Adult Cancer Risk Research Articles

Ecological and health risk assessment of heavy metals contamination in mangrove sediments, Red Sea coast

Due to the significance of mangroves for the diversity of marine and terrestrial life along the Red Sea coast, the present work aimed to evaluate the environmental and health risk of heavy metals in Wadi el-Gemal sediments. The findings of single and integrated indices demonstrated no significant pollution with Fe, Cu, Zn, Ni, Co, and Cd, while the sediments showed severe and minor enrichment with Mn and Cd, respectively, which might be attributed to the presence of some mining activities in the mountains near the study area. The possible carcinogenic and non-carcinogenic risks due to their dermal absorption from the sediments were analyzed and the findings demonstrated that the non-carcinogenic health hazards were within tolerable and safe limits. Moreover, the evaluation of chronic daily intake and the overall cancer risk (LCR) for adults and children for Pb and Cd both ruled out any current potential carcinogenic health risks.

Cumulative exposure to metabolic syndrome increases thyroid cancer risk in young adults: a population-based cohort study.

A re-increasing trend of thyroid cancer since 2015 has been observed despite a similar examination rate, and the incidence of thyroid cancer among young adults continues to rise. This study used data from the Korean National Health Insurance Service. Individuals 20-39 years of age who underwent ≥ 4 health checkups from 2009-2013 were enrolled and followed throughout 2019. To quantify the metabolic burden, groups were divided by the number of diagnoses of metabolic syndrome across four consecutive health examinations. Among the study population (n = 1,204,646), 5,929 (0.5%) were diagnosed with thyroid cancer during a follow- up period of 5 years. The hazard ratio (95% confidence interval) values of thyroid cancer occurrence according to the number (1-4) of diagnoses of metabolic syndrome across the four health examinations compared to the group without metabolic syndrome were significantly greater, as follows: 1.12 (1.02-1.23), 1.25 (1.10-1.42), 1.33 (1.15-1.55), and 1.48 (1.25-1.75) (p for trend < 0.01), respectively. Each component of metabolic syndrome showed a significant increase in hazard ratio according to the number of diagnoses except for impaired fasting glucose criteria. Cumulative exposure to metabolic syndrome was associated with thyroid cancer risk in young adults.

Heavy Metal Concentrations in Mollusks and Crustaceans Harvested from Eastern Samar’s Taft River in the Philippine and the Health Risks Posed to Consumers

Heavy metal (HM) contamination from mining activities poses a health risk to humans who consume mollusks and crustaceans from mine-affected environments. One such example is the Taft River, which receives drainage water and sediments from the Bagacay mines in Samar, Philippines. To assess the accumulation of HM in mollusks and crustaceans and the associated risks to the humans, a comprehensive analysis was conducted on representative specimens, which were gathered from different sections of the river. The concentrations of Cu (97.67 mg kg–1), Ni (29.30 mg kg–1), Pb (0.59 mg kg–1), and Sr (14.67 mg kg–1) in the flesh of “bebe” (Batissa violacea Lamarck) were significantly higher than those in “tangili” (Telescopium telescopium Linn.), “tuway” (Mercenaria mercenaria Linn.), and “sihi” (Nerita albicilla Linn.); whereas for crustaceans, the flesh of mud crabs (Scylla serrata) contained higher concentrations of As (17.67 mg kg–1), Cu (118.67 mg kg–1), Ni (25.79 mg kg–1), Rb (31.33 mg kg–1), Sr (60.67 mg kg–1), and Zn (331.00 mg kg–1) compared with giant freshwater prawns (Macrobrachium rosenbergii). The consumption of T. telescompium, N. albicilla, and B. violacea may result in an estimated daily intake (EDI) that is greater than the provisional tolerable daily intake (PTDI) for As [2.03–4.48 μg kg–1 body weight (BW) d–1], while all mollusks may have an EDI for Cr of between 124.59–136.23 48 μg kg–1 BW d–1. This may subsequently lead to a high target hazard quotient (THQ), high hazard index (HI), and high target cancer risk (TCR) for adults. With respect to crustaceans, the consumption of S. serrata exceeds the PTDI index for As. Both S. serrata and M. rosenbergii exceed the PTDI for Cr by 20–21 times, as well as the elevated health risk values of 22.36 and 28.57 48 μg kg–1 d–1 for M. rosenbergii and S. serrata, respectively. Overall, current results indicate that human consumption of the Taft River mollusks and crustaceans may inadvertently lead to an increased intake of As and Cr that could negatively impact human health.

