To assess in a feasibility study the mobility of persons with transfemoral amputations using data collected from a popular, consumer-oriented activity monitor (Fitbit). Observational cohort study. Research hospital outpatient evaluation. Nine subjects with transfemoral amputations (4 women and 5 men, ages 21-64 years) and Medicare functional assessments (K level) of K3 (n= 7), K2 (n= 1), and K4 (n= 1). One-week monitoring of physical activity using the Fitbit One activity monitor. Daily estimates of step counts, distance walked, floors/stairs climbed, calories burned, and proprietary Fitbit activity scores. For each day, the amount of time in each of the following levels of activity was also reported: sedentary, lightly active, fairly active, and highly active. The percentage of movement time above the fairly active level had a predictable relationship to the designated K level. The average activity measures show decreased levels of activity for obese subjects (body mass index >30). Estimated step counts were highly predictive/redundant with estimated miles walked without setting individual stride lengths. Using linear regression prediction models, calorie estimates were found to be highly dependent on subject age, height, and weight, whereas the proprietary activity score was independent of all 3 demographic factors. This feasibility study demonstrates that the Fitbit activity monitor estimates the activity of subjects with transfemoral amputations, producing results that correlate with their K-level functional activity classifications. The Fitbit activity score is independent of individual variations in age, weight, and height compared with estimated calories for this small sample size. These tools may provide useful insights into prosthetic use in an at-home environment.