Many patients utilize the emergency department (ED) as their primary site for medical care. This raises the issue of whether simple preventative measures may be appropriately integrated into the flow of a busy ED. Here we sought to study whether a paper-based educational curriculum and referral program can improve secondary cancer prevention. We conducted a randomized, controled trial with a convenient sample of patients presenting to 2 tertiary care EDs from 11/2017 – 10/2018. Trained research associates administered a brief questionnaire to assess patient demographics, cancer screening history, and access to primary care to identify patients who were deficient in screening for breast, colorectal, cervical and lung cancers, as defined by the National Comprehensive Cancer Network. If deficient, the control group would receive verbal education on what screening was necessary, while the intervention group received both verbal education and a brief educational handout. Both groups received referral to a primary care physician as necessary. Following this intervention, a 30-day chart review and follow-up phone call was performed to ascertain whether a primary care visit was attended to obtain the appropriate cancer screening guidance or testing. We utilized the chi square test to compare follow-up frequency with an alpha of .05. We enrolled 170 patients over the course of our study. The sample was 48% female with a median age range from 55-64. The rates of compliance with screening for each cancer were: breast – 52.7%; cervical – 77.7%; colorectal – 63.9%; and lung – 20%. Approximately 41% of patients surveyed were out of screening compliance and were randomized to control vs intervention. In the control group, 20% of patients reported seeing a doctor to discuss screening vs 50% in the intervention group (p<.001). At the 30-day follow-up, 50% of the intervention group reported receiving the recommended screening. Our patient population demonstrated overall poor adherence to recommended cancer screening guidelines, especially with regard to lung cancer. With minimal education and an informational handout, however, we demonstrated a significant increase in cancer screening follow-up and testing.