LipoCol Forte capsules reduce the risk of liver cancer: A propensity score-matched, nationwide, population-based cohort study.

Liver cancer is among the top five most common cancers globally. Lipid-lowering drugs such as statins can lower the risk of liver cancer, but may also cause liver damage. LipoCol Forte capsules (LFC), a red yeast rice product, have demonstrated significant antihypercholesterolemic effects and a good safety profile in clinical studies. To evaluate whether LFC lowers the risk of liver cancer in adults in this propensity score-matched, nationwide, population-based cohort study. We used data from Taiwan's National Health Insurance Research Database, which includes electronic medical records for up to 99.99% of Taiwan's population. LFC users and LFC non-users were matched 1:1 by propensity scores between January 2010 and December 2017. All had follow-up data for at least 1 year. Statistical analyses compared demographic distributions including sex, age, comorbidities, and prescribed medications. Cox regression analyses estimated adjusted hazard ratios (aHRs) after adjusting for potential confounders. We enrolled 33231 LFC users and 33231 non-LFC users (controls). No significant differences between the study cohorts were identified regarding comorbidities and medications [standardized mean difference (SMD) < 0.05]. At follow-up, the overall incidence of liver cancer was significantly lower in the LFC cohort compared with controls [aHR 0.91; 95% confidence interval (CI): 0.86-0.95; P < 0.001]. The risk of liver cancer was significantly reduced in both females (aHR 0.87; 95%CI: 0.8-0.94; P < 0.001) and males (aHR 0.93; 95%CI: 0.87-0.98; P < 0.01) in the LFC cohort compared with their counterparts in the non-LFC cohort. The antitumor protective effects applied to patients with comorbidities (including hypertension, ischemic stroke, diabetes mellitus, hyperlipidemia, hepatitis B infection and hepatitis C infection). Those using LFC for more than 84 drug days had a 0.64-fold lower risk of liver cancer compared with controls (P < 0.001). Compared with controls, the risk of developing liver cancer in the LFC cohort progressively decreased over time; the lowest incidence of liver cancer occurred in LFC users followed-up for more than 6 years (27.44 vs 31.49 per 1,000 person-years; aHR 0.75; 95%CI: 0.68-0.82; P < 0.001). This retrospective cohort study indicates that LFC has a significantly protective effect on lowering the risk of liver cancer, in a dose-dependent and time-dependent manner.

Risk of Melanoma and Nonmelanoma Skin Cancer in People with Vitiligo: United Kingdom Population−Based Cohort Study

Although genetic studies have found an inverse relationship between vitiligo and skin cancer, epidemiological evidence is conflicting. We investigated the risk of skin cancer in adults with vitiligo using United Kingdom electronic primary care records from the Optimum Patient Care Research Database 2010-2020. Vitiligo cases were age, sex, and general practitioner practice matched to population controls without vitiligo. Incidence of melanoma, nonmelanoma skin cancers (squamous cell carcinoma and basal cell carcinoma), and actinic keratoses was compared between vitiligo cases and controls using Cox regression. A total of 15,156 vitiligo cases were matched to 60,615 controls. Vitiligo was associated with a 38% reduced risk of new-onset skin cancer (adjusted hazard ratio [aHR]= 0.62, 95% confidence interval [CI]= 0.52-0.75, P < 0.001) and skin cancer subtypes; melanoma (aHR= 0.39, 95% CI= 0.23-0.65, P < 0.001), squamous cell carcinoma (aHR= 0.67, 95% CI= 0.49-0.90, P < 0.01), basal cell carcinoma (aHR= 0.65, 95% CI= 0.51-0.83, P < 0.001). There was no significant association for actinic keratosis (aHR= 0.88, 95% CI= 0.77-1.01). People with vitiligo have a markedly reduced incidence of melanoma and nonmelanoma skin cancer. Given concerns that some treatments, such as phototherapy, may increase skin cancer risk, this finding provides reassurance to people with vitiligo and clinicians managing the condition.

