S645 Choice of Sedation for Initial Colonoscopy Determines Compliance With Follow-Up Colonoscopy in Patients With a History of Trauma

Abstract

Introduction: Approximately 7% of Americans report post-traumatic stress disorder (PTSD). Despite the invasive and often sensitive nature of our specialty, little has been studied regarding best practices for trauma-informed care in gastroenterology. We hypothesize that endoscopy with conscious sedation (CS) may reactive trauma and impact follow-up care. We therefore designed a retrospective study to assess factors that may determine colonoscopy compliance in this population. Methods: All patients aged 50-74 years old seen at our hospital system’s primary care practices from 12/31/2009-12/31/2019 were included. Diagnoses were assessed by ICD-coding, and demographics and procedure documentation were obtained from the medical record. Adjusted odds ratios were calculated via logistic regression. Results: 65,062 patients were included in the study, of which 3.7% had a diagnosis of PTSD. The majority of those with PTSD were female (62%). Those who underwent a colonoscopy (N=7,356) versus those who did not (N=57,706) were similar in demographics. However, PTSD patients were more likely to undergo colonoscopy than those without trauma (OR 7.31, 95% CI 5.67-9.42). This was attenuated after additionally controlling for irritable bowel syndrome or chronic diarrhea (OR 3.37 95% CI 2.5-4.52). In contrast, after initial colonoscopy, PTSD patients trended toward lower likelihood of receiving follow-up colonoscopy (OR 0.85, 95% 0.49-1.46). Notably, all patients were more likely to undergo follow-up colonoscopy if the initial procedure was performed with general anesthesia (GA) (OR 2.05, 95% CI 1.82-2.30), however, this effect was significantly amplified among PTSD patients (OR 6.25, 95% CI 2.70-11.46) compared to patients without trauma (OR 2.05, 95% CI 1.82-2.31). (Table) Conclusion: PTSD patients comprise a notable portion of the outpatient screening population. These patients are more likely to be compliant with follow-up colonoscopy if initial procedure is performed under GA, an effect that is significantly magnified compared to the non-PTSD population. Current paradigms do not routinely screen for PTSD when considering candidates for GA, and so while the choice must be individualized, this finding has important clinical implications. PTSD patients may be keener to undergo initial colonoscopy due to active GI symptoms given the strong overlap with functional GI disorders. However, poor tolerance or a negative experience with CS may impact follow-up. This remains to be validated in future prospective studies. Table 1. - Odds Ratios of Surveillance Colonoscopy Among Eligible Patients Who Underwent Initial Colonoscopy Between 2009-2019 Primary adjusted odds ratio* 95% Confidence Interval p-value Conscious sedation - - - General Anesthesia 2.05 1.82-2.30 < .0001 History of trauma 6.25 2.70-11.46 < .0001 No trauma 2.05 1.82-2.31 < .0001 *Adjusted for age, race, sex, and poverty as defined by living in a residential zip code with >30% population below poverty line