Presence Of Cancer Research Articles

Dynamic MR imaging as a predictor of prognosis in breast cancer

Contrast‐enhanced MR imaging (CE‐MRI) has become a widely accepted complementary method for diagnosing breast cancer. It has been suggested for evaluating patients with breast implants, patients at risk of tumour multifocality or recurrence, search for occult primary cancer in presence of axillary metastasis and monitoring the effect of preoperative chemotherapy. The clinical usefulness of MR imaging in patients with increased genetic risk of breast cancer is still under investigation. There is scientific evidence to support the hypothesis that CE‐MRI may carry the prognostic significance of angiogenesis, and one of the future indications of this method can be the prognostic evaluation of breast cancer patients by the functional mapping of the angiogenic activity of tumours. On the basis of the promising results of recent reports, further large‐scale studies are needed to evaluate the impact of MR parameters on long term overall survival of patients with breast cancer.

Prospective seroepidemiological study of role of human papillomavirus in non-cervical anogenital cancers

Objective: To evaluate the association between infection with the major oncogenic types of human papillomavirus and the risk of developing non-cervical anogenital cancers in a cohort followed up prospectively.Design: Data...

Melaena Caused by Small Bowel Metastases of Colorectal Cancer in Presence of Anastomotic Recurrence

Discussion Secondary tumours of the bladder are rare and are usually from direct invasion from adjacent organs. In an extensive retrospective study, Ganem & Batal (1956) reported on 80 cases of secondary tumours of the urinary bladder, of which 25 were from a primary in the stomach, 18 from melanoma and 6 from bronchial carcinomas of unspecified type. There have been no recent reports in the literature of small cell carcinoma of the bronchus metastasizing to the bladder. However, there have been two recent reports of small cell neuroendocrine tumours occurring in the bladder without any evidence of a primary bronchial neoplasm (Davis et al. 1983, Cramer et al. 1981). Two of the 4 patients had disseminated disease and chemotherapy for small cell bronchial tumours induced partial remissions. Our patient had too low a Karnofsky score to be considered suitable for intensive chemotherapy. However, in suitable patients with disseminated small cell carcinomatosis, modern chemotherapeutic regimens containing an alkylating agent with etoposide can induce complete remissions in up to 25% of cases (Sprio 1985). It is suggested that an oncological opinion be sought should the initial diagnosis be made by an urologist, so that effective chemoand radiotherapy can be started.