Probabilistic non-carcinogenic and carcinogenic risk assessments of potential toxic metals (PTMs) and polycyclic aromatic hydrocarbons (PAHs) in canned foods in Nigeria: understanding the size of the problem

The purpose of the study was to determine the concentrations of potential toxic metals (PTMs) and polycyclic aromatic hydrocarbons (PAHs) in 20 canned food samples (fish, meat, vegetable, non-alcoholic drink and beverage) sold in markets of Port Harcourt city (Nigeria) and to assess their potential human health risks (non-carcinogenic and carcinogenic). The methodology comprised the Graphite Furnace Atomic Absorption Spectrometry (GFAAS) analysis of metals and Gas Chromatography-Mass Spectrometry (GC-MS) analysis of PAHs, and then the calculation of the estimated daily intake (EDI), target hazard quotient (THQ) and cancer risk (CR) in adults and children. Results showed that the EDI values for As, Cd, Cu, and Pb from consumption of canned foods were below the provisional tolerable daily/provisional tolerable weekly intakes (PTDI/PTWI), and for Fe and Zn below the recommended daily intake (RDI), in both adults and children. The EDI value for B[a]P from consumption of canned foods was less than the PTWI value in both adults and children. Whilst the individual THQ values of metals were less than 1, the ∑THQ values were higher than 1 thus indicating a potential health risk arising from consumption of canned foods containing a mixture of metals. Moreover, the CR values by individual carcinogenic metals indicated a priority risk in both adults and children for As (mean, 2.43E-02 and 9.73E-03) and Cd (mean, 6.03E-03 and 1.95E-03), while the risk was acceptable for PAHs exposure (2.13E-09). In addition, the total CR (TCR), which was used to assess the effects of multiple carcinogenic metals, ranged from 1.24E-02 to 6.237E-02 indicating a carcinogenic risk for adults and children. In conclusion, the consumption of canned foods by Nigerian community can bring about worst health risks due to the residual concentration of PTMs in these products and the health hazard associated with them.

Associations between urinary parabens and lung cancer.

Parabens are a family of endocrine-disrupting chemicals. Environmental estrogens may play a vital role in the development of lung cancer. To date, the association between parabens and lung cancer is unknown. Based on the 189 cases and 198 controls recruited between 2018 and 2021 in Quzhou, China, we measured 5 urinary parabens concentrations and examined the association between urinary concentrations of parabens and lung cancer risk. Cases showed significantly higher median concentrations of methyl-paraben (MeP) (2.1 versus 1.8ng/mL), ethyl-paraben (0.98 versus 0.66ng/mL), propyl-paraben (PrP) (2.2 versus 1.4ng/mL), and butyl-paraben (0.33 versus 0.16ng/mL) than controls. The detection rates of benzyl-paraben were only 8 and 6% in the control and case groups, respectively. Therefore, the compound was not considered in the further analysis. The significant correlation between urinary concentrations of PrP and the risk of lung cancer (odds ratio (OR)adjusted = 2.22, 95% confidence interval (CI): 1.76, 2.75; Ptrend < 0.001) was identified in the adjusted model. In the stratification analysis, we found that urinary concentrations of MeP were significantly associated with lung cancer risk (OR = 1.16, 95% CI: 1.01, 1.27 for the highest quartile group). Besides, comparing the second, third, and fourth quartile groups with the lowest group of PrP, we also observed urinary PrP concentrations associated with lung cancer risk, with the adjusted OR of 1.52 (95% CI: 1.29, 1.65, Ptrend = 0.007), 1.39 (95% CI: 1.15, 1.60, Ptrend = 0.010), and 1.85 (95% CI: 1.53, 2.30, Ptrend = 0.001), respectively. MeP and PrP exposure, reflected in urinary concentrations of parabens, may be positively associated with the risk of lung cancer in adults.

Potential toxic elements in costal sediment of the Persian Gulf: a systematic review-meta-analysis, non-dietary risk assessment and ecological risk assessment

