Response Capacity Research Articles

Pull-out behavior of twin-twisted steel fibers from various strength cement-based matrices

This research explores a novel steel fiber made by twisting together two straight steel wires. The pull-out behavior of the twin-twisted steel fiber was investigated, proving its slip-hardening ability in cement-based matrices. The number of twists per unit length, fiber embedment length, matrix compressive strength, and fiber equivalent diameter were the experimental variables. Hooked-end fibers were also investigated for comparison. Pull-out test results of twin-twisted steel fibers quantified the mechanisms of frictional bonding and mechanical untwisting and their effects on the pull-out response and slip hardening of steel fibers. The maximum pull-out load increased with the increase of fiber twists per unit length, which increased the likelihood of damage to the matrix tunnel and had a negative effect on the energy absorption capacity. Defects at interfaces and scratches on fiber surfaces were examined using SEM imaging. Twin-twisted steel fibers reached an enhanced hardening response and energy absorption capacity compared to hooked fibers yet showed lower maximum bond strength. New bond strength and energy dissipation indexes were introduced and could effectively be used for fiber optimization.

Efficacy of FERscore in predicting sensitivity to ferroptosis inducers in breast cancer

Recent studies have highlighted the potential of ferroptosis in treating breast cancer. However, the efficacy of ferroptosis induction in the most common subtype, estrogen receptor-positive (ER + ) breast cancer, remains inadequately explored. This study unveils that both short-term and long-term treatment with ER-targeted endocrine agents sensitizes ER+ breast cancer cells to ferroptosis inducers, particularly the GPX4 inhibitor, revealing a non-mutational sensitization mechanism. Based on this finding, we introduce a 55-gene signature score (FERscore) tailored to assess ferroptosis susceptibility in breast cancer. Data from cell lines and primary tumors demonstrate significant lower FERscores in ER+ breast cancer compared to other subtypes; however, FERscores dramatically increase in endocrine-resistant ER+ tumor cells and residual tumors post-endocrine therapy. Furthermore, FERscore correlates positively with mesenchymal traits, stemness, immune cell infiltration, and cancer-associated fibroblasts enrichment, while inversely correlating with estrogen responsiveness and DNA repair capacity. Additionally, the FERscore proves effective in predicting therapeutic responses to anti-ER, anti-HER2, poly (ADP-ribose) polymerase inhibitor, and anti-angiogenesis therapies in breast cancer. In summary, ferroptosis induction emerges as a promising avenue in breast cancer therapy. The FERscore offers an innovative tool for identifying patients who may benefit from ferroptosis-inducing therapies, especially those responsive to GPX4 inhibitors.

Phosphorus use efficiency in common bean genotypes

Phosphorus absorption in plants can vary depending on the genotypes, mineral levels, and environmental conditions. Thus, this study aimed to evaluate phosphorus use efficiency and the response capacity of five common bean genotypes in two cultivation cycles. A 2x5 factorial scheme was used with three replicates. Factor A consisted of using and not phosphorus fertilization, and factor B consisted of five common bean genotypes (BRS Expedito, Iraí, Pérola, Maronze, and Vermelho). The evaluated yield components were the number of pods per plant (NPP), the number of grains per plant (NGP), and the mass of 1000 grains (M1000G). The yield was calculated and extrapolated to kg ha-1. We also evaluated the phosphorus levels accumulated in the leaves and grains (mg and %) and estimated the use efficiency of using phosphorus in the grains. The data obtained were subjected to analysis of variance and compared using the Scott-Knott test at a 5% significance level. There was a significant interaction for all studied variables, indicating the interference of phosphorus fertilization in the behavior of the genotypes. The growing season influenced the genotypes' responses regarding phosphorus use. Yields increased with phosphorus fertilization and changed according to genotype. The phosphorus accumulated in the leaves and grains showed little divergence. The Iraí, Pérola, and Maronze genotypes stand out for their efficient use of phosphorus, presenting an increase above 50% when grown in soil with phosphorus fertilization. When fertilized, the Vermelho variety most accumulated phosphorus in the grains in the first season. In the second season, it showed a significant change in its response when using the phosphate fertilizer, indicating a change in behavior due to the environmental component.

