Cancer Health Disparities Research Research Articles

Association of electronic-health record (EHR)-derived race with BRCA testing in patients (pts) with breast cancer (BC) with similar genetic ancestry (GA) in a clinicogenomic database (CGDB).

6524 Background: Disparities in health outcomes can be affected by biological factors associated with GA and social determinants of health. These factors can be teased apart using GA data from comprehensive genomic profiling (CGP) in pts with cancer. CGDBs that link EHR data with CGP enable the selection of pts with similar GA. Holding GA constant provides an opportunity to directly study the effects of reported race in health disparities. This study evaluated a published racial disparity (BRCA testing rates in African American [AA] vs White pts with BC) in a population with fixed, similar GA. Methods: The nationwide (US-based) deidentified Flatiron Health and Foundation Medicine (FMI) BC CGDB (Q3 2020) was used. For each pt, GA fractions from 5 geographic ancestry groups (African [AFR]; Admixed American; East Asian; European [EUR]; South Asian) were derived by FMI using an admixture analysis workflow using genes captured in the CGP assay. To focus on BRCA testing in AA vs White pts and find a sufficient population with similar GA but AA or White race, pts with admixture of both EUR and AFR ancestry were selected. The chosen fractions were: Cohort 1=35%-65% AFR and EUR each; Cohort 2=25%-60% AFR and EUR each; Cohort 3=30%-60% AFR. Cohorts overlap but were chosen to increase sample size. In each cohort, documented BRCA testing prevalence, time from diagnosis to BRCA test date, age at BRCA test and overall survival (OS) were compared between races. Other race (OR) and missing race (MR) were also reported. Results: Most pts (4130/6903) in the BC CGDB had ≥75% EUR ancestry; 129 pts had AFR ancestry fractions ≥25% with EUR ancestry >0%. AA pts had the lowest BRCA testing rates (39%, 43%, 44% for Cohorts 1-3, respectively), which were 18%, 10% and 17% lower compared with White pts, respectively (Table). In Cohorts 1-3, AA pts experienced a longer median time between diagnosis and testing (399, 668, 900 days) compared with White pts (93, 667, 106 days). The median age at BRCA test was 16, 9 and 8 years younger in AA pts (49, 47 and 50 years) compared with White pts. Although pts with MR data had the lowest OS compared with the other races within each cohort, the sample size of each arm for all cohorts was too small to make conclusions. Conclusions: This study demonstrated that when holding GA constant, racial disparities persist in BRCA testing patterns and outcome in pts with BC from a CGDB. With increasing availability of linked clinical and genomic data, further exploration of disparities in genetically similar cohorts can provide deeper insight for cancer outcomes and health disparities research.[Table: see text]

Abstract PO-066: Establishing long-term tracking to evaluate the effectiveness of a partnership-led training program to advance the careers of cancer health disparities trainees from underrepresented groups

Abstract Women and racial/ethnic minorities are underrepresented in the biomedical, clinical, behavioral, and social sciences. One of the main goals of the Synergistic Partnership for Enhancing Equity in Cancer Health (SPEECH), a comprehensive regional cancer health disparity partnership between Temple University/Fox Chase Cancer Center (TUFCCC) and Hunter College (HC), is to diversify and expand the pool of researchers trained to conduct research on cancer and cancer health disparities. Specifically, the SPEECH partnership’s efforts towards mentorship and training involve several cores that capitalize on numerous strengths in training and research education across TUFCCC, an NIH-designated Comprehensive Cancer Center, and HC, a Minority Serving Institution, to facilitate the professional enrichment of students and junior investigators underrepresented in cancer research. To effectively monitor and evaluate the training activities under the SPEECH partnership, we established a long- term tracking system. The development of the tracking system began by identifying the fields of research training (basic, translational, behavioral/population science), levels of trainees (undergraduate, graduate, early-stage-investigators), and types of training activities (Summer Cancer Research Institute, Mentored Research Projects, Cancer Research Fellows, etc.). Next, was the identification of several outcome measures, including trainee’s interests, preparedness, and professional accomplishments in cancer and cancer health disparities research. To facilitate data collection, we established a web-based, centralized evaluation portal to document trainees’ and mentee information and achievements, as well as research grant submissions and publications within the SPEECH partnership. For long-term tracking of trainee education and career progressions, we intend to maintain contact with previous and on-going trainees through emails and social media. In the interest of comparing the understanding of cancer biology and of health disparities, we intend to conduct a cross-sectional survey of a random sample of SPEECH trainees and a random sample of non-SPEECH trainees with the goal of identifying any differences between the two groups in familiarity with and understanding of cancer biology and of health disparities. We will present the process of developing the long-term tracking system, our achievements, as well as challenges. Citation Format: Lin Zhu, Marsha Zibalese- Crawford, Sarah-Jane Dodd, Carolyn Y. Fang, Yin Tan, Olorunseun O. Ogunwobi, Grace X. Ma. Establishing long-term tracking to evaluate the effectiveness of a partnership-led training program to advance the careers of cancer health disparities trainees from underrepresented groups [abstract]. In: Proceedings of the AACR Virtual Conference: Thirteenth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2020 Oct 2-4. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(12 Suppl):Abstract nr PO-066.

Abstract PO-036: University of Guam/University of Hawai‘i Cancer Center Partnership: A seventeen-year investment in cancer health equity in Pacific Islanders

