Candidates For General Anesthesia Research Articles

A Comparative Study of the Effect of Low-Dose Epinephrine and Ketamine on Rapid-Sequence Endotracheal Intubation by the Priming Dose Method of Cisatracurium in Patients under General Anesthesia.

Low-dose ephedrine and ketamine may accelerate the onset time of action of neuromuscular blocking agents. We studied the effect of ephedrine and ketamine and cisatracurium priming on endotracheal intubation conditions and the onset time of action of cisatracurium. The study was a double-blind clinical trial performed on American Society of Anesthesiologists (ASA) class 1 and 2 patients, who were candidates for general anesthesia. In total, 120 patients were entered into the study and were divided into 4 groups, E, K, E + K, and N. The first group was given 70 mcg/kg ephedrine (E group), the second group was given 0.5 ml/kg ketamine (K group), the third group was given the same amount of ketamine plus ephedrine (E + K group), and the fourth group was given the same volume of normal saline (control group); a single dose of 0.1 mg/kg cisatracurium was given, and intubating conditions were evaluated at 60 seconds after cisatracurium administration. The mean Cooper score based on the response to laryngoscopy, the position of the vocal cords, and the movement of the diaphragm of patients in the control group with a mean of 2.53 ± 1.07 was significantly lower than in the three groups of E, K, and E + K with the means of 4.47. 1.17, 4.53 ± 1.14, and 7.63 ± 1.42, respectively (P value < 0.001). In the (E + K) group, it was significantly higher than in the two other drugs alone (P value < 0.001). The two groups of E and K alone were not significantly different from each other (P value = 0.997). The means of hemodynamic parameters were not significantly different in any of the groups (P value > 0.05). According to the results of the present study, the use of low-dose ephedrine and ketamine alone can improve intubation conditions. In addition, the combined use of these drugs not only had any Positive effect on patients' hemodynamic parameters but also greatly improved intubation conditions.

S645 Choice of Sedation for Initial Colonoscopy Determines Compliance With Follow-Up Colonoscopy in Patients With a History of Trauma

Introduction: Approximately 7% of Americans report post-traumatic stress disorder (PTSD). Despite the invasive and often sensitive nature of our specialty, little has been studied regarding best practices for trauma-informed care in gastroenterology. We hypothesize that endoscopy with conscious sedation (CS) may reactive trauma and impact follow-up care. We therefore designed a retrospective study to assess factors that may determine colonoscopy compliance in this population. Methods: All patients aged 50-74 years old seen at our hospital system’s primary care practices from 12/31/2009-12/31/2019 were included. Diagnoses were assessed by ICD-coding, and demographics and procedure documentation were obtained from the medical record. Adjusted odds ratios were calculated via logistic regression. Results: 65,062 patients were included in the study, of which 3.7% had a diagnosis of PTSD. The majority of those with PTSD were female (62%). Those who underwent a colonoscopy (N=7,356) versus those who did not (N=57,706) were similar in demographics. However, PTSD patients were more likely to undergo colonoscopy than those without trauma (OR 7.31, 95% CI 5.67-9.42). This was attenuated after additionally controlling for irritable bowel syndrome or chronic diarrhea (OR 3.37 95% CI 2.5-4.52). In contrast, after initial colonoscopy, PTSD patients trended toward lower likelihood of receiving follow-up colonoscopy (OR 0.85, 95% 0.49-1.46). Notably, all patients were more likely to undergo follow-up colonoscopy if the initial procedure was performed with general anesthesia (GA) (OR 2.05, 95% CI 1.82-2.30), however, this effect was significantly amplified among PTSD patients (OR 6.25, 95% CI 2.70-11.46) compared to patients without trauma (OR 2.05, 95% CI 1.82-2.31). (Table) Conclusion: PTSD patients comprise a notable portion of the outpatient screening population. These patients are more likely to be compliant with follow-up colonoscopy if initial procedure is performed under GA, an effect that is significantly magnified compared to the non-PTSD population. Current paradigms do not routinely screen for PTSD when considering candidates for GA, and so while the choice must be individualized, this finding has important clinical implications. PTSD patients may be keener to undergo initial colonoscopy due to active GI symptoms given the strong overlap with functional GI disorders. However, poor tolerance or a negative experience with CS may impact follow-up. This remains to be validated in future prospective studies. Table 1. - Odds Ratios of Surveillance Colonoscopy Among Eligible Patients Who Underwent Initial Colonoscopy Between 2009-2019 Primary adjusted odds ratio* 95% Confidence Interval p-value Conscious sedation - - - General Anesthesia 2.05 1.82-2.30 < .0001 History of trauma 6.25 2.70-11.46 < .0001 No trauma 2.05 1.82-2.31 < .0001 *Adjusted for age, race, sex, and poverty as defined by living in a residential zip code with >30% population below poverty line

