Objectives. The purpose of this study was to compare several different single-cone obturations in the gutta-percha-filled areas (PGFA), sealer-filled areas (PSFA) and voids, also determining the volumetric characteristics of the tested cones. Materials and methods. Curved mesial roots of 120 mandibular molars were instrumented using several different systems (ProTaper Next, Twisted File Adaptive, OneShape, ProTaper Universal, WaveOne and Reciproc) and filled with corresponding single cones. The teeth were then sectioned horizontally at 2, 4, 6 and 8 mm from the apex. The area values of each section were calculated and converted to percentages (PGFA, PSFA and voids) of the total area. To determine volumetric characteristics of the tested cones, 20 gutta-percha points of each tested group were scanned with CBCT using the same parameters. Results. The ProTaper Next and WaveOne groups presented the most PGFA and least PSFA. The Twisted File Adaptive group presented the least PGFA and most PSFA (p < 0.05) and the least gutta-percha volume. Conclusions. The Twisted File Adaptive system matched cones had the least volume and the least PGFA in severely curved mesiobuccal canals of mandibular first molars. Single matched cones volume varied.