Abstract The University of Guam (UOG)/University of Hawai‘i Cancer Center (UHCC) Partnership aims to grow cancer research capacity at UOG, develop cancer health disparities research at UHCC focusing on Pacific Islanders (PI), raise awareness of cancer and cancer prevention in Guam (GU), Hawai‘i (HI) and the United States Associated Pacific Islands (USAPI), and increase the number of cancer and biomedical science researchers of PI ancestry in the US. An infrastructure comprised of 4 principal investigators, over 30 participating faculty, administrative staff, and external and internal reviewers, backed by institutional support and NCI sponsorship, has supported 17 years of research, training, and outreach designed to reduce cancer health disparities and advance health equity among PI in GU, HI, and the USAPI. Since 2009, the Partnership has funded 22 cancer research projects addressing cancer research priorities of global and regional relevance, including cervical cancer and Areca (betel) nut chewing - a traditional practice associated with oral pre/carcinoma, affecting 600 million users worldwide. Over 100 peer-reviewed manuscripts have been published, over 100 abstracts presented, and 21 grants secured. To address the underrepresentation of PI in biomedical sciences, the Partnership has supported and trained 35 graduate scholars; 23 master’s students at UOG and 12 doctoral students at UH. Two PhD graduates are now faculty members at UOG and engaged in cancer health disparities research. UOG’s Micronesian Studies Program offers a cancer health disparities track, developed by the Partnership and tailored for the Pacific region. In addition, UOG/UHCC faculty, junior investigators, and pre/postdocs receive mentorship, career development, and summer research fellowships; since 2015, 16 early career professionals have received support. Outreach projects have explored community-based participatory approaches to cancer prevention. Youth tobacco use prevention and cessation projects in Guam resulted in landmark tobacco control legislation, decreased tobacco use and increased tobacco taxes, which now sustain cancer programs and patient services in Guam including the Guam Cancer Registry. Current outreach efforts aim to increase colorectal cancer screening and HPV vaccination while building knowledge and awareness among physicians serving PI in GU and HI. Dedicated leadership and longstanding partner collaborations led to the first NCI Community Oncology Research Program site in 2019, providing therapeutic cancer clinical trials in Guam. In conclusion, research capacity at UOG has significantly increased, disparities research at UHCC has expanded, underrepresented PI students are pursuing careers in cancer research, and communities have been engaged in research, training and outreach to advance cancer health equity in HI, GU and the USAPI. Supported by NCI grants U54CA143727 and U54CA143728. Citation Format: Rachael T. Leon Guerrero, Margaret Hattori-Uchima, Hali R. Robinett, Carl-Wilhelm Vogel, Neal A. Palafox. University of Guam/University of Hawai‘i Cancer Center Partnership: A seventeen-year investment in cancer health equity in Pacific Islanders [abstract]. In: Proceedings of the AACR Virtual Conference: Thirteenth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2020 Oct 2-4. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(12 Suppl):Abstract nr PO-036.

Abstract IA33: The immunogenomic landscape of primary prostate cancer in African-American men

Abstract African-American (AA) men have a 1.5-fold higher incidence of prostate cancer (PCa) than non-Latino White (WH) men and are nearly 2.5 times more likely to die from their disease. These disparities are likely due to a combination of social, environmental, and biological factors. Discerning the biological determinants of aggressive PCa in AA men remains a critical and unmet need in cancer health disparities research. Although there have been several large-scale genome sequencing studies that identified unique molecular drivers in primary and metastatic PCa, these have included few AA patients, even fewer with potentially lethal PCa, and have generally lacked clinical outcome data. Work by our group and others demonstrates that the most common somatic genomic alterations in primary PCa (such as ERG rearrangement and PTEN deletion) occur at significantly different frequencies in AA and WH men, providing the first direct evidence for molecular differences between PCa arising in AA and WH patients. Similarly, gene expression studies by other groups have consistently found that various immune response pathways are more highly expressed in PCa arising in AA compared to WH patients. However to date, few studies have integrated somatic molecular subtype data with immune tumor microenvironment (TME) characterization across different populations. To begin to address these knowledge gaps, we have studied primary PCa tissues from a unique cohort comprising 200 self-identified AA and 200 WH patients, matched by grade and other clinical-pathologic parameters, with long-term follow-up for biochemical recurrence and metastasis. This cohort is unique in that it is highly enriched for high-risk disease and has now been profiled for somatic genomic, epigenomic, transcriptomic and tumor microenvironment landscapes, enabling one of the first integrative molecular portraits of AA PCa. We find that tumor infiltrating T-lymphocyte density is significantly correlated with underlying tumor molecular subtype and oncologic outcomes, but does not vary by racial ancestry. In contrast, using a combination of transcriptomic, methylation and quantitative immunohistochemical analyses, we demonstrate that tumor infiltrating B-lymphocyte density is significantly higher among AA compared to WH PCa patients, irrespective of molecular subtype, and trends towards improved outcomes. Citation Format: Tamara L. Lotan. The immunogenomic landscape of primary prostate cancer in African-American men [abstract]. In: Proceedings of the AACR Virtual Conference: Thirteenth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2020 Oct 2-4. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(12 Suppl):Abstract nr IA33.

Abstract PO-040: Florida-California CaRE2 Health Equity Center Citizen Scientist Training Program: Going virtual in response to COVID-19

Abstract INTRODUCTION Citizen scientists are an essential part of research. After a successful pilot in 2019, the Florida-California Cancer Research Education and Engagement (CaRE2) Health Equity Center held a full CaRE2 Cancer Citizen Scientist Training Program in 2020. However, COVID-19 forced a program reliant on in-lab experiences to develop a cadre of citizen scientists to drive cancer health disparity research in Black and Latinx communities, to maintain meaningful, bi-directional communication between advocates and cancer scientist in a virtual environment. The program is open to cancer survivors and advocates. METHODS The CaRE2 Cancer Citizen Scientist training program builds on the pilot, as well as collaboration techniques used by the bi-costal CaRE2 Center on a regular basis. Selection of trainees was through a competitive application process. Multiple training techniques were employed, including independent learning, lectures, in depth discussion between research stakeholders, and implementation of research advocacy. The CaRE2 Center Planning and Evaluation Core conducted the evaluation for the program to foster continuous improvement. RESULTS Three applications were received and accepted for the program. All program activities were held over a virtual conference platform. The training program focused on Research Ethics, Social Determinants of Health, Community Engagement, Biobanking, Cancer Epidemiology, and Omics. The trainees participated in a three-part curriculum: (1) Two weeks of lectures by expert mentors, supplemented with a virtual reader of learning materials in a variety of digital formats. (2) Sessions with each of the CaRE2 research project to evaluate projects’ existing community engagement efforts. (3) Implementation of an outreach project that addresses needs found in the evaluation sessions. A student ambassador from the C-ReTOOL Program funded by NCI also participated to support outreach activities as needed. A virtual symposium held on July 30, culminates the program and includes a webinar presentation of the Citizen Scientists’ advocacy project. A mean responses to a midpoint program impact evaluation on a four-point scale (Strongly Disagree 1, Strongly Agree=4), about the self-learning materials (3.67), expert mentors (3.33), the advocacy project (3.33), and the program structure (3.33) show that overall participants agree that the program has a positive impact. CONCLUSION Continuing this work in a rapidly changing landscape is a credit to the collaborative infrastructure and resources of NCI CPACHE programs, such as the CaRE2 Health Equity Center for the training of Citizen Scientists. This model has successfully continued access to outstanding cancer scientists and advocates, who are well experienced in developing research education programs as well as mentoring minority trainees. The development of these virtual tools sustains crucial work in the current environment, and open doors for enrichment to the in person model for future, bi-costal cohorts. Citation Format: Nissa Askins, Fern J. Webb, Linda Behar-Horenstein, Lourdes Baezconde-Garbanati, Sandra Suther, Diana J. Wilkie, Folakemi T. Odedina. Florida-California CaRE2 Health Equity Center Citizen Scientist Training Program: Going virtual in response to COVID-19 [abstract]. In: Proceedings of the AACR Virtual Conference: Thirteenth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2020 Oct 2-4. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(12 Suppl):Abstract nr PO-040.

