Cancer In Japanese Population Research Articles

399: Genomewide Linkage Analysis of Familial Prostate Cancer in Japanese Population

You have accessJournal of UrologyDiscussed Poster, Sunday, May 9, 2004, 8:00 am - 12:00 pm1 Apr 2004399: Genomewide Linkage Analysis of Familial Prostate Cancer in Japanese Population Hiroshi Matsui, Kazuhiro Suzuki, Nobuaki Ohtake, Seiji Nakata, Toshiyuki Takeuchi, Ituro Inoue, and Hidetoshi Yamanaka Hiroshi MatsuiHiroshi Matsui More articles by this author , Kazuhiro SuzukiKazuhiro Suzuki More articles by this author , Nobuaki OhtakeNobuaki Ohtake More articles by this author , Seiji NakataSeiji Nakata More articles by this author , Toshiyuki TakeuchiToshiyuki Takeuchi More articles by this author , Ituro InoueIturo Inoue More articles by this author , and Hidetoshi YamanakaHidetoshi Yamanaka More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(18)37661-4AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail "399: Genomewide Linkage Analysis of Familial Prostate Cancer in Japanese Population." The Journal of Urology, 171(4S), p. 105 © 2016 by American Urological AssociationFiguresReferencesRelatedDetails Volume 171Issue 4SApril 2004Page: 105 Advertisement Copyright & Permissions© 2016 by American Urological AssociationMetricsAuthor Information Hiroshi Matsui More articles by this author Kazuhiro Suzuki More articles by this author Nobuaki Ohtake More articles by this author Seiji Nakata More articles by this author Toshiyuki Takeuchi More articles by this author Ituro Inoue More articles by this author Hidetoshi Yamanaka More articles by this author Expand All Advertisement PDF downloadLoading ...

Lack of Evidence for the Association of E-Cadherin Gene Polymorphism with Increased Risk or Progression of Prostate Cancer

Background: E-cadherin is an epithelial cell adhesion molecule, and decreased E-cadherin expression in human prostate cancer is associated with tumor grade and advanced clinical stage. A –160 C→A polymorphism in the promoter region of E-cadherin has been shown to decrease gene transcription. This allelic variation may be a potential genetic marker that can help identify those individuals at higher risk for invasive/metastatic disease. Materials and Methods: We studied the effect of E-cadherin gene polymorphism on prostate cancer susceptibility in a case control study of 219 prostate cancer patients and 219 male controls, to determine whether this polymorphism is a biomarker for the risk and how aggressive the disease is. Results: The genotype frequencies in the prostate cancer group were C/C: 0.607, C/A: 0.352, A/A: 0.041, and in the control group C/C: 0.671, C/A: 0.301, A/A: 0.027. A significant difference between the two groups was not found (p = 0.34), and the adjusted OR for A/A genotype was not statistically significant (OR = 1.66, 95% CI 0.58–4.78). Subdividing prostate cancer according to tumor differentiation and stage, we found no association between E-cadherin polymorphism and poor differentiation and invasiveness of prostate cancer. Conclusions: These data do not support an association between the E-cadherin genotype and the occurrence or progression of prostate cancer in Japanese populations.

Enhanced oncogenicity of human papillomavirus type 16 (HPV16) variants in Japanese population

To investigate whether HPV16 E6 variants carry an elevated risk for cervical cancer in Japanese population, we investigated the E6 sequence variation in 40 cervical intraepithelial neoplasias (CINs) I-III and 43 invasive cervical cancers (ICCs), all positive for HPV16. HPV16 E6 variants were frequently found in ICCs than in CINs (88 vs. 65%, P=0.01). The E6 D25E, a rare variant in Western countries, was most frequently observed in ICC (44%). CIN I/II lesions with HPV16 variants were less likely to regress than those with HPV16 prototype ( P=0.048). The finding that HPV16 E6 variants represent a significant risk factor is common between Western and Japanese women despite the different distribution of each variant.