Comparison of Dexmedetomidine, Lidocaine, Magnesium Sulfate, and Remifentanil in Cough Suppression During Endotracheal Extubation

Abstract Background: This study was undertaken to compare the effects of several drugs on attenuation of stimulatory responses and cough suppression at the end of endotracheal extubation under general anesthesia. Patients and Methods: This trial was conducted on 120 patients who were candidates for general anesthesia in Arak, Iran. The patients were randomly assigned into four groups. All groups received the study drugs 10 min prior to the end of surgery in the following manner: group 1, 0.5 μg/kg intravenous (IV) dexmedetomidine; group 2, 1.5 mg/kg IV lidocaine; group 3, 1 μg/kg IV remifentanil; and group 4, 30 mg/kg IV magnesium sulfate 50%. Laryngospasm, the presence of cough, mean arterial pressure, heart rate (HR), arterial oxygen saturation, and sedation were assessed and recorded. Results: No significant difference was observed in the number of coughs (P = .740) among the study groups. Although the dexmedetomidine group showed more sedation, the lowest increase in HR (P = .001) was observed in lidocaine and dexmedetomidine groups, respectively. The lowest and highest HR was observed in lidocaine and magnesium sulfate groups, respectively. The patients did not have laryngospasm during the assessment. In addition, dexmedetomidine had the highest Ramsay score (P = .019). Conclusion: There was no difference in the amount of laryngospasm and cough in the groups, and due to the lack of no serious complication requiring treatment, the study drugs can be recommended to be used for attenuating and suppressing stimulatory responses during endotracheal extubation.

Comparison of Two Dosages of Ketamine in Preventing Fentanyl-Induced Coughs in Children.

Background:Fentanyl is a short-acting drug used to induce anesthesia. Here, we aimed to compare the two doses of ketamine to prevent fentanyl-induced cough in children under general anesthesia.Materials and Methods:This is a randomized, clinical trial which was performed in 2019 in Imam Hossein Hospital in Isfahan, Iran. The study population consisted of children between 6 months and 2 years who were candidates for general anesthesia. Patients were randomized into three groups, each containing 31 patients. Groups 1 and 2 received 0.1 mg/kg and 0.2 mg/kg intravenous ketamine, respectively, 1 min before fentanyl injections. Group 3 received the same volumes of normal saline 0.9%. Patients were observed and evaluated for the incidence and intensity of coughs 1 min and 3 min after fentanyl injections.Results:We showed that the frequency of coughs 1 min after fentanyl injection was significantly lower in Group 2 compared to other groups (P < 0.001). Three min after fentanyl injection, the frequencies of coughs were significantly lower in Groups 1 and 2 compared to Group 3 (P < 0.001). We also showed that the intensity of coughs was significantly lower in Group 2 compared to other Groups 1 and 3 min after fentanyl injection (P < 0.001).Conclusion:The administration of 0.2 mg/kg ketamine is more effective than 0.1 mg/kg dosage in the prevention of fentanyl-induced cough. We also showed that this method could bring more stable hemodynamics and oxygenation saturation inpatients. The comparison of the two dosages was a novel issue in the recent literature.

Bilayer Graft for Incisionless In-Office Endoscopic Repair of Tympanic Membrane Perforations: A Pilot Study.

Tympanic membrane (TM) perforations may result in significant patient morbidity. While intraoperative myringoplasty or tympanoplasty allow for effective repair, not all patients are candidates for general anesthesia. Herein, we describe a novel graft design and technique for in-office repair of TM perforations in the clinic setting. Two pieces of porcine submucosa material were interdigitated to create a bilayer design with lateral and medial flanges. Topical and injected lidocaine were used for local anesthesia. The perforation was rimmed. Grafts were grasped, and medial flanges were placed through the perforation, with lateral flanges resting on the TM surface. TM repair occurred in 5 awake patients with a mean age of 72 years. There were no complications. All perforations healed, with 1 case requiring a minor in-office revision. Audiometry was performed at 4 weeks. The preoperative air-bone gap (mean 0.25, 0.5, 1, 2, and 4 kHz) was 12.2 ± 4.1 dB, and postoperatively, it was 4.2 ± 2.4 dB (P = .001). Novel design of available graft material may allow for effective in-office TM repair.