An overview of cancer health disparities: new approaches and insights and why they matter.

Cancer health disparities remain stubbornly entrenched in the US health care system. The Affordable Care Act was legislation to target these disparities in health outcomes. Expanded access to health care, reduction in tobacco use, uptake of other preventive measures and cancer screening, and improved cancer therapies greatly reduced cancer mortality among women and men and underserved communities in this country. Yet, disparities in cancer outcomes remain. Underserved populations continue to experience an excessive cancer burden. This burden is largely explained by health care disparities, lifestyle factors, cultural barriers, and disparate exposures to carcinogens and pathogens, as exemplified by the COVID-19 epidemic. However, research also shows that comorbidities, social stress, ancestral and immunobiological factors, and the microbiome, may contribute to health disparities in cancer risk and survival. Recent studies revealed that comorbid conditions can induce an adverse tumor biology, leading to a more aggressive disease and decreased patient survival. In this review, we will discuss unanswered questions and new opportunities in cancer health disparity research related to comorbid chronic diseases, stress signaling, the immune response, and the microbiome, and what contribution these factors may have as causes of cancer health disparities.

Genomic Ancestry in B Cell Lymphoid Malignancies

Genomic Ancestry in B Cell Lymphoid Malignancies

Abstract IA14: Emerging priorities for the Center to Reduce Cancer Health Disparities in diversity workforce training and cancer health disparities research

Abstract This panel presentation will provide an overview of the current training and research funding priorities at National Cancer Institute's (NCI) Center to Reduce Cancer Health Disparities (CRCHD). CRCHD is NCI's focal point for the training of competitive cancer researchers from diverse populations and supporting cancer health disparities research across the cancer continuum. The NCI's CRCHD's Continuing Umbrella of Research Experiences (CURE), Intramural CURE (iCURE), and the Partnerships to Advance Cancer Health Equity (PACHE) will be highlighted as successful models for diversity training and cancer health disparities research. The CURE Program supports extramural research training and education experiences for under-represented individuals beginning in middle school and continuing through to first academic appointment. The newly launched iCURE Program supports mentored research experiences within the NCI Intramural Research Program for students and fellows. In addition, the PACHE Program supports cancer and cancer health disparities research, education, and outreach through partnerships between Minority-Serving Institutions and NCI-designated Cancer Centers. New and established NCI funding opportunities in cancer health disparities research, including opportunities supporting both basic and translational research addressing cancer health disparities, will also be presented. Additionally, strategies will be explored for navigating successful cancer research careers and for developing competitive grant applications. Citation Format: Sanya A. Springfield. Emerging priorities for the Center to Reduce Cancer Health Disparities in diversity workforce training and cancer health disparities research [abstract]. In: Proceedings of the Eleventh AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2018 Nov 2-5; New Orleans, LA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(6 Suppl):Abstract nr IA14.

Abstract A059: Promoting workforce diversity for cancer and cancer health disparities researchers: Approaches used by the Geographic Management of Cancer Health Disparities Program (GMaP) Regions 3 and 5

Abstract Background/Rationale: A barrier to improving access to quality care for underserved minority groups, as well as advancing research on health disparities, is the lack of workforce diversity in the United States. Research reports that minority physicians and scientists continue to be significantly under-represented in medical and scientific communities. Funded by the National Cancer Institute's Center to Reduce Cancer Health Disparities (CRCHD), GMaP is rooted in the conviction that a diverse workforce is essential for advancing cancer research and reducing cancer health disparities (CHD). We consider the overall scope and programming of two GMaP Regions, Region 3, serving Central to Southern California, Arizona, New Mexico, Texas, Oklahoma, Kansas, Nebraska, and Colorado, and Region 5, serving Central to Northern California, Oregon, Washington, Alaska, Hawaii, America Samoa, and Guam. We will focus on approaches to professional development training and consider how each enhances opportunities for minority students and early-career investigators to participate in a diverse research workforce and create health equity in the U.S. Approaches: We will discuss the multidisciplinary strategies used by GMaP Regions 3 and 5 to recruit students, early-career investigators, and cancer and CHD researchers into sustainable networks designed to provide meaningful training, engagement, and funding opportunities for ethnically/racially and/or geographically diverse individuals. We will review Region 3's travel-based strategy in which training encounters are conducted at multiple regional partner institutions, and Region 5's Career Development Workshop in which individuals from partner institutions travel to Seattle for an annual multiday training. Results: We will share feedback from these learning encounters, and specific examples of these approaches to ascertain that although time and resource intensive, such training encounters are successful and beneficial to GMaP individuals. Outcomes will include data from our overall GMaP programmatic evaluations, training feedback, and scientific product publication/dissemination and successful funding received by under-represented participant members. Conclusion: Creating a diverse cancer research workforce is challenging; however, continued engagement with under-represented students, faculty, and early-career researchers who desire training to participate fully in NIH/NCI funding mechanisms is vital to reverse structural, educational, and resource-related trends that perpetuate an inequitable research workforce. Although identifying promising candidates and providing support in sufficient flexible ways to be truly beneficial for each individual member may be slow and resource intensive, this research demonstrates that each encounter and training helps take members one step closer to her/his professional goal. Citation Format: Miria Kano, Sara Cole, Shiraz I. Mishra, Andrew L. Sussman, Beti Thompson. Promoting workforce diversity for cancer and cancer health disparities researchers: Approaches used by the Geographic Management of Cancer Health Disparities Program (GMaP) Regions 3 and 5 [abstract]. In: Proceedings of the Eleventh AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2018 Nov 2-5; New Orleans, LA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(6 Suppl):Abstract nr A059.

