Combination of two or more resins, which crosslink separately or co crosslink with each other in various extents, means a great potential for property modification. A commercial breakthrough with this concept was already achieved with unsaturated polyester-urethane and vinylester-urethane hybrid resins. The driving force of resin hybridization in the future is linked with the necessary use of resins made (at least partly) from renewable resources. Note that the crosslinked network of resins of natural origin (e.g. from plant oils which will come sooner or later from gene-manipulated plants) can never be so tight as that of ‘traditional’ ones derived from petrochemical resources. This is due to the fact that the molecular segments between the crosslinking sites are much longer (and at the same time usually less reactive) than in the present systems. So, the related products are closer to rubbers than to thermosets which is well reflected by their low glass transition temperature (Tg). Consequently, additional co reactions and/or formation of IPN or IPN-like structures are needed to push the stiffness, strength and Tg toward higher values. It can be prophesied that the polyurethane chemistry will be one of the right tools to reach this target due to its versatility. However, we are faced with severe problems when following resin hybridization routes, from which only one has to be borne in mind here. The end-users prefer to utilize 1or (maximum) 2-component systems, which can not always fulfilled by hybrids. To develop ‘userfriendly’, robust 2-component systems is a great challenge that can likely be met by adopting suitable blocking, end capping strategies. So, there is much to do, but it is of worth, is not it?

Scaling Methods of Sediment Bioremediation Processes and Applications

AbstractBioremediation has been argued to be one of the most cost‐effective remediation technologies available to reduce soil, sediment, or groundwater contamination, particularly because this approach may allow for the implementation of in‐place strategies. Recent trends have advocated the application of innovative sediment stabilization strategies through placement of (reactive) capping material to allow long‐term biodegradation of contaminants in these complex biogeochemical environments. The potential long‐term risk reduction associated with this approach requires a demonstration of causal relationships between sediment or contaminant stability on the one hand, and microbial reactivity on the other. The spatial analysis needed to fully understand and quantify these correlations requires sensitive probabilistic techniques. Geostatistics has been used for the characterization of multi‐scale spatial patterns for the last few decades, and the analysis of microbial attributes has shown significant spatial structures on microbial abundance and activity. However, there is a dearth of information on the applicability of geostatistics to quantitatively describe the interaction between the microorganisms and their environment. Using the Passaic River (NJ) dioxin data as a model dataset, multiple scaling models were applied to scale and interpolate sampled dioxin data and derive dechlorination signatures in sediments. Unlike conventional geostatistic tools that are based on the point‐to‐point spatial structures, the new multi‐scale model (M‐Scale) introduces a new framework for spatial analysis in which regional values at different scales are anchored by the correlations to each other. Spatial dioxin distributions and microbial dechlorination signatures were used as benchmarks for comparison of M‐Scale to ordinary kriging. The results from cross‐validation and jackknifing approaches applied to these datasets were analyzed and compared using Quantile‐Quantile (Q–Q) plots and reproduction coefficients. These plots indicated that the M‐Scale better preserves the local features of hotspots during data interpolation to a basin‐wide scale. Current efforts focus on mapping microbial abundance and respiratory competence in the Anacostia River, based on measurements at three different scales. The outcomes of this work will be used to develop an uncertainty‐based spatial decision tool for site remediation in this watershed using various capping strategies.

A Fluorous Capping Strategy for Fmoc‐Based Automated and Manual Solid‐Phase Peptide Synthesis

AbstractJust add water: Peptides synthesized by the use of standardized Fmoc protocols with commercial automated synthesizers can be purified from deletion products by simple centrifugation of aqueous solutions. The deletion products are capped with fluorous trivalent iodonium salts. At the end of the synthesis, the crude peptide is dissolved in water and centrifuged, and the deletion products precipitate leaving only the full length peptide in solution. Protocols for generalized use of this strategy are reported. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)

Design of Water-Soluble Quantum Dots with Novel Surface Ligands for Biological Applications

