BACKGROUND CONTEXT Cauda equina syndrome (CES) is a devastating spinal condition without a clear consensus on evidence-based treatment guidelines and reported patient outcomes. Due to the relative infrequency of this condition at individual institutions, the majority of the studies that investigate CES are underpowered with results that are difficult to apply to the general population. PURPOSE The purpose of this investigation was to use a large, nationwide patient sample of CES patients to identify demographic and procedural trends and recognize factors that influence outcomes. STUDY DESIGN/SETTING This investigation was a retrospective cohort study that identified patients with CES registered in the Nationwide Inpatient Sample (NIS) database from 2000 to 2014. PATIENT SAMPLE Patients were identified using the International Classification of Diseases, 9th Edition, Clinical Modification (ICD-9-CM) code for cauda equina syndrome (344.61) and the ICD-9-CM procedure code for either disc excision (8051) or spinal canal exploration and decompression (0309). Demographic analysis included patient age, sex, median income per patient's zip code, and presenting institution (urban teaching vs urban non-teaching vs rural). ICD-9-CM codes for lumbar disc herniation (722.10, 722.73), spinal stenosis (724.02), tumor (198.5), postoperative hematoma (998.12), and trauma (806.4) were utilized to identify the most frequent etiologies of CES. OUTCOME MEASURES Outcome measures were retained for each observation, including inpatient mortality, total complications, postoperative length of stay, total charges, discharge disposition, average total charges and urinary catheterization rates. METHODS The impact of surgical timing on outcomes was investigated by separating patients into an early surgical intervention cohort (surgery on hospital day 0 or 1) versus a delayed intervention cohort (surgery on hospital day 2 or later). Patient outcomes and trends in the timing of surgical decompression were analyzed using linear regression. RESULTS A total of 20,924 cauda equina syndrome patients met inclusion criteria. Following adjustment for age, sex, race and median area code income, the delayed surgical intervention group was associated with significant differences including increased inpatient mortality (OR 9.60, p=.002), total complications (OR 1.41, p=.018) and non-routine discharge (OR 2.37, p CONCLUSIONS This study represents the largest investigation to date examining trends and outcomes in patients with CES. The results reveal that the timing of surgical management in CES patients has not changed appreciably from 2000-2014 despite mounting evidence of the benefit of early decompression. CES patients that undergo surgical decompression on hospital day 0 or 1 are observed to have improved inpatient outcomes, including lower complication and mortality rates. FDA DEVICE/DRUG STATUS This abstract does not discuss or include any applicable devices or drugs.
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