LONDON. Royal Society, May 20.—Sir Archibald Geikie, K.C.B., president,. in the chair.—Observations, in the urine in diseases of the pancreas: P. J. Cammidge. In the course of a series of observations on the metabolic changes associated with diseases of the pancreas it was found that if the urine of a patient suffering from an inflammatory affection, of the gland were boiled with hydrochloric acid, the excess neutralised with lead carbonate, and the freed glycuronic acid precipitated out with tri-basic lead acetate, treatment of the filtrate, with phenylhydrazine, after the excess of lead had been removed with sulphuretted hydrogen, yielded a crystalline, product which varied in amount with the intensity and stage of the disease. Normal urines, and specimens from, patients suffering from diseases in which there was no reason to think that the pancreas was involved, gave no reaction. Twenty-eight cases in which the urine had been examined during life were investigated post-mortem, and the results of the urinary examination confirmed. The urines of three dogs with experimentally induced acute or chronic pancreatitis were found to give a characteristic reaction. A detailed examination of a large quantity of urine from each of eight patients giving a well-marked reaction showed that it was due to a sugar having the reactions of a pentose, and yielding an osazone with a melting point of 178° C. to 180° C. Attempts to isolate the mother-substance were not successful; it would appear to be derived from the pancreas, and is probably set free as the result of degenerative changes in the gland, passing into the blood, and being excreted in the urine.—Trypanosoma ingens, n.sp.: Sir David Bruce and Captains A. E. Hamerton, H. R. Bateman, and F. P. Mackie.—The incidence of cancer in mice of known age: Dr. E. F. Bashford and Dr. J. A. Murray. The relative frequency of cancer at different age periods in female mice has been determined on animals bred for the purpose, the ages, sex, and parentage being carefully recorded. The diagnoses have been made by combining clinical observation with microscopical examination and transplantation of the tumours, and with post-mortem examination of the animals. Following Jensen, the authors demonstrated in 1903–4 that cancer can be transmitted artificially from one individual to another of the same species by the implantation and continued growth of living cancer-cells, and have shown that this form of transmission is not responsible for the great frequency of the disease. Other authors have since described “epidemics” of cancer in animals, especially mice. In the course of a year the present authors observed nineteen cases of cancer in their mice. This aggregation of cases corresponds to the “epidemics” adduced as evidence that the disease is infective. The cases have been analysed with reference to the age at which the tumours were first observed. The following table gives the liability to cancer at different age-periods:—