The aim of the study was to establish the features of the histological organization of pancreatic tissues on the example of a domestic bull. For its implementation, pancreatic tissue samples of five sexually mature one-year-old cows of a black-and-white breed obtained by biopsy were used. The selected material was fixed in a 10.0% solution of neutral formalin for a day, after which it was poured into paraffin according to the generally accepted method. Histological sections were made from the obtained blocks, which were stained with hematoxylin and eosin, according to Van Gieson and trichrome according to Mosson. It has been established that the studied organ in the studied animals belongs to complex alveolartubular glands. From the outside, it is covered with a delicate connective tissue capsule, giving rise to connective tissue strands (trabeculae) passing between its lobules. Vascular elements, nerve trunks and excretory ducts are identified as part of these structures. The gland itself, in accordance with its function, includes two parts – endocrine and exocrine. The terminal sections of its exocrine part are represented by pancreatic acinuses. As part of the latter, two departments can be distinguished - secretory (formed by serous endocrinocytes) and ductal (formed by epithelial cells (centroacinous) of the initial sections of the insertion excretory ducts). The secretory department of the acinus includes from seven to eleven cells having a pyramidal shape. They contain one welldeveloped basophilic rounded nucleus, and two zones are revealed in their cytoplasm. The basal – homogeneous – zone has a basophilic color and is located in the basal part of the cell. The apical – zymogenic (apical) zone contains secret granules and is colored oxyphilically. The endocrine part of the gland is represented by pancreatic islets (islets of Langerhans) formed by strands of closely interconnected endocrine cells (isulocytes) surrounded by abundant capillary loops forming branched networks inside the islet. Insulocytes are small cells having a polygonal shape with a poorly defined border. In their composition, one rounded or oval nucleus is revealed, containing evenly distributed small-smiley chromatin.