Economic evaluation of GnRH-agonist long protocol and GnRH-antagonist protocol in IVT/ICSI among the Chinese population: using pharmacoeconomic models

ObjectiveThis paper uses health economics methods to discuss the cost-effectiveness value of long protocol and antagonist protocol for in vitro fertilisation and embryo transfer (ET) in the Chinese population.DesignHealth economic...

Seismic design of buildings in the context of regions: A case study of a site in Semnan city, Iran

The seismic codes focus on single buildings and ignore the interdependencies between various sectors and infrastructure. This approach cannot ensure resilient communities and ignores essential aspects of seismic risk (e.g., exposure element). This paper proposes a regional-based design (RBD) method that considers the performance of individual components as well as the interactive consequences of their design on the communities. Unlike most studies, the proposed RBD method considers a dynamic behavior for a region/city and utilizes its master plan to model the stochastic variations in the future built environment. The method determines buildings' seismic design requirement (SDR) by considering the building-level and regional goals. Building-level goals address the most important performance objectives (e.g., safety in residential buildings) and should be satisfied for each structural system and occupancy. However, the method satisfies the regional goals for any structural system. This implies that if (hypothetically) all the buildings in a region/city were designed and constructed with only one structural system (e.g., special steel moment resisting frames, SMRFs), the regional goals should be satisfied. The method starts with the determination of the SDRs by satisfying equal building-level objectives for each occupancy in various locations of the region with one structural system. Then, to achieve the regional goals, the calculated SDRs are uniformly raised to improve the performance of the buildings (if required). The method also considers factors other than the buildings/facilities' performance that could affect the achievement of the regional goals (e.g., emergency response capacity). As a proof-of-concept, the proposed method is used in a site in Semnan City, Iran, to determine the SDR of steel SMRFs. The case study shows that there might be situations where elevating the seismic design requirements of the buildings could not guarantee the achievement of some regional goals. Moreover, the results indicate that factors like the design of the built environment could affect regional risks. Therefore, attention to factors other than the buildings' seismic performance is also essential in achieving the regional goals.

Modulation of the K/BxN arthritis mouse model and the effector functions of human fibroblast-like synoviocytes by liver X receptors.

The role of liver X receptors (LXR) in rheumatoid arthritis (RA) remains controversial. We studied the effect of LXR agonists on fibroblast-like synoviocytes (FLS) from RA patients and the K/BxN arthritis model in LXRα and β double-deficient (Nr1h2/3-/-) mice. Two synthetic LXR agonists, GW3965 and T0901317, were used to activate LXRs and investigate their effects on cell growth, proliferation and matrix metalloproteinases, and chemokine production in cultured FLS from RA patients. The murine model K/BxN serum transfer of inflammatory arthritis in Nr1h2/3-/- animals was used to investigate the role of LXRs on joint inflammation in vivo. LXR agonists inhibited the FLS proliferative capacity in response to TNF, the chemokine-induced migration, the collagenase activity in FLS supernatant and FLS CXCL12 production. In the K/BxN mouse model, Nr1h2/3-/- animals showed aggravated arthritis, histological inflammation, and joint destruction, as well as an increase in synovial metalloproteases and expression of proinflammatory mediators such as IL-1β and CCL2 in joints compared with wild type animals. Taken together, these data underscore the importance of LXRs in modulating the joint inflammatory response and highlight them as potential therapeutic targets in RA.

Lactating striped hamsters (Cricetulus barabensis) do not decrease the thermogenic capacity to cope with extreme cold temperature

For small non-hibernating mammals, a high thermogenic capacity is important to increase activity levels in the cold. It has been previously reported that lactating females decrease their thermogenic activity of brown adipose tissue (BAT), whereas their capacity to cope with extreme cold remains uncertain. In this study we examined food intake, body temperature and locomotor behavior, resting metabolic rate, non-shivering thermogenesis, and cytochrome c oxidase activity, and the rate of state 4 respiration of liver, skeletal muscle, and BAT in striped hamsters (Cricetulus barabensis) at peak lactation and non- breeding hamsters (controls). The lactating hamsters and non- breeding controls were acutely exposed to −15°C, and several markers indicative of thermogenic capacity were examined. In comparison to non-breeding females, lactating hamsters significantly increased food intake and body temperature, but decreased locomotor behavior, and the BAT mass, indicative of decreased BAT thermogenesis at peak lactation. Unexpectedly, lactating hamsters showed similar body temperature, resting metabolic rate, non-shivering thermogenesis with non-breeding females after acute exposure to −15°C. Furthermore, cytochrome c oxidase activity of liver, skeletal muscle and BAT, and serum thyroid hormone concentration, and BAT uncoupling protein 1 expression, in lactating hamsters were similar with that in non-breeding hamsters after acute extreme cold exposure. This suggests that lactating females have the same thermogenic capacity to survive cold temperatures compared to non-breeding animals. This is particularly important for females in the field to cope with cold environments during the period of reproduction. Our findings indicate that the females during lactation, one of the highest energy requirement periods, do not impair their thermogenic capacity in response to acute cold exposure.