Potential toxic element (PTE) contamination in the Persian Gulf has become an important health concern in recent decades. This investigation aimed to meta-analyses of potential toxic elements including lead (Pb), inorganic arsenic (As), cadmium (Cd), nickel (Ni), and mercury (Hg) in the coastal sediment of the Persian Gulf. In this study, an attempt was made to retrieve papers conducted on the concentration of PTE in the coastal sediment of the Persian Gulf by searching in international databases including Web of Science, Scopus, Embase, and PubMed. Meta-analysis concentration of PTE in the coastal sediment of the Persian Gulf was conducted using random effects model based on the country subgroup. Additionally, non-dietary risk assessment including non-carcinogenic and carcinogenic risks from ingestion, inhalation and dermal contact routes and ecological risk assessment was estimated. Seventy-eight papers with 81 data-reports (1650 sample size) were included in our meta-analysis. The rank order of heavy metals in coastal sediment of the Persian Gulf based on pooled concentration was Ni (65.44mg/kg) > Pb (58.35mg/kg) > As (23.78mg/kg) > Cd (1.75mg/kg) > Hg (0.77mg/kg). The highest concentration of As, Cd, Pb, Ni, and Hg was observed in the coastal sediment of Saudi Arabia, Arab Emirates, Qatar, Iran, and Saudi Arabia, respectively. Although the Igeo index in coastal sediment of the Persian Gulf was in grade 1 (uncontaminated) and grade 2 (slightly contaminated) but total target hazard quotient (TTHQ) of adults and adolescent was higher than 1 value in Iran, Saudi Arabic, United Arab Emirates, and Qatar. Total cancer risk (TCR) for adults and adolescent due to As was higher than 1E-6 in Iran, United Arab Emirates, and Qatar but TCR for adolescents due to As was higher than 1E-6 in Saudi Arabic. Therefore, it is recommended to monitor the concentration of PTE and implementation of programs to reduce the emission of PTE from resources in the Persian Gulf.

Longitudinal Analysis of Cancer Risk in Children and Adults With Germline PTEN Variants

Identifying hereditary cancer predisposition facilitates high-risk organ-specific cancer surveillance and prevention. In PTEN hamartoma tumor syndrome (PHTS), longitudinal studies remain lacking, and there are insufficient data on cancers in children and young adults, as well as individuals with neurodevelopmental disorders (NDD). To evaluate lifetime cancer risks, including second malignant neoplasms (SMN), among patients with PHTS. Prospective longitudinal cohort study (September 1, 2005, through January 6, 2022). General population risks from the Surveillance, Epidemiology, and End Results database. Patients with PHTS, molecularly defined as carrying germline PTEN variants, were accrued from community and academic medical centers throughout North America, South America, Europe, Australia, and Asia. Data were analyzed from July 2022 to February 2023. Review of physical and electronic medical records, and follow-up through clinical visits or telephone interviews. Lifetime cancer risks in PHTS relative to the general population. A total of 7302 patients were prospectively accrued, 701 of whom had germline PTEN variants (median [IQR] age at consent, 38 [12-52] years; 413 female patients [59%]). Longitudinal follow-up data could be obtained for 260 patients (37%), with a median (IQR) follow-up of 4 (2-8) years. Of the 701 patients, 341 (49%) received at least 1 cancer diagnosis, with 144 (42%) of those having SMN. The study found significantly elevated lifetime risks for breast (91%), endometrial (48%), thyroid (33%), kidney (30%), and colorectal cancers (17%), as well as melanoma (5%). Cancer diagnoses were also observed in children and young adults with PHTS (15%) and in patients with PHTS with neurodevelopmental disorders (11%). Elevated risks (P < .001) of thyroid (age-adjusted standardized incidence ratios [SIR], 32.1; 95% CI, 26.0-39.0), kidney (SIR, 26.5; 95% CI, 18.8-36.3), endometrial (SIR, 26.0; 95% CI, 19.5-34.1), breast (SIR, 20.3; 95% CI, 17.3-23.7), and colorectal (SIR, 7.9; 95% CI, 5.2-11.7) cancers, and melanoma (SIR, 6.3; 95% CI, 3.5-10.5) were observed. Of the 341 patients with PHTS with cancer, 51 (15%) had 1 or more cancers diagnosed at age 29 years or younger, and 16 (31.4%) of those developed SMN at final follow-up. Twenty-three patients with PHTS with NDD and cancer were identified, with 5 (22%) having developed SMN at final follow-up. Individuals with PHTS and NDD showed higher lifetime cancer risks compared with individuals with PHTS but without NDD (hazard ratio, 2.7; 95% CI, 1.7-4.2; P < .001). This cohort study found consistently elevated lifetime cancer risks in PHTS. Organ-specific surveillance should continue in patients with PHTS. Additional study is required to ascertain elevated cancer risks in patients with PHTS with NDD.