Abstract A004: Introducing single-cell sequencing genomic DNA copy number analysis to study cancer heterogeneity in renal cell carcinoma and its potential benefits in cancer health disparities research

Abstract Renal cell carcinoma (RCC) is one of the most lethal urological malignancies and is responsible for around 80 percent of all primary renal neoplasms. In the US, every year are reported approximately 74,000 new cases and almost 15,000 deaths. It has been reported significant racial disparities in survival for renal cell carcinoma (RCC) between African Americans patients (AA), Hispanics and Caucasians Americans (CA) but more efforts are needed in order to have a high resolution genomic profile of the tumor. Currently, RCC has been characterized by extensive cancer heterogeneity using bulk sequencing. In order to get new insight in the study of RCC cancer heterogeneity, we applied DNA single cell sequencing since it has the potential to improve our understanding of this genetic feature by providing sub-clonal and variant information in high resolution. To this end, we studied cancer heterogeneity applying single cell copy number analysis and clonotype detection in four RCC tumors. 10x Chromium™ Technology was used for processing single cells. This technology provides 100 Kb CNV events, calling clonotypes down to 10 of 1000 cell inputs. The most representative sample resulted with more than 50% of tumor content. Analysis of the tumor cells showed variable median ploidies. In addition, regional copy number was estimated by processing our data in 20 Kb cases of reads. Multiple sub-clones were identified in sample number one where four clusters of sub-clones characterized cancer heterogeneity. By using Fast maximum-likelihood and Bayesian Information Criterion, the clustering process were implemented on the most representative sample to select the optimal clustering solution. This allowed us to provide a better insight of sub-clonal evolution. We detected copy number changes on entire chromosome arms and mutations at variant detection level. For this last, we identified previously reported VHL gene mutations that have been reported in RCC samples as signatures of clinical prognosis. The use of single cell copy number analysis has the potential to uncover and characterize the evolution of hidden sub-clones, highlighting their important uses in cancer health disparities research to identify genomic racial differences in RCC risk and progression of AA, Hispanics and CA patients. Citation Format: Enrique I. Velazquez Villarreal, David W. Craig, John D. Carpten. Introducing single-cell sequencing genomic DNA copy number analysis to study cancer heterogeneity in renal cell carcinoma and its potential benefits in cancer health disparities research [abstract]. In: Proceedings of the Twelfth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2019 Sep 20-23; San Francisco, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(6 Suppl_2):Abstract nr A004.

Abstract IA52: Tools for assessing social determinants of health

Abstract In 2017, AACR, ASCO, ACS, and NCI published a statement stemming from a think tank on the future of research in cancer health disparities. This statement, published in several leading oncology journals, offered recommendations in five areas for advancing cancer health disparities research. This presentation will review the recommendations for the area “defining measures and tools for the next generation of cancer health disparities research,” describe efforts to standardize data collection for social determinants of health, and explore emerging methodologic challenges in the measurement of social determinants in cancer health disparities research. Citation Format: Scarlett Lin Gomez. Tools for assessing social determinants of health [abstract]. In: Proceedings of the Eleventh AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2018 Nov 2-5; New Orleans, LA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(6 Suppl):Abstract nr IA52.

Abstract A064: The Meharry Cancer Summer Undergraduate Research Program: Increasing undergraduate exposure to cancer health disparities via summer research experiences

Abstract Few under-represented minorities (URM) pursue careers as physicians and biomedical researchers. This lack of diversity within the scientific and clinical workforce greatly influences our ability to address the public health burden and disparities associated with cancer. To enhance the diversity of the cancer workforce and fully address the problem of cancer health disparities, we must increase the number of URM students who obtain the MD and/or PhD degrees and train in the areas of cancer biology and oncology. To address this issue, we established the Meharry Cancer Summer Undergraduate Research Program (SURP). The Meharry Cancer SURP is a 10-week intensive, cancer-focused research experience that exposes undergraduate students to the area of cancer health disparities. It is designed to provide participants with a better understanding of how biomedical, behavioral, and clinical research influences cancer outcomes and to inspire participants to pursue careers in cancer research. In the first year of the program, a nationwide search was conducted to identify and select ten undergraduate students who were interested in pursuing careers in medicine and biomedical science. Each student performed a research project with an experienced cancer investigator from either Meharry Medical College or Vanderbilt University Medical Center. The research projects, which included preclinical studies, translational research, and epidemiologic/community-based studies, focused on cancers that disproportionately affect African-Americans and other racial and ethnic minorities. To ensure students understood fundamental concepts common to all cancers and cancer health disparities research, all program participants attended a weeklong cancer biology minicourse. They also attended cancer biology/cancer health disparities research seminars that allowed them to interact with oncologists and cancer researchers from groups traditionally under-represented in biomedical science and to be exposed to career opportunities within the areas of cancer research, oncology, and cancer health disparities. Furthermore, students participated in career development workshops that allowed them to explore cancer-related career options, create individual development plans, and obtain information needed to apply and successfully gain entrance into MD and PhD training programs. Together, these program activities increased student awareness of the fields of cancer biology and cancer health disparities and provided knowledge and tools necessary to successfully pursue cancer-focused careers. Citation Format: Evangeline Motley-Johnson, Katelyn Atkinson, Aliecia Bouligny, Del-vecie Brown, Samuel Delk, Jordan Finch, Kennedi Fitts, Dorian Hill, Faith Mungai, Dalancee Trabue, Kierra Whitelow, LaMonica Stewart. The Meharry Cancer Summer Undergraduate Research Program: Increasing undergraduate exposure to cancer health disparities via summer research experiences [abstract]. In: Proceedings of the Eleventh AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2018 Nov 2-5; New Orleans, LA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(6 Suppl):Abstract nr A064.

