Scaphoid fracture is a common injury, representing 60–70 % of all carpal bone fractures. It usually results from a fall and occurs predominantly in young males. Percutaneous osteosynthesis with a cannulated headless compression screw has been described as a minimally invasive, safe, highly successful treatment for this pathology. The objective of the present study was to analyze the results of percutaneous osteosynthesis with a cannulated headless screw of scaphoid fractures (of a type A, B1 or B2 according to the classification by Herbert and Fisher) in the context of work-related injuries. Between March and December of 2016, 27 patients were submitted to surgical treatment of a scaphoid fracture. Out of those 27, 18 patients who underwent percutaneous osteosynthesis were identified, with an average age of 37 years and an average follow-up of 8 months. All cases were evaluated regarding postoperative pain, return to work, ability to perform activities of daily living (ADL), mobility, grip strength, disability (QuickDASH Score), patient satisfaction, and radiographic result (scapholunate, radiolunate angles). The surgery was performed in an out-patient basis and patients were allowed to mobilize as tolerated in the immediate postoperative (PO) period. Pain was at 1,4 (VAS – visual analog scale) at the end of the follow-up. Patients were able to return to work at 2 weeks PO if they had a low-demand occupation, such as a desk job, and at 4–8 weeks, as tolerated, according to the radiographic imaging and the patient's activity demands. Mobility was slightly decreased in all cases. The average PO QuickDASH Score was 10,25 points. Patient's satisfaction with the procedure was high. All fractures evolved to union. There were no permanent complications resulting from the procedure. Percutaneous osteosynthesis of scaphoid fractures is a safe surgical technique, with a high rate of fracture union. This technique allows a faster return to work with a low resulting disability and high patient's satisfaction. The results of the present series are in line with previously published results with the same technique. The advent of minimally invasive techniques has revolutionized the treatment of traumatic lesions. Percutaneous osteosynthesis of scaphoid fractures has the advantage of allowing a faster return to work and a high union rate in the context of work related injuries. Further studies and randomized clinical trials with a longer follow-up time are needed in order to adequately evaluate this technique.