Association between nut consumption and prostate cancer risk in adults: A systematic review and dose-response meta-analysis of observational studies

AimsData on the association between nut consumption and prostate cancer risk are conflicting. Therefore, this systematic review and dose-response meta-analysis aimed to summarize available findings from observational studies on the associations of nut intake with risk of total, advanced, non-advanced, and fatal prostate cancers. Data synthesisWe searched the online databases of PubMed, Scopus, and Web of Science as well as Google Scholar using appropriate keywords to identify eligible articles up to September 2022. In total, 11 articles with a total sample size of 287,786 participants and 32,213 cases of prostate cancer were included in the current systematic review and meta-analysis. By comparing the highest and lowest intake of total nuts, pooled relative risks (RRs) and 95% confidence intervals (95% CIs) for total, advanced, non-advanced, and fatal prostate cancers were 0.94 (95% CI: 0.85–1.04, P = 0.22), 1.10 (95% CI: 0.98–1.24, P = 0.12), 0.97 (95% CI: 0.85–1.11, P = 0.69), 0.97 (95% CI: 0.79–1.18, P = 0.73), respectively, which indicated non-significant inverse associations for total, non-advanced, and fatal prostate cancers and a non-significant positive association for advanced prostate cancer. In the dose-response analyses, we found no evidence of a linear or non-linear association between total nut intake and prostate cancer risk. Data on other types of nuts, including walnut, tree nuts, peanut, and peanut butter, were not sufficient for performing a meta-analysis. ConclusionWe found no significant association between nut intake and risk of total, advanced, non-advanced, and fatal prostate cancer. Further studies are required to confirm our findings. Prospero registration codeCRD42022347094. Ethical approvalNot required.

Chronic Use of Hydrochlorothiazide and Risk of Skin Cancer in Caucasian Adults: A PharmLines Initiative Inception Cohort Study.

Photosensitizing properties of hydrochlorothiazide may increase skin cancer risk. To date, study findings on the association between hydrochlorothiazide use and skin cancer risk are inconsistent, notably regarding confounding and dose-response. The aim of this study was to investigate the association between hydrochlorothiazide use and incidence of skin cancer in a cohort of unselected Caucasian adults, taking dosing into account. As part of the PharmLines Initiative, which links data from the Lifelines Cohort Study and prescription database IADB.nl, patients aged ≥ 40 years were included from Lifelines, a prospective population-based cohort study in the north of the Netherlands. Skin cancer incidence was compared between subjects starting hydrochlorothiazide treatment (n = 608), subjects starting treatment with other antihypertensives (n = 508), and non-antihypertensive long-term medication users (n = 1,710). Cox regression analyses were performed to obtain hazard ratios, adjusted for potential confounders. The risk of any skin cancer, keratinocyte carcinoma, basal cell carcinoma and squamous cell carcinoma was not significantly increased in general hydrochlorothiazide users. A clear association was observed between high cumulative hydrochlorothiazide use (≥ 5,000 defined daily dose; ≥ 125,000 mg) and the risk of any skin cancer (adjusted hazard ratio 5.32, 95% confidence interval (95% CI) 2.40-11.81), keratinocyte carcinoma (adjusted hazard ratio 7.31, 95% CI 3.12-17.13), basal cell carcinoma (adjusted hazard ratio 7.72, 95% CI 3.11-19.16) and squamous cell carcinoma (adjusted hazard ratio 19.63, 95% CI 3.12-123.56). These findings should lead to awareness with high use of hydrochlorothiazide in Caucasian adults.

Abstract 1977: Body mass index genetic risk score and obesity related cancer risk in Black and White adults