Abstract A068: Results to date: Efforts to increase cancer health disparities training in Geographic Management of Cancer Health Disparities Program Region 1 North

Abstract Introduction: The National Cancer Institute (NCI) Center to Reduce Center Health Disparities (CRCHD) Geographic Management of Cancer Health Disparities Program (GMaP) initiated in 2009 brings together investigators, trainees, students, and community health educators to network and share information, scientific resources, and tools to promote cancer and cancer health disparities research, as well as community education outreach within and across regions. To reach their goals, CRCHD initiated 7 GMaP regional “hubs” across the United States to enhance their capacity in areas of disparities research, contribute to the next generation of researchers, and achieve measurable reductions in cancer health disparities. Each hub is led by Regional Coordinating Directors (RCDs) who facilitate connections, provide funding and training resources and “leverage the strengths of its people, programs, and resources to provide greater access to cancer information.” Methods: The GMaP Region 1 North (R1N) hub is based at the Markey Cancer Center in Lexington, Kentucky. R1N partners with Johns Hopkins University's Sidney Kimmel Comprehensive Cancer Center, the University of South Carolina, and the University of Virginia Cancer Center to serve Delaware, Kentucky, Maryland, Maine, New Hampshire, Vermont, Virginia, West Virginia, Washington, DC, and West Virginia. The overall goal of GMaP R1N is to enhance the capacity of regional cancer centers, associated academic partners, community partners, and early-stage investigators to contribute to the reduction of cancer health disparities in the region. As part of the Continuing Umbrella of Research Experiences (CURE) Program, GMaP R1N promotes the F31, K series, and Diversity Supplement funding opportunities to potential applicants. R1N implemented pilot awards and travel scholarships for CURE-eligible candidates; developed a listserv to communicate with researchers, trainees, and potential applicants; and maintains regular contact with trainees to answer questions and encourage applications for NCI CURE Program and other grant opportunities. Results: R1N awarded 11 pilot projects, 22 travel scholarships, helped identify mentors and 146 potential applicants for NCI CURE Program grants, and collaborated with points of contact (POC) at colleges and universities, including Historically Black Colleges and Universities to identify potential applicants for NCI CURE and other funding. Conclusions: Methods have been successful in increasing interest in NCI Cancer health disparities training opportunities. RCDs are critical in establishing and maintaining linkages to support mentor-mentee relationships supported by available funding mechanisms; to engage institutional support for pre- and post-award activities, especially for new investigators; and for shrinking delays in the IRB review and approval process. RCDs have identified process barriers and work with regional POCs to eliminate these barriers and increase efficiencies to further the GMaP mission. Citation Format: Marcela Blinka, Mark Cromo, Julia F. Houston, Mark Dignan, Nathan Vanderford, B. Mark Evers, Janice Bowie, Adrian Dobs, James Hebert, Tisha Felder, Roger Anderson. Results to date: Efforts to increase cancer health disparities training in Geographic Management of Cancer Health Disparities Program Region 1 North [abstract]. In: Proceedings of the Eleventh AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2018 Nov 2-5; New Orleans, LA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(6 Suppl):Abstract nr A068.

Abstract D019: SGM Cancer CARE: Creating a health workforce trained to conduct sexual and gender minority (SGM) affirmative research from prevention to survivorship

Abstract Background: A health workforce trained to conduct SGM-inclusive cancer research is needed for SGM persons seeking comprehensive cancer care including prevention, screening, treatment, and survivorship. Research on SGM cancer care has described many disparities, and a number of studies of SGM individuals have documented increased exposure to cancer-risk factors and certain cancers, as well as poorer cancer outcomes. Yet SGM patients are extremely diverse, presenting with unique and varied care needs. Although research on SGM groups has grown, gaps persist in the knowledge of specific SGM cancer risk factors and treatment experiences that are critical for developing evidence-based oncology care guidelines across the cancer care continuum. As no nationally available resource routinely trains and prepares the oncology/biomedical workforce for SGM cancer research, we were recently awarded, a National Cancer Institute 1R25CA240113=01 (Chang and Sanchez PIs), SGM Cancer CARE (Sexual and Gender Minority Cancer: Curricular Advances for Research and Education), to design an up-to-date, competency-based interactive 2-day workshop for early career researchers. We will present results from the needs assessment of researcher and oncology provider needs for SGM cancer research training, clinical care, and health care advocacy that supported our application. Approaches: We distributed an electronic survey containing 32 questions to determine health and research professional interest in, and need for, SGM specific cancer training and education through several professional organization list serves including the LGBTQ Workforce Conference and the Geographic Management of Cancer Health Disparities Program (GMaP). Results: Respondents (n=138) worked predominantly in academic medical centers and public health/government, as researchers (54.62%), clinicians (14.62%), educators (22.31%), and administrators (7.69%). They identified 3 key priorities for improving SGM cancer health research: 1) Increased knowledge of SGM cancer research priorities (3.99 Mean, SD 1.22); 2) Updates on current SGM cancer literature (5.61 Mean, SD 1.45); and 3) Assistance building advisory committees of relevant stakeholders to ensure design and conduct of culturally competent SGM cancer and cancer health disparities research (5.64 Mean, SD 1.40). Importantly, 90.6% lacked sufficient resources for travel to attend SGM cancer research training opportunities, indicating desires for web-based education or blending learning modalities. Conclusion: Findings from our needs assessment suggest that the SGM Cancer CARE curriculum in development is responsive to the needs of health and research professionals. Intended for presentation in a 1.5 day pilot workshop, however, financial constraints may necessitate designing flexible learning formats in order to reach an array of professionals and stimulate learning, thereby increasing SGM cancer research leading to more equitable health for vulnerable SGM populations. Citation Format: Miria Kano, Dominique Jasperse, Irene Tami-Murray, Yen Nhi Pham, Nelson Sanchez, Shine Chang. SGM Cancer CARE: Creating a health workforce trained to conduct sexual and gender minority (SGM) affirmative research from prevention to survivorship [abstract]. In: Proceedings of the Twelfth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2019 Sep 20-23; San Francisco, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(6 Suppl_2):Abstract nr D019.

