In fast time-varying environment, orthogonal frequency division multiplexing (OFDM) systems lose the orthogonality between subcarriers due to the Doppler effect, resulting in inter-carrier interference (ICI), which greatly affects the performance of the communication system. Based on the analysis of the principle of ICI generation in time-varying environment, an ICI triple cancellation scheme is proposed to reduce the ICI of the OFDM systems in fast time-varying environment. In the scheme, the ICI self-cancellation modulation is performed at the transmitter of the OFDM system. Then, the time-varying channel is modeled as a linearly time-varying (LTV) model for ICI dual cancellation. Finally, the ICI self-cancellation demodulation is executed at the receiver of the system. Simulation experiment results show that the proposed ICI triple cancellation scheme can achieve a better effect of ICI cancellation than ICI self-cancellation scheme and ICI dual cancellation scheme, improving the performance of the communication system.