Abstract A total of 13 cancers are known to be strongly associated with obesity. The purpose of this study was to examine the association between a composite genotype risk score (GRS) for high body mass index (BMI) and the odds of obesity-related cancer. A nested case-control study was created within the Pennington Center Longitudinal Study, an ongoing prospective cohort study of the effects of obesity and lifestyle factors on the development of chronic diseases and premature mortality in Black and White Americans. A total of 459 participants developed an obesity-related cancer, and after stratification by sex and race, incidence density sampling was applied to select matched control participants (2:1) of the same age as cases (± 2 y). After deletion of participants with missing data, the analytic sample included 1242 participants (435 cases;136 Black, 299 White). A BMI GRS was derived using 21 single nucleotide polymorphisms (SNPs) with consistent evidence of association from the literature and which showed concordant associations in effect size and direction in our cohort. The GRS score was computed by summing the number of BMI risk alleles. In a model including age, race, sex, exam year and smoking as covariates, the BMI GRS was significantly associated with obesity-related cancer [odds ratio (OR): 1.18; 95% confidence interval: 1.04, 1.34; p=0.01]. Further adjustment for BMI did not change the association [1.20; 1,06-1.36; p=0.004]. In conclusion, the BMI GRS appears to provide added value in identifying obesity-related cancer risk, even after adjustment for BMI. Future studies are required to validate these results and better delineate the phenotypic and genetic contributions of BMI to obesity-related cancer risk. Citation Format: Peter T. Katzmarzyk, Shengping Yang, Justin C. Brown, Emily F. Mire, Jovanny Zabaleta. Body mass index genetic risk score and obesity related cancer risk in Black and White adults [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2023; Part 1 (Regular and Invited Abstracts); 2023 Apr 14-19; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2023;83(7_Suppl):Abstract nr 1977.

Orchidopexy for congenital cryptorchidism in childhood and adolescence and testicular cancer in adults: an updated systematic review and meta-analysis of observational studies.

Congenital cryptorchidism is a well-established risk factor of testicular malignancies. However, there is still remarkable variability in the measures of associations betweenof these two clinical entities. The current meta-analysis investigates the up-to-date risk of testicular cancer in adults with a history of surgically corrected congenital cryptorchidism until adolescence. The meta-analysis was conducted with strict criteria for the identification of the congenital cryptorchidism cases that underwent surgery before adulthood. The study was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. A search of the PubMed and the Scopus databases was conducted, using a defined strategy, from inception to February 2023. Two independent authors screened the literature and extracted the data, using inclusion and exclusion criteria. Of the 2176 articles identified, 93 articles were fully retrieved, and 6 articles met all the inclusion criteria. The Newcastle-Ottawa scale was applied for the studies' quality assessment. The random-effects model in RevMan 5.4 program was used for the meta-analysis. Three case-control studies and three cohort studies were selected. They included 371,681 patients and 1786 incidents of testicular cancer. The pooled odds ratio (OR) was 3.99 (95% confidence intervals (CI): 2.80-5.71). The heterogeneity was moderate and estimated at 51% with the I-squared statistic. A forest plot and a funnel plot were produced to evaluate the ORs and the probable publication bias, respectively. The mean Newcastle-Ottawa score was 8/9 for all the included reports. Conclusion: This systematic review and meta-analysis verifies, with an updated estimate, the increased risk of testicular cancer in adults with an orchidopexy history. New evidence on the maldescent laterality supports that the cancer risk remains increased and for the contralateral, unaffected testicle, although to a lesser extent. The orchidopexy in the first year of life prevents the testicular damage and decreases the overall cancer risk. What is Known: • Congenital cryptorchidism is the commonest genitourinary abnormality and a risk factor for testicular cancer. • The most recent meta-analysis reporting this association was in 2013. What is New: • After reviewing literature until February 2023, the association of congenital cryptorchidism with testicular cancer risk in adulthood was verified: odds ratio=3.99 [2.80-5.71], 95% CI. • The meta-analysis highlights the protective role of early orchidopexy and the controversial data about maldescent and testicular cancer laterality.

Outdoor Atmospheric Micro-/Nanomineral-Mediated Organochlorine Pesticides in Sichuan Basin, China: Adsorption, Occurrence, and Risk Assessment.

Atmospheric micro-/nanominerals play an important role in the adsorption, enrichment, and migration of organochlorine pesticides (OCPs). In the present study, the correlations between OCPs and minerals in outdoor atmospheric dustfall were investigated, and the correlations were used to speculate the source of p,p'-(dicofol+dichlorobenzophenone [DBP]), which is the sum of p,p'-dicofol and p,p'-DBP. Atmospheric dustfall samples were collected from 53 sites in the Chengdu-Deyang-Mianyang economic region in the Sichuan basin. In this region, 24 OCPs were analyzed by gas chromatography-tandem mass spectrometry. The average concentration of 24 OCPs was 51.2 ± 27.4 ng/g. The results showed that the concentration of Σ24 OCPs in urban areas was higher than that in suburban areas (p < 0.05). Minerals in atmospheric dustfall were semiquantitatively analyzed by X-ray diffraction. The primary minerals were quartz, calcite, and gypsum. A Spearman correlation analysis of OCPs and minerals showed that low-volatility OCPs could be adsorbed by minerals in atmospheric dustfall. A density functional theory simulation verified that p,p'-(dicofol+DBP) in atmospheric dustfall was primarily derived from the p,p'-dicofol adsorbed by gypsum. Isomeric ratio results suggested that the samples had weathered lindane and chlordane profiles and confirmed that residents in the Sichuan basin used technical dichlorodiphenyltrichloroethane. Finally, the OCPs were evaluated to determine the potential risk of cancer in adults and children from OCP exposure. Exposure to OCPs via atmospheric dustfall was safe for adults. The cancer risk for children exposed to OCPs was slightly lower than the threshold value (10-6 ) under a high dust ingestion rate, which poses a concern. Environ Toxicol Chem 2023;42:594-604. © 2022 SETAC.