Abstract Tu080: Unique Physiology of Fibroblast and Immune Cells in the Right Ventricle

Introduction: Failure of the right ventricle (RV) is a main component of the morbidity and mortality of pulmonary hypertension (PH). There exists no specific treatment for RV dysfunction and failure and the only cure for many patients (especially in the case of pulmonary arterial hypertension) remains transplantation. This is partially due to the critical lack of understanding of RV biology; therapeutic strategies that are beneficial for LV failure have worse outcomes when applied to those with RV failure. RV dysfunction is characterized by exaggerated fibrosis and divergent contractile and hypertrophic responses to several drugs when compared to LV dysfunction. Thus, the RV may contain distinct cellular physiology compared to the LV that has high significance for the treatment of PH. Methods: Tissue digests from the RV and LV of Sprague Dawley rats were collected. We utilized digests to collect RNA for RNA-seq, and prepared cells for flow cytometry and fibroblast isolations. Fibroblasts were cultured for proliferation assays and cell signaling studies. Results: We found that the RV and LV have significant differences in expression of immune-related and fibrotic genes. The RV of control rats had an average of four-fold higher density of immune cells, namely macrophages/monocytes, compared to the LV (P<0.05 via paired t-test). Fibroblasts from the RV of control rats, which had a higher proliferation rate and an alteration of metabolic genes than those from the LV (P<0.05 via two-way ANOVA), also had a higher fold-change increase in periostin and CTGF expression upon treatment with TGFβ. Conclusions: The results demonstrate that in comparison to the LV, the RV is made up of a unique population of cells and has a unique capacity for fibrotic response that is reflected in its molecular makeup, which may contribute to its distinct response to PH. Future experiments will focus on determining the molecular mechanisms driving these differences. This knowledge is expected to yield new therapeutic approaches for RV dysfunction and failure occurring with PH, which currently have no specific treatment.

Smoking, Symptoms Improvement, and Total Antioxidant Capacity in Patients with Drug-naive First-episode Schizophrenia: A Prospective Cohort Study.

It has been hypothesized that smoking is associated with the severity of negative symptoms. Until now, no studies have investigated whether the impact of smoking on negative symptoms is dependent on antioxidants. This study was designed to evaluate the effect of smoking on therapeutic response and total antioxidants capacity (TAOC) in antipsychotic-naïve first-episode (ANFE) patients. The severity of the patient's symptoms was assessed using the Positive and Negative Syndrome Scale (PANSS). A total of 237 ANFE patients were recruited and treated with risperidone (oral tablets, 4-6 mg/day twice a day) for 12 weeks. PANSS was assessed at baseline and a 12-week follow-up. Plasma TAOC levels were also assayed at baseline and week 12. Relative to nonsmokers with ANFE SZ, smokers had higher PANSS negative subscores. There was no significant difference in TAOC changes after 12 weeks of treatment with risperidone between smokers and non-smokers. However, we found greater improvement in negative symptoms in smokers compared to non-smokers. Further analysis in smokers with SZ demonstrated that improvements in negative symptoms were not associated with changes in TAOC. Our study suggested that smoking affected the severity of baseline negative symptoms and further contributed to their reduction after risperidone treatment. However, improvement in negative symptoms was not dependent on the changes in TAOC.

Magnetic Cell Targeting for Cardiovascular Tissue Engineering.

