Background and objectives: This study aimed to Find the causes of upper gastrointestinal bleeding in Erbil hospitals and to study these causes for the purpose of reducing their mortality. Methods: One hundred cases of upper gastrointestinal bleeding have been collected. All the cases have been admitted to Erbil hospitals from March 2019 to March 2021. Demographic data, blood investigation, ultrasound, and endoscopy with rapid urease test for Helicobacter pylori infection have been done for all patients to find the cause of upper gastrointestinal bleeding. Data analysis has been done by using a statistical package for Social Sciences -22. Results: A total number of fifty seven males and fourty three females, with upper gastrointestinal bleeding were included, eighty of them had positive rapid urease test by endoscopy, seventy five patients had duodenal ulcer, six cases had gastroesophageal varices, tumors found in five patients after histopathological investigation of the endoscopic biopsies, gastric erosions found in twelve patients. Ninty five of patients had first time bleeding, low hemoglobin found in fifty nine patients, that thiry of them presented in shock state, from these patients twenty two cases received more than five units of blood. Conclusion: Upper gastrointestinal bleeding mainly has been the cause duodenal ulcer bleeding which itself has been caused by infection with Helicobacter pylori. Secondly, drugs, which had been used, have been regarded as the main causes of bleeding.