Aim. To determine the informativeness of genealogical and morphological characteristics of patients with endometrial hyperplasia and cancer. Methods. Clinical and genealogical analysis, mathematical and statistical method, method of selection of informative factors – Kullback informativeness criterion. Results. Information about the health of 243 first- and 413 second-degree relatives was received from 50 patients with endometrial hyperplasia. Data on 2026 first- and 3685 second-degree relatives was also obtained from 413 patients with endometrial cancer. It was found that the most significant clinical indicators (I>0,5) for risk of endometrial cancer are the next: age over 60 years (I=2,76); presence of cancer of female reproductive organs and gastrointestinal tract in pedigrees of patients with atypical hyperplasia (I=1,51); duration of menopause more than 11 years (I=1,40); dysfunctional uterine bleeding (I=0,85); III–IV class of obesity (I=0,59); bleeding in menopause (I=0,55). Conclusions. Predicative effectiveness of studies of family histories of patients with atypical endometrial hyperplasia was substantiated that has clinical value and allow assessing the personalized risk of endometrial cancer.
 Keywords: endometrial hyperplasia and cancer, clinical and genealogical analysis, pedigrees.