There is a critical need for novel approaches to translate cell therapy and regenerative medicine to clinical practice. Magnetic cell targeting with site specificity has started to open avenues in these fields as a potential therapeutic platform. Magnetic targeting is gaining popularity in the field of biomedicine due to its ability to concentrate and retain at a target site while minimizing deleterious effects at off-target sites. It is regarded as a relatively straightforward and safe approach for a wide range of therapeutic applications. This review discusses the latest advancements and approaches in magnetic cell targeting using endocytosed and surface-bound magnetic nanoparticles as well as invivo tracking using magnetic resonance imaging (MRI). The most common form of magnetic nanoparticles is superparamagnetic iron oxide nanoparticles (SPION). The biodegradable and biocompatible properties of these magnetically responsive particles and capacity for rapid endocytosis into cells make them a breakthrough in targeted therapy. This review further discusses specific applications of magnetic targeting approaches in cardiovascular tissue engineering including myocardial regeneration, therapeutic angiogenesis, and endothelialization of implantable cardiovascular devices.

Emergency preparedness in the central sterile supply department: a multicenter cross-sectional survey

ObjectiveTo investigate the current situation of emergency preparation and emergency drill in the CSSD, and analyze its influence on the nurses’ emergency attitude and ability.MethodsThis study employed a multicenter stratified sampling method, conducted from January to June 2023 using the online survey, participants completed the general data, emergency preparedness and drill questionnaire, public health emergency response questionnaire and emergency capacity scale. An independent samples t test or Kruskal-Wallis test was used to analyse differences in nurses’ emergency capacity and attitudes.ResultsThe data from 15 provinces 55 hospitals in China. Overall, 77.58% of participants’ institutions set up emergency management teams, 85.45% have an emergency plan and revise it regularly. 92.12% store emergency supplies. All survey staff participated in the emergency drill, which predominantly consisted of individual drills (51.52%), with 90.30% being real combat drills, 49.09% of participants engaging in drills every quarter, and 91.52% of the drill’s participants exceeding 50%. The respondents’ emergency attitude score was (29.346 ± 6.029), their emergency ability score was (63.594 ± 10.413), and those with rescue experience showed a more positive attitude (Z = -2.316, P = 0.021). Different titles, education levels, rescue experience and the frequency of emergency drill affected the emergency rescue ability of the respondents (P < 0.05).ConclusionsMost medical institutions establish emergency management systems and plans, yet the content lacks geographical specificity.The duration and participation of emergency drills are high, but the effectiveness of the drills needs to be further improved, and the response capacity and attitudes of CSSD nurses are low. It is recommended that agencies develop comprehensive and targeted contingency plans to strengthen the inspection and evaluation of team strength, equipment and safeguards against the contingency plans, so as to ensure that the measures mandated by the contingency plans can be implemented promptly after the emergency response is initiated.

Two-stage evolutionary game model on complex networks for emergency logistics based on blockchain platform

Enhancing the efficiency of emergency logistics is essential to reinforce the response capacity to emergencies. It requires collaborative efforts from both the emergency management departments and logistics enterprises. However, the capability for information docking between these organizations substantially influences the efficiency of emergency materials transportation. Blockchain, as an emerging information technology, has the potential to substantially enhance the efficiency and security of information docking through its unique characteristics. Additionally, logistics enterprises share information and resources based on the blockchain platform, aiming to ensure fast, efficient, and reliable collaborative transportation of emergency materials to impacted regions. Therefore, we propose a two-stage evolutionary game analysis of emergency materials collaborative transportation based on this platform. First, we develop a first-stage evolutionary game model to analyze the challenges associated with building a blockchain platform among emergency management departments and logistics enterprises. Subsequently, a second-stage evolutionary game model is devised to bolster the willingness of logistics enterprises based on this platform for collaborative transportation of emergency materials. Third, to validate the theoretical findings of the two-stage game model, two scale-free networks are employed for numerical simulations. As those networks evolve, the edges among nodes and the strategy choices of nodes in those networks likewise change. Numerical simulations are performed based on those networks to scrutinize the sensitivity of factors influencing strategic choice among game stakeholders. Ultimately, certain management insights gleaned from the findings can assist emergency management departments and logistics enterprises in making more informed decisions in the future.