Abstract C125: University of Guam/University of Hawaii Cancer Center partnership: Fifteen years of progress in addressing cancer health disparities in Pacific Islanders

Abstract The University of Guam (UOG)/University of Hawaii Cancer Center (UHCC) Partnership aims to grow cancer research capacity at UOG; develop cancer health disparities research at UHCC focusing on Pacific Islanders (PI); raise awareness of cancer and cancer prevention in Guam (GU), Hawaii (HI) and the US Associated Pacific Islands (USAPI); and increase the number of cancer and biomedical science researchers of PI ancestry in the United States. An infrastructure comprising 5 principal investigators, over 30 participating faculty, administrative staff, and external and internal reviewers, backed by institutional support and NCI sponsorship, has supported 15 years of research, training, and outreach designed to reduce cancer health disparities and advance health equity among PI in GU, HI, and the USAPI. Since 2009, the Partnership has funded 18 cancer research projects addressing cancer research priorities of global and regional relevance, including cervical cancer and betel nut chewing—a traditional practice associated with oral pre/carcinoma, affecting 600 million users worldwide. Approximately 75 manuscripts have been published, approximately 100 abstracts presented, and 16 grants secured. To address the under-representation of PI in biomedical sciences, the Partnership has supported 30 graduate fellows, including 8 doctoral students at UH. Two PhD graduates are now faculty members at UOG and engaged in cancer health disparities research. UOG's Micronesian Studies Program now offers a cancer health disparities track, developed by the Partnership and tailored for the Pacific region. In addition, UOG/UHCC faculty, junior investigators, and pre/postdocs receive mentorship, career development, and summer research fellowships; to date, 8 UOG faculty have participated in the summer fellowship program at UHCC, and two have subsequently secured pilot funding. Outreach projects have explored community-based participatory approaches to youth tobacco use prevention and cessation in Guam, and the use of social networking to reduce tobacco-related cancer risk. Community-based participatory research has also led to landmark tobacco-control legislation in Guam, resulting in decreased tobacco use and increased tobacco taxes, a percentage of which supports cancer programs and patient services in Guam, including the Guam Cancer Registry. Current outreach efforts aim to increase cervical cancer screening among Micronesian migrants and build cancer-prevention knowledge and awareness among physicians who serve them in Guam and Hawaii. In conclusion, the Partnership has significantly increased research capacity at UOG and cultivated interest in cancer research among under-represented minority students at the partnering institutions. Supported by NCI grants U54CA143727 and U54CA143728. Citation Format: Carl-Wilhelm Vogel, David C. Ward, Neal A. Palafox, Hali R. Robinett, Rachael T. Leon Guerrero, John A. Peterson. University of Guam/University of Hawaii Cancer Center partnership: Fifteen years of progress in addressing cancer health disparities in Pacific Islanders [abstract]. In: Proceedings of the Eleventh AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2018 Nov 2-5; New Orleans, LA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(6 Suppl):Abstract nr C125.

Abstract D040: University of Guam/University of Hawaii Cancer Center Partnership: Sixteen years of progress in addressing cancer health disparities in Pacific Islanders

Abstract The University of Guam (UOG)/University of Hawaii Cancer Center (UHCC) Partnership aims to grow cancer research capacity at UOG, develop cancer health disparities research at UHCC focusing on Pacific Islanders (PI), raise awareness of cancer and cancer prevention in Guam (GU), Hawaii (HI) and the US Associated Pacific Islands (USAPI), and increase the number of cancer and biomedical science researchers of PI ancestry in the United States. An infrastructure comprised of 4 principal investigators, over 30 participating faculty, administrative staff, and external and internal reviewers, backed by institutional support and NCI sponsorship, has supported 16 years of research, training, and outreach designed to reduce cancer health disparities and advance health equity among PI in GU, HI, and the USAPI. Since 2009, the Partnership has funded 19 cancer research projects addressing cancer research priorities of global and regional relevance, including cervical cancer and Areca (betel) nut chewing - a traditional practice associated with oral pre/carcinoma, affecting 600 million users worldwide. Ninety peer-reviewed manuscripts have been published, over 100 abstracts presented, and 19 grants secured. To address the underrepresentation of PI in biomedical sciences, the Partnership has supported 33 graduate students including 7 doctoral students at UH. Two PhD graduates are now faculty members at UOG and engaged in cancer health disparities research. UOG’s Micronesian Studies Program now offers a cancer health disparities track, developed by the Partnership and tailored for the Pacific region. In addition, UOG/UHCC faculty, junior investigators, and pre/postdocs receive mentorship, career development, and summer research fellowships; to date, eight UOG faculty have participated in the summer fellowship program at UHCC and most had received U54pilot funding. Outreach projects have explored community-based participatory approaches to youth tobacco use prevention and cessation in Guam, and the use of social networking to reduce tobacco-related cancer risk. Community-based participatory research has also led to landmark tobacco control legislation in Guam, resulting in decreased tobacco use and increased tobacco taxes, a percentage of which supports cancer programs and patient services in Guam including the Guam Cancer Registry. Current outreach efforts aim to increase colorectal cancer screening and HPV vaccination while building knowledge and awareness among physicians who serve Pacific Islanders in Guam and Hawaii. In conclusion, research capacity at UOG has significantly increased, disparities research at UHCC has expanded, and underrepresented minority students are pursuing careers in cancer research. Supported by NCI grants U54CA143727 and U54CA143728. Citation Format: Rachael T Leon Guerrero, Margaret Hattori-Uchima, Hali R Robinett, Carl-Wilhelm Vogel, Neal A Palafox. University of Guam/University of Hawaii Cancer Center Partnership: Sixteen years of progress in addressing cancer health disparities in Pacific Islanders [abstract]. In: Proceedings of the Twelfth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2019 Sep 20-23; San Francisco, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(6 Suppl_2):Abstract nr D040.

