In revision total knee arthroplasty (TKA), the internal diameter of metal cones may limit the ability of the stem to properly fill the medullary canal. We prospectively studied 115 patients who underwent revision TKA with uncemented stems to evaluate the effect of metal cones on mechanical alignment and stem positioning. Correction on the mechanical alignment was well achieved in all patients, regardless of whether a metal cone was used. The proportion of patients achieving restoration of neutral mechanical alignment was similar between groups, as were the mean canal fill ratio (CFR) and the proportion of patients achieving CFR ≥85%. The use of porous tantalum cones in revision TKA with uncemented stems is not an obstacle in achieving optimal mechanical alignment and stem positioning.