Nursing leadership in disaster preparedness and response lessons learned and future directions

Nursing leadership is integral to effective disaster preparedness and response, demanding agility, strategic planning, and robust resource management. Disasters, both natural and man-made, present unique challenges that require nursing leaders to be adept in rapid decision-making and efficient coordination. The unpredictability of disasters necessitates comprehensive and regularly updated preparedness plans, ensuring nursing teams are well-versed in their roles through continuous training and simulations. Interprofessional collaboration and strong community partnerships are essential, fostering a unified response and efficient resource distribution. Communication remains a cornerstone of disaster management, with clear, timely information dissemination being crucial for coordinating efforts and maintaining public trust. Resource scarcity during disasters, such as shortages of medications and personal protective equipment (PPE), poses significant challenges. Effective resource management strategies are essential to maintain patient care standards and protect healthcare workers. The psychological toll on healthcare providers is another critical issue, with nursing leaders needing to implement support systems that address mental health and promote resilience. Integrating advanced technologies like telehealth and data analytics can enhance disaster response, providing remote care options and enabling predictive modeling for better resource allocation. Innovative approaches in nursing leadership include the use of telehealth for remote consultations and monitoring, data analytics for predictive modeling, and interprofessional education to improve teamwork and coordination. Strengthening community partnerships enhances overall disaster response capacity, ensuring that community-specific needs are addressed. Mental health support for healthcare providers, both immediate and long-term, is vital for maintaining a resilient workforce. Policy advocacy by nursing leaders is crucial to developing robust disaster preparedness frameworks and securing adequate funding. In summary, nursing leadership is pivotal in disaster preparedness and response, with a focus on strategic planning, interprofessional collaboration, effective communication, resource management, mental health support, and the integration of advanced technologies. Emphasizing these areas will enhance the resilience and responsiveness of healthcare systems, ultimately improving outcomes for patients and healthcare providers during disasters.

Designing high performance hydrogel sensor for real-time sensing applications

Achieving high performance conductive hydrogel sensor which is capable of combining as many advantages as possible in one is highly desired to satisfy real-world tasks. To this end, novel hydrogel sensors PVA/NaDa (polyvinyl alcohol/D-Gluconic acid sodium salt) and PVA/NaLa (polyvinyl alcohol/L-Glutamic acid monosodium salt) have been successfully constructed via a facile and effective strategy. The hydrogels realize the combination of robust mechanical properties (stress, strain, elastic modulus, toughness, fatigue resistance, anti-breakage ability and recovery performance), excellent conductivity, sensitive sensitivity, rapid response capacity and high cytocompatibility. The increasing hydrogen bond cross-linking density and hydrogen bond interactions of NaDa (NaLa) with PVA are mainly responsible for significantly intensified mechanical properties of PVA/NaDa and PVA/NaLa hydrogels. Benefiting from the prominent performances, the hydrogels can be processed into flexible membrane sensors to not only effectively detect the human joint motions but also sensitively simulate manual control of the mobile phone screen for writing text, demonstrating a promising application in multifunctional intelligent robots, electronic skins, artificial intelligence and among others.

PGD 2 /DP1 axis promotes liver regeneration by secreting Wnt2 in KCs in mice.

The liver possesses a remarkable regenerative capacity in response to injuries or viral infections. Various growth factors and cytokines are involved in regulating liver regeneration. Prostaglandin D 2 , a pro-resolution lipid mediator, is the most abundant hepatic prostanoid. However, the role of prostaglandin D 2 in the injury-induced liver regeneration remains unclear. Two-thirds partial hepatectomy (70% PH), massive hepatectomy (85% resection), and carbon tetrachloride-induced chronic injury were performed in mice to study the mechanisms of live regeneration. Hepatic prostaglandin D 2 production was elevated in mice after PH. Global deletion of D prostanoid receptor (DP) 1, but not DP2, slowed PH-induced liver regeneration in mice, as evidenced by lower liver weight to body weight ratio, less Ki67 + hepatocyte proliferation, and G2/M phase hepatocytes. In addition, DP1 deficiency, specifically in resident KCs, and not in endothelial cells or HSCs, retarded liver regeneration in mice after PH. Conversely, the overexpression of exogenous DP1 in KCs accelerated liver regeneration in mice. Mechanistically, DP1 activation promoted Wnt2 transcription in a PKA/CREB-dependent manner in resident KCs and mediated hepatocyte proliferation through Frizzled8/β-catenin signaling. Adeno-associated virus vector serotype 8-mediated Frizzled8 knockdown in hepatocytes attenuated accelerated liver regeneration in KC-DP1 transgenic mice after PH. Treatment with the DP1 receptor agonist BW245C promotes PH-induced liver regeneration in mice. DP1 activation mediates crosstalk between KCs and hepatocytes through Wnt2 and facilitates liver regeneration. Hence, DP1 may serve as a novel therapeutic target in acute and chronic liver diseases.

Insights on early response to acute heat shock of bovine mammary epithelial cells through a multimethod approach

Heat stress is a significant challenge in dairy cattle herds, affecting milk production and quality, and generating important changes at the cellular level. Most in vitro research on heat shock (HS) effects on dairy cow mammary cells was focused on medium-long-term effects. In recent years, Fourier transform-infrared (FT-IR) micro-spectroscopy has been increasingly used to study the effects of several external stresses on different cell lines, down to the level of single cellular components, such as DNA/RNA, lipids, and proteins. In this study, the possible changes at the biochemical and molecular level induced by acute (30 min-2 h) HS in bovine mammary epithelial (BME-UV1) cells were investigated. The cells were exposed to different temperatures, thermoneutral (TN, 37 °C) and HS (42 °C), and FT-IR spectra were acquired to analyse the effects of HS on biochemical characteristics of BME-UV1 cellular components (proteins, lipids, and DNA/RNA). Moreover, cell viability assay, reactive oxygen species production, and mRNA expression of heat shock proteins (HSPA1A, HSP90AA1, GRP78, GRP94) and antioxidant genes (SOD1, SOD2) by RT-qPCR were also analysed. The FT-IR results showed a change already at 30 min of HS exposure, in the content of long-chain fatty acids, which probably acted as a response to a modification of membrane fluidity in HS cells compared with TN cells. After 2 h of HS exposure, modification of DNA/RNA activity and accumulation of aggregated proteins was highlighted in HS cells. The gene expression analyses showed the overexpression of HSPA1A and HSP90AA1 starting from 30 min up to 2 h in HS cells compared with TN cells. At 2 h of HS exposure, also the overexpression of GRP94 was observed in HS cells. Acute HS did not affect cell viability, reactive oxygen species level, and SOD1 and SOD2 gene expression of BME-UV1 cells. According to the results obtained, cells initiate early defence mechanisms in case of acute HS and probably this efficient response capacity may be decisive for tolerance to heat stress of dairy cattle.

Highly dispersed Ag quantum dots anchored on palmitic acid/ graphitic carbon nitride composite phase change materials for enhanced photo-thermal storage

Phase change materials (PCM) have attracted much attention in the field of thermal energy storage because of exceptional heat storage capacity, stable operating temperature, and recyclability. However, organic phase change materials, represented by palmitic acid (PA), are limited by inherent leakage problem, unsatisfactory thermal responsiveness and inefficient photo-thermal storage capacity, which severely hamper the development of PCMs technology. As a means of addressing these challenges, we developed one novel support material with 2D/0D structure for palmitic acid via thermal polymerization, specifically, in which highly dispersed Ag quantum dots (Ag QDs) was firmly anchored on graphitic carbon nitride (g-C3N4). PA was further infiltrated into the layered structure of nanoporous g-C3N4/Ag QDs to successfully synthesize novel shape-stabilized PA/g-C3N4/Ag QDs composite phase change materials (CPCM). On the one hand, benefiting from the tightly stacked porous structure of g-C3N4/Ag QDs, PA is effectively encapsulated to avoid leakage problem during the solid-liquid transition with a superior adsorption capacity up to 65 %. On the other hand, the combination of g-C3N4 and Ag QDs in PA/g-C3N4/Ag QDs CPCM demonstrated a synergistic effect resulting in faster heat transfer capability and more efficient solar energy capture capability compared to pure PA, which is capable of dual utilization of heat and solar energy. The newly developed PA/g-C3N4/Ag QDs CPCM features a high melting latent heat and an appropriate phase change temperature, which are 128.35 J/g and 61.92 °C, respectively. The corresponding solidification enthalpy and temperature are 121.70 J/g and 60.02 °C. The photo-thermal conversion efficiency of the material is improved to 78.6 %, facilitating a rapid capture and storage of solar energy. Furthermore, through the optimization of the preparation process, Ag QDs are densely anchored on the surface of g-C3N4, which retains the excellent properties of metallic silver while eliminates the metal agglomeration phenomenon after repeated utilization of CPCMs. PA/g-C3N4/Ag QDs CPCM is proved to be extremely recyclable and thermally stable after massive thermal cycles. This innovative and operational encapsulation modified method significantly optimizes the practicality of phase change materials. The obtained shape-stabilized PA/g-C3N4/Ag QDs CPCM is more versatile, and its unique comprehensive properties can provide high-quality materials for photo-thermal storage systems.