Prostate Artery Embolization: Current Status 2018

Prostate artery embolization (PAE) is a promising new treatment option for men with symptomatic benign prostatic hyperplasia (BPH). Our goal is to review the data on PAE with regard to outcomes, risks versus benefits, and safety. Current data suggests that PAE is safe and effective for men with symptomatic BPH. The two most robust randomized controlled trials comparing PAE with TURP both found comparable short-term results with regard to improvements in symptoms. However, the side effects of PAE were higher than those of TURP. There remain ongoing randomized controlled trials comparing the two modalities of treatment. Though the largest randomized controlled trials comparing these two modalities of treatment of BPH are still underway, current data suggest PAE may be a promising, safe, and effective treatment option for men with symptomatic BPH. Additionally, PAE can be safely performed on larger prostates of any size and is generally performed via a single, femoral artery puncture under local anesthesia. Therefore, it is particularly appealing for patients with prostate glands > 80 g and who are poor candidates for general anesthesia.

Staggered Sub-Tenon’s Blocks: A Novel Anesthetic Approach for Bilateral Strabismus Surgery

Bilateral strabismus surgery is usually performed under general anesthesia. However, sometimes general anesthesia is not in the best interest of patients presenting with advanced multiple comorbidities. These patients are best treated with local anesthesia instead. However, the bilateral nature of the surgery becomes an issue because bilateral akinetic needle blocks for ophthalmic surgery have not been described before. This article describes a novel approach for bilateral eye surgery in three patients who were at high risk from general anesthesia but needed to have the surgery performed in the same sitting. Staggered blunt needle sub-Tenon's blocks were chosen over sharp needle akinetic extraconal peribulbar or intraconal retrobulbar blocks on account of their predictability, relative safety, and efficacy. The potential systemic complications of bilateral injections were minimized by staggering the blocks. This technique may be an option for high-risk patients who are not candidates for general anesthesia but require bilateral ophthalmic surgery performed in a single surgical episode.

General anesthesia mediated by effects on ion channels

Although it has been more than 165 years since the first introduction of modern anesthesia to the clinic, there is surprisingly little understanding about the exact mechanisms by which general anesthetics induce unconsciousness. As a result, we do not know how general anesthetics produce anesthesia at different levels. The main handicap to understanding the mechanisms of general anesthesia is the diversity of chemically unrelated compounds including diethyl ether and halogenated hydrocarbons, gases nitrous oxide, ketamine, propofol, benzodiazepines and etomidate, as well as alcohols and barbiturates. Does this imply that general anesthesia is caused by many different mechanisms Until now, many receptors, molecular targets and neuronal transmission pathways have been shown to contribute to mechanisms of general anesthesia. Among these molecular targets, ion channels are the most likely candidates for general anesthesia, in particular γ-aminobutyric acid type A, potassium and sodium channels, as well as ion channels mediated by various neuronal transmitters like acetylcholine, amino acids amino-3-hydroxy-5-methyl-4-isoxazolpropionic acid or N-methyl-D-aspartate. In addition, recent studies have demonstrated the involvement in general anesthesia of other ion channels with distinct gating properties such as hyperpolarization-activated, cyclic- nucleotide-gated channels. The main aim of the present review is to summarize some aspects of current knowledge of the effects of general anesthetics on various ion channels.

Laparoscopic peritoneal dialysis catheter implantation using a Tenckhoff trocar under local anesthesia with nitrous oxide gas insufflation

Background Laparoscopic implantation of peritoneal dialysis catheters has many advantages over conventional methods. The ability to perform laparoscopy with the patient under local anesthesia allows renal failure patients, who ordinarily might not be considered candidates for general anesthesia, an opportunity to undergo this procedure. Methods Using local anesthesia and nitrous oxide pneumoperitoneum, 175 catheters were implanted in long musculofascial tunnels under laparoscopic guidance to minimize the risk of catheter migration and flow dysfunction. Results Nitrous oxide pneumoperitoneum was well tolerated, allowing all procedures to be safely completed with the patients under local anesthesia. The overall 1- and 2-year catheter survival rates were 92.7% and 91.3%, respectively. The incidence of catheter tip migration and omental entrapment was 1.7% and 2.9%, respectively. Temporary pericatheter leak occurred in 7.4% of cases. Conclusions Nitrous oxide insufflation enables safe performance of laparoscopic surgery with the patient under local anesthesia. Patients benefit from a minimally invasive technique with the assurance of obtaining successful long-term catheter function.

Anesthetic Induction in a Sitting Position for a Patient with Congestive Heart Failure

A 67-year-old woman with severe congestive heart failure (New York Heart Association, NYHA class IV) was set to receive general anesthesia for cardiac surgery. For several months, she had been in a constant sitting position from which the slightest change evoked dyspnea. A patient in such a condition is rarely considered a candidate for general anesthesia, because such patients are never eligible for any type of surgery other than that used to fix the heart problem itself. We report this case to explain how anesthesia was induced with the patient sitting in a crouching position and discuss other methods of induction that can probably be used in similar situations.

