Basketball coaches in the Cape Coast Metropolis have long been struggling with their basketball players' shooting accuracy especially those in the senior high schools. This is because it does not compare well to the standards of players in the same age group because players in the metropolis have poor shooting rates. There is strong evidence from literature indicating that athletes with high levels of fitness, particularly performance related fitness, also known as skill-related fitness, do better than their peers in the various games and sport. The purpose of this study therefore was to find out the effect that performance related fitness training will have on shooting accuracy of senior high school basketball players in the Cape Coast Metropolis'. The researchers randomly sampled and assigned twenty (20) male and twenty (20) female basketball players to the experimental and control groups by same means. The males had a mean age of 17.15yrs, weight of 73.20kg, and height of 1.79m, and the females had a mean age of 17.15yrs, weight of 68.65kg, and height of 1.64m. The control group went through mini-clinic that concentrated on passing and dribbling as a placebo, while the experimental group participated in a series of drills over a twelve-week period intended to improve their performance related fitness. Standardized tests were employed for the performance related fitness tests and the researchers modified the tests used by Uzicanin et al. for shooting accuracy. Data was analyzed using the t test. There was a statistically significant difference in the shooting accuracy of the male experimental group between Pretest and Week six t(9) = 0.568, P = < 0.001. Pretest mean (M) = 3.67, SD = 1.19; Week six mean (M) = 5.06, SD = 1.13). There was also a statistically significant difference in the shooting accuracy between Pretest and Week nine t(9) = 0.685, P = < 0.001 Pretest mean (M) = 3.67, SD = 1.19; Week nine mean (M) = 6.67, SD = 0.77). Statistical significant difference was also observed between Pretest and Week twelve t(9) = -13.062, P = < 0.001, Pretest mean (M) = 3.67, SD = 1.13; Week twelve mean (M) = 7.06, SD = 0.68. Nonetheless, There was no statistically significantly between Pretest and Week three (t(9) = -0.844, P = 0.388; Pretest mean (M) = 3.67, SD = 1.19; Week three mean (M) = 3.96, SD = 1.37). A similar finding was found for the female as well. Between the experimental group of male and female the researchers found no statistically significant differences them after the twelve weeks of intervention. Basketball coaches should as part of their plan design a program that intends to improve on their players' performance related fitness, particularly during the conditioning phase of preparation for tournaments. They should also conduct regular assessment of the players throughout the season to identify when fitness especially performance related fitness begin to go down to find ways of improving on it.