Background: In recent years, Candida has become a common pathogen isolated in blood cultures, reaching the fourth place in intranosocomial blood stream infections. Species of non-albicans Candida are becoming more frequent and their susceptibility to drugs is less predictable. These infections are associated with high mortality, particularly in hemodynamically unstable patients. The survival rate is directly related to the initiation of adequate and early empiric therapy. Methods & Materials: Evaluate the impact of adequate and early treatment in patients with candidemia Prospective study of 195 episodes of candidemia from March 2010 to June 2017. Neutropenic patients and bone marrow transplant recipients were excluded. The empirical treatment was classified as adequate (AET) or inadequate (IET), according to susceptibility or resistance of the isolated strains. EUCAST- established sensitivity criteria were used. Results: Our study detected 195 Candida blood culture isolations. Seventy nine cases (40.5%) were caused by C. albicans, whereas 116 cases (59.5%) were caused by non-albicans Candida. Of the latter, 56 cases (28.5%) were C. glabrata, 29 cases (15%) C. parapsilosis, 19 cases (10%) C. tropicalis, 9 cases (4.5%) C. krusei and 3 cases of other Candida species. Of the 116 isolations of non-albicans Candida, 72 (62%) were resistance to fluconazole, while only 3 (4%) resistant strains were found in the Candida albicans isolations. There was no resistance to echinocandins or amphotericin BOf all patients, 151 received AET (77.5%) and 44 IET (22.5%). The mortality rate was 22% in those patients with AET and 77% in the IET group (p < 0.001), RR 3.5 (2.5-4.9)We observed that in the group of AET patients who died, 64% had delayed catheter removal beyond 5 days. There were no deaths in those patients with AET and catheter removal within 24 hours. Conclusion: Candidemias were mostly caused by non-albicans Candida species, with an important level of resistance to fluconazole. The highest mortality rates were observed in patients with IET and those with delayed catheter removal. According to these results, the empirical treatment should be initiated with Echinocandins, eventually de-escalation and early catheter removal.