Total Mastectomy Under Local Anesthesia: The Tumescent Technique

The management of breast cancer in elderly women is controversial. Breast cancer in this age group tends to be biologically less aggressive and is highly responsive to hormonal intervention. The risk of dying of other causes often exceeds the risk of cancer recurrence. For these reasons, older patients tend to be treated less aggressively. One large study of elderly women with breast cancer found that half of the patients were undertreated. Four patients (mean age 72 years, range 61-95 years) underwent a unilateral total mastectomy for cancer under local anesthesia using the tumescent technique of infiltrating dilute lidocaine with epinephrine (25 ml of 1% lidocaine [250 mg] and 1 ml of 1:1000 epinephrine [1 mg] to 1 L of Ringers lactate) via an infusion pump. Three of the patients had estrogen receptor (ER)-negative tumors and one patient had tumor progression despite switching from tamoxifen to anastrozole. All four patients were class IV as defined by the American Society of Anesthesiology (ASA). There was no morbidity related to the surgery in the form of hematoma, wound infection, or skin flap necrosis. The patients were discharged 1-4 days after surgery. The anesthesia was adequate in all four cases and there was no deviation from the described technique. The mean operative time was 35 minutes (range 24-46 minutes). The tumescent technique is a safe, effective method for performing a total mastectomy in patients who would not be considered candidates for general anesthesia.

Predictive value of preoperative tests in facectomy

To establish the prevalence of abnormal results in routine preoperative tests prior to facectomies and whether they influence the occurrence of perioperative clinical complications. This prospective study was developed in an academic medical center in Brazil. Besides a clinical evaluation, all patients were requested to undergo an electrocardiogram, complete blood work and fasting blood glucose test. Patients younger than 40 years of age who had had previous eye surgery, candidates for general anesthesia or who had suffered acute myocardial infarction up to three months before surgery were excluded from the study. Intraoperative medical events were recorded in a protocol form. Analysis was carried out using Fisher's test and ANOVA (analysis of variance). The sample was composed of 746 patients, 405 (54.3%) were men. The average age was 66.6+/-11.6 years. Intraoperative complications occurred in 71 (9.5%) patients. There were abnormal results in 13.5% (101 patients) of hemoglobin dosages and in 16.6% (124) of fasting blood glucose. As for electrocardiograms, abnormalities were found in 46.6% (348) of the subjects. There was a higher prevalence of electrocardiograms with abnormal values in patients who had perioperative clinical complications (p=0.02). There were no statistically significant differences between hemoglobin dosages (14.0+/-1.6 g/dL in patients without intraoperative complications and 14.3+/-1.3 g/dL in patients with complications - p=0.150) and fasting blood glucose (104+/-29 mg/dL in patients without complications and 105+/-41 mg/dL in patients with complications - p=0.850). Within the investigated routine of preoperative testing for facectomy, only the abnormal electrocardiogram results influenced the occurrence of complications in the perioperative period.

Stereotactic Radiosurgery for Pituitary Tumors

Objective Report the clinical result of SRS for pituitary adenoma.Methods 18 selected pituitary tumors were treated with SRS between Aug 1994 to Aug 1998.The median tumor diameter was 10mm,median SRS target volum was 1.37mm\+3,median margine target dose was 20Gy.Results The median follow\|up period was 47 months,87.5% cases obtained clinical improvement and 78.5% obtained hormone level lowered,37.5% show reduction of tumor size,only 1 PRL\|producing adenoma received reoperation for tumor progression.Conclusion The most important advantage of SRS is low treatment morbidity,it offers an alternative option for patients who do not require decompression of the optic apparatus or more rapid normalization of their endocrine status or for patients who have failed prior microsurgery.SRS is suitable for the patients who are poor candidates for general anesthesia due to concomitant systemic medical diseases.

Transoral laryngeal surgery under flexible laryngovideostroboscopy.

Although direct microlaryngoscopic surgery is universally accepted as the standard procedure for endolaryngeal surgery, general anesthesia and direct laryngoscopy are necessary during the procedure. Suspended laryngeal position also impedes intraoperative functional monitoring. Transoral laryngeal surgery under indirect laryngeal mirror or telescope has the advantage of sparing general anesthesia and direct laryngoscopy, but lower precision, difficult manipulation, and a high patient cooperation requirement make the procedure of limited application. Trying to overcome the above shortcomings, transoral laryngeal surgery under flexible laryngovideostroboscopy (FLVS) is undertaken at our institute. The surgery is performed at an outpatient office under topical anesthesia, with the help of high-resolution fiberoptic stroboscopy, high-quality CCD videocamera, and monitor. From October, 1993 to March, 1996, 157 patients with selected laryngeal problems were operated upon using this technique, and 150 patients smoothly completed the procedure with satisfactory results. The technique is highly effective, especially for limited-manipulation, lower precision procedures and for patients who are not candidates for general anesthesia. With proper patient selection, this is a cost-effective surgery of low invasiveness and high applicability.