VacA seropositivity is not associated with the development of gastric cancer in a Japanese population.

Infection with Helicobacter pylori strains producing vacuolating cytotoxin (VacA) is associated with enhanced gastric mucosal damage and the development of gastric mucosal atrophy. The aim of this study was to investigate whether VacA seropositivity is associated with increasing risk of gastric cancer in Japanese populations which have much higher incidence of gastric cancer than Western populations. Serum sample was collected from 81 patients with gastric cancer and 81 sex- and age-matched endoscopically evaluated control subjects. Histologically, 62 cancers were of the intestinal type and 76 were early gastric cancer. H. pylori and VacA IgG antibodies were assayed by Western blotting using Chiron Diagnostics' Recombinant Immunoblot Assay (RIBAa). VacA seropositivity was 68% (55/81) in patients with gastric cancer and 70% (57/81) in controls. The odds ratio for the risk of gastric cancer in VacA seropositives was 0.89 (95% CI 0.46-1.74). In H. pylori seropositive patients and their control subjects (matched H. pylori-positive controls), VacA seropositivity was the same 80.6% (50/62). The odds ratio for the risk of gastric cancer in H. pylori-positive patients if VacA seropositive was 1.00 (95% CI 0.41-2.44). The mean relative intensity of VacA antibody titre was 3.01+/-0.18 in the 55 VacA seropositive cancer patients and 3.09+/-0.17 in the 57 VacA seropositive control subjects (difference not significant). These results suggest that VacA seropositivity is not associated with increasing risk of gastric cancer in Japanese populations.

CagA seropositivity associated with development of gastric cancer in a Japanese population.

BACKGROUND/AIMS: Infection with Helicobacter pylori strains possessing the cagA gene is associated with increased risk of gastric cancer of the intestinal type. The aims of this study were to investigate...

DNA typing of HLA class I (HLA-A) and class II genes (HLA-DR, -DQ and -DP) in Japanese patients with gastric cancer.

Gastric cancer is multifactorial disease and several reports have described genetic factors involved in pathogenesis of gastric cancer. Recently, it was reported that HLA class II gene DQB1*0301 was strongly associated with gastric cancer in Caucasian population (20). We performed DNA typing of HLA class I (HLA-A) and HLA class II genes (HLA-DR, DQ and DP) to elucidate the HLA alleles or HLA haplotypes associated with gastric cancer in Japanese population using polymerase chain reaction-sequence-specific oligonucleotide probe analysis in 88 unrelated patients with gastric cancer and 525 unrelated healthy controls. We observed slight difference in frequencies of some HLA alleles and haplotypes between gastric cancer patients and controls; however, after Bonferroni correction, statistical significance was not confirmed. It is possible that environmental factors such as diet cover the contribution of genetic factors to the disease in Japanese population, which has a higher frequency of gastric cancer than do Caucasian populations, most likely due to more exposure to environmental risk factors.

Pathology of Gastric Carcinoma in Japanese Populations: Comparisons Between Miyagi Prefecture, Japan, and Hawaii 2

The pathology and related epidemiologic aspects of gastric cancer in Japanese populations of Japan and Hawaii were studied through data and specimens from 407 cases in Miyagi prefecture, Japan, and 256 cases in Hawaii. The estimated incidence rates for diffuse carcinomas were the same in both localities, but the corresponding rates for intestinal, mixed, and other (IMO) types were substantially lower in Hawaii. The slopes of the IMO incidence curves were similar in the 4 subgroups considered, but the curves were displaced horizontally to the right (to older ages) in Hawaii as compared to Japan and in females as compared to males. The slope of the incidence curves for diffuse were less steep than for IMO types and did not exhibit horizontal displacement. The slopes and displacement of the type-specific incidence curves can be reconciled with the variation in sex ratios by age observed in Japan and Hawaii. An association with blood group A in the Japanese populations studied was limited to diffuse-type tumors.