Mobile Source Benzene Regulations and Risk of Childhood and Young Adult Hematologic Cancers in Alaska: A Quasi-experimental Study.

We aimed to evaluate the impact of the EPA's Mobile Source Air Toxics rules (MSAT), which targeted benzene emissions, on childhood and young adult leukemia and lymphoma incidence in Alaska. MSAT was implemented in 2011 and produced a dramatic decline in ambient benzene in Alaska. Due to previous benzene-related regulations enacted in the continental United States, MSAT had relatively modest impacts in other states. This created quasi-experimental conditions leveraged in this study. Using 2-year state-level incidence rates of childhood and young adult leukemia and lymphoma for each US state 2001-2018, we examined MSAT-attributable changes in incidence by applying a difference-in-differences approach. We found evidence of a substantial reduction associated with MSAT in incidence of childhood and young adult lymphoma (-1.23 [-1.84, -0.62] cases per 100,000), but not in leukemia (-0.13 [-0.77, 0.51] cases per 100,000). Our findings are consistent with the hypothesis that MSAT, which reduced benzene levels in Alaska, led to a decline in lymphoma incidence in children and young adults.

The association of serum serine levels with the risk of incident cancer: results from a nested case-control study.

Background: Cancer is associated with the dysregulation of serum serine levels, and tumor growth is supported by increased serine biosynthesis. This study aims to explore the association of serum serine levels with incident cancer risk in Chinese hypertensive adults. Materials and methods: 1391 patients with incident cancer and 1391 matched controls in terms of age, sex, and residence with cases in a 1 : 1 ratio were included in this nested case-control study. The serum serine concentrations were determined by liquid chromatography with tandem quadrupole mass spectrometry (LC-MS/MS) at the baseline. The associations of serum serine levels with the risk of overall, digestive system, non-digestive system, and lung cancers (the most common type) were assessed by conditional logistic regression. Results: When serum serine concentration was assessed as quartiles, a significantly higher risk of total cancer (OR = 1.32; 95% CI: 1.01-1.71; P = 0.038) was found in participants in the highest quartile (≥17.68 μg mL-1) compared with participants in the lowest quartile (<13.27 μg mL-1). Similar results were also observed for non-digestive system and lung cancers, but not for digestive system cancers. Significant associations of serum with overall cancer risk were found among all age subgroups, men, non-smokers, non-drinkers, and individuals with lower folic acid levels. Conclusion: High serum serine concentrations were associated with an increased risk of overall, non-digestive system, and lung cancers among Chinese hypertensive adult patients.

Association between Diet-related Behaviour and Risk of Colorectal Cancer: A Scoping Review.

Individual dietary patterns may be influenced by diet-related behaviours, which may eventually play a significant role in contributing to colorectal cancer risk. As nearly half of colorectal cancer cases can be prevented through diet and lifestyle modification, in this study, we aimed to present an overview of the literature on diet-related behaviour and its effect on colorectal cancer risk among adults. Articles published from 2011 until July 2021 were selected. Out of the 1,198 articles retrieved, 25 were analyzed. There were 16 case-control studies, and nine of them were cohort studies. As a finding, the instruments used in this review were food frequency questionnaires (n = 23), followed by a semi-structured interview (n = 1), and diet records (n = 1). We demonstrated that unhealthy diet-related behaviours are linked to an increased risk of colorectal cancer in adults and those food frequency questionnaires or food records are common instruments used to collect diet-related behaviours. This article imparts the research trends and directions of colorectal cancer risk factors and shows that diet-related behaviour varies and changes over time.