Abstract A065: The Cancer Research Education Program (CREP): Training the next generation of cancer health disparities researchers through the Southeast Partnership for Improving Research and Training in Cancer Health Disparities (SPIRIT-CHD)

Abstract The Southeast Partnership for Improving Research and Training in Cancer Health Disparities (SPIRIT-CHD) unites Louisiana State University Health Sciences Center (LSUHSC) and Moffitt Cancer Center (MCC) to advance translational research on cancer health disparities and to establish a Cancer Research Education Program (CREP). The CREP addresses a national priority to develop an educational training pipeline for one-on-one mentoring of undergraduates and medical students by a diverse group of LSUHSC and MCC faculty with unique expertise to conduct cancer health disparities research and outreach in underserved communities. The CREP supports 8-week internships providing: (1) hands-on summer research experiences; (2) a curriculum focusing on biobanking, precision medicine, and cancer health disparities; and (3) community outreach experiences in underserved communities. The curriculum includes web-based training modules, immersion experiences (e.g., biobank tour), professional development workshops, and learning activities (e.g., book and journal clubs). Data from the students' pre/post summative (impact/outcome) evaluations determine the acceptability and impact of these research and educational activities, students' knowledge, career aspirations, goal attainment, and their satisfaction based on nationally normed scales. Baseline and post-training data will be analyzed in August, at training completion, to assess program impact. Long-term yearly follow-up data will focus on the impact of CREP on student career trajectories. These data will help modify the CREP for years 2-4 of the SPIRIT-CHD. Seventy-five percent of the student participants in the first cohort were female. Students self-identified as Black/African American non-Hispanic (62.5%), White Hispanic (25%), and Asian non-Hispanic (12.5%). Student projects included genomic, immunologic, and cellular wet-lab research (analyzing proliferation of renal cell carcinoma, RNA sequencing and bioinformatics of Luminal B breast carcinomas, expression differences of polyamine enzymes in prostate cancer) and clinical studies (detection, prevention, and treatment of anal cancer in HIV-positive populations). Dry-lab projects focused on the analysis of Behavioral Risk Factor Surveillance System to assess policy-related trends in colorectal cancer screenings, studying the effectiveness of barbers as lay health educators for skin cancer prevention, and smoking cessation among Hispanics. CREP students also participated in cancer education outreach events to explain their projects to the communities at an elevated risk for certain types of cancer. This program has applicability to undergraduate and medical students nationwide on best practices for efficacious training in cancer health disparities, precision medicine, and biobanking. Ultimately, these efforts will enhance the diversity of the cancer research workforce, while contributing to the reduction of cancer health disparities. Citation Format: Fern Tsien, Paula Gregory, Gwendolyn Quinn, Vani N. Simmons, Z'Kera Sims, Megan E. Sutter, Ayesha Umrigar, Arnold H. Zea, Cathy Meade, Clement K. Gwede. The Cancer Research Education Program (CREP): Training the next generation of cancer health disparities researchers through the Southeast Partnership for Improving Research and Training in Cancer Health Disparities (SPIRIT-CHD) [abstract]. In: Proceedings of the Eleventh AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2018 Nov 2-5; New Orleans, LA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(6 Suppl):Abstract nr A065.

Abstract D043: Éxito!: Building a new pipeline of Latino doctors and cancer researchers

Abstract Introductory sentence with purpose of study: The Éxito! Latino Cancer Research Leadership Training (Éxito!) program was developed to encourage Latino master’s level students and graduates to pursue a doctoral degree and career in Latino cancer health disparities (CHD) research. Cancer is the leading cause of death among Latinos who represent 18% of the population. However, similar to under-represented groups there is a disproportionate representation at the terminal degree level. Thus, it t is imperative that the next generation of health practitioners and researchers is representative of the diverse U.S. population and that culturally competent solutions are implemented to eliminate cancer related CHD among all ethno-cultural groups especially Latinos. Brief description of pertinent experimental procedures: Twenty-five selected participants are invited to complete an intense five-day Summer Institute (SI). The SI is led by successful Latinx researchers and Latinx role models. For the week, trainees are immersed in intense interactive learning activities, presentations on succeeding in academia/research, on how to obtain funding and tips/tools for applying and overcoming barriers in completing a doctoral degree, specific for Latinx students. Ten, 6-month internships in Latino CHD research are then available for SI alums annually. Evaluation is done through change (“post-pre” SI training) in Social Cognitive Theory based constructs of academic self-efficacy and confidence in overcoming barriers. Alumni are monitored through acceptance and completing doctoral programs. Summary of the new published data: In nine years, 200 individuals have completed SI training and 49 internships have been awarded. SI training has been associated with a significant improvement in academic self-efficacy (p < .001) as well as significant improvement in attendees’ confidence toward obtaining a doctoral degree (p < .001). Internship experiences have improved research skills (p < .001). 23% (n=46) of alumni are enrolled in a doctoral program. Eight have graduated with two more anticipated this summer. Statement of conclusions: Éxito! is an excellent model increasing the pipeline of Latino doctoral graduates and cancer researchers. Despite differences within Latinx cultures, Éxito! proves that with a shared Latinx ethnicity, students encounter very similar obstacles/concerns in continuing their education, in part because of cultural incongruence. Éxito! is framed in cultural congruence. The application of which in academia is a key concern for under-represented ethno-cultural students seeking higher education. The cultural congruence components of the Éxito! model in are generalizable to other under-represented groups as well to model not only demonstrated success in increasing the pipeline of Latinx researchers but other underrepresented biomedical researchers as well. Citation Format: Arely Perez, Daniel C. Hughes, Rena Pasick, Amelie G. Ramirez. Éxito!: Building a new pipeline of Latino doctors and cancer researchers [abstract]. In: Proceedings of the Twelfth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2019 Sep 20-23; San Francisco, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(6 Suppl_2):Abstract nr D043.