ABSTRACTWe have designed a series of organic oligo- and polyethylene glycol (PEG) based surface capping ligands that allow for QD manipulation in aqueous media. We utilized readily available thioctic acid and various oligo- and polyethylene glycols in simple esterification schemes, followed by reduction of the dithiolane to produce multi-gram quantities of capping substrates. Cap exchange of the native trioctyl-phosphine and -phosphine oxide based ligands with the PEG-terminated dithiol-alkyl cap readily resulted in aqueous dispersions of QDs that were homogeneous and stable in various pH ranges over an extended period of time. Mixed surface capping strategies utilizing ratios of dihydrolipoic acid to the pegylated dihydrolipoic acid were also prepared. We anticipate that such systems should allow one to covalently attach amine containing biomolecules to nanoparticle systems bearing carboxylates, employing known coupling agents, such as (dimethylamino) propyl-3-ethyl-carbodiimide (EDC). This design and conjugation strategy may facilitate the development of a new generation of QD-bioconjugates, which can be directly utilized in bio-related applications such as sensing and cellular imaging.

Cap-Weighted Indexing Revisited

The author first observes that arguments that indexing is a momentum strategy, a large cap strategy, or even a style of investing that is sometimes in fashion and sometimes out of fashion are misleading. He then counters these arguments with a careful, non-standard definition of cap-weighted indexing, which distinguishes between the amount of the company being purchased and the amount of money that this purchase costs. He concludes that the argument that cap-weighted indexing is a momentum play is false, as it fails to distinguish between the amount of the company being purchased and the cost of this purchase. It also fails to distinguish between a bet that a portfolio is making relative to the market, and one that is made by the market as a whole. Thus, by defining indexing as the purchase of the same fractional amount of each company, it becomes apparent that indexing is not a momentum play, a size play, nor a style play.

A High-Throughput Homogeneous Assay for Reverse Transcriptase Using Generic Reagents and Time-Resolved Fluorescence Detection

A homogeneous time-resolved fluorescence (HTRF) assay has been developed for determining the activity of HIV reverse transcriptase (HIV-RT). By using a sequential capping strategy, the assay has been configured to utilize only generic reagents such as biotinylated dUTP, streptavidin–allophycocyanin, and streptavidin–europium. The assay was optimized for a HIV-RT high-throughput screen. Under optimized conditions, a signal-to-background ratio of approximately 10:1 and a Z′ factor of 0.8 were obtained. The titration curves of several known HIV-RT inhibitors have been evaluated with this assay format. This HTRF format can be used for high-throughput assays with other nucleotide polymerases.

α-Chloroacetyl capping of peptides: an N-terminal capping strategy suitable for Edman sequencing

Use of an α-chloroacetyl group allows for the conditional N -terminal capping of peptides. This capping group is easily introduced and stable over a broad pH range, but can be converted to glycine by aqueous ammonia treatment in order to perform N -terminal Edman peptide sequencing.

Capping South Asia's Nuclear Weapons Programs: A Window of Opportunity?

The nuclear weapons programs of India and Pakistan are now well advanced. India, in particular, has a depth and breadth in its nuclear industries unmatched by any other threshold power. In these circumstances, it is doubtful whether attempts to force the South Asian threshold powers to roll back hard-won capabilities are any longer efficacious. If this is indeed the case, then major actors such as the United States will need to recognize the nuclear status quo in South Asia and begin to explore other means of preventing a spiraling nuclear competition from developing in the region. In its dying days, the Bush administration was moving toward an acceptance of the nuclear realities in South Asia, drawing back from the previous insistence on denuclearization and adherence to the Non-Proliferation Treaty (NPT) as the primary objective of U.S. policy in favor of attempts to cap the production of fissionable material. The strategy also sought guarantees designed to prevent the spread of nuclear technologies outside South Asia. The capping strategy had been developed after extensive canvassing by a number of leading academics and think tanks throughout 1991 and 1992.1