Spatial Distribution Profiles and Human-Health Risks of Heavy Metals in Surrounding Area Surface Soils of a Petrochemical Complex

Despite the growing concern raised by organic pollutants from the petrochemical industry to the surrounding soils, the heavy metal (HM) pollution in these soils remains understudied. This study investigated the levels, potential sources, and human-health risks of 12 HMs in soils inside and in surrounding areas of a petrochemical complex. Generally, the levels of 12 HMs in all soil samples were lower than the national standard of China, except for the Cd in one surrounding soil sample. Approximately 40.9% and 98.1% of soils around and inside the petrochemical complex, respectively, were at slightly contaminated levels. The HM pollution in 94.4% of soils inside and 32% of soils in surrounding areas were mainly affected by petrochemical production. Human-health risk showed that although As posed an acceptable cancer risk for adults both in and around the complex, high cancer risk for surrounding children from As was observed. Moreover, around the complex, Cr, Cd, and Pb posed acceptable cancer risks for children, while Cd posed an acceptable cancer risk for adults. The spatial distribution of the health risks decreased with increasing distance from the complex. Overall, our results demonstrate that it is essential to minimize human exposure to HMs originating from the petrochemical industry, especially As, Cr, Cd, and Pb.

Source appointment and health risk assessment of polycyclic aromatic hydrocarbons in paddy grain from Thailand and Laos.

Rice is a staple meal for the majority of Asians. However, human exposure to polycyclic aromatic hydrocarbons from paddy grain is largely unknown in Thailand and Laos. Therefore, information on the quantitative measurement and assessment of the health problems caused by PAHs was analyzed. The results showed that the concentrations of total PAHs in paddy grain in Thailand and Laos were 38.86 ± 5.13 and 11.35 ± 1.96ngg-1, respectively. The highest concentration of PAHs in Thailand was B[k]F, whereas D[a,h]A was found to be the highest in Laos. A p-value less than 0.05 was defined, which showed B[b]F and B[k]F from Thailand and Laos were significant, which indicated that they could be from a different pollutant source. The main finding of this study, which was supported by the diagnostic ratios of PAHs and HCA, was that the primary source of PAHs was assumed to be incomplete combustion of petroleum products, which was caused by the burning of industrial fuels or vehicle exhausts, as well as open burning. The findings suggest that these two nations have similar PAH origins. Agricultural waste burning and transportation emissions are well-known sources of PAHs in Thailand and Laos. The cancer risk assessment method was based on the accumulation of PAHs from paddy grains. An ILCR of 1.0E-06 to 1.0E-04 was considered a tolerable limit of cancer risk, while a risk > 1.0E-04 was considered a concern in terms of cancer risk. The findings indicated that while PAH emissions exist, their contribution to global toxicity may be anticipated to be low in inhalation exposure. The higher values of ingestion and dermal risk estimated were regarded as the tolerable limit of cancer risk in children and adults from both countries, indicating that cancer risk in both nations falls within the "acceptable level" range.

The Association of Serum L-Carnitine Concentrations with the Risk of Cancer in Chinese Adults with Hypertension

The effect of serum L-carnitine (LC) concentrations on cancer risk remains unclear. This study aims to explore the association between serum LC and the risk of incident cancer. This is a case-control study, including 574 patients with incident cancer and 574 controls matched in a 1:1 ratio by age, sex, and residence, nested within the China H-Type Hypertension Registry Study (CHHRS). Conditional logistic regression analysis was used to assess the association of serum LC and incident cancer risk. When LC was assessed as quartiles, compared with patients with low LC (Q1), patients in the highest quartile (Q4) had a 33% (OR = 0.67, 95% CI: 0.46 to 0.99), 52% (OR = 0.48, 95% CI: 0.23 to 0.99), and 39% (OR = 0.61, 95% CI: 0.38 to 0.99) decreased risk of overall, digestive system, and non-digestive system cancer in the adjusted models, respectively. In subgroup analyses, an inverse association of LC with cancer risk was observed in individuals who were overweight (obese), who never drink, who never smoke, and who were female. In the mediation analysis, serum trimethylamine-N-oxide (TMAO) concentrations did not mediate the reversed association of LC with cancer risk. This study showed that serum LC concentrations had a protective impact on overall, digestive system, and non-digestive system cancer risk.