Abstract B003: The Geographic Management of Cancer Health Disparities Program “CURE Tour”: Increasing awareness of the NCI Continuing Umbrella of Research Experiences Program through outreach to Historically Black Colleges and Universities

Abstract Introduction: The Geographic Management of Cancer Health Disparities Program (GMaP) Region 1 North (R1N) is one of seven NCI GMaP Regional “hubs”, covering the states of KY, ME, MD, NH, VA, VT, WV and DC. A primary goal of GMaP R1N is to facilitate the career development of the next generation of underrepresented cancer researchers by promoting and increasing applications to the NCI Continuing Umbrella of Research Experiences (CURE) Program. CURE provides funded training opportunities to students at all career levels to ensure a continuum of career development opportunities in cancer health disparities (CHD) research. CURE is an underutilized option for training for underrepresented minority (URM) students interested in CHD research. GMaP R1N developed and piloted an outreach program targeted to Historically Black Colleges and Universities (HBCUs) with the goal of increasing interest in CHD research and increasing awareness of CURE among HBCU students. Methods: GMaP R1N staff conducted a series of planning calls with NCI GMaP staff to develop a customizable agenda for HBCU pilot events. The group decided on the name “CURE Tour” for branding purposes for promotion and advertising. The agenda for the events included: a) presentation from an experienced CHD researcher; b) presentation from a former CURE trainee regarding his/her experiences; c) introduction to the GMaP Program; and d) knowledge quiz about presentation content (with prizes for winners). GMaP R1N staff developed relationships with staff at HBCUs for promotion of the events and logistics. Pilot “CURE Tour” events were implemented in the spring of 2019. Results: A total of 99 students attended three “CURE Tour” pilot events at Delaware State University (n=38); Coppin State University (n=44); and Morgan State University (n=17). Approximately 98% of attendees were undergraduate students with 2% graduate/doctoral students. Students (n=81) completed post-event surveys. 98% reported learning something new about CHD/CURE that they did not know previously. 92% responded that the event was engaging; 63% expressed interest in CHD research; 66% said they were interested in applying for CURE funding; 96% said they would tell a friend about the event; and 90% reported that they would participate in a future event. Conclusions: The GMaP R1N “CURE Tour” pilot was effective at reaching a primarily undergraduate population of URM students at HBCUs who are interested in CHD research careers. All “CURE Tour” attendees will be tracked in the future regarding CURE funding and CHD careers. The agenda for the “CURE Tour” events was successful in keeping students engaged and providing new information to them regarding CHD research and CURE. Based on the success of the pilot, the same methods will be followed in developing future “CURE Tour” events at other HBCUs. In addition, materials and methods can be used to replicate “CURE Tour” events in other GMaP Regions and for other URM student populations. Citation Format: Mabinty Conteh, James Zabora, Laundette Jones, Mark Cromo, Julia Houston. The Geographic Management of Cancer Health Disparities Program “CURE Tour”: Increasing awareness of the NCI Continuing Umbrella of Research Experiences Program through outreach to Historically Black Colleges and Universities [abstract]. In: Proceedings of the Twelfth AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2019 Sep 20-23; San Francisco, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(6 Suppl_2):Abstract nr B003.

Abstract A015: Integrating research and outreach to increase CRC screening knowledge in underserved communities: The Geographic Management of Cancer Health Disparities Program and National Outreach Network Screen to Save partnership

Abstract Introduction: The Geographic Management of Cancer Health Disparities Program (GMaP) is a national NCI program with the goal of increasing cancer health disparities (CHD) research. GMaP Region 1 North (R1N) is one of seven GMaP Regional “hubs” based at NCI-designated cancer centers (CCs) across the country, covering the states of DE, KY, ME, MD, NH, VA, VT, WV, and the District of Columbia. The National Outreach Network (NON) is a national NCI program with the goal of conducting cancer education and outreach in underserved communities to reduce CHD. NON Community Health Educators (CHEs) are based at 38 NCI-designated CCs across the country. Six NCI-designated CCs with NON CHEs fall within the GMaP R1N coverage area. Methods: GMaP R1N staff and NON CHEs within the R1N coverage area met bimonthly to collaborate on the Screen to Save (S2S): NCI Colorectal Cancer (CRC) Outreach and Screening Initiative. The goal of S2S was to educate underserved communities on CRC and CRC screening. NON CHEs conducted the projects in diverse urban and rural communities within their CC catchment areas. Participants attended a CRC education event that provided an inflatable colon or a PowerPoint presentation and completed demographic and pre-/post-event surveys to gauge their knowledge of CRC screening. Surveys were submitted to NCI Center to Reduce Cancer Health Disparities program staff for review and data entry. Raw data files were returned to NON CHEs and shared with GMaP R1N staff for analysis. R1N staff provided research expertise to compare results between urban and rural S2S participants. Results: There were a total of 328 participants in S2S (n=200 urban; n=128 rural) in the GMaP R1N/NON coverage area. The median age of urban participants was 59.5 vs. 49.0 for rural participants. 95% of urban participants and 96.1% of rural participants reported having health insurance (public or private). 92.9% of urban and 88.1% of rural participants attained at least a high school diploma or GED. 76.5% of urban and 41.4% of rural participants reported ever being screened for CRC by any method. The percent increase between pre- and post-test scores for the educational intervention was 15% for urban vs. 13.3% for rural participants, with an overall percent increase in knowledge of 14.2%. Conclusions: The urban and rural participants were similar in educational and health insurance attainment levels. Urban residents reported much higher rates of previous CRC screening than rural residents, but this is likely due to the fact that more rural participants were younger than the recommended CRC initial screening age at the time (age 50). The S2S educational intervention was effective in increasing knowledge of CRC screening among both rural and urban participants, with similar increase between the two groups. Overall, this project demonstrated that two different yet complementary programs, GMaP and NON, can work together by utilizing program strengths to successfully implement an educational intervention conducted across a wide and diverse geographic area. Citation Format: Mark Cromo, Rhonda Boozer-Yeary, Melinda L. Rogers, Katelyn Schifano, Jenna Schiffelbein, Katherine L. Jones, Marcela Blinka, Julia F. Houston, Betsy Grossman, Lindsay Hauser, James Zabora, Mark B. Dignan, Tracy Onega. Integrating research and outreach to increase CRC screening knowledge in underserved communities: The Geographic Management of Cancer Health Disparities Program and National Outreach Network Screen to Save partnership [abstract]. In: Proceedings of the Eleventh AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2018 Nov 2-5; New Orleans, LA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(6 Suppl):Abstract nr A015.