A meta‐analysis of the effects of black soldier fly meal on fish immune response and antioxidant capacity

Black soldier fly (BSF) meal possesses a balanced nutritional profile, making it a promising substitute for fishmeal. Several studies have been conducted to investigate the effects of replacing fishmeal with BSF meal on fish immune response and antioxidant capacity. However, considering the varying effects of BSF meal on different fish species demonstrated in earlier studies, a meta-analysis study was imperative to determine the efficacy of BSF meal in aquafeed. This meta-analysis examined 38 studies on finfish. Subgroup analysis and meta-regression were conducted to investigate the source of heterogeneity in the immunostimulant and antioxidant efficacy of BSF meal. Categorical variables used in subgroup analysis included the BSF development stage (larvae versus prepupae or pupae), BSF processing method (full-fat versus defatted), and fish dietary habits. Two continuous variables were evaluated for meta-regression analysis: dietary BSF inclusion level and treatment duration. The datasets were assessed for publication bias using funnel plots and Egger's test with the Pustejovsky–Rodgers Approach. The results revealed that BSF meal influences immune performance and antioxidant ability. Subgroup analysis indicated that different BSF development stages significantly influence the immunostimulant and antioxidant efficacy of BSF meals, with BSF prepupae or pupae outperforming BSF larvae. In terms of processing, full-fat BSF was superior to defatted BSF. Furthermore, BSF meal demonstrated the highest efficacy in omnivorous fishes. Meta-regression outcomes revealed that a higher concentration of BSF meal may inhibit immune response and antioxidant ability and that treatment duration exerts little impact. In conclusion, the present meta-analysis demonstrated that BSF is a promising ingredient in aquafeed to improve fish immune response and antioxidant capacity.

Peningkatan Ketaggapan Warga Pesisir Terhadap Bencana Banjir Rob : Warga Tangguh Bencana

Introduction: Unexpectedly high sea water can cause flooding which can damage, threaten lives and endanger the community, especially residents who live close to the shoreline or coastline. Objective: increase the response capacity of coastal residents to tidal flood disasters. Method: conducting outreach and simulating tidal flood disasters. Results: The average posttest score reached 17.5 out of a maximum score of 20, indicating the success of counseling in increasing respondents' knowledge and preparedness. Conclusion: Increasing community understanding, as reflected in a high average posttest score, can make a significant contribution to increasing community preparedness and adaptation to the risk of tidal floods. Furthermore, efforts are needed to maintain this positive momentum through sustainable programs, collaboration with related parties, and strengthening community participation in mitigation efforts.

Novel self-powered anti-interference photoelectrochemical sensor via zirconium porphyrin-based metal–organic framework as multifunctional signal label for oxytetracycline detection in food and environment

As a newly developed sensing mode, self-powered PEC sensing may successfully address issues like individual photoanode or photocathode sensing with poor signal responsiveness and weak anti-interference capacity. Herein, a self-powered PEC sensor was developed to detect oxytetracycline (OTC) by integrating SnS2/Sb2S3 photoanode with Cu2O photocathode, and zirconium porphyrin-based metal–organic framework (ZPM) as multifunctional signal label to achieve signal amplification. The highly efficient and stable self-powered biosensor not only delivers a sustained and robust photocurrent response for bioanalysis, thanks to its well-designed stepped band structure, but also successfully mitigates interference from reducing agents. Furthermore, the ZPM was firstly used as a multifunctional nano label in PEC biosensing platform. On the one hand, the ZPM has a large specific surface area and abundant functional groups that can be used to immobilize the aptamer. On the other hand, because of steric hindrance, poor conductivity, competition for dissolved oxygen and light source with the substrate, the ZPM can as photocathode quenching source to affect the photocurrent response. In optimized experimental conditions, the fabricated PEC sensing platform showed a broad linear range of 0.1 pM to 100 nM for assay of OTC with a low limit of detection (LOD=0.03 pM), coupled by its quantification in human serum samples with acceptable results. This work provides an avenue for the development of high-performance photoelectrochemical materials and opens up the possibility of designing more sensitive self-powered PEC biosensors.