A method to construct a non-Dirac–Hermitian supersymmetric quantum system that is isospectral with a Dirac–Hermitian Hamiltonian is presented. The general technique involves a realization of the basic canonical (anti-)commutation relations involving both bosonic and fermionic degrees of freedom in terms of non-Dirac–Hermitian operators which are Hermitian in a Hilbert space that is endowed with a pre-determined positive-definite metric. A pseudo-Hermitian realization of the Clifford algebra for a pre-determined positive-definite metric is used to construct supersymmetric systems with one or many degrees of freedom. It is shown that exactly solvable non-Dirac–Hermitian supersymmetric quantum systems can be constructed corresponding to each exactly solvable Dirac–Hermitian system. Examples of non-Dirac–Hermitian (i) non-relativistic Pauli Hamiltonian, (ii) super-conformal quantum system, and (iii) supersymmetric Calogero-type models